Oxytocin and appetite

Progress in Brain Research

Volumn 170, Issue , 2008, Pages 137-151

  Leng, Gareth ^a   Onaka, Tatsushi ^a   Caquineau, Celine ^a   Sabatier, Nancy ^a   Tobin, Vicky A ^a   Takayanagi, Yuki ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

dendritic release; prolactin releasing peptide; supraoptic nucleus; ventromedial hypothalamus

Indexed keywords

ALPHA INTERMEDIN; ARGIPRESTOCIN; CHOLECYSTOKININ; CHOLECYSTOKININ A RECEPTOR; G PROTEIN COUPLED RECEPTOR; ISOTOCIN; MESOTOCIN; NEUROHYPOPHYSIS HORMONE; NEUROPEPTIDE; NEUROPEPTIDE Y; NEUROTRANSMITTER RECEPTOR; OXYTOCIN; OXYTOCIN RECEPTOR; PHEROMONE; PROLACTIN RELEASING FACTOR; PROOPIOMELANOCORTIN; STEROIDOGENIC FACTOR 1; VASOPRESSIN;

ACTION POTENTIAL; ANIMAL BEHAVIOR; APPETITE; COPULATION; DENDRITE; EGG LAYING; ENERGY EXPENDITURE; ENERGY METABOLISM; EXPERIMENTAL MOUSE; FEEDING; FEEDING BEHAVIOR; FOOD INTAKE; GASTROPOD; GIANT CELL; HYPOTHALAMUS; INVERTEBRATE; KNOCKOUT MOUSE; LIBIDO; MAMMAL; MATE CHOICE; MATING; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; MOTIVATION; NERVE CELL; NERVE ENDING; NERVE FIBER; NERVE PROJECTION; NEUROENDOCRINE SYSTEM; NEUROHYPOPHYSIS; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; OSMOREGULATION; OXYTOCIN RELEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PUFFER FISH; RECEPTOR BINDING; REGULATORY MECHANISM; REVIEW; SATIETY; SEXUAL AROUSAL; SEXUAL BEHAVIOR; SOCIAL BEHAVIOR; SOLITARY TRACT NUCLEUS; SPIKE WAVE; STIMULUS SECRETION COUPLING; STRESS; SUPRAOPTIC NUCLEUS; TELEOST; THALAMUS MIDLINE NUCLEUS; THALAMUS VENTRAL NUCLEUS; VASOPRESSIN BLOOD LEVEL;

ANIMALS; APPETITE; DENDRITES; EVOLUTION; FEEDING BEHAVIOR; FEMALE; FISHES; HUMANS; HUNGER; LACTATION; MAMMALS; MARSUPIALIA; MILK; NEURONS; OXYTOCIN; PITUITARY GLAND, POSTERIOR; SEXUAL BEHAVIOR; SEXUAL BEHAVIOR, ANIMAL; SIGNAL TRANSDUCTION; SOCIAL BEHAVIOR;

EID: 47549101401     PISSN: 00796123     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6123(08)00413-5     Document Type: Review

References (79)

