The use of antioxidants in pre-eclampsia

Studies on Women's Health

Volumn , Issue , 2013, Pages 115-129

  Bilodeau, Jean François ^a  

^a Université Laval   (Canada)

Author keywords

Carotenoids; Clinical importance; Maternal antioxidant imbalance; Physiopathology of PE; Placental antioxidant imbalance; Pre eclampsia; ROS production; Use of antioxidants

Indexed keywords

EID: 84894363211     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-62703-041-0_6     Document Type: Chapter

References (109)

1. Report of the national high blood pressure education program working group on high blood pressure in pregnancy. Am J Obstet Gynecol. 200; 183: S1-S22
2. Weinstein L (1982) Syndrome of hemolysis, elevated liver enzymes, and low platelet count: a severe consequence of hypertension in pregnancy. Am J Obstet Gynecol 142:159-167
3. Canada S (1997) Causes of death 1993, 1994, 1995, 1996, 1997. Ottawa: Health Statistics Division
4. Roberts J (1998) Pregnancy related hypertension. In: Creasy R, Resnik R (eds) Maternal Fetal Medicine. WB Saunders, Philiadelphia
5. Frederick IO, Rudra CB, Miller RS, Foster JC, Williams MA (2006) Adult weight change, weight cycling, and prepregnancy obesity in relation to risk of preeclampsia. Epidemiology 17:428-434
6. Innes KE, Marshall JA, Byers TE, Calonge N (1999) A woman's own birth weight and gestational age predict her later risk of developing preeclampsia, a precursor of chronic disease. Epidemiology 10:153-160
7. Klonoff-Cohen HS, Cross JL, Pieper CF (1996) Job stress and pre-eclampsia. Epidemiology 7:245-249
8. Lie RT, Rasmussen S, Brunborg H, Gjessing HK, Lie-Nielsen E, Irgens LM (1998) Fetal and maternal contributions to risk of pre-eclampsia: population based study. BMJ 316:1343-1347
9. Stephansson O, Kieler H, Granath F, Falconer H (2009) Endometriosis, assisted reproduction technology, and risk of adverse pregnancy outcome. Hum Reprod 24:2341-2347
10. Shevell T, Malone FD, Vidaver J, Porter TF, Luthy DA, Comstock CH, Hankins GD, Eddleman K, Dolan S, Dugoff L, Craigo S, Timor IE, Carr SR, Wolfe HM, Bianchi DW, D'Alton ME (2005) Assisted reproductive technology and pregnancy outcome. Obstet Gynecol 106:1039-1045
11. Broughton Pipkin F (2001) Risk factors for preeclampsia. N Engl J Med 344:925-926
12. Roberts JM, Gammill H (2005) Pre-eclampsia and cardiovascular disease in later life. Lancet 366:961-962
13. Roberts JM (2000) Preeclampsia: what we know and what we do not know. Semin Perinatol 24:24-28
14. Lim KH, Zhou Y, Janatpour M, McMaster M, Bass K, Chun SH, Fisher SJ (1997) Human cytotrophoblast differentiation/invasion is abnormal in pre-eclampsia. Am J Pathol 151:1809-1818
15. Pijnenborg R, Bland JM, Robertson WB, Brosens I (1983) Uteroplacental arterial changes related to interstitial trophoblast migration in early human pregnancy. Placenta 4:397-413
16. Redman CW, Sargent IL (2000) Placental debris, oxidative stress and pre-eclampsia. Placenta 21:597-602
17. Roberts JM, Taylor RN, Musci TJ, Rodgers GM, Hubel CA, McLaughlin MK (1989) Preeclampsia: an endothelial cell disorder. Am J Obstet Gynecol 161:1200-1204
18. Page NM, Woods RJ, Gardiner SM, Lomthaisong K, Gladwell RT, Butlin DJ, Manyonda IT, Lowry PJ (2000) Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia. Nature 405:797-800
19. Hung TH, Lo LM, Chiu TH, Li MJ, Yeh YL, Chen SF, Hsieh TT (2010) A longitudinal study of oxidative stress and antioxidant status in women with uncomplicated pregnancies throughout gestation. Reprod Sci 17:401-409
