Hypooxytocinaemia in obese Zucker rats relates to oxytocin degradation in liver and adipose tissue

Journal of Endocrinology

Volumn 220, Issue 3, 2014, Pages 333-343

  Gajdosechova, Lucia ^a   Krskova, Katarina ^a   Segarra, Ana Belen ^b   Spolcova, Andrea ^c   Suski, Maciej ^d   Olszanecki, Rafal ^d   Zorad, Stefan ^a  

^a INSTITUTE OF EXPERIMENTAL ENDOCRINOLOGY   (Slovakia)

^b UNIVERSITY OF JAÉN   (Spain)

^c INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^d JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Insulin resistance; Obesity; Oxytocin; Oxytocin receptor; Oxytocinase

Indexed keywords

INSULIN RESISTANCE; OBESITY; OXYTOCIN; OXYTOCIN RECEPTOR; OXYTOCINASE;

ADIPOSE TISSUE; ANIMALS; CYSTINYL AMINOPEPTIDASE; HUMANS; LIVER; MALE; MUSCLE, SKELETAL; OBESITY, MORBID; OXYTOCIN; PROTEOLYSIS; RATS; RATS, ZUCKER; RECEPTORS, OXYTOCIN;

EID: 84894294009     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-13-0417     Document Type: Article

References (49)

