Are women more susceptible than men to drug-induced QT prolongation? Concentration-QTc modelling in a phase 1 study with oral rac-sotalol

British Journal of Clinical Pharmacology

Volumn 77, Issue 3, 2014, Pages 522-531

  Darpo, Borje ^a   Karnad, Dilip R ^b   Badilini, Fabio ^c   Florian, Jeff ^d   Garnett, Christine E ^e   Kothari, Snehal ^b   Panicker, Gopi Krishna ^b   Sarapa, Nenad ^f  

^a DANDERYD HOSPITAL   (Sweden)

^b IQVIA   (United States)

^c AMPS LLC   (United States)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^e CERTARA   (United States)

^f HOFFMANN LA ROCHE INC   (United States)

Author keywords

gender; gender difference; PK PD; QT prolongation; QT QTc; rac sotalol

Indexed keywords

GENDER; GENDER DIFFERENCE; PK/PD; QT PROLONGATION; QT/QTC; RAC-SOTALOL;

ADMINISTRATION, ORAL; ADRENERGIC BETA-ANTAGONISTS; ANTI-ARRHYTHMIA AGENTS; DRUG ADMINISTRATION SCHEDULE; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; HUMANS; LINEAR MODELS; LONG QT SYNDROME; MALE; RISK ASSESSMENT; RISK FACTORS; SEX FACTORS; SOTALOL;

EID: 84894504531     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/bcp.12201     Document Type: Article

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