Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia

Nature

Volumn 405, Issue 6788, 2000, Pages 797-800

  Page, N M ^a   Woods, R J ^a   Gardiner, S M ^b   Lomthaisong, K ^a   Gladwell, R T ^a   Butlin, D J ^a   Manyonda, I T ^c   Lowry, P J ^a  

^a UNIVERSITY OF READING   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c ST GEORGE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA; NEUROKININ B; PROTEIN PRECURSOR;

ANIMAL TISSUE; ARTICLE; FEMALE; HUMAN; HUMAN TISSUE; MOLECULAR CLONING; NONHUMAN; PLACENTA; PREECLAMPSIA; PRESSOR RESPONSE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; SYNCYTIOTROPHOBLAST; THIRD TRIMESTER PREGNANCY;

ANIMALS; BLOOD PRESSURE; CLONING, MOLECULAR; FEMALE; HEART RATE; HUMANS; MOLECULAR SEQUENCE DATA; NEUROKININ B; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY TRIMESTER, THIRD; PROTEIN PRECURSORS; RATS;

EID: 0034660105     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35015579     Document Type: Article

References (29)

1. Kangawa, K., Minamino, N., Fukuda, A. & Matsuo, H. Neuromedin K: a novel mammalian tachykinin identified in porcine spinal cord. Biochem. Biophys. Res. Commun. 114, 533-540 (1983).
2. von Euler, U. S. & Gaddum, J. H. An unidentified depressor substance in certain tissue extracts. J. Physiol. 72, 74-87 (1931).
3. Kimura, S., Okada, K., Sugita, Y., Kanazawa, I. & Munekata, E. Novel peptides neuropeptides, neurokinina and β, isolated from porcine spinal cord. Proc. Japan Acad. B 59, 101-104 (1983).
4. Longmore, J., Hill, R. G. & Hargreaves, R. J. Neurokinin-receptor antagonists: pharmacological tools and therapeutic drugs. Canadian J. Physio. & Pharmacol. 75, 612-621 (1997).
5. Mastrangelo, D. et al. The rat isolated portal vein: a preparation sensitive to neurokinins, particularly neurokinin B. Eur. J. Pharmacol. 134, 321-326 (1987).
6. D'Orleans-Juste, P., Claing, A., Telemaque, S., Warner, T. D. & Regoli, D. Neurokinins produce selective venoconstriction via NK-3 receptors in the rat mesenteric vascular bed. Eur. J. Pharmacol. 204, 329-334 (1991).
7. Thompson, G. W., Hoover, D. B., Ardell, J. L. & Armour, J. A. Canine intrinsic cardiac neurons involved in cardiac regulation possess NK1, NK2 and NK3 receptors. Am. J. Physiol.-Regul. Integrative Comp. Physiol. 44, 1683-1689 (1998).
8. Moussaoui, S. M. et al. Distribution of neurokinin B in rat spinal cord and peripheral tissues: comparison with neurokinin A and substance P and effects of neonatal capsaican treatment. Neuroscience 48, 969-978 (1992).
9. Jansen, I., Alafaci, C., McCulloch, I., Uddman, R. & Edvinsson, L. Tachykinins (substance P, neurokinin A, neuropeptide K, and neurokinin B) in the cerebral circulation: vasomotor responses in vitro and in situ. J Cereb. Blood Flow Metab. 11, 567-575 (1991).
10. Baumann, H. & Huch, R. Maternal hemodynamics in pregnancy. Am. J. Obstet. Gynecol. 165, 237-238 (1991).
11. Lim, K. H. et al. Human cytotrophoblast differentiation/invasion is abnormal in pre-eclampsia. Am. J. Pathol. 151, 1809-1818 (1997).
12. Lyall, F. & Greer, I. A. The vascular endothelium in normal pregnancy and pre-eclampsia. Rev. Reprod. 1, 107-116 (1996).
13. Hayman, R., Brockelsby, J., Kenny, L. & Baker, P. Preeclampsia: the endothelium, circulating factor(s) and vascular endothelial growth factor. J. Soc. Gynecol. Investig. 6, 3-10 (1999).
14. Campbell, A. et al. Plasma corticotrophin-releasing hormone concentrations during pregnancy and parturition. J. Clin. Endocrinol. Metab. 64, 1054-1059 (1987).
15. Page, N. M., Manyonda, I., Butlin, D. J., Bicknell, A. B. & Lowry, P. J. Identification of novel differentially expressed secretory proteins from the human placenta. J. Endocr. 156 (Suppl.), P257 (1998).
16. Boguski, M. S., Lowe, T. M. & Tolstoshev, C. M. dbEST - database for "expressed sequence tags". Nature Genet. 4, 332-333 (1993).
17. Adams, M. D. et al. Initial assessment of human gene diversity and expression patterns based upon 83-million nucleotides of cDNA sequence. Nature 377, Genome Directory 3S (1995).
18. Couture, R., Laneuville, O., Guimond, C., Drapeau, G. & Regoli, D. Characterization of the peripheral actions of neurokinins and neurokinin receptor selective agonists on the rat cardiovascular system. Naunyn Schmied. Arch. Pharmacol. 340, 547-557 (1989).
19. Cellier, E., Barbot, L., Regoli, D. & Couture, R. Cardiovascular and behavioural effects of intracerebroventricularly administered tachykinin NK3 receptor antagonists in the conscious rat. Br. J. Pharmacol. 122, 643-654 (1997).
20. Roccon, A., Marchionni, D. & Nisato, D. Study of SR 142801, a new potent non-peptide NK3 receptor antagonist on cardiovascular responses in conscious guinea-pig. Brit. J. Pharmacol. 118, 1095-1102 (1996).
21. Conrad, K. P., Kerchner, L. J. & Mosher, M. D. Plasma and 24h NOx and cGMP during normal pregnancy and preeclampsia in women on a reduced NOx diet. Am. J. Physiol. 46, F48-F57 (1999).
22. Gecse, A., Kis, B., Mezei, Z. & Telegdy, G. The effect of bradykinin and substance P on the arachidonate cascade of platelets. Immunopharmacology 33, 167-170 (1996).
23. Perianin, A., Snyderman, R. & Malfroy, B. Substance P primes human neutrophil activation: a mechanism for neurological regulation of inflammation. Biochem. Biophys. Res. Commun. 161, 520-524 (1989)
24. Perretti, M., Ahluwalia, A., Flower, R J. & Manzini, S. Endogenous tachykinins play a role in IL-1-induced neutrophil accumulation: involvement of NK-1 receptors. Immunology 80, 73-77 (1993).
25. Kobari, M. et al. Intravascular substance P dilates cerebral parenchymal vessels through a specific tachykinin NK1 receptor in cats. Eur. J. Pharmacol. 317, 269-274 (1996).
26. Shimizu, T. et al. Occurrence and distribution of substance P receptors in the cerebral blood vessels of the rat. Brain Res. 830, 372-378 (1999).
27. Stables, J. M. et al. GR138676, a novel peptidic tachykinin antagonist which is potent at NK3 receptors. Neuropeptides 27, 333-341 (1994).
28. Baigent, S. M. & Lowry, P. J. Urocortin is the principal ligand for the corticotrophin-releasing factor binding protein in the ovine brain with no evidence for a sauvagine-like peptide. J. Mol. Endocrinol. 24, 53-63 (2000).
29. Clement-Jones, V., Lowry, P. J., Rees, L. H. & Besser, G. M. Met-enkephalin circulates in human plasma. Nature 283, 295-297 (1980).