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Volumn 67, Issue 1, 2014, Pages 21-28

Safety and feasibility of long term administration of recombinant human granulocyte-colony stimulating factor in patients with amyotrophic lateral sclerosis

Author keywords

ALS; Amyotrophic lateral sclerosis; G CSF; Granulocyte colony stimulating factor

Indexed keywords

RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE COLONY STIMULATING FACTOR; NEUROPROTECTIVE AGENT; RECOMBINANT PROTEIN;

EID: 84894527844     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2014.02.003     Document Type: Article
Times cited : (19)

References (46)
  • 2
    • 77953503937 scopus 로고    scopus 로고
    • Riluzole, neuroprotection and amyotrophic lateral sclerosis
    • 1942-1959
    • Cheah B.C., Vucic S., Krishnan A.V., Kiernan M.C. Riluzole, neuroprotection and amyotrophic lateral sclerosis. Curr Med Chem 2010, 17. 1942-1959.
    • (2010) Curr Med Chem , vol.17
    • Cheah, B.C.1    Vucic, S.2    Krishnan, A.V.3    Kiernan, M.C.4
  • 3
    • 77649284778 scopus 로고    scopus 로고
    • G-CSF protects motoneurons against axotomy-induced apoptotic death in neonatal mice
    • Henriques A., Pitzer C., Dupuis L., Schneider A. G-CSF protects motoneurons against axotomy-induced apoptotic death in neonatal mice. BMC Neurosci 2010, 11:25.
    • (2010) BMC Neurosci , vol.11 , pp. 25
    • Henriques, A.1    Pitzer, C.2    Dupuis, L.3    Schneider, A.4
  • 4
    • 58149119552 scopus 로고    scopus 로고
    • Granulocyte-colony stimulating factor improves outcome in a mouse model of amyotrophic lateral sclerosis
    • Pitzer C., Krüger C., Plaas C., Kirsch F., Dittgen T., Müller R., et al. Granulocyte-colony stimulating factor improves outcome in a mouse model of amyotrophic lateral sclerosis. Brain 2008, 131:3335-3347.
    • (2008) Brain , vol.131 , pp. 3335-3347
    • Pitzer, C.1    Krüger, C.2    Plaas, C.3    Kirsch, F.4    Dittgen, T.5    Müller, R.6
  • 5
    • 79959618231 scopus 로고    scopus 로고
    • Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis
    • Pollari E., Savchenko E., Jaronen M., Kanninen K., Malm T., Wojciechowski S., et al. Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis. J Neuroinflammation 2011, 8:74.
    • (2011) J Neuroinflammation , vol.8 , pp. 74
    • Pollari, E.1    Savchenko, E.2    Jaronen, M.3    Kanninen, K.4    Malm, T.5    Wojciechowski, S.6
  • 6
    • 78650310477 scopus 로고    scopus 로고
    • Restoration of microglial function by granulocyte-colony stimulating factor in ALS model mice
    • Yamasaki R., Tanaka M., Fukunaga M., Tateishi T., Kikuchi H., Motomura K., et al. Restoration of microglial function by granulocyte-colony stimulating factor in ALS model mice. J Neuroimmunol 2010, 229:51-62.
    • (2010) J Neuroimmunol , vol.229 , pp. 51-62
    • Yamasaki, R.1    Tanaka, M.2    Fukunaga, M.3    Tateishi, T.4    Kikuchi, H.5    Motomura, K.6
  • 7
    • 23644445498 scopus 로고    scopus 로고
    • The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis
    • Schneider A., Kruger C., Steigleder T., Weber D., Pitzer C., Laage R., et al. The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis. J Clin Invest 2005, 115:2083-2098.
    • (2005) J Clin Invest , vol.115 , pp. 2083-2098
    • Schneider, A.1    Kruger, C.2    Steigleder, T.3    Weber, D.4    Pitzer, C.5    Laage, R.6
  • 8
    • 0037293264 scopus 로고    scopus 로고
    • Fetal human hematopoietic stem cells can differentiate sequentially into neural stem cells and then astrocytes in vitro
    • Hao H.N., Zhao J., Thomas R.L., Parker G.C., Lyman W.D. Fetal human hematopoietic stem cells can differentiate sequentially into neural stem cells and then astrocytes in vitro. J Hematother Stem Cell Res 2003, 12:23-32.
