Suramin is a novel activator of PP5 and biphasically modulates S100-activated PP5 activity

Applied Biochemistry and Biotechnology

Volumn 172, Issue 1, 2014, Pages 237-247

  Yamaguchi, Fuminori ^a   Yamamura, Sho ^a   Shimamoto, Seiko ^a   Tokumitsu, Hiroshi ^a   Tokuda, Masaaki ^a   Kobayashi, Ryoji ^a  

^a KAGAWA UNIVERSITY   (Japan)

Author keywords

Hsp90; Protein phosphatase 5; S100 protein; Suramin; Tetratricopeptide repeat

Indexed keywords

DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HSP90 HEAT-SHOCK PROTEINS; HUMANS; NUCLEAR PROTEINS; PHOSPHOPROTEIN PHOSPHATASES; PROTEIN STRUCTURE, TERTIARY; S100 PROTEINS; SURAMIN;

EID: 84894478771     PISSN: 02732289     EISSN: 15590291     Source Type: Journal    
DOI: 10.1007/s12010-013-0522-6     Document Type: Article

References (39)

1. Hawking, F. (1978). Suramin: with special reference to onchocerciasis. Advances in Pharmacology and Chemotherapy, 15, 289-322.
2. Larsen, A. K. (1993). Suramin: an anticancer drug with unique biological effects. Cancer Chemotherapy and Pharmacology, 32, 96-98.
3. Siafaka-Kapadai, A.; Svetlov, S.; Hanahan, D. J.; Javors, M. A. (1998). Effects of suramin on human platelet aggregation and Ca2+ mobilization induced by thrombin and other agonists. Life Sciences, 63, 1769-1777.
4. De Clercq, E. (1979). Suramin: a potent inhibitor of the reverse transcriptase of RNA tumor viruses. Cancer Letters, 8, 9-22.
5. Fortes, P. A.; Ellory, J. C.; Lew, V. L. (1973). Suramin: a potent ATPase inhibitor which acts on the inside surface of the sodium pump. Biochimica et Biophysica Acta, 318, 262-272.
6. Daller, J. A.; Buckley, A. R.; Van Hook, F. W.; Buckley, D. J.; Putnam, C. W. (1994). Suramin, a protein kinase C inhibitor, impairs hepatic regeneration. Cell Growth and Differentiation, 5, 761-767.
7. Klinger, M.; Freissmuth, M.; Nickel, P.; Stabler-Schwarzbart, M.; Kassack, M.; Suko, J.; et al. (1999). Suramin and suramin analogs activate skeletal muscle ryanodine receptor via a calmodulin binding site. Molecular Pharmacology, 55, 462-472.
8. Klinger, M.; Bofill-Cardona, E.; Mayer, B.; Nanoff, C.; Freissmuth, M.; Hohenegger, M. (2001). Suramin and the suramin analogue NF307 discriminate among calmodulin-binding sites. Biochemical Journal, 355, 827-833.
9. Wright, N. T.; Prosser, B. L.; Varney, K. M.; Zimmer, D. B.; Schneider, M. F.; Weber, D. J. (2008). S100A1 and calmodulin compete for the same binding site on ryanodine receptor. Journal of Biological Chemistry, 283, 26676-26683.
10. Treves, S.; Scutari, E.; Robert, M.; Groh, S.; Ottolia, M.; Prestipino, G.; et al. (1997). Interaction of S100A1 with the Ca2+ release channel (ryanodine receptor) of skeletal muscle. Biochemistry, 36, 11496-11503.
11. Schafer, B. W.; Heizmann, C. W. (1996). The S100 family of EF-hand calcium-binding proteins: functions and pathology. Trends in Biochemical Sciences, 21, 134-140.
12. Santamaria-Kisiel, L.; Rintala-Dempsey, A. C.; Shaw, G. S. (2006). Calcium-dependent and -independent interactions of the S100 protein family. Biochemical Journal, 396, 201-214.
13. Donato, R. (1986). S-100 proteins. Cell Calcium, 7, 123-145.
14. Zimmer, D. B.; Wright Sadosky, P.; Weber, D. J. (2003). Molecular mechanisms of S100-target protein interactions. Microscopy Research and Technique, 60, 552-559.
15. 2+ signal transduction and protein dephosphorylation. Journal of Biological Chemistry, 287, 13787-13798.
16. Becker, W.; Kentrup, H.; Klumpp, S.; Schultz, J. E.; Joost, H. G. (1994). Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain. Journal of Biological Chemistry, 269, 22586-22592.
17. Chen, M. X.; McPartlin, A. E.; Brown, L.; Chen, Y. H.; Barker, H. M.; Cohen, P. T. (1994). A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus. EMBO Journal, 13, 4278-4290.
18. D'Andrea, L. D.; Regan, L. (2003). TPR proteins: the versatile helix. Trends in Biochemical Sciences, 28, 655-662.
19. Zeytuni, N.; Zarivach, R. (2012). Structural and functional discussion of the tetra-trico-peptide repeat, a protein interaction module. Structure, 20, 397-405.
