-
1
-
-
80052242132
-
Targeting cancer metabolism: A therapeutic window opens
-
Vander Heiden MG. Targeting cancer metabolism: A therapeutic window opens. Nat Rev Drug Discov 2011; 10:671-684.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 671-684
-
-
Vander Heiden, M.G.1
-
2
-
-
0023881236
-
Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy
-
Pegg AE. Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. Cancer Res 1988; 48:759-774.
-
(1988)
Cancer Res
, vol.48
, pp. 759-774
-
-
Pegg, A.E.1
-
3
-
-
0025786779
-
Estimation of polyamine binding to macromolecules and ATP in bovine lymphocytes and rat liver
-
Watanabe S, Kusama-Eguchi K, Kobayashi H, Igarashi K. Estimation of polyamine binding to macromolecules and ATP in bovine lymphocytes and rat liver. J Biol Chem 1991; 266:20803-20809.
-
(1991)
J Biol Chem
, vol.266
, pp. 20803-20809
-
-
Watanabe, S.1
Kusama-Eguchi, K.2
Kobayashi, H.3
Igarashi, K.4
-
4
-
-
34547676811
-
Posttranslational synthesis of hypusine: Evolutionary progression and specificity of the hypusine modification
-
Wolff EC, Kang KR, Kim YS, Park MH. Posttranslational synthesis of hypusine: Evolutionary progression and specificity of the hypusine modification. Amino Acids 2007; 33:341-350.
-
(2007)
Amino Acids
, vol.33
, pp. 341-350
-
-
Wolff, E.C.1
Kang, K.R.2
Kim, Y.S.3
Park, M.H.4
-
5
-
-
4944242891
-
Polyamines and cancer: Old molecules, new understanding
-
Gerner EW, Meyskens FL, Jr. Polyamines and cancer: Old molecules, new understanding. Nat Rev Cancer 2004; 4:781-792.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 781-792
-
-
Gerner, E.W.1
Meyskens Jr, F.L.2
-
6
-
-
70349690458
-
Disrupting polyamine homeostasis as a therapeutic strategy for neuroblastoma
-
Evageliou NF, Hogarty MD. Disrupting polyamine homeostasis as a therapeutic strategy for neuroblastoma. Clin cancer Res 2009; 15:5956-5961.
-
(2009)
Clin cancer Res
, vol.15
, pp. 5956-5961
-
-
Evageliou, N.F.1
Hogarty, M.D.2
-
7
-
-
0032847292
-
APC-dependent changes in expression of genes influencing polyamine metabolism, and consequences for gastrointestinal carcinogenesis, in the Min mouse
-
Erdman SH, Ignatenko NA, Powell MB, et al. APC-dependent changes in expression of genes influencing polyamine metabolism, and consequences for gastrointestinal carcinogenesis, in the Min mouse. Carcinogenesis 1999; 20:1709-1713.
-
(1999)
Carcinogenesis
, vol.20
, pp. 1709-1713
-
-
Erdman, S.H.1
Ignatenko, N.A.2
Powell, M.B.3
-
8
-
-
33846988274
-
Role of c-Myc in intestinal tumorigenesis of the ApcMin/+ mouse
-
Ignatenko NA, Holubec H, Besselsen DG, et al. Role of c-Myc in intestinal tumorigenesis of the ApcMin/+ mouse. Cancer Biol Ther 2006; 5:1658-1664.
-
(2006)
Cancer Biol Ther
, vol.5
, pp. 1658-1664
-
-
Ignatenko, N.A.1
Holubec, H.2
Besselsen, D.G.3
-
9
-
-
58349114268
-
Targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma
-
Rounbehler RJ, Li W, Hall MA, Yang C, Fallahi M, Cleveland JL. Targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma. Cancer Res 2009; 69:547-553.
-
(2009)
Cancer Res
, vol.69
, pp. 547-553
-
-
Rounbehler, R.J.1
Li, W.2
Hall, M.A.3
Yang, C.4
Fallahi, M.5
Cleveland, J.L.6
-
10
-
-
55549132996
-
Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: A randomized placebo-controlled, double-blind trial
-
Meyskens FL, Jr., McLaren CE, Pelot D, et al. Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: A randomized placebo-controlled, double-blind trial. Cancer Prev Res 2008; 1:32-38.
