Lysosomal network proteins as potential novel CSF biomarkers for Alzheimer's disease

NeuroMolecular Medicine

Volumn 16, Issue 1, 2014, Pages 150-160

  Armstrong, Andrea ^a,b   Mattsson, Niklas ^c,d   Appelqvist, Hanna ^a   Janefjord, Camilla ^a   Sandin, Linnea ^a   Agholme, Lotta ^a   Olsson, Bob ^c   Svensson, Samuel ^a,b   Blennow, Kaj ^c   Zetterberg, Henrik ^c,e   Kågedal, Katarina ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b AlzeCure Foundation   (Sweden)

^c SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Cathepsins; DRAM; hsc70; PICALM; Proteasome; TFEB

Indexed keywords

ADULT; AGED; AGED, 80 AND OVER; ALBUMINS; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AUTOPHAGY; BIOLOGICAL MARKERS; CEREBROSPINAL FLUID PROTEINS; ENDOSOMES; FEMALE; HUMANS; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; LYSOSOMES; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; PEPTIDE FRAGMENTS; PHAGOSOMES; RAB GTP-BINDING PROTEINS; RAB3 GTP-BINDING PROTEINS; TAU PROTEINS; VESICULAR TRANSPORT PROTEINS;

EID: 84894283814     PISSN: 15351084     EISSN: 15591174     Source Type: Journal    
DOI: 10.1007/s12017-013-8269-3     Document Type: Article

References (43)