1. Amico J.A., Mantella R.C., and Vollmer R.R. Consumption of solutions containing sodium chloride is enhanced in female oxytocin-deficient mice. Behav. Neurosci. 117 (2003) 32-37
2. Arletti R., Benelli A., and Bertolini A. Oxytocin inhibits food and fluid intake in rats. Physiol. Behav. 48 (1990) 825-830
3. Bale T.L., Davis A.M., Auger A.P., Dorsa D.M., and McCarthy M.M. CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior. J. Neurosci. 21 (2001) 2546-2552
4. Bale T.L., and Dorsa D.M. Sex differences in and effects of estrogen on oxytocin receptor messenger ribonucleic acid expression in the ventromedial hypothalamus. Endocrinology 136 (1995) 27-32
5. Bale T.L., Dorsa D.M., and Johnston C.A. Oxytocin receptor mRNA expression in the ventromedial hypothalamus during the estrous cycle. J. Neurosci. 15 (1995) 5058-5064
6. Bechtold D.A., and Luckman S.M. Prolactin-releasing peptide mediates cholecystokinin-induced satiety in mice. Endocrinology 147 (2006) 4723-4729
7. Bechtold D.A., and Luckman S.M. The role of RFamide peptides in feeding. J. Endocrinol. 192 (2007) 3-15
8. Bi S., Scott K.A., Kopin A.S., and Moran T.H. Differential roles for cholecystokinin A receptors in energy balance in rats and mice. Endocrinology 145 (2004) 3873-3880
9. Black M.P., Reavis R.H., and Grober M.S. Socially induced sex change regulates forebrain isotocin in Lythrypnus dalli. NeuroReport 15 (2004) 185-189
10. Blevins J.E., Eakin T.J., Murphy J.A., Schwartz M.W., and Baskin D.G. Oxytocin innervation of caudal brainstem nuclei activated by cholecystokinin. Brain Res. 993 (2003) 30-41
11. Blevins J.E., Schwartz M.W., and Baskin D.G. Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size. Am. J. Physiol. 287 (2004) R87-R96
12. Botzer D., Blumberg S., Ziv I., and Susswein A.J. Common regulation of feeding and mating in Aplysia fasciata: Pheromones released by mating and by egg cordons increase feeding behavior. Behav. Neural Biol. 56 (1991) 251-261
13. Caldwell J.D., Jirikowski G.F., Greer E.R., Stumpf W.E., and Pedersen C.A. Ovarian steroids and sexual interaction alter oxytocinergic content and distribution in the basal forebrain. Brain Res. 446 (1988) 237-244
14. Caquineau C., Leng G., Guan X.M., Jiang M., Van der Ploeg L., and Douglas A.J. Effects of alpha-melanocyte-stimulating hormone on magnocellular oxytocin neurones and their activation at intromission in male rats. J. Neuroendocrinol. 18 (2006) 685-691
15. Coirini H., Johnson A.E., and McEwen B.S. Estradiol modulation of oxytocin binding in the ventromedial hypothalamic nucleus of male and female rats. Neuroendocrinology 50 (1989) 193-198
16. Cone R.D. Anatomy and regulation of the central melanocortin system. Nat. Neurosci. 8 (2005) 571-578
17. Daniels D., and Flanagan-Cato L.M. Functionally-defined compartments of the lordosis neural circuit in the ventromedial hypothalamus in female rats. J. Neurobiol. 45 (2000) 1-13
18. De Boer P.A.C.M., Ter Maat A., Pieneman A.W., Croll R.P., Kurokawa M., and Jansen R.F. Functional role of peptidergic anterior lobe neurons in male sexual behaviour of the snail Lymnaea stagnalis. J. Neurophysiol. 78 (1997) 2823-2833
19. de Kloet E.R., Voorhuis D.A., Boschma Y., and Elands J. Estradiol modulates density of putative 'oxytocin receptors' in discrete rat brain regions. Neuroendocrinology 44 (1986) 415-421
20. Dhillon H., Zigman J.M., Ye C., Lee C.E., McGovern R.A., Tang V., Kenny C.D., Christiansen L.M., White R.D., Edelstein E.A., et al. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 49 (2006) 191-203
21. Douglas A.J., Johnstone L.E., and Leng G. Neuroendocrine mechanisms of change in food intake in pregnancy: a potential role for brain oxytocin. Physiol. Behav. 91 (2007) 352-365