20. Little RE, Gladen BC (1999) Levels of lipid peroxides in uncomplicated pregnancy: a review of the literature. Reprod Toxicol 13:347-352
21. McKinney ET, Shouri R, Hunt RS, Ahokas RA, Sibai BM (2000) Plasma, urinary, and salivary 8-epi-prostaglandin f2alpha levels in normotensive and preeclamptic pregnancies. Am J Obstet Gynecol 183:874-877
22. Staff AC, Halvorsen B, Ranheim T, Henriksen T (1999) Elevated level of free 8-isoprostaglandin F2alpha in the decidua basalis of women with preeclampsia. Am J Obstet Gynecol 181:1211-1215
23. Walsh SW, Vaughan JE, Wang Y, Roberts LJ 2nd (2000) Placental isoprostane is significantly increased in preeclampsia. Faseb J 14:1289-1296
24. Harsem NK, Roald B, Braekke K, Staff AC (2007) Acute atherosis in decidual tissue: not associated with systemic oxidative stress in preeclampsia. Placenta 28:958-964
25. Mandang S, Manuelpillai U, Wallace EM (2007) Oxidative stress increases placental and endothelial cell activin A secretion. J Endocrinol 192:485-493
26. Peter Stein T, Scholl TO, Schluter MD, Leskiw MJ, Chen X, Spur BW, Rodriguez A (2008). Oxidative stress early in pregnancy and pregnancy outcome. Free Radic Res 42:841-848
27. Ouyang YQ, Li SJ, Zhang Q, Cai HB, Chen HP (2009) Interactions between inflammatory and oxidative stress in preeclampsia. Hypertens Pregnancy 28:56-62
28. Zhang J, Masciocchi M, Lewis D, Sun W, Liu A, Wang Y (2008) Placental anti-oxidant gene polymorphisms, enzyme activity, and oxidative stress in preeclampsia. Placenta 29:439-443
29. Norris LA, Higgins JR, Darling MR, Walshe JJ, Bonnar J (1999) Nitric oxide in the uteroplacental, fetoplacental, and peripheral circulations in preeclampsia. Obstet Gynecol 93:958-963
30. Walsh SW, Wang Y (1993) Deficient glutathione peroxidase activity in preeclampsia is associated with increased placental production of thromboxane and lipid peroxides. Am J Obstet Gynecol 169:1456-1461
31. Boutet M, Roland L, Thomas N, Bilodeau JF (2009) Specific systemic antioxidant response to preeclampsia in late pregnancy: the study of intracellular glutathione peroxidases in maternal and fetal blood. Am J Obstet Gynecol 200:530.e1-7
32. Roland-Zejly L, Moisan V, St-Pierre I, Bilodeau JF (2011) Altered placental glutathione peroxidase mRNA expression in preeclampsia according to the presence or absence of labor. Placenta 32:161-167
33. Mutlu-Turkoglu U, Ademoglu E, Ibrahimoglu L, Aykac-Toker G, Uysal M (1998) Imbalance between lipid peroxidation and antioxidant status in preeclampsia. Gynecol Obstet Invest 46:37-40
34. Padmini E, Lavany S, Uthra V (2009) Preeclamptic placental stress and over expression of mitochondrial HSP70. Clin Chem Lab Med 47:1073-1080
35. Patil SB, Kodliwadmath MV, Kodliwadmath M (2009) Lipid peroxidation and antioxidant activity in complicated pregnancies. Clin Exp Obstet Gynecol 36:110-112
36. Vanderlelie J, Gude N, Perkins AV (2008) Antioxidant gene expression in preeclamptic placentae: a preliminary investigation. Placenta 29:519-522
37. Zusterzeel PL, Peters WH, De Bruyn MA, Knapen MF, Merkus HM, Steegers EA (1999) Glutathione S-transferase isoenzymes in decidua and placenta of preeclamptic pregnancies. Obstet Gynecol 94:1033-1038
38. Shibata E, Nanri H, Ejima K, Araki M, Fukuda J, Yoshimura K, Toki N, Ikeda M, Kashimura M (2003) Enhancement of mitochondrial oxidative stress and up-regulation of antioxidant protein peroxiredoxin III/SP-22 in the mitochondria of human pre-eclamptic placentae. Placenta 24:698-705