    • (2003) J Hematother Stem Cell Res , vol.12 , pp. 23-32
    • Hao, H.N.1    Zhao, J.2    Thomas, R.L.3    Parker, G.C.4    Lyman, W.D.5
  • 10
    • 37249090235 scopus 로고    scopus 로고
    • Detection and quantification of functionally defined hematopoietic progenitor cells and tissue specific mRNA within the peripheral blood of myeloma patients after administration of granulocyte colony-stimulating factor and erythropoietin
    • Grassinger J., Mueller G., Hart C., Nilsson S.K., Haylock D.N., Andreesen R., et al. Detection and quantification of functionally defined hematopoietic progenitor cells and tissue specific mRNA within the peripheral blood of myeloma patients after administration of granulocyte colony-stimulating factor and erythropoietin. Eur J Haematol 2008, 80:20-30.
    • (2008) Eur J Haematol , vol.80 , pp. 20-30
    • Grassinger, J.1    Mueller, G.2    Hart, C.3    Nilsson, S.K.4    Haylock, D.N.5    Andreesen, R.6
  • 11
    • 78751665486 scopus 로고    scopus 로고
    • Repeated courses of granulocyte colony-stimulating factor in amyotrophic lateral sclerosis: clinical and biological results from a prospective multicenter study
    • Chio A., Mora G., La Bella V., Caponnetto C., Mancardi G., Sabatelli M., et al. Repeated courses of granulocyte colony-stimulating factor in amyotrophic lateral sclerosis: clinical and biological results from a prospective multicenter study. Muscle Nerve 2011, 43:189-195.
    • (2011) Muscle Nerve , vol.43 , pp. 189-195
    • Chio, A.1    Mora, G.2    La Bella, V.3    Caponnetto, C.4    Mancardi, G.5    Sabatelli, M.6
  • 12
    • 79952680419 scopus 로고    scopus 로고
    • G-CSF prevents the progression of structural disintegration of white matter tracts in amyotrophic lateral sclerosis: a pilot trial
    • Duning T., Schiffbauer H., Warnecke T., Mohammadi S., Floel A., Kolpatzik K., et al. G-CSF prevents the progression of structural disintegration of white matter tracts in amyotrophic lateral sclerosis: a pilot trial. PLoS One 2011, 6:e17770.
    • (2011) PLoS One , vol.6
    • Duning, T.1    Schiffbauer, H.2    Warnecke, T.3    Mohammadi, S.4    Floel, A.5    Kolpatzik, K.6
  • 13
    • 75449087365 scopus 로고    scopus 로고
    • Consistent bone marrow-derived cell mobilization following repeated short courses of granulocyte-colony-stimulating factor in patients with amyotrophic lateral sclerosis: results from a multicenter prospective trial
    • Tarella C., Rutella S., Gualandi F., Melazzini M., Scime R., Petrini M., et al. Consistent bone marrow-derived cell mobilization following repeated short courses of granulocyte-colony-stimulating factor in patients with amyotrophic lateral sclerosis: results from a multicenter prospective trial. Cytotherapy 2010, 12:50-59.
    • (2010) Cytotherapy , vol.12 , pp. 50-59
    • Tarella, C.1    Rutella, S.2    Gualandi, F.3    Melazzini, M.4    Scime, R.5    Petrini, M.6
  • 14
    • 0020960887 scopus 로고
    • Purification of a factor inducing differentiation in murine myelomonocytic leukemia cells. Identification as granulocyte colony-stimulating factor
    • Nicola N.A., Metcalf D., Matsumoto M., Johnson G.R. Purification of a factor inducing differentiation in murine myelomonocytic leukemia cells. Identification as granulocyte colony-stimulating factor. J Biol Chem 1983, 258:9017-9023.