-
(2008)
Cancer Prev Res
, vol.1
, pp. 32-38
-
-
Meyskens Jr, F.L.1
McLaren, C.E.2
Pelot, D.3
-
11
-
-
77649195334
-
A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects with previous history of skin cancer
-
Bailey HH, Kim K, Verma AK, et al. A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects with previous history of skin cancer. Cancer Prev Res 2010; 3:35-47.
-
(2010)
Cancer Prev Res
, vol.3
, pp. 35-47
-
-
Bailey, H.H.1
Kim, K.2
Verma, A.K.3
-
12
-
-
77949715450
-
Cancer chemoprevention locks onto a new polyamine metabolic target
-
Gerner EW. Cancer chemoprevention locks onto a new polyamine metabolic target. Cancer Prev Res 2010; 3:125-127.
-
(2010)
Cancer Prev Res
, vol.3
, pp. 125-127
-
-
Gerner, E.W.1
-
13
-
-
69249118597
-
Formation of the first peptide bond: The structure of EF-P bound to the 70S ribosome
-
Blaha G, Stanley RE, Steitz TA. Formation of the first peptide bond: The structure of EF-P bound to the 70S ribosome. Science 2009; 325:966-970.
-
(2009)
Science
, vol.325
, pp. 966-970
-
-
Blaha, G.1
Stanley, R.E.2
Steitz, T.A.3
-
14
-
-
65549167195
-
Hypusine-containing protein eIF5A promotes translation elongation
-
Saini P, Eyler DE, Green R, Dever TE. Hypusine-containing protein eIF5A promotes translation elongation. Nature 2009; 459:118-121.
-
(2009)
Nature
, vol.459
, pp. 118-121
-
-
Saini, P.1
Eyler, D.E.2
Green, R.3
Dever, T.E.4
-
15
-
-
60849121059
-
eIF5A has a function in the elongation step of translation in yeast
-
Gregio AP, Cano VP, Avaca JS, Valentini SR, Zanelli CF. eIF5A has a function in the elongation step of translation in yeast. Biochem Biophys Res Commun 2009; 380:785-790.
-
(2009)
Biochem Biophys Res Commun
, vol.380
, pp. 785-790
-
-
Gregio, A.P.1
Cano, V.P.2
Avaca, J.S.3
Valentini, S.R.4
Zanelli, C.F.5
-
16
-
-
84871992265
-
eIF5A isoforms and cancer: Two brothers for two functions
-
Caraglia M, Park MH, Wolff EC, Marra M, Abbruzzese A. eIF5A isoforms and cancer: Two brothers for two functions? Amino acids 2013. 44:103-109.
-
(2013)
Amino acids
, vol.44
, pp. 103-109
-
-
Caraglia, M.1
Park, M.H.2
Wolff, E.C.3
Marra, M.4
Abbruzzese, A.5
-
17
-
-
77951219633
-
The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation
-
Landau G, Bercovich Z, Park MH, Kahana C. The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation. J Biol Chem 2010; 285:12474-12481.
-
(2010)
J Biol Chem
, vol.285
, pp. 12474-12481
-
-
Landau, G.1
Bercovich, Z.2
Park, M.H.3
Kahana, C.4
-
18
-
-
0029840194
-
Hypusine modification in eukaryotic initiation factor 5A in rodent cells selected for resistance to growth inhibition by ornithine decarboxylase-inhibiting drugs
-
Tome ME, Gerner EW. Hypusine modification in eukaryotic initiation factor 5A in rodent cells selected for resistance to growth inhibition by ornithine decarboxylase-inhibiting drugs. Biochem J 1996; 320:55-60.
-
(1996)
Biochem J
, vol.320
, pp. 55-60
-
-
Tome, M.E.1
Gerner, E.W.2
-
19
-
-
44349133214
-
Hypusine modification for growth is the major function of spermidine in Saccharomyces cerevisiae polyamine auxotrophs grown in limiting spermidine
-
Chattopadhyay MK, Park MH, Tabor H. Hypusine modification for growth is the major function of spermidine in Saccharomyces cerevisiae polyamine auxotrophs grown in limiting spermidine. Proc Natl Acad Sci USA 2008; 105:6554-6559.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 6554-6559
-
-
Chattopadhyay, M.K.1
Park, M.H.2
Tabor, H.3
-
20
-
-
56349121125
-
An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer
-
Zender L, Xue W, Zuber J, et al. An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell 2008; 135:852-864.