39. Roland L, Beauchemin D, Acteau G, Fradette C, St-Pierre I, Bilodeau JF (2010) Effects of labor on placental expression of superoxide dismutases in preeclampsia. Placenta 31:392-400
40. Mistry HD, Kurlak LO, Williams PJ, Ramsay MM, Symonds ME, Pipkin FB (2010) Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy. Placenta 31:401-408
41. Mistry HD, Wilson V, Ramsay MM, Symonds ME (2008) Broughton Pipkin F. Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies. Hypertension 52:881-888
42. Dordevic NZ, Babic GM, Markovic SD, Ognjanovic BI, Stajn AS, Zikic RV, Saicic ZS (2008) Oxidative stress and changes in antioxidative defense system in erythrocytes of preeclampsia in women. Reprod Toxicol 25:213-218
43. Kumar CA, Das UN (2000) Lipid peroxides, anti-oxidants and nitric oxide in patients with pre-eclampsia and essential hypertension. Med Sci Monit 6:901-907
44. Bayhan G, Atamer Y, Atamer A, Yokus B, Baylan Y (2000) Significance of changes in lipid peroxides and antioxidant enzyme activities in pregnant women with preeclampsia and eclampsia. Clin Exp Obstet Gynecol 27:142-146
45. Diedrich F, Renner A, Rath W, Kuhn W, Wieland E (2001) Lipid hydroperoxides and free radical scavenging enzyme activities in preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome: no evidence for circulating primary products of lipid peroxidation. Am J Obstet Gynecol 185:166-172
46. Chappell LC, Seed PT, Kelly FJ, Briley A, Hunt BJ, Charnock-Jones DS, Mallet A, Poston L (2002) Vitamin C and E supplementation in women at risk of preeclampsia is associated with changes in indices of oxidative stress and placental function. Am J Obstet Gynecol 187:777-784
47. Hubel CA (1997) Plasma vitamin E in preeclampsia. Am J Obstet Gynecol 177:484-485
48. Mikhail MS, Anyaegbunam A, Garfinkel D, Palan PR, Basu J, Romney SL (1994) Preeclampsia and antioxidant nutrients: decreased plasma levels of reduced ascorbic acid, alpha-tocopherol, and beta-carotene in women with preeclampsia. Am J Obstet Gynecol 171:150-157
49. Zhang C, Williams MA, King IB, Dashow EE, Sorensen TK, Frederick IO, Thompson ML, Luthy DA (2002) Vitamin C and the risk of preeclampsia-results from dietary questionnaire and plasma assay. Epidemiology 13:409-416
50. Chambers JC, Fusi L, Malik IS, Haskard DO, De Swiet M, Kooner JS (2001) Association of maternal endothelial dysfunction with preeclampsia. J Am Med Assoc 285:1607-1612
51. Dudgeon S, Benson DP, MacKenzie A, Paisley-Zyszkiewicz K, Martin W (1998) Recovery by ascorbate of impaired nitric oxide-dependent relaxation resulting from oxidant stress in rat aorta. Br J Pharmacol 125:782-786
52. Huang A, Vita JA, Venema RC, Keaney JF Jr (2000) Ascorbic acid enhances endothelial nitric-oxide synthase activity by increasing intracellular tetrahydrobiopterin. J Biol Chem 275:17399-17406
53. Jackson TS, Xu A, Vita JA, Keaney JF Jr (1998) Ascorbate prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations. Circ Res 83:916-922
54. Xu A, Vita JA, Keaney JF Jr (2000) Ascorbic acid and glutathione modulate the biological activity of S-nitrosoglutathione. Hypertens 36:291-295
55. Rumbold A, Crowther CA (2005) Vitamin C supplementation in pregnancy. Cochrane Database Syst Rev CD004072
56. Banerjee S, Chambers AE, Campbell S (2006) Is vitamin E a safe prophylaxis for preeclampsia. Am J Obstet Gynecol 194:1228-1233