    • (1983) J Biol Chem , vol.258 , pp. 9017-9023
    • Nicola, N.A.1    Metcalf, D.2    Matsumoto, M.3    Johnson, G.R.4
  • 15
    • 0027460675 scopus 로고
    • Mobilization of hematopoietic stem and progenitor cell subpopulations from the marrow to the blood of mice following cyclophosphamide and/or granulocyte colony-stimulating factor
    • Neben S., Marcus K., Mauch P. Mobilization of hematopoietic stem and progenitor cell subpopulations from the marrow to the blood of mice following cyclophosphamide and/or granulocyte colony-stimulating factor. Blood 1993, 81:1960-1967.
    • (1993) Blood , vol.81 , pp. 1960-1967
    • Neben, S.1    Marcus, K.2    Mauch, P.3
  • 16
    • 0023807286 scopus 로고
    • In vitro and in vivo analysis of the effects of recombinant human granulocyte colony-stimulating factor in patients
    • Bronchud M.H., Potter M.R., Morgenstern G., Blasco M.J., Scarffe J.H., Thatcher N., et al. In vitro and in vivo analysis of the effects of recombinant human granulocyte colony-stimulating factor in patients. Br J Cancer 1988, 58:64-69.
    • (1988) Br J Cancer , vol.58 , pp. 64-69
    • Bronchud, M.H.1    Potter, M.R.2    Morgenstern, G.3    Blasco, M.J.4    Scarffe, J.H.5    Thatcher, N.6
  • 17
    • 27644517442 scopus 로고    scopus 로고
    • G-CSF potently inhibits osteoblast activity and CXCL12mRNA expression in the bone marrow
    • Semerad C.L., Christopher M.J., Liu F., Short B., Simmons P.J., Winkler I., et al. G-CSF potently inhibits osteoblast activity and CXCL12mRNA expression in the bone marrow. Blood 2005, 106:3020-3027.
    • (2005) Blood , vol.106 , pp. 3020-3027
    • Semerad, C.L.1    Christopher, M.J.2    Liu, F.3    Short, B.4    Simmons, P.J.5    Winkler, I.6
  • 18
    • 56349137097 scopus 로고    scopus 로고
    • Degradation of BM SDF-1 by MMP-9: the role in G-CSF-induced hematopoietic stem/progenitor cell mobilization
    • Jin F., Zhai Q., Qiu L., Meng H., Zou D., Wang Y., et al. Degradation of BM SDF-1 by MMP-9: the role in G-CSF-induced hematopoietic stem/progenitor cell mobilization. Bone Marrow Transplant 2008, 42:581-588.
    • (2008) Bone Marrow Transplant , vol.42 , pp. 581-588
    • Jin, F.1    Zhai, Q.2    Qiu, L.3    Meng, H.4    Zou, D.5    Wang, Y.6
  • 19
    • 0036265635 scopus 로고    scopus 로고
    • Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment
    • Lévesque J., Hendy J., Takamatsu Y., Williams B., Winkler I., Simmons P. Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment. Exp Hematol 2002, 30:440-449.
    • (2002) Exp Hematol , vol.30 , pp. 440-449
    • Lévesque, J.1    Hendy, J.2    Takamatsu, Y.3    Williams, B.4    Winkler, I.5    Simmons, P.6
  • 20
    • 0026315815 scopus 로고
    • Recombinant human granulocyte-colony-stimulating factor in the treatment of patients with neutropenia
    • Boxer L.A., Hutchinson R., Emerson S. Recombinant human granulocyte-colony-stimulating factor in the treatment of patients with neutropenia. Clin Immunol Immunopathol 1992, 62:S39-S46.
    • (1992) Clin Immunol Immunopathol , vol.62
    • Boxer, L.A.1    Hutchinson, R.2    Emerson, S.3
  • 21
    • 0023585071 scopus 로고
    • Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer
    • Bronchud M.H., Scarffe J.H., Thatcher N., Crowther D., Souza L.M., Alton N.K., et al. Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer. Br J Cancer 1987, 56:809-813.