20. Ramsey, A. J.; Chinkers, M. (2002). Identification of potential physiological activators of protein phosphatase 5†. Biochemistry, 41, 5625-5632.
21. Blatch, G. L.; Lassle, M. (1999). The tetratricopeptide repeat: a structural motif mediating protein-protein interactions. Bioessays, 21, 932-939.
22. Smith, D. F. (2004). Tetratricopeptide repeat cochaperones in steroid receptor complexes. Cell Stress & Chaperones, 9, 109-121.
23. Allan, R. K.; Ratajczak, T. (2011). Versatile TPR domains accommodate different modes of target protein recognition and function. Cell Stress & Chaperones, 16, 353-367.
24. Smith, D. F.; Sullivan, W. P.; Marion, T. N.; Zaitsu, K.; Madden, B.; McCormick, D. J.; et al. (1993). Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70. Molecular and Cellular Biology, 13, 869-876.
25. Young, J. C.; Hoogenraad, N. J.; Hartl, F. U. (2003). Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70. Cell, 112, 41-50.
26. Ratajczak, T.; Carrello, A. (1996). Cyclophilin 40 (CyP-40), mapping of its hsp90 binding domain and evidence that FKBP52 competes with CyP-40 for hsp90 binding. Journal of Biological Chemistry, 271, 2961-2965.
27. Radanyi, C.; Chambraud, B.; Baulieu, E. E. (1994). The ability of the immunophilin FKBP59-HBI to interact with the 90-kDa heat shock protein is encoded by its tetratricopeptide repeat domain. Proceedings of the National Academy of Sciences of the United States of America, 91, 11197-11201.
28. Das, A. K.; Cohen, P. W.; Barford, D. (1998). The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions. EMBO Journal, 17, 1192-1199.
29. Shimamoto, S.; Kubota, Y.; Tokumitsu, H.; Kobayashi, R. (2010). S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats. FEBS Letters, 584, 1119-1125.
30. Shimamoto, S.; Takata, M.; Tokuda, M.; Oohira, F.; Tokumitsu, H.; Kobayashi, R. (2008). Interactions of S100A2 and S100A6 with the tetratricopeptide repeat proteins, Hsp90/Hsp70-organizing protein and kinesin light chain. Journal of Biological Chemistry, 283, 28246-28258.
31. Okada, M.; Tokumitsu, H.; Kubota, Y.; Kobayashi, R. (2002). Interaction of S100 proteins with the antiallergic drugs, olopatadine, amlexanox, and cromolyn: identification of putative drug binding sites on S100A1 protein. Biochemical and Biophysical Research Communications, 292, 1023-1030.
32. Okada, M.; Hatakeyama, T.; Itoh, H.; Tokuta, N.; Tokumitsu, H.; Kobayashi, R. (2004). S100A1 is a novel molecular chaperone and a member of the Hsp70/Hsp90 multichaperone complex. Journal of Biological Chemistry, 279, 4221-4233.
33. Yamashita, K.; Oyama, Y.; Shishibori, T.; Matsushita, O.; Okabe, A.; Kobayashi, R. (1999). Purification of bovine S100A12 from recombinant Escherichia coli. Protein Expression and Purification, 16, 47-52.
34. Chen, M. S.; Silverstein, A. M.; Pratt, W. B.; Chinkers, M. (1996). The tetratricopeptide repeat domain of protein phosphatase 5 mediates binding to glucocorticoid receptor heterocomplexes and acts as a dominant negative mutant. Journal of Biological Chemistry, 271, 32315-32320.
35. Prodromou, C.; Siligardi, G.; O'Brien, R.; Woolfson, D. N.; Regan, L.; Panaretou, B.; et al. (1999). Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones. EMBO Journal, 18, 754-762.
36. Chung, W. C.; Kermode, J. C. (2005). Suramin disrupts receptor-G protein coupling by blocking association of G protein alpha and betagamma subunits. Journal of Pharmacology and Experimental Therapeutics, 313, 191-198.
37. Zhang, Y. L.; Keng, Y. F.; Zhao, Y.; Wu, L.; Zhang, Z. Y. (1998). Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases. Journal of Biological Chemistry, 273, 12281-12287.
38. Shimamoto, S.; Kubota, Y.; Yamaguchi, F.; Tokumitsu, H.; Kobayashi, R. (2013). Ca2+/S100 proteins act as upstream regulators of the chaperone-associated ubiquitin ligase CHIP. Journal of Biological Chemistry, 288(10), 7158-7168.
39. Kielian, M. C.; Steinman, R. M.; Cohn, Z. A. (1982). Intralysosomal accumulation of polyanions: I. Fusion of pinocytic and phagocytic vacuoles with secondary lysosomes. Journal of Cell Biology, 93, 866-874.