57. Morris JM, Gopaul NK, Endresen MJ, Knight M, Linton EA, Dhir S, Anggard EE, Redman CW (1998) Circulating markers of oxidative stress are raised in normal pregnancy and preeclampsia. Br J Obstet Gynaecol 105:1195-1199
58. Wang YP, Walsh SW, Guo JD, Zhang JY (1991) Maternal levels of prostacyclin, thromboxane, vitamin E, and lipid peroxides throughout normal pregnancy. Am J Obstet Gynecol 165:1690-1694
59. Traber MG (1994) Determinants of plasma vitamin E concentrations. Free Radical Biol Med 16:229-239
60. Hubel CA, Kagan VE, Kisin ER, McLaughlin MK, Roberts JM (1997) Increased ascorbate radical formation and ascorbate depletion in plasma from women with preeclampsia: implications for oxidative stress. Free Radical Biol Med 23:597-609
61. Jendryczko A, Drozdz M (1989) Plasma retinol, beta-carotene and vitamin E levels in relation to the future risk of pre-eclampsia. Zentralbl Gynakol 111:1121-1123
62. Roland L, Gagne A, Belanger MC, Boutet M, Berthiaume L, Fraser WD, Julien P, Bilodeau JF (2010) Existence of compensatory defense mechanisms against oxidative stress and hypertension in preeclampsia. Hypertens Pregnancy 29:21-37
63. Schiff E, Friedman SA, Stampfer M, Kao L, Barrett PH, Sibai BM (1996) Dietary consumption and plasma concentrations of vitamin E in pregnancies complicated by preeclampsia. Am J Obstet Gynecol 175:1024-1028
64. Uotila JT, Tuimala RJ, Aarnio TM, Pyykko KA, Ahotupa MO (1993) Findings on lipid peroxidation and antioxidant function in hypertensive complications of pregnancy. Br J Obstet Gynaecol 100:270-276
65. Williams MA, Woelk GB, King IB, Jenkins L, Mahomed K (2003) Plasma carotenoids, retinol, tocopherols, and lipoproteins in preeclamptic and normotensive pregnant Zimbabwean women. Am J Hypertens 16:665-672
66. Zhang C, Williams MA, Sanchez SE, King IB, Ware-Jauregui S, Larrabure G, Bazul V, Leisenring WM (2001) Plasma concentrations of carotenoids, retinol, and tocopherols in preeclamptic and normotensive pregnant women. Am J Epidemiol 153:572-580
67. Chappell LC, Seed PT, Briley A, Kelly FJ, Hunt BJ, Charnock-Jones DS, Mallet AI, Poston L (2002) A longitudinal study of biochemical variables in women at risk of preeclampsia. Am J Obstet Gynecol 187:127-136
68. Chappell LC, Seed PT, Briley AL, Kelly FJ, Lee R, Hunt BJ, Parmar K, Bewley SJ, Shennan AH, Steer PJ, Poston L (1999) Effect of antioxidants on the occurrence of preeclampsia in women at increased risk: a randomised trial. Lancet 354:810-816
69. Poston L, Raijmakers M, Kelly F (2004) Vitamin E in preeclampsia. Ann N Y Acad Sci 1031:242-248
70. Poston L, Briley AL, Seed PT, Kelly FJ, Shennan AH (2006) Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial. Lancet 367:1145-1154
71. Klemmensen A, Tabor A, Osterdal ML, Knudsen VK, Halldorsson TI, Mikkelsen TB, Olsen SF (2009) Intake of vitamin C and E in pregnancy and risk of pre-eclampsia: prospective study among 57 346 women. BJOG 116:964-974
72. Rahimi R, Nikfar S, Rezaie A, Abdollahi M (2009) A meta-analysis on the efficacy and safety of combined vitamin C and E supplementation in preeclamptic women. Hypertens Pregnancy 28:417-434
73. Roberts JM, Myatt L, Spong CY, Thom EA, Hauth JC, Leveno KJ, Pearson GD, Wapner RJ, Varner MW, Thorp JM Jr, Mercer BM, Peaceman AM, Ramin SM, Carpenter MW, Samuels P, Sciscione A, Harper M, Smith WJ, Saade G, Sorokin Y, Anderson GB (2010) Vitamins C and E to prevent complications of pregnancy-associated hypertension. N Engl J Med 362:1282-1291