    • (1987) Br J Cancer , vol.56 , pp. 809-813
    • Bronchud, M.H.1    Scarffe, J.H.2    Thatcher, N.3    Crowther, D.4    Souza, L.M.5    Alton, N.K.6
  • 22
    • 0028340717 scopus 로고
    • G-CSF-mobilized peripheral blood progenitor cells for allogeneic transplantation: safety, kinetics of mobilization, and composition of the graft
    • Dreger P., Haferlach T., Eckstein V., Jacobs S., Suttorp M., Löffler H., et al. G-CSF-mobilized peripheral blood progenitor cells for allogeneic transplantation: safety, kinetics of mobilization, and composition of the graft. Br J Haematol 1994, 87:609-613.
    • (1994) Br J Haematol , vol.87 , pp. 609-613
    • Dreger, P.1    Haferlach, T.2    Eckstein, V.3    Jacobs, S.4    Suttorp, M.5    Löffler, H.6
  • 23
    • 0034574407 scopus 로고    scopus 로고
    • Diseases WFoNRGoMN. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis
    • Brooks B.R., Miller R.G., Swash M., Munsat T.L. Diseases WFoNRGoMN. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 2000, 1:293-299.
    • (2000) Amyotroph Lateral Scler Other Motor Neuron Disord , vol.1 , pp. 293-299
    • Brooks, B.R.1    Miller, R.G.2    Swash, M.3    Munsat, T.L.4
  • 25
    • 80052397641 scopus 로고    scopus 로고
    • Mobilization of hematopoietic stem cells from the bone marrow niche to the blood compartment
    • Hoggatt J., Pelus L.M. Mobilization of hematopoietic stem cells from the bone marrow niche to the blood compartment. Stem Cell Res Ther 2011, 2:13.
    • (2011) Stem Cell Res Ther , vol.2 , pp. 13
    • Hoggatt, J.1    Pelus, L.M.2
  • 26
    • 0030945058 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor receptor at various differentiation stages of normal and leukemic hematopoietic cells
    • Shinjo K., Takeshita A., Ohnishi K., Ohno R. Granulocyte colony-stimulating factor receptor at various differentiation stages of normal and leukemic hematopoietic cells. Leuk Lymphoma 1997, 25:37-46.
    • (1997) Leuk Lymphoma , vol.25 , pp. 37-46
    • Shinjo, K.1    Takeshita, A.2    Ohnishi, K.3    Ohno, R.4
  • 28
    • 1842430607 scopus 로고    scopus 로고
    • Acute myelogenous leukemia in a donor after granulocyte colony-stimulating factor-primed peripheral blood stem cell harvest
    • Makita K., Ohta K., Mugitani A., Hagihara K., Ohta T., Yamane T., et al. Acute myelogenous leukemia in a donor after granulocyte colony-stimulating factor-primed peripheral blood stem cell harvest. Bone Marrow Transplant 2004, 33:661-665.
    • (2004) Bone Marrow Transplant , vol.33 , pp. 661-665
    • Makita, K.1    Ohta, K.2    Mugitani, A.3    Hagihara, K.4    Ohta, T.5    Yamane, T.6
  • 29
    • 33847758628 scopus 로고    scopus 로고
    • Acute myeloid leukemia or myelodysplastic syndrome following use of granulocyte colony-stimulating factors during breast cancer adjuvant chemotherapy
    • Hershman D., Neugut A.I., Jacobson J.S., Wang J., Tsai W.Y., McBride R., et al. Acute myeloid leukemia or myelodysplastic syndrome following use of granulocyte colony-stimulating factors during breast cancer adjuvant chemotherapy. J Natl Cancer Inst 2007, 99:196-205.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 196-205
    • Hershman, D.1    Neugut, A.I.2    Jacobson, J.S.3    Wang, J.4    Tsai, W.Y.5    McBride, R.6
  • 30
    • 34547182356 scopus 로고    scopus 로고
    • Granulocyte-colony stimulating factor administration to healthy individuals and persons with chronic neutropenia or cancer: an overview of safety considerations from the Research on Adverse Drug Events and Reports project
    • Tigue C.C., McKoy J.M., Evens A.M., Trifilio S.M., Tallman M.S., Bennett C.L. Granulocyte-colony stimulating factor administration to healthy individuals and persons with chronic neutropenia or cancer: an overview of safety considerations from the Research on Adverse Drug Events and Reports project. Bone Marrow Transplant 2007, 40:185-192.