22. 3H]oxytocin-binding sites in the Wistar rat brain studied by autoradiography. Neuroscience 20 (1987) 599-614
23. Garcia L.R., and Sternberg P.W. Caenorhabditis elegans UNC-103 ERG-like potassium channel regulates contractile behaviours of sex muscles in males before and during mating. J. Neurosci. 23 (2003) 2696-2705
24. Gilligan P., Brenner S., and Venkatesh B. Neurone-specific expression and regulation of the pufferfish isotocin and vasotocin genes in transgenic mice. J. Neuroendocrinol. 11 (2003) 1027-1036
25. Inenaga K., Kannan H., Yamashita H., Tribollet E., Raggenbass M., and Dreifuss J.J. Oxytocin excites neurons located in the ventromedial nucleus of the guinea-pig hypothalamus. J. Neuroendocrinol. 3 (1991) 569-573
26. Isse T., Ueta Y., Serino R., Noguchi J., Yamamoto Y., Nomura M., Shibuya I., Lightman S.L., and Yamashita H. Effects of leptin on fasting-induced inhibition of neuronal nitric oxide synthase mRNA in the paraventricular and supraoptic nuclei of rats. Brain Res. 846 (1999) 229-235
27. Jirikowski G.F., Caldwell J.D., Pedersen C.A., and Stumpf W.E. Estradiol influences oxytocin-immunoreactive brain systems. Neuroscience 25 (1988) 237-248
28. John T.M., Thomas E., George J.C., and Beamish F.W. Effect of vasotocin on plasma free fatty acid level in the migrating anadromous sea lamprey. Arch. Int. Physiol. Biochim. 85 (1977) 865-870
29. Johnson A.E., Harbaugh C.R., and Gelhard R.E. Projections from the ventromedial nucleus of the hypothalamus contain oxytocin binding sites. Brain Res. 567 (1991) 332-336
30. Johnstone L.E., Fong T.M., and Leng G. Neuronal activation in the hypothalamus and brainstem during feeding in rats. Cell Metab. 4 (2006) 313-321
31. Jonaidi H., Oloumi M.M., and Denbow D.M. Behavioral effects of intracerebroventricular injection of oxytocin in birds. Physiol. Behav. 79 (2003) 725-729
32. Kow L.M., Johnson A.E., Ogawa S., and Pfaff D.W. Electrophysiological actions of oxytocin on hypothalamic neurons in vitro: neuropharmacological characterization and effects of ovarian steroids. Neuroendocrinology 54 (1991) 526-535
33. Kow L.M., and Pfaff D.W. Vasopressin excites ventromedial hypothalamic glucose-responsive neurons in vitro. Physiol. Behav. 37 (1986) 153-158
34. Kremarik P., Freund-Mercier M.J., and Stoeckel M.E. Oxytocin and vasopressin binding sites in the hypothalamus of the rat: histoautoradiographic detection. Brain Res. Bull. 36 (1995) 195-203
35. Leng G., Caquineau C., and Sabatier N. Regulation of oxytocin secretion. Vitamins Hormones 71 (2005) 27-58
36. Leng G., and Ludwig M. Information processing in the hypothalamus: peptides and analogue computation. J. Neuroendocrinol. 18 (2006) 379-392
37. Lipton J., Kleemann G., Ghosh R., Lints R., and Emmons S.W. Mate searching in Caenorhabditis elegans: a genetic model for sex drive in a simple invertebrate. J. Neurosci. 24 (2004) 7427-7434
38. Liu W., Liu M., Fan W., Nawata H., and Yanase T. The Gly146Ala variation in human SF-1 gene: its association with insulin resistance and type 2 diabetes in Chinese. Diabetes Res. Clin. Pract. 73 (2006) 322-328
39. Lokrantz C.M., Uvnäs-Moberg K., and Kaplan J.M. Effects of central oxytocin administration on intraoral intake of glucose in deprived and nondeprived rats. Physiol. Behav. 62 (1997) 347-352
40. Ludwig M., and Leng G. Dendritic peptide release and peptide-dependent behaviours. Nat. Neurosci. Rev. 7 (2006) 126-136
41. Majdic G., Young M., Gomez-Sanchez E., Anderson P., Szczepaniak L.S., Dobbins R.L., McGarry J.D., and Parker K.L. Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity. Endocrinology 143 (2002) 607-614