1. Becker EE & Grinker JA 1977 Meal patterns in the genetically obese Zucker rat. Physiology & Behavior 18 685-692. (doi:10.1016/0031-9384(77)90067-1)
2. Boland D & Goren HJ 1987 Binding and structural properties of oxytocin receptors in isolated rat epididymal adipocytes. Regulatory Peptides 18 7-18. (doi:10.1016/0167-0115(87)90045-0)
3. Bonne D & Cohen P 1975 Characterization of oxytocin receptors on isolated rat fat cells. European Journal of Biochemistry 56 295-303. (doi:10.1111/j.1432-1033.1975.tb02233.x)
4. Bray MS & Young ME 2007 Circadian rhythms in the development of obesity: potential role for the circadian clock within the adipocyte. Obesity Reviews 8 169-181. (doi:10.1111/j.1467-789X.2006.00277.x)
5. Breton C, Haenggeli C, Barberis C, Heitz F, Bader CR, Bernheim L & Tribollet E 2002 Presence of functional oxytocin receptors in cultured human myoblasts. Journal of Clinical Endocrinology and Metabolism 87 1415-1418. (doi:10.1210/jc.87.3.1415)
6. Camerino C 2009 Low sympathetic tone and obese phenotype in oxytocindeficient mice. Obesity 17 980-984. (doi:10.1038/oby.2009.12)
7. Coiro V, Passeri M, Davoli C, d'Amato L, Gelmini G, Fagnoni F, Schianchi L, Bentivoglio M, Volpi R & Chiodera P 1988 Oxytocin response to insulin-induced hypoglycemia in obese subjects before and after weight loss. Journal of Endocrinological Investigation 11 125-128.
8. Deblon N, Veyrat-Durebex C, Bourgoin L, Caillon A, Bussier AL, Petrosino S, Piscitelli F, Legros JJ, Geenen V, Foti M et al. 2011 Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats. PLoS ONE 6 e25565. (doi:10.1371/journal.pone.0025565)
9. Devost D, Wrzal P & Zingg HH 2008 Oxytocin receptor signalling. Progress in Brain Research 170 167-176. (doi:10.1016/S0079-6123(08)00415-9)
10. DiGirolamo M, Fine JB, Tagra K & Rossmanith R 1998 Qualitative regional differences in adipose tissue growth and cellularity in male Wistar rats fed ad libitum. American Journal of Physiology 274 R1460-R1467.
11. Eckertova M, Ondrejcakova M, Krskova K, Zorad S & Jezova D 2011 Subchronic treatment of rats with oxytocin results in improved adipocyte differentiation and increased gene expression of factors involved in adipogenesis. British Journal of Pharmacology 162 452-463. (doi:10.1111/j.1476-5381.2010.01037.x)
12. Fjellestad-Paulsen A & Lundin S 1996 Metabolism of vasopressin, oxytocin and their analogues [Mpa1, D-Arg8]-vasopressin (dDAVP) and [Mpa1, D-Tyr(Et)2, Thr4, Orn8]-oxytocin (antocin) in human kidney and liver homogenates. Regulatory Peptides 67 27-32. (doi:S0167-0115(96)00103-6)
13. Froy O 2010 Metabolism and circadian rhythms - implications for obesity. Endocrine Reviews 31 1-24. (doi:10.1210/er.2009-0014)
14. Fukagawa K, Sakata T, Yoshimatsu H, Fujimoto K, Uchimura K & Asano C 1992 Advance shift of feeding circadian rhythm induced by obesity progression in Zucker rats. American Journal of Physiology 263 R1169-R1175.
15. Gimpl G & Fahrenholz F 2001 The oxytocin receptor system: structure, function, and regulation. Physiological Reviews 81 629-683.
16. Gutkowska J, Jankowski M, Mukaddam-Daher S & McCann SM 2000 Oxytocin is a cardiovascular hormone. Brazilian Journal of Medical and Biological Research 33 625-633. (doi:10.1590/S0100-879X2000000 600003)
17. Hoybye C, Barkeling B, Espelund U, PeterssonM& ThorenM2003 Peptides associated with hyperphagia in adults with Prader-Willi syndrome before and during GH treatment. Growth Hormone & IGF Research 13 322-327. (doi:10.1016/S1096-6374(03)00077-7)
18. Jezova D, Skultetyova I, Tokarev DI, Bakos P & Vigas M 1995 Vasopressin and oxytocin in stress. Annals of the New York Academy of Sciences 771 192-203. (doi:10.1111/j.1749-6632.1995.tb44681.x)
19. Johnson PR, Stern JS, Greenwood MR & Hirsch J 1978 Adipose tissue hyperplasia and hyperinsulinemia on Zucker obese female rats: a developmental study. Metabolism 27 1941-1954. (doi:10.1016/S0026-0495(78)80011-0)
20. Kaplan ML, Trout JR & Smith P 1980 Adipocyte size distribution in fa/fa rats during development. Metabolism 29 333-339. (doi:10.1016/0026-0495(80)90006-2)
21. Keller SR 2003 The insulin-regulated aminopeptidase: a companion and regulator of GLUT4. Frontiers in Bioscience 8 s410-s420. (doi:10.2741/1078)
22. Keller SR, Scott HM, Mastick CC, Aebersold R & Lienhard GE 1995 Cloning and characterization of a novel insulin-regulated membrane aminopeptidase from Glut4 vesicles. Journal of Biological Chemistry 270 23612-23618. (doi:10.1074/jbc.270.35.20497)
23. Kemp JG, Blazev R, Stephenson DG & Stephenson GM 2009 Morphological and biochemical alterations of skeletal muscles from the genetically obese (ob/ob) mouse. International Journal of Obesity 33 831-841. (doi:10.1038/ijo.2009.100)
24. King PA, Horton ED, Hirshman MF & Horton ES 1992 Insulin resistance in obese Zucker rat (fa/fa) skeletal muscle is associated with a failure of glucose transporter translocation. Journal Clinical Investigation 90 1568-1575. (doi:10.1172/JCI116025)
25. Lee ES, Uhm KO, Lee YM, Kwon J, Park SH & Soo KH 2008 Oxytocin stimulates glucose uptake in skeletal muscle cells through the calcium-CaMKK-AMPK pathway. Regulatory Peptides 151 71-74. (doi:10.1016/ j.regpep.2008.05.001)
26. Leng G, Onaka T, Caquineau C, Sabatier N, Tobin VA & Takayanagi Y 2008 Oxytocin and appetite. Progress in Brain Research 170 137-151. (doi:10.1016/S0079-6123(08)00413-5)