74. Xu H, Perez-Cuevas R, Xiong X, Reyes H, Roy C, Julien P, Smith G, von Dadelszen P, Leduc L, Audibert F, Moutquin JM, Piedboeuf B, Shatenstein B, Parra-Cabrera S, Choquette P, Winsor S, Wood S, Benjamin A, Walker M, Helewa M, Dube J, Tawagi G, Seaward G, Ohlsson A, Magee LA, Olatunbosun F, Gratton R, Shear R, Demianczuk N, Collet JP, Wei S, Fraser WD (2010) An international trial of antioxidants in the prevention of preeclampsia (INTAPP). Am J Obstet Gynecol 202:239.e1-239.e10
75. Burton GJ, Jauniaux E (2004) Placental oxidative stress: from miscarriage to preeclampsia. J Soc Gynecol Investig 11:342-352
76. Stocker R, Bowry VW, Frei B (1991) Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc Natl Acad Sci U S A 88:1646-1650
77. Stoyanovsky DA, Osipov AN, Quinn PJ, Kagan VE (1995) Ubiquinone-dependent recycling of vitamin E radicals by superoxide. Arch Biochem Biophys 323:343-351
78. Lagendijk J, Ubbink JB, Vermaak WJ (1996) Measurement of the ratio between the reduced and oxidized forms of coenzyme Q10 in human plasma as a possible marker of oxidative stress. J Lipid Res 37:67-75
79. Yamashita S, Yamamoto Y (1997) Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress. Anal Biochem 250:66-73
80. Palan PR, Shaban DW, Martino T, Mikhail MS (2004) Lipid-soluble antioxidants and pregnancy: maternal serum levels of coenzyme Q10, alpha-tocopherol and gammatocopherol in preeclampsia and normal pregnancy. Gynecol Obstet Invest 58:8-13
81. Teran E, Racines-Orbe M, Vivero S, Escudero C, Molina G, Calle A (2003) Preeclampsia is associated with a decrease in plasma coenzyme Q10 levels. Free Radic Biol Med 35:1453-1456
82. Teran E, Vivero S, Racines-Orbe M, Castellanos A, Chuncha G, Enriquez G, Moya W (2005) Coenzyme Q10 is increased in placenta and cord blood during preeclampsia. Bio Factors 25:153-158
83. Roland L, Gagne A, Belanger MC, Boutet M, Julien P, Bilodeau JF (2010) Plasma interleukin-18 (IL-18) levels are correlated with antioxidant vitamin coenzyme Q(10) in preeclampsia. Acta Obstet Gynecol Scand 89:360-366
84. Teran E, Hernandez I, Nieto B, Tavara R, Ocampo JE, Calle A (2009) Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia. Int J Gynaecol Obstet 105:43-45
85. Palan PR, Mikhail MS, Romney SL (2001) Placental and serum levels of carotenoids in preeclampsia. Obstet Gynecol 98:459-462
86. Tsen KT, Tsen SW, Kiang JG (2006) Lycopene is more potent than beta carotene in the neutralization of singlet oxygen: role of energy transfer probed by ultrafast Raman spectroscopy. J Biomed Opt 11:064025
87. Banerjee S, Jeyaseelan S, Guleria R (2009) Trial of lycopene to prevent pre-eclampsia in healthy primigravidas: results show some adverse effects. J Obstet Gynaecol Res 35:477-482
88. Sharma JB, Kumar A, Malhotra M, Arora R, Prasad S, Batra S (2003) Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas. Int J Gynaecol Obstet 81:257-262
89. Viskova H, Vesela K, Janosikova B, Krijt J, Visek JA, Calda P (2007) Plasma cysteine concentrations in uncomplicated pregnancies. Fetal Diagn Ther 22:254-258
90. Raijmakers MT, Zusterzeel PL, Steegers EA, Hectors MP, Demacker PN, Peters WH (2000) Plasma thiol status in preeclampsia. Obstet Gynecol 95:180-184
91. Raijmakers MT, Zusterzeel PL, Roes EM, Steegers EA, Mulder TP, Peters WH (2001) Oxidized and free whole blood thiols in preeclampsia. Obstet Gynecol 97:272-276
92. Kaur G, Mishra S, Sehgal A, Prasad R (2008) Alterations in lipid peroxidation and antioxidant status in pregnancy with preeclampsia. Mol Cell Biochem 313:37-44
