Transgenic mouse α- and β-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences

Journal of Biological Chemistry

Volumn 288, Issue 21, 2013, Pages 14780-14787

  Lowey, Susan ^a   Bretton, Vera ^a   Gulick, James ^b   Robbins, Jeffrey ^b   Trybus, Kathleen M ^a  

^a UNIVERSITY OF VERMONT   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FAMILIAL HYPERTROPHIC CARDIOMYOPATHIES; MECHANOCHEMICALS; MYOSIN HEAVY CHAIN; NUCLEOTIDE BINDING; STOPPED-FLOW KINETICS; SUDDEN CARDIAC DEATHS; TRANSIENT KINETIC STUDIES; TRANSIENT KINETICS;

CLONING; EQUILIBRIUM CONSTANTS; HEART; KINETICS; MAMMALS;

PROTEINS;

ADENOSINE DIPHOSPHATE; ADENOSINE DIPHOSPHATE MAGNESIUM; ADENOSINE TRIPHOSPHATE; MYOSIN ADENOSINE TRIPHOSPHATASE; MYOSIN HEAVY CHAIN ALPHA; MYOSIN HEAVY CHAIN BETA; MYOSIN SUBFRAGMENT 1;

ACTIN FILAMENT; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CELL MOTILITY; CELL MOTION; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVE SITE; EQUILIBRIUM CONSTANT; FAMILIAL HYPERTROPHIC CARDIOMYOPATHY; FLOW KINETICS; HEART DISEASE; IN VITRO STUDY; KINETICS; MOLECULAR CLONING; MOLECULAR MECHANICS; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN SECRETION; PROTEIN STRUCTURE; TRANSGENIC MOUSE;

CARDIAC MYOSIN ISOFORMS; CARDIOMYOPATHY; CARDIOVASCULAR DISEASE; FAMILIAL HYPERTROPHIC CARDIOMYOPATHY; KINETICS; MYOSIN; MYOSIN HEAVY CHAIN MUTATIONS; TRANSGENIC MICE; TRANSIENT KINETICS;

ADENOSINE DIPHOSPHATE; AMINO ACID SUBSTITUTION; ANIMALS; KINETICS; MICE; MICE, TRANSGENIC; MUTATION, MISSENSE; MYOSIN HEAVY CHAINS; PROTEIN BINDING; VENTRICULAR MYOSINS;

EID: 84878253324     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.450668     Document Type: Article

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