-
(2008)
Cell
, vol.135
, pp. 852-864
-
-
Zender, L.1
Xue, W.2
Zuber, J.3
-
21
-
-
84863720872
-
A tumour suppressor network relying on the polyamine-hypusine axis
-
Scuoppo C, Miething C, Lindqvist L, et al. A tumour suppressor network relying on the polyamine-hypusine axis. Nature 2012; 487:244-248.
-
(2012)
Nature
, vol.487
, pp. 244-248
-
-
Scuoppo, C.1
Miething, C.2
Lindqvist, L.3
-
22
-
-
61449183501
-
Regulation by c-Myc of ncRNA expression
-
Kenneth NS, White RJ. Regulation by c-Myc of ncRNA expression. Curr Opin Genet Dev 2009; 19:38-43.
-
(2009)
Curr Opin Genet Dev
, vol.19
, pp. 38-43
-
-
Kenneth, N.S.1
White, R.J.2
-
23
-
-
84858446579
-
MicroRNAs and their targets: Recognition, regulation and an emerging reciprocal relationship
-
Pasquinelli AE. MicroRNAs and their targets: Recognition, regulation and an emerging reciprocal relationship. Nat Rev Genet 2012; 13:271-282.
-
(2012)
Nat Rev Genet
, vol.13
, pp. 271-282
-
-
Pasquinelli, A.E.1
-
24
-
-
38349169664
-
Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight
-
Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight? Nat Rev Genet 2008; 9:102-114.
-
(2008)
Nat Rev Genet
, vol.9
, pp. 102-114
-
-
Filipowicz, W.1
Bhattacharyya, S.N.2
Sonenberg, N.3
-
25
-
-
20044395613
-
RAS is regulated by the let-7 microRNA family
-
Johnson SM, Grosshans H, Shingara J, et al. RAS is regulated by the let-7 microRNA family. Cell 2005; 120:635-647.
-
(2005)
Cell
, vol.120
, pp. 635-647
-
-
Johnson, S.M.1
Grosshans, H.2
Shingara, J.3
-
26
-
-
34247565615
-
The tumor suppressor microRNA let-7 represses the HMGA2 oncogene
-
Lee YS, Dutta A. The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Genes Dev 2007; 21:1025-1030.
-
(2007)
Genes Dev
, vol.21
, pp. 1025-1030
-
-
Lee, Y.S.1
Dutta, A.2
-
27
-
-
33947431322
-
Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation
-
Mayr C, Hemann MT, Bartel DP. Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science 2007; 315:1576-1579.
-
(2007)
Science
, vol.315
, pp. 1576-1579
-
-
Mayr, C.1
Hemann, M.T.2
Bartel, D.P.3
-
28
-
-
52949091534
-
The let-7 family of microRNAs
-
Roush S, Slack FJ. The let-7 family of microRNAs. Trends Cell Biol 2008; 18:505-516.
-
(2008)
Trends Cell Biol
, vol.18
, pp. 505-516
-
-
Roush, S.1
Slack, F.J.2
-
29
-
-
62549160957
-
Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation
-
Chang TC, Zeitels LR, Hwang HW, et al. Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation. Proc Natl Acad Sci USA 2009; 106:3384-3389.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 3384-3389
-
-
Chang, T.C.1
Zeitels, L.R.2
Hwang, H.W.3
-
30
-
-
0034708122
-
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
-
Reinhart BJ, Slack FJ, Basson M, et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 2000; 403:901-906.
-
(2000)
Nature
, vol.403
, pp. 901-906
-
-
Reinhart, B.J.1
Slack, F.J.2
Basson, M.3
-
31
-
-
77049099101
-
Lin28: A microRNA regulator with a macro role
-
Viswanathan SR, Daley GQ. Lin28: A microRNA regulator with a macro role. Cell 2010; 140:445-449.
-
(2010)
Cell
, vol.140
, pp. 445-449
-
-
Viswanathan, S.R.1
Daley, G.Q.2
-
32
-
-
68749102148
-
TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation
-
Heo I, Joo C, Kim YK, et al. TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. Cell 2009; 138:696-708.