    • (2007) Bone Marrow Transplant , vol.40 , pp. 185-192
    • Tigue, C.C.1    McKoy, J.M.2    Evens, A.M.3    Trifilio, S.M.4    Tallman, M.S.5    Bennett, C.L.6
  • 31
    • 0028474547 scopus 로고
    • Secondary myelodysplastic syndromes and leukemias
    • Giles F.J., Koeffler H.P. Secondary myelodysplastic syndromes and leukemias. Curr Opin Hematol 1994, 1:256-260.
    • (1994) Curr Opin Hematol , vol.1 , pp. 256-260
    • Giles, F.J.1    Koeffler, H.P.2
  • 33
    • 84881369765 scopus 로고    scopus 로고
    • Long-term follow up of patients proceeding to transplant using plerixafor mobilized stem cells and incidence of secondary myelodysplastic syndrome/AML
    • Deol A., Abrams J., Masood A., Al-Kadhimi Z., Abidi M.H., Ayash L., et al. Long-term follow up of patients proceeding to transplant using plerixafor mobilized stem cells and incidence of secondary myelodysplastic syndrome/AML. Bone Marrow Transplant 2013, 48(8):1112-1116.
    • (2013) Bone Marrow Transplant , vol.48 , Issue.8 , pp. 1112-1116
    • Deol, A.1    Abrams, J.2    Masood, A.3    Al-Kadhimi, Z.4    Abidi, M.H.5    Ayash, L.6
  • 34
    • 33845445939 scopus 로고    scopus 로고
    • Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches
    • Sugiyama T., Kohara H., Noda M., Nagasawa T. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 2006, 25:977-988.
    • (2006) Immunity , vol.25 , pp. 977-988
    • Sugiyama, T.1    Kohara, H.2    Noda, M.3    Nagasawa, T.4
  • 36
    • 0032817697 scopus 로고    scopus 로고
    • Repeated peripheral stem cell mobilization in healthy donors: time-dependent changes in mobilization efficiency
    • Tichelli A., Passweg J., Hoffmann T., Gregor M., Kühne T., Favre G., et al. Repeated peripheral stem cell mobilization in healthy donors: time-dependent changes in mobilization efficiency. Br J Haematol 1999, 106:152-158.
    • (1999) Br J Haematol , vol.106 , pp. 152-158
    • Tichelli, A.1    Passweg, J.2    Hoffmann, T.3    Gregor, M.4    Kühne, T.5    Favre, G.6
  • 37
    • 0036327552 scopus 로고    scopus 로고
    • Second mobilization and collection of peripheral blood progenitor cells in healthy donors is associated with lower CD34(+) cell yields
    • De la Rubia J., Arbona C., Del Canizo C., Arrieta R., De Arriba F., Pascual M.J., et al. Second mobilization and collection of peripheral blood progenitor cells in healthy donors is associated with lower CD34(+) cell yields. J Hematother Stem Cell Res 2002, 11:705-709.
    • (2002) J Hematother Stem Cell Res , vol.11 , pp. 705-709
    • De la Rubia, J.1    Arbona, C.2    Del Canizo, C.3    Arrieta, R.4    De Arriba, F.5    Pascual, M.J.6
  • 38
    • 0031053943 scopus 로고    scopus 로고
    • Peripheral blood stem cell apheresis in normal donors: feasibility and yield of second collections
    • Anderlini P., Lauppe J., Przepiorka D., Seong D., Champlin R., Körbling M. Peripheral blood stem cell apheresis in normal donors: feasibility and yield of second collections. Br J Haematol 1997, 96:415-417.
