Gabapentin is ineffective as an analgesic adjunct in the immediate postburn period

Journal of Burn Care and Research

Volumn 35, Issue 2, 2014, Pages 136-142

  Wibbenmeyer, Lucy ^a   Eid, Anas ^a   Liao, Junlin ^a   Heard, Jason ^a   Horsfield, Aaron ^a   Kral, Lee ^a   Kealey, Pat ^a   Rosenquist, Richard ^b  

^a UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AMINES; ANALGESICS; BURN UNITS; BURNS; CYCLOHEXANECARBOXYLIC ACIDS; DOUBLE-BLIND METHOD; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; MALE; PAIN; PAIN MANAGEMENT; PAIN MEASUREMENT; PLACEBOS; PROSPECTIVE STUDIES; QUESTIONNAIRES; TREATMENT OUTCOME;

EID: 84894481432     PISSN: 1559047X     EISSN: 15590488     Source Type: Journal    
DOI: 10.1097/BCR.0b013e31828a4828     Document Type: Article

References (33)

1. Faucher L, Furukawa K. Practice guidelines for the management of pain. J Burn Care Res. 2006;27(5):659-68.
2. Summer GJ, Puntillo KA, Miaskowski C, Green PG, Levine JD. Burn injury pain: the continuing challenge. J Pain. 2007;8(7):533-48. Epub 2007 Apr 2016.
3. Carrougher GJ, Ptacek JT, Sharar SR, et al. Comparison of patient satisfaction and self-reports of pain in adult burninjured patients. J Burn Care Rehabil. 2003;24(1):1-8.
4. Edwards RR, Magyar-Russell G, Thombs B, et al. Acute pain at discharge from hospitalization is a prospective predictor of long-term suicidal ideation after burn injury. Arch Phys Med Rehabil 2007;88(12 Suppl 2):S36-42.
5. Edwards RR, Smith MT, Klick B, et al. Symptoms of depression and anxiety as unique predictors of pain-related outcomes following burn injury. Ann Behav Med 2007;34(3):313-22.
6. Patterson DR, Tininenko J, Ptacek JT. Pain during burn hospitalization predicts long-term outcome. J Burn Care Res 2006;27(5):719-26.
7. Ptacek JT, Patterson DR, Montgomery BK, Heimbach DM. Pain, coping, and adjustment in patients with burns: preliminary findings from a prospective study. J Pain Symptom Manage 1995;10:446-55.
8. Dray A. Neuropathic pain: emerging treatments. Br J Anaesth 2008;101(1):48-58.
9. Woolf CJ. A new strategy for the treatment of inflammatory pain. Prevention or elimination of central sensitization. Drugs 1994;47(Suppl 5):1-9; discussion 46-7.
10. Junger H, Moore AC, Sorkin LS. Effects of full-thickness burns on nociceptor sensitization in anesthetized rats. Burns 2002;28(8):772-7.
11. Siddall PJ, Cousins MJ. Persistent pain as a disease entity: implications for clinical management. Anesth Analg 2004;99:510-20, table of contents.
12. Cuignet O, Pirson J, Soudon O, Zizi M. Effects of gabapentin on morphine consumption and pain in severely burned patients. Burns 2007;33:81-6.
13. Jun JH, Yaksh TL. The effect of intrathecal gabapentin and 3-isobutyl gamma-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat. Anesth Analg 1998;86:348-54.
14. Partridge BJ, Chaplan SR, Sakamoto E, Yaksh TL. Characterization of the effects of gabapentin and 3-isobutylgamma-aminobutyric acid on substance P-induced thermal hyperalgesia. Anesthesiology 1998;88:196-205.
15. Werner MU, Perkins FM, Holte K, Pedersen JL, Kehlet H. Effects of gabapentin in acute inflammatory pain in humans. Reg Anesth Pain Med 2001;26(4):322-8.
16. Gray P, Williams B, Cramond T. Successful use of gabapentin in acute pain management following burn injury: a case series. Pain Med 2008;9(3):371-6.
17. Fishbain DA, Lewis JE, Cutler R, Cole B, Rosomoff HL, Rosomoff RS. Can the neuropathic pain scale discriminate between non-neuropathic and neuropathic pain? Pain Med 2008;9(2):149-60.
18. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983;67(6):361-70
19. Bergner M, Bobbitt RA, Carter WB, Gilson BS. The Sickness Impact Profile: development and final revision of a health status measure. Med Care 1981;19:787-805.
20. Derogatis LR, Melisaratos N. The Brief Symptom Inventory: an introductory report. Psychol Med 1983;13:595-605.
21. University of Iowa Carver College of Medicine, Adult Opioid Reference Guide, revised 4/2005.-guideline.pdf-guideline.pdf. Accessed August 2012.
22. http://www.compassionandsupport.org/pdfs/professionals/pain/ methadone-dose
23. Clinical Anesthesia Procedures of the Massachusetts General Hospital: Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School: Lippincott, Williams and Wilkins Handbook Series; 2012.
24. http://dassa.sa.gov.au/webdata/resources/files/Benzo-Conversion-Chart. pdf. Accessed June 2012.
25. http://www.anaesthetist.com/icu/manage/drugs/ethanol/aws/Findex. htm#index.htm. Accessed August 2012.
26. Tschudy MM, Arcara KM. The Harriet Lane handbook: a manual for pediatric house officers. Philadelphia, PA: Mosby Elsevier; 2011.
27. Gilron I. Gabapentin and pregabalin for chronic neuropathic and early postsurgical pain: current evidence and future directions. Curr Opin Anaesthesiol 2007;20(5):456-72.
28. Pandey CK, Navkar DV, Giri PJ, et al. Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, doubleblind, placebo-controlled study. J Neurosurg Anesthesiol 2005;17:65-8.
29. Bockbrader HN, Wesche D, Miller R, Chapel S, Janiczek N, Burger P. A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin. Clin Pharmacokinet 2010;49:661-9.
30. Rice AS, Maton S; Postherpetic Neuralgia Study Group. Gabapentin in postherpetic neuralgia: a randomised, double blind, placebo controlled study. Pain 2001;94: 215-24.
31. Rowbotham M, Harden N, Stacey B, Bernstein P, Magnus-Miller L. Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. JAMA 1998;280:1837-42.
32. Blanchet B, Jullien V, Vinsonneau C, Tod M. Influence of burns on pharmacokinetics and pharmacodynamics of drugs used in the care of burn patients. Clin Pharmacokinet 2008;47:635-54.
33. Field MJ, Oles RJ, Lewis AS, McCleary S, Hughes J, Singh L. Gabapentin (neurontin) and S-(+)-3-isobutylgaba represent a novel class of selective antihyperalgesic agents. Br J Pharmacol 1997;121:1513-22.