42. McClellan K.M., Parker K.L., and Tobet S. Development of the ventromedial nucleus of the hypothalamus. Front. Neuroendocrinol. 27 (2006) 193-209
43. Mera T., Fujihara H., Saito J., Kawasaki M., Hashimoto H., Saito T., Shibata M., Onaka T., Tanaka Y., Oka .T., Tsuji S., and Ueta Y. Downregulation of prolactin-releasing peptide gene expression in the hypothalamus and brainstem of diabetic rats. Peptides 28 (2007) 1596-1604
44. Miedlar J.A., Rinaman L., Vollmer R.R., and Amico J.A. Oxytocin gene deletion mice overconsume palatable sucrose solution but not palatable lipid emulsions. Am. J. Physiol. 293 (2007) R1063-R1068
45. Morris J.F. Distribution of neurosecretory granules among the anatomical compartments of the neurosecretory processes of the pituitary gland: a quantitative ultrastructural approach to hormone storage in the neural lobe. J. Endocrinol. 68 (1976) 225-234
46. Morris J.F. Hormone storage in individual neurosecretory granules of the pituitary gland: a quantitative ultrastructural approach to hormone storage in the neural lobe. J. Endocrinol. 68 (1976) 209-224
47. Nedvetzki Y., Markovich S., and Susswein A.J. Inhibition of mating in Aplysia fasciata by food stimuli in the environment, but not by post-ingestion stimuli causing satiation. J. Comp. Physiol. A 182 (1998) 183-190
48. Nordmann J.J., and Morris J.F. Method for quantitating the molecular content of a subcellular organelle: hormone and neurophysin content of newly formed and aged neurosecretory granules. Proc. Natl. Acad. Sci. U.S.A. 81 (1984) 180-184
49. Nozaki M., and Gorbman A. Immunocytochemical localization of somatostatin and vasotocin in the brain of the Pacific hagfish, Eptatretus stouti. Cell Tissue Res. 229 (1983) 541-550
50. Oldfield B.J., Giles M.E., Watson A., Anderson C., Colvill L.M., and McKinley M.J. The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat. Neuroscience 110 (2002) 515-526
51. Olson B.R., Drutarosky M.D., Chow M.S., Hruby V.J., Stricker E.M., and Verbalis J.G. Oxytocin and an oxytocin agonist administered centrally decrease food intake in rats. Peptides 12 (1991) 113-118
52. Olson B.R., Drutarosky M.D., Stricker E.M., and Verbalis J.G. Brain oxytocin receptor antagonism blunts the effects of anorexigenic treatments in rats: evidence for central oxytocin inhibition of food intake. Endocrinology 129 (1991) 785-791
53. Onaka T. Neural pathways controlling central and peripheral oxytocin release during stress. J. Neuroendocrinol. 16 (2004) 308-312
54. Pfaff D., and Keiner M. Atlas of estradiol-concentrating cells in the central nervous system of the female rat. J. Comp. Neurol. 151 (1973) 121-158
55. Pfaff D., and Sakuma Y. Facilitation of the lordosis reflex of female rats from the ventromedial nucleus of the hypothalamus. J. Physiol. 288 (1979) 189-202
56. Pow D.V., and Morris J.F. Dendrites of hypothalamic magnocellular neurons release neurohypophysial peptides by exocytosis. Neuroscience 32 (1989) 435-439
57. Puryear R., Rigatto K.V., Amico J.A., and Morris M. Enhanced salt intake in oxytocin deficient mice. Exp. Neurol. 171 (2001) 323-328
58. Rinaman L., Vollmer R.R., Karam J., Phillips D., Li X., and Amico J.A. Dehydration anorexia is attenuated in oxytocin-deficient mice. Am. J. Physiol. 288 (2005) R1791-R1799
59. Russell J.A., Leng G., and Douglas A.J. The magnocellular oxytocin system. The fount of maternity: adaptations in pregnancy. Front. Neuroendocrinol. 24 (2003) 27-61
60. Sabatier N. Alpha-melanocyte-stimulating hormone and oxytocin: a peptide signalling cascade in the hypothalamus. J. Neuroendocrinol. 18 (2006) 703-710