93. Kharb S (2000) Low whole blood glutathione levels in pregnancies complicated by preeclampsia and diabetes. Clin Chim Acta 294:179-183
94. Kharb S, Gulati N, Singh V, Singh GP (2000) Superoxide anion formation and glutathione levels in patients with preeclampsia. Gynecol Obstet Invest 49:28-30
95. Knapen MF, Mulder TP, Van Rooij IA, Peters WH, Steegers EA (1998) Low whole blood glutathione levels in pregnancies complicated by preeclampsia or the hemolysis, elevated liver enzymes, low platelets syndrome. Obstet Gynecol 92:1012-1015
96. Rani N, Dhingra R, Arya DS, Kalaivani M, Bhatla N, Kumar R (2010) Role of oxidative stress markers and antioxidants in the placenta of preeclamptic patients. J obstetrics gynaecology res 36:1189-1194
97. Knapen MF, Peters WH, Mulder TP, Merkus HM, Jansen JB, Steegers EA (1999) Glutathione and glutathione-related enzymes in decidua and placenta of controls and women with pre-eclampsia. Placenta 20:541-546
98. Roes EM, Raijmakers MT, Boo TM, Zusterzeel PL, Merkus HM, Peters WH, Steegers EA (2006) Oral N-acetylcysteine administration does not stabilise the process of established severe preeclampsia. Eur J Obstet Gynecol Reprod Biol 127:61-67
99. Dodd S, Dean O, Copolov DL, Malhi GS, Berk M (2008) N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility. Expert Opin Biol Ther 8:1955-1962
100. Bisseling TM, Maria Roes E, Raijmakers MT, Steegers EA, Peters WH, Smits P (2004) Nacetylcysteine restores nitric oxide-mediated effects in the fetoplacental circulation of preeclamptic patients. Am J Obstet Gynecol 191:328-333
101. Ryu S, Huppmann AR, Sambangi N, Takacs P, Kauma SW (2007) Increased leukocyte adhesion to vascular endothelium in preeclampsia is inhibited by antioxidants. Am J Obstet Gynecol 196:400.e1-7, discussion 400.e7-8
102. Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigo R, Gladyshev VN (2003) Characterization of mammalian selenoproteomes. Science 300:1439-1443
103. Kumar KS, Kumar A, Prakash S, Swamy K, Jagadeesan V, Jyothy A (2002) Role of red cell selenium in recurrent pregnancy loss. J obstet gynaecol: j Inst Obstet Gynaecol 22:181-183
104. Rayman MP, Bode P, Redman CW (2003) Low selenium status is associated with the occurrence of the pregnancy disease preeclampsia in women from the United Kingdom. Am J Obstet Gynecol 189:1343-1349
105. Atamer Y, Kocyigit Y, Yokus B, Atamer A, Erden AC (2005) Lipid peroxidation, antioxidant defense, status of trace metals and leptin levels in preeclampsia. Eur J Obstet Gynecol Reprod Biol 119:60-66
106. Maleki A, Fard MK, Zadeh DH, Mamegani MA, Abasaizadeh S (2010) Mazloomzadeh S. The Relationship between Plasma Level of Se and Preeclampsia, Hypertens Pregnancy 30:180-187
107. Tara F, Maamouri G, Rayman MP, Ghayour-Mobarhan M, Sahebkar A, Yazarlu O, Ouladan S, Tavallaie S, Azimi-Nezhad M, Shakeri MT, Boskabadi H, Oladi M, Sangani MT, Razavi BS, Ferns G (2010) Selenium supplementation and the incidence of preeclampsia in pregnant Iranian women: a randomized, double-blind, placebo-controlled pilot trial. Taiwan J Obstet Gynecol 49:181-187
108. Milczarek R, Hallmann A, Sokolowska E, Kaletha K, Klimek J (2010) Melatonin enhances antioxidant action of alpha-tocopherol and ascorbate against NADPH- and iron-dependent lipid peroxidation in human placental mitochondria. J Pineal Res 49:149-155
109. Okatani Y, Wakatsuki A, Shinohara K, Kaneda C, Fukaya T (2001) Melatonin stimulates glutathione peroxidase activity in human chorion. J Pineal Res 30:199-205