27. Maejima Y, Iwasaki Y, Yamahara Y, Kodaira M, Sedbazar U & Yada T 2011 Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass. Aging 3 1169-1177.
28. Maianu L, Keller SR & Garvey WT 2001 Adipocytes exhibit abnormal subcellular distribution and translocation of vesicles containing glucose transporter 4 and insulin-regulated aminopeptidase in type 2 diabetes mellitus: implications regarding defects in vesicle trafficking. Journal of Clinical Endocrinology and Metabolism 86 5450-5456.
29. Mistlberger RE, Lukman H & Nadeau BG 1998 Circadian rhythms in the Zucker obese rat: assessment and intervention. Appetite 30 255-267. (doi:10.1006/appe.1997.0134)
30. Morton GJ, Thatcher BS, Reidelberger RD, Ogimoto K, Wolden-Hanson T, Baskin DG, Schwartz MW & Blevins JE 2012 Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats. American Journal of Physiology. Endocrinology and Metabolism 302 E134-E144. (doi:10.1152/ajpendo.00296.2011)
31. Olszewski PK, Fredriksson R, Eriksson JD, Mitra A, Radomska KJ, Gosnell BA, Solvang MN, Levine AS & Schioth HB 2011 Fto colocalizes with a satiety mediator oxytocin in the brain and upregulates oxytocin gene expression. Biochemical and Biophysical Research Communications 408 422-426. (doi:10.1016/j.bbrc.2011.04.037)
32. Ondrejcakova M, Ravingerova T, Bakos J, Pancza D & Jezova D 2009 Oxytocin exerts protective effects on in vitro myocardial injury induced by ischemia and reperfusion. Canadian Journal of Physiology and Pharmacology 87 137-142. (doi:10.1139/Y08-108)
33. Phillips MS, Liu Q, Hammond HA, Dugan V, Hey PJ, Caskey CJ & Hess JF 1996 Leptin receptor missense mutation in the fatty Zucker rat. Nature Genetics 13 18-19. (doi:10.1038/ng0596-18)
34. Ramirez MJ, Martinez JM, Prieto I, Alba F & Ramirez M 1998 Dietary supplementation with olive oil influences aminopeptidase activities in mice. Nutrition Research 18 99-107. (doi:10.1016/S0271-5317 (97)00204-2)
35. Rogi T, Tsujimoto M, Nakazato H, Mizutani S & Tomoda Y 1996 Human placental leucine aminopeptidase/oxytocinase. A new member of type II membrane-spanning zinc metallopeptidase family. Journal of Biological Chemistry 271 56-61. (doi:10.1074/jbc.271.1.56)
36. Sackmann-Sala L, Berryman DE, Munn RD, Lubbers ER & Kopchick JJ 2012 Heterogeneity among white adipose tissue depots in male C57BL/6J mice. Obesity 20 101-111. (doi:10.1038/oby.2011.235)
37. Schaffler A, Binart N, Scholmerich J & Buchler C 2005 Hypothesis paper brain talks with fat-evidence for a hypothalamic-pituitary-adipose axis?. Neuropeptides 39 363-367. (doi:10.1016/j.npep.2005.06.003)
38. Schroeder M, Zagoory-Sharon O, Shbiro L, Marco A, Hyun J, Moran TH, Bi S & Weller A 2009 Development of obesity in the Otsuka Long-Evans Tokushima Fatty rat. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 297 R1749-R1760. (doi:10.1152/ ajpregu.00461.2009)
39. Segarra AB, Arechaga G, Prieto I, Ramirez-ExpositoMJ, Martinez-Martos JM, Ramirez M, Alba F, Ruiz-Larrea MB & Ruiz-Sanz JI 2002 Effects of dietary supplementation with fish oil, lard, or coconut oil on oxytocinase activity in the testis of mice. Archives of Andrology 48 233-236. (doi:10.1080/01485010252869333)
40. Sjoholm I & Ryden G 1996 Uptake of oxytocin in tissues after intravenous administration of tritiated oxytocin in rats. Acta Endocrinologica (Copenhagen) 61 432-440. (doi:10.1530/acta.0.0610432)
41. Stock S, Granstrom L, Backman L, Matthiesen AS & Uvnas-Moberg K 1989 Elevated plasma levels of oxytocin in obese subjects before and after gastric banding. International Journal of Obesity 13 213-222.
42. Szeto A, Nation DA, Mendez AJ, Dominguez-Bendala J, Brooks LG, Schneiderman N & McCabe PM 2008 Oxytocin attenuates NADPHdependent superoxide activity and IL-6 secretion in macrophages and vascular cells. American Journal of Physiology. Endocrinology and Metabolism 295 E1495-E1501. (doi:10.1152/ajpendo.90718.2008)
43. Szeto A, McCabe PM, Nation DA, Tabak BA, Rossetti MA, McCullough ME, Schneiderman N & Mendez AJ 2011 Evaluation of enzyme immunoassay and radioimmunoassay methods for the measurement of plasma oxytocin. Psychosomatic Medicine 73 393-400. (doi:10.1097/PSY.0b013e31821df0c2)
44. Takayanagi Y, Kasahara Y, Onaka T, Takahashi N, Kawada T & Nishimori K 2008 Oxytocin receptor-deficient mice developed late-onset obesity.Neuroreport 19 951-955.(doi:10.1097/WNR.0b013e3283021ca9)
45. Wallis MG, Lankford MF & Keller SR 2007 Vasopressin is a physiological substrate for the insulin-regulated aminopeptidase IRAP.American Journal of Physiology.Endocrinology and Metabolism 293 E1092-E1102.(doi:10.1152/ajpendo.00440.2007)
46. Whittington K, Assinder SJ, Parkinson T, Lapwood KR & Nicholson HD 2001 Function and localization of oxytocin receptors in the reproductive tissue of rams.Reproduction 122 317-325.(doi:10.1530/rep.0.1220317)
47. Zhang G & Cai D 2011 Circadian intervention of obesity development via resting-stage feeding manipulation or oxytocin treatment.American Journal of Physiology.Endocrinology and Metabolism 301 E1004-E1012.(doi:10.1152/ajpendo.00196.2011)
48. Zhang G, Bai H, Zhang H, Dean C, Wu Q, Li J, Guariglia S, Meng Q & Cai D 2011 Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance.Neuron 69 523-535.(doi:10.1016/j.neuron.2010.12.036)
49. Zhang H, Wu C, Chen Q, Chen X, Xu Z, Wu J & Cai D 2013 Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models.PLoS ONE 8 e61477.(doi:10.1371/journal.pone.0061477)