1. Andreasson, U., Lautner, R., Schott, J. M., Mattsson, N., Hansson, O., Herukka, S. K., et al. (2013). CSF biomarkers for Alzheimer's pathology and the effect size of APOE varepsilon4. Molecular Psychiatry. doi: 10.1038/mp.2013.18.
2. Baig, S., Joseph, S. A., Tayler, H., Abraham, R., Owen, M. J., Williams, J., et al. (2010). Distribution and expression of picalm in Alzheimer disease. Journal of Neuropathology and Experimental Neurology, 69(10), 1071-1077. (Research Support, Non-U.S. Gov't).
3. Barrachina, M., Maes, T., Buesa, C., & Ferrer, I. (2006). Lysosome-associated membrane protein 1 (LAMP-1) in Alzheimer's disease. Neuropathology and Applied Neurobiology, 32(5), 505-516.
4. Bateman, R. J., Xiong, C., Benzinger, T. L., Fagan, A. M., Goate, A., Fox, N. C., et al. (2012). Clinical and biomarker changes in dominantly inherited Alzheimer's disease. New England Journal of Medicine, 367(9), 795-804.
5. Blennow, K., Bogdanovic, N., Alafuzoff, I., Ekman, R., & Davidsson, P. (1996). Synaptic pathology in Alzheimer's disease: Relation to severity of dementia, but not to senile plaques, neurofibrillary tangles, or the ApoE4 allele. Journal of Neural Transmission, 103(5), 603-618.
6. Blennow, K., de Leon, M. J., & Zetterberg, H. (2006). Alzheimer's disease. Lancet, 368(9533), 387-403.
7. Blennow, K., Hampel, H., Weiner, M., & Zetterberg, H. (2010). Cerebrospinal fluid and plasma biomarkers in Alzheimer disease. Nature Reviews Neurology, 6(3), 131-144.
8. Blennow, K., Wallin, A., Agren, H., Spenger, C., Siegfried, J., & Vanmechelen, E. (1995). Tau protein in cerebrospinal fluid: A biochemical marker for axonal degeneration in Alzheimer disease? Molecular and Chemical Neuropathology, 26(3), 231-245.
9. Boland, B., & Nixon, R. A. (2006). Neuronal macroautophagy: From development to degeneration. Molecular Aspects of Medicine, 27(5-6), 503-519.
10. Bronfman, F. C., Escudero, C. A., Weis, J., & Kruttgen, A. (2007). Endosomal transport of neurotrophins: Roles in signaling and neurodegenerative diseases. Dev Neurobiol, 67(9), 1183-1203.
11. Cataldo, A. M., Barnett, J. L., Pieroni, C., & Nixon, R. A. (1997). Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: Neuropathologic evidence for a mechanism of increased β-amyloidogenesis. Journal of Neuroscience, 17(16), 6142-6151.
12. Cataldo, A. M., Peterhoff, C. M., Troncoso, J. C., Gomez-Isla, T., Hyman, B. T., & Nixon, R. A. (2000). Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: Differential effects of APOE genotype and presenilin mutations. American Journal of Pathology, 157(1), 277-286.
13. Ciechanover, A., & Brundin, P. (2003). The ubiquitin proteasome system in neurodegenerative diseases: Sometimes the chicken, sometimes the egg. Neuron, 40(2), 427-446.
14. Davidsson, P., Bogdanovic, N., Lannfelt, L., & Blennow, K. (2001). Reduced expression of amyloid precursor protein, presenilin-1 and rab3a in cortical brain regions in Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 12(4), 243-250.
15. Delcroix, J. D., Valletta, J. S., Wu, C., Hunt, S. J., Kowal, A. S., & Mobley, W. C. (2003). NGF signaling in sensory neurons: Evidence that early endosomes carry NGF retrograde signals. Neuron, 39(1), 69-84.
16. Ginsberg, S. D., Mufson, E. J., Counts, S. E., Wuu, J., Alldred, M. J., Nixon, R. A., et al. (2010). Regional selectivity of rab5 and rab7 protein upregulation in mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's Disease, 22(2), 631-639.
17. Hampel, H., Buerger, K., Zinkowski, R., Teipel, S. J., Goernitz, A., Andreasen, N., et al. (2004). Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: A comparative cerebrospinal fluid study. Archives of General Psychiatry, 61(1), 95-102.
18. Hansson, O., Zetterberg, H., Buchhave, P., Londos, E., Blennow, K., & Minthon, L. (2006). Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: A follow-up study. Lancet Neurology, 5(3), 228-234.
19. Hardy, J., & Selkoe, D. J. (2002). The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science, 297(5580), 353-356.
20. Hu, Y., Malone, J. P., Fagan, A. M., Townsend, R. R., & Holtzman, D. M. (2005). Comparative proteomic analysis of intra-and interindividual variation in human cerebrospinal fluid. Molecular and Cellular Proteomics, 4(12), 2000-2009.
21. Hua, C. T., Hopwood, J. J., Carlsson, S. R., Harris, R. J., & Meikle, P. J. (1998). Evaluation of the lysosome-associated membrane protein LAMP-2 as a marker for lysosomal storage disorders. Clinical Chemistry, 44(10), 2094-2102.
22. Ihara, Y., Morishima-Kawashima, M., & Nixon, R. (2012). The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease. Cold Spring Harbor Perspectives in Medicine, 2(8), a006361.
23. Jiang, Y., Mullaney, K. A., Peterhoff, C. M., Che, S., Schmidt, S. D., Boyer-Boiteau, A., et al. (2010). Alzheimer's-related endosome dysfunction in down syndrome is Aβ-independent but requires APP and is reversed by BACE-1 inhibition. Proceedings of the National Academy of Sciences U S A, 107(4), 1630-1635.
24. Kågedal, K., Kim, W. S., Appelqvist, H., Chan, S., Cheng, D., Agholme, L., et al. (2010). Increased expression of the lysosomal cholesterol transporter NPC1 in Alzheimer's disease. Biochimica et Biophysica Acta, 1801(8), 831-838.
25. Klionsky, D. J., Cregg, J. M., Dunn, W. A., Jr, Emr, S. D., Sakai, Y., Sandoval, I. V., et al. (2003). A unified nomenclature for yeast autophagy-related genes. Developmental Cell, 5(4), 539-545.
26. Lipinski, M. M., Zheng, B., Lu, T., Yan, Z., Py, B. F., Ng, A., et al. (2010). Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proceedings of the National Academy of Sciences USA, 107(32), 14164-14169.
27. Mawuenyega, K. G., Sigurdson, W., Ovod, V., Munsell, L., Kasten, T., Morris, J. C., et al. (2010). Decreased clearance of CNS β-