Topical delivery of siRNA into skin using SPACE-peptide carriers

Journal of Controlled Release

Volumn 179, Issue 1, 2014, Pages 33-41

  Chen, Ming ^a   Zakrewsky, Michael ^a   Gupta, Vivek ^a,c   Anselmo, Aaron C ^a   Slee, Deborah H ^b   Muraski, John A ^b   Mitragotri, Samir ^a,b  

^a University of California   (United States)

^b Convoy Therapeutics ^*  (United States)

^c KECK GRADUATE INSTITUTE   (United States)

Author keywords

Cationic lipids; Cell penetrating peptide; Gene delivery; Silencing; Topical

Indexed keywords

1,2-DIOLEOYLOXY-3-(TRIMETHYLAMMONIUM)PROPANE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MONOUNSATURATED FATTY ACID; PEPTIDE; QUATERNARY AMMONIUM DERIVATIVE; SMALL INTERFERING RNA;

ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; EPIDERMIS; FEMALE; GENE EXPRESSION REGULATION; GENE TRANSFER; GENETICS; HUMAN; INTRADERMAL DRUG ADMINISTRATION; KERATINOCYTE; METABOLISM; MOUSE; PERMEABILITY; RNA INTERFERENCE; SKIN ABSORPTION; SWINE;

ADMINISTRATION, CUTANEOUS; ANIMALS; CELLS, CULTURED; EPIDERMIS; FATTY ACIDS, MONOUNSATURATED; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE TRANSFER TECHNIQUES; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HUMANS; KERATINOCYTES; MICE; MICE, INBRED BALB C; PEPTIDES; PERMEABILITY; QUATERNARY AMMONIUM COMPOUNDS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SKIN ABSORPTION; SWINE;

EID: 84894370041     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.01.006     Document Type: Article

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