-
(2009)
Cell
, vol.138
, pp. 696-708
-
-
Heo, I.1
Joo, C.2
Kim, Y.K.3
-
33
-
-
81855183636
-
Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms
-
Piskounova E, Polytarchou C, Thornton JE, et al. Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell 2011; 147:1066-1079.
-
(2011)
Cell
, vol.147
, pp. 1066-1079
-
-
Piskounova, E.1
Polytarchou, C.2
Thornton, J.E.3
-
34
-
-
67649881121
-
Lin28 promotes transformation and is associated with advanced human malignancies
-
Viswanathan SR, Powers JT, Einhorn W, et al. Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet 2009; 41:843-848.
-
(2009)
Nat Genet
, vol.41
, pp. 843-848
-
-
Viswanathan, S.R.1
Powers, J.T.2
Einhorn, W.3
-
35
-
-
39449086676
-
The effect of difluoromethylornithine on decreasing prostate size and polyamines in men: Results of a year-long phase IIb randomized placebo-controlled chemoprevention trial
-
Simoneau AR, Gerner EW, Nagle R, et al. The effect of difluoromethylornithine on decreasing prostate size and polyamines in men: Results of a year-long phase IIb randomized placebo-controlled chemoprevention trial. Cancer Epidemiol Biomarkers Prev 2008; 17:292-299.
-
(2008)
Cancer Epidemiol Biomarkers Prev
, vol.17
, pp. 292-299
-
-
Simoneau, A.R.1
Gerner, E.W.2
Nagle, R.3
-
36
-
-
0001677717
-
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
-
Benjamini Y, Hochberg Y. Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. J Royal Stat Soc Ser B Methodol 1995; 57:289-300.
-
(1995)
J Royal Stat Soc Ser B Methodol
, vol.57
, pp. 289-300
-
-
Benjamini, Y.1
Hochberg, Y.2
-
37
-
-
79954578408
-
Overexpression of HMGA2 promotes metastasis and impacts survival of colorectal cancers
-
Wang X, Liu X, Li AY, et al. Overexpression of HMGA2 promotes metastasis and impacts survival of colorectal cancers. Clin Cancer Res 2011; 17:2570-2580.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 2570-2580
-
-
Wang, X.1
Liu, X.2
Li, A.Y.3
-
38
-
-
36448992338
-
Roles of HMGA proteins in cancer
-
Fusco A, Fedele M. Roles of HMGA proteins in cancer. Nat Rev Cancer 2007; 7:899-910.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 899-910
-
-
Fusco, A.1
Fedele, M.2
-
39
-
-
79953202455
-
Silencing of microRNA families by seed-targeting tiny LNAs
-
Obad S, dos Santos CO, Petri A, et al. Silencing of microRNA families by seed-targeting tiny LNAs. Nat Genet 2011; 43:371-378.
-
(2011)
Nat Genet
, vol.43
, pp. 371-378
-
-
Obad, S.1
dos Santos, C.O.2
Petri, A.3
-
40
-
-
0022521372
-
Post-translational modification of the protein-synthesis initiation factor eIF-4D by spermidine in rat hepatoma cells
-
Gerner EW, Mamont PS, Bernhardt A, Siat M. Post-translational modification of the protein-synthesis initiation factor eIF-4D by spermidine in rat hepatoma cells. Biochem J 1986; 239:379-386.
-
(1986)
Biochem J
, vol.239
, pp. 379-386
-
-
Gerner, E.W.1
Mamont, P.S.2
Bernhardt, A.3
Siat, M.4
-
41
-
-
0023645825
-
Hypusine formation in protein by a two-step process in cell lysates
-
Murphey RJ, Gerner EW. Hypusine formation in protein by a two-step process in cell lysates. J Biol Chem 1987; 262:15033-15036.
-
(1987)
J Biol Chem
, vol.262
, pp. 15033-15036
-
-
Murphey, R.J.1
Gerner, E.W.2
-
42
-
-
79952199559
-
The early history of polyamine research
-
Bachrach U. The early history of polyamine research. Plant Physiol Biochem 2010; 48:490-495.
-
(2010)
Plant Physiol Biochem
, vol.48
, pp. 490-495
-
-
Bachrach, U.1
-
43
-
-
0032525327
-
A single amino acid substitution in yeast eIF-5A results in mRNA stabilization
-
Zuk D, Jacobson A. A single amino acid substitution in yeast eIF-5A results in mRNA stabilization. EMBO J 1998; 17:2914-2925.