    • (1997) Br J Haematol , vol.96 , pp. 415-417
    • Anderlini, P.1    Lauppe, J.2    Przepiorka, D.3    Seong, D.4    Champlin, R.5    Körbling, M.6
  • 39
    • 84882280333 scopus 로고    scopus 로고
    • Predictors of unsuccessful mobilization with granulocyte colony-stimulating factor alone in patients undergoing autologous hematopoietic stem cell transplantation
    • Chow S., Lazo-Langner A., Ormond G., Howson-Jan K., Xenocostas A. Predictors of unsuccessful mobilization with granulocyte colony-stimulating factor alone in patients undergoing autologous hematopoietic stem cell transplantation. J Clin Apher 2013.
    • (2013) J Clin Apher
    • Chow, S.1    Lazo-Langner, A.2    Ormond, G.3    Howson-Jan, K.4    Xenocostas, A.5
  • 40
    • 78349254580 scopus 로고    scopus 로고
    • Mobilization strategies in hard-to-mobilize patients with lymphoid malignancies
    • Jantunen E., Kvalheim G. Mobilization strategies in hard-to-mobilize patients with lymphoid malignancies. Eur J Haematol 2010, 85:463-471.
    • (2010) Eur J Haematol , vol.85 , pp. 463-471
    • Jantunen, E.1    Kvalheim, G.2
  • 41
    • 54249107906 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor induces osteoblast apoptosis and inhibits osteoblast differentiation
    • Christopher M.J., Link D.C. Granulocyte colony-stimulating factor induces osteoblast apoptosis and inhibits osteoblast differentiation. J Bone Miner Res 2008, 23:1765-1774.
    • (2008) J Bone Miner Res , vol.23 , pp. 1765-1774
    • Christopher, M.J.1    Link, D.C.2
  • 42
    • 21344474104 scopus 로고    scopus 로고
    • Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells
    • Nilsson S.K., Johnston H.M., Whitty G.A., Williams B., Webb R.J., Denhardt D.T., et al. Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells. Blood 2005, 106:1232-1239.
    • (2005) Blood , vol.106 , pp. 1232-1239
    • Nilsson, S.K.1    Johnston, H.M.2    Whitty, G.A.3    Williams, B.4    Webb, R.J.5    Denhardt, D.T.6
  • 43
    • 36749049256 scopus 로고    scopus 로고
    • Bone morphogenetic protein (BMP)-7 but not BMP-2 and BMP-4 improves maintenance of primitive peripheral blood-derived hematopoietic progenitor cells (HPC) cultured in serum-free medium supplemented with early acting cytokines
    • Grassinger J., Simon M., Mueller G., Drewel D., Andreesen R., Hennemann B. Bone morphogenetic protein (BMP)-7 but not BMP-2 and BMP-4 improves maintenance of primitive peripheral blood-derived hematopoietic progenitor cells (HPC) cultured in serum-free medium supplemented with early acting cytokines. Cytokine 2007, 40:165-171.
    • (2007) Cytokine , vol.40 , pp. 165-171
    • Grassinger, J.1    Simon, M.2    Mueller, G.3    Drewel, D.4    Andreesen, R.5    Hennemann, B.6
  • 44
    • 0032079745 scopus 로고    scopus 로고
    • Interactions of erythropoietin, granulocyte colony-stimulating factor, stem cell factor, and interleukin-11 on murine hematopoiesis during simultaneous administration
    • Roeder I., de Haan G., Engel C., Nijhof W., Dontje B., Loeffler M. Interactions of erythropoietin, granulocyte colony-stimulating factor, stem cell factor, and interleukin-11 on murine hematopoiesis during simultaneous administration. Blood 1998, 91:3222-3229.
    • (1998) Blood , vol.91 , pp. 3222-3229
    • Roeder, I.1    de Haan, G.2    Engel, C.3    Nijhof, W.4    Dontje, B.5    Loeffler, M.6


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