The hypertrophic cardiomyopathy myosin mutation R453C alters ATP binding and hydrolysis of human cardiac β-myosin

Journal of Biological Chemistry

Volumn 289, Issue 8, 2014, Pages 5158-5167

  Bloemink, Marieke ^a,c   Deacon, John ^b,d   Langer, Stephen ^b   Vera, Carlos ^b   Combs, Ariana ^b   Leinwand, Leslie ^b   Geeves, Michael A ^a  

^a UNIVERSITY OF KENT   (United Kingdom)

^b UNIVERSITY OF COLORADO   (United States)

^c CANTERBURY CHRIST CHURCH UNIVERSITY   (United Kingdom)

^d YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROLYSIS;

ATP BINDING; CONFORMATIONAL CHANGE; DETAILED KINETICS; HIGH INCIDENCE; HYPERTROPHIC CARDIOMYOPATHY; MOTOR DOMAIN; SUDDEN CARDIAC DEATHS;

HEART;

ADENOSINE TRIPHOSPHATE; ARGININE; CARDIAC BETA MYOSIN; CARDIAC MYOSIN; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; BINDING AFFINITY; CHEMICAL REACTION KINETICS; CONFORMATIONAL TRANSITION; DISEASE ASSOCIATION; GENE MUTATION; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; IN VITRO STUDY; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN HYDROLYSIS;

ACTIN; CARDIAC MUSCLE; CARDIOMYOPATHY; FLUORESCENCE; HOMOLOGY MODELS; KINETICS; MYOSIN; PROTEIN STRUCTURE-FUNCTION; SEQUENCE ALIGNMENT;

ACTINS; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; AMINO ACID SUBSTITUTION; CARDIAC MYOSINS; CARDIOMYOPATHY, HYPERTROPHIC; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROLYSIS; KINETICS; MODELS, MOLECULAR; MUTATION; MYOSIN HEAVY CHAINS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 84894452473     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.511204     Document Type: Article

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