-
(1998)
EMBO J
, vol.17
, pp. 2914-2925
-
-
Zuk, D.1
Jacobson, A.2
-
44
-
-
84871921644
-
EF-P is essential for rapid synthesis of proteins containing consecutive proline residues
-
Doerfel LK, Wohlgemuth I, Kothe C, Peske F, Urlaub H, Rodnina MV. EF-P is essential for rapid synthesis of proteins containing consecutive proline residues. Science 2013; 339:85-88.
-
(2013)
Science
, vol.339
, pp. 85-88
-
-
Doerfel, L.K.1
Wohlgemuth, I.2
Kothe, C.3
Peske, F.4
Urlaub, H.5
Rodnina, M.V.6
-
45
-
-
84871918588
-
Translation elongation factor EF-P alleviates ribosome stalling at polyproline stretches
-
Ude S, Lassak J, Starosta AL, Kraxenberger T, Wilson DN, Jung K. Translation elongation factor EF-P alleviates ribosome stalling at polyproline stretches. Science 2013; 339:82-85.
-
(2013)
Science
, vol.339
, pp. 82-85
-
-
Ude, S.1
Lassak, J.2
Starosta, A.L.3
Kraxenberger, T.4
Wilson, D.N.5
Jung, K.6
-
47
-
-
84863244900
-
AMD1 is essential for ESC self-renewal and is translationally down-regulated on differentiation to neural precursor cells
-
Zhang D, Zhao T, Ang HS, et al. AMD1 is essential for ESC self-renewal and is translationally down-regulated on differentiation to neural precursor cells. Genes Dev 2012; 26:461-473.
-
(2012)
Genes Dev
, vol.26
, pp. 461-473
-
-
Zhang, D.1
Zhao, T.2
Ang, H.S.3
-
48
-
-
84865589321
-
How does Lin28 let-7 control development and disease
-
Thornton JE, Gregory RI. How does Lin28 let-7 control development and disease? Trends Cell Biol 2012; 22:474-482.
-
(2012)
Trends Cell Biol
, vol.22
, pp. 474-482
-
-
Thornton, J.E.1
Gregory, R.I.2
-
49
-
-
84868160135
-
LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance
-
Wilbert ML, Huelga SC, Kapeli K, et al. LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance. Mol Cell 2012; 48:195-206.
-
(2012)
Mol Cell
, vol.48
, pp. 195-206
-
-
Wilbert, M.L.1
Huelga, S.C.2
Kapeli, K.3
-
50
-
-
80053481600
-
The Lin28/let-7 axis regulates glucose metabolism
-
Zhu H, Shyh-Chang N, Segre AV, et al. The Lin28/let-7 axis regulates glucose metabolism. Cell 2011; 147:81-94.
-
(2011)
Cell
, vol.147
, pp. 81-94
-
-
Zhu, H.1
Shyh-Chang, N.2
Segre, A.V.3
-
51
-
-
0025740183
-
Increased glucose oxidation and contents of insulin and ATP in polyamine-depleted rat insulinoma cells (RINm5F)
-
Sjoholm A, Welsh N, Hoftiezer V, Bankston PW, Hellerstrom C. Increased glucose oxidation and contents of insulin and ATP in polyamine-depleted rat insulinoma cells (RINm5F). Biochem J 1991; 277:533-540.
-
(1991)
Biochem J
, vol.277
, pp. 533-540
-
-
Sjoholm, A.1
Welsh, N.2
Hoftiezer, V.3
Bankston, P.W.4
Hellerstrom, C.5
-
52
-
-
79960211493
-
Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma
-
Buechner J, Tomte E, Haug BH, et al. Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma. Br J Cancer 2011; 105:296-303.
-
(2011)
Br J Cancer
, vol.105
, pp. 296-303
-
-
Buechner, J.1
Tomte, E.2
Haug, B.H.3
-
53
-
-
84868210731
-
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression
-
Molenaar JJ, Domingo-Fernandez R, Ebus ME, et al. LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression. Nat Genet 2012; 44:1199-1206.
-
(2012)
Nat Genet
, vol.44
, pp. 1199-1206
-
-
Molenaar, J.J.1
Domingo-Fernandez, R.2
Ebus, M.E.3
|