61. Sabatier N., Caquineau C., Bull P., Douglas A.J., Dayanithi G., Guan X.M., Jiang M., Van der Ploeg L., and Leng G. Alpha-melanocyte-stimulating hormone stimulates oxytocin release from the dendrites of hypothalamic neurons while inhibiting oxytocin release from their terminals in the neurohypophysis. J. Neurosci. 23 (2003) 10351-10358
62. Sabatier N., and Leng G. Presynaptic actions of endocannabinoids mediate α-MSH-induced inhibition of oxytocin cells. Am. J. Physiol. 290 (2006) R577-R684
63. Satake H., Takuwa K., Minakata H., and Matsushima O. Evidence for conservation of the vasopressin/oxytocin superfamily in Annelida. J. Biol. Chem. 274 (1999) 5605-5611
64. Schumacher M., Coirini H., Frankfurt M., and McEwen B.S. Localized actions of progesterone in hypothalamus involve oxytocin. PNAS 86 (1989) 6798-6801
65. Sclafani A., Rinaman L., Vollmer R.R., and Amico J.A. Oxytocin knockout mice demonstrate enhanced intake of sweet and nonsweet carbohydrate solutions. Am. J. Physiol. 292 (2007) R1828-R1833
66. Shiraishi T., Oomura Y., Sasaki K., and Wayner M.J. Effects of leptin and orexin-A on food intake and feeding related hypothalamic neurons. Physiol. Behav. 71 (2000) 251-261
67. Song Z., Levin B.E., McArdle J.J., Bakhos N., and Routh V.H. Convergence of pre- and postsynaptic influences on glucosensing neurons in the ventromedial hypothalamic nucleus. Diabetes 50 (2001) 2673-2681
68. Sternson S.M., Shepherd G.M., and Friedman J.M. Topographic mapping of VMH-arcuate nucleus microcircuits and their reorganization by fasting. Nat. Neurosci. 8 (2005) 1356-1363
69. Susswein A.J. Effects of food deprivation upon behavioral patterns and time budgeting of Aplysia fasciata. Behav. Neural Biol. 42 (1984) 127-133
70. Takuwa-Kuroda K., Iwakoshi-Ukena E., Kanda A., and Minakata H. Octopus, which owns the most advanced brain in invertebrates, has two members of vasopressin/oxytocin superfamily as in vertebrates. Regul. Pept. 115 (2003) 139-149
71. Tribollet E., Barberis C., Jard S., Dubois-Dauphin M., and Dreifuss J.J. Localization and pharmacological characterization of high affinity binding sites for vasopressin and oxytocin in the rat brain by light microscopic autoradiography. Brain Res. 442 (1988) 105-118
72. Tribollet E., Li Z., Inenaga K., Yamashita H., Raggenbass M., Dubois-Dauphin M., and Dreifuss J.J. Functional neuronal binding sites for oxytocin in the ventromedial hypothalamus of the guinea pig after gonadectomy. Brain Res. 588 (1992) 346-350
73. Ukena K., Oumi T., Matsushima O., Ikeda T., Fujita T., Minankata H., and Nomoto K. Effects of annetocin, an oxytocin-related peptide isolated from the earthworm Eisenia foetida, and some putative neurotransmitters on gut motility of the earthworm. J. Exp. Zool. 272 (1995) 184-193
74. Vollmer R.R., Li X., Karam J.R., and Amico J.A. Sodium ingestion in oxytocin knockout mice. Exp. Neurol. 202 (2006) 441-448
75. Waldherr M., and Neumann I.D. Centrally released oxytocin mediates mating-induced anxiolysis in male rats. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 16681-16684
76. Watanabe Y., Sakihara T., Mukuda T., and Ando M. Antagonistic effects of vasotocin and isotocin on the upper esophageal sphincter muscle of the eel acclimated to seawater. J. Comp. Physiol. 177 (2007) 867-873
77. Yoshimura R., Kiyama H., Kimura T., Araki T., Maeno H., Tanizawa O., and Tohyama M. Localization of oxytocin receptor messenger ribonucleic acid in the rat brain. Endocrinology 133 (1993) 1239-1246
78. Young L.J., Huot B., Nilsen R., Wang Z., and Insel T.R. Species differences in central oxytocin receptor gene expression: comparative analysis of promoter sequences. J. Neuroendocrinol. 10 (1996) 777-783
79. Young L.J., Murphy Young A.Z., and Hammock E.A. Anatomy and neurochemistry of the pair bond. J. Comp. Neurol. 493 (2005) 51-57