Sangivamycin induces apoptosis by suppressing Erk signaling in primary effusion lymphoma cells

Biochemical and Biophysical Research Communications

Volumn 444, Issue 2, 2014, Pages 135-140

  Wakao, Kazufumi ^a   Watanabe, Tadashi ^b   Takadama, Tadatoshi ^a   Ui, Sadaharu ^a   Shigemi, Zenpei ^b   Kagawa, Hiroki ^b   Higashi, Chizuka ^a   Ohga, Rie ^a   Taira, Takahiro ^a   Fujimuro, Masahiro ^b  

^a UNIVERSITY OF YAMANASHI   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Akt; Apoptosis; Erk; KSHV; Primary effusion lymphoma; Sangivamycin

Indexed keywords

AKT; APOPTOSIS; ERK; KSHV; PRIMARY EFFUSION LYMPHOMA; SANGIVAMYCIN;

APOPTOSIS; BLOTTING, WESTERN; CASPASE 7; CASPASE 9; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 8, HUMAN; HOST-PATHOGEN INTERACTIONS; HUMANS; LYMPHOMA, PRIMARY EFFUSION; MALE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-AKT; PYRIMIDINE NUCLEOSIDES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84894528347     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.01.017     Document Type: Article

References (24)

1. D.E. Bergstrom, A.J. Brattesani, M.K. Ogawa, P.A. Reddy, M.J. Schweickert, J. Balzarini, and E. De Clercq Antiviral activity of C-5 substituted tubercidin analogues J. Med. Chem. 27 1984 285 292
2. S.R. Turk, C. Shipman Jr., R. Nassiri, G. Genzlinger, S.H. Krawczyk, L.B. Townsend, and J.C. Drach Pyrrolo[2,3-d]pyrimidine nucleosides as inhibitors of human cytomegalovirus Antimicrob. Agents Chemother. 31 1987 544 550
3. P.S. Ritch, R.I. Glazer, R.E. Cunningham, and S.E. Shackney Kinetic effects of sangivamycin in sarcoma 180 in vitro Cancer Res. 41 1981 1784 1788
4. S.A. Lee, and M. Jung The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activation J. Biol. Chem. 282 2007 15271 15283
5. M.B. Cohen, and R.I. Glazer Comparison of the cellular and RNA-dependent effects of sangivamycin and toyocamycin in human colon carcinoma cells Mol. Pharmacol. 27 1985 349 355
6. C.R. Loomis, and R.M. Bell Sangivamycin, a nucleoside analogue, is a potent inhibitor of protein kinase C J. Biol. Chem. 263 1988 1682 1692
7. M.K. Kim, Y.H. Cho, J.M. Kim, M.W. Chun, S.K. Lee, Y. Lim, and C.H. Lee Induction of apoptosis in human leukemia cells by MCS-C2 via caspase-dependent Bid cleavage and cytochrome c release Cancer Lett. 223 2005 239 247
8. J.J. Russo, R.A. Bohenzky, M.C. Chien, J. Chen, M. Yan, D. Maddalena, J.P. Parry, D. Peruzzi, I.S. Edelman, Y. Chang, and P.S. Moore Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8) Proc. Natl. Acad. Sci. U. S. A. 93 1996 14862 14867
9. R.G. Nador, E. Cesarman, A. Chadburn, D.B. Dawson, M.Q. Ansari, J. Sald, and D.M. Knowles Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus Blood 88 1996 645 656
10. Y. Chang, E. Cesarman, M.S. Pessin, F. Lee, J. Culpepper, D.M. Knowles, and P.S. Moore Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposis sarcoma Science 266 1994 1865 1869
11. A. Järviluoma, and P.M. Ojala Cell signaling pathways engaged by KSHV Biochim. Biophys. Acta 1766 2006 140 158
12. M. Fujimuro, F.Y. Wu, C. apRhys, H. Kajumbula, D.B. Young, G.S. Hayward, and S.D. Hayward A novel viral mechanism for dysregulation of β-catenin in Kaposis sarcoma-associated herpesvirus latency Nat. Med. 9 2003 300 306
13. A. Ashizawa, C. Higashi, K. Masuda, R. Ohga, T. Taira, and M. Fujimuro The Ubiquitin System and Kaposi's sarcoma-associated herpesvirus Front. Microbiol. 3 2012 66
14. P.P. Naranatt, S.M. Akula, C.A. Zien, H.H. Krishnan, and B. Chandran Kaposi's sarcoma-associated herpesvirus induces the phosphatidylinositol 3-kinase-PKC-zeta-MEK-ERK signaling pathway in target cells early during infection: implications for infectivity J. Virol. 77 2003 1524 1539
15. M.J. Smit, D. Verzijl, P. Casarosa, M. Navis, H. Timmerman, and R. Leurs Kaposi's sarcoma-associated herpesvirus-encoded G protein-coupled receptor ORF74 constitutively activates p44/p42 MAPK and Akt via G(i) and phospholipase C-dependent signaling pathways J. Virol. 76 2002 1744 1752
16. A. Cohen, C. Brodie, and R. Sarid An essential role of ERK signaling in TPA-induced reactivation of Kaposi's sarcoma-associated herpesvirus J. Gen. Virol. 87 2006 795 802
17. C. Saji, C. Higashi, Y. Niinaka, K. Yamada, K. Noguchi, and M. Fujimuro Proteasome inhibitors induce apoptosis and reduce viral replication in primary effusion lymphoma cells Biochem. Biophys. Res. Commun. 415 2011 573 578
18. M. Fujimuro, J. Liu, J. Zhu, H. Yokosawa, and S.D. Hayward Regulation of the interaction between glycogen synthase kinase 3 and the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen J. Virol. 79 2005 10429 10441
19. C. Higashi, C. Saji, K. Yamada, H. Kagawa, R. Ohga, T. Taira, and M. Fujimuro The effects of heat shock protein 90 inhibitors on apoptosis and viral replication in primary effusion lymphoma cells Biol. Pharm. Bull. 35 2012 725 730
20. P.M. Chaudhary, A. Jasmin, M.T. Eby, and L. Hood Modulation of the NF-κ B pathway by virally encoded death effector domains-containing proteins Oncogene 18 1999 5738 5746
21. T.J. Nelson, M.K. Sun, J. Hongpaisan, and D.L. Alkon Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair Eur. J. Pharmacol. 585 2008 76 87
22. S. Montaner, A. Sodhi, S. Pece, E.A. Mesri, and J.S. Gutkind The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor promotes endothelial cell survival through the activation of Akt/protein kinase B Cancer Res. 61 2001 2641 2648
23. J.M. Haughian, E.M. Reno, A.M. Thorne, and A.P. Bradford Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis Int. J. Cancer 125 2009 2556 2564
24. C.M. Klass, L.T. Krug, V.P. Pozharskaya, and M.K. Offermann The targeting of primary effusion lymphoma cells for apoptosis by inducing lytic replication of human herpesvirus 8 while blocking virus production Blood 105 2005 4028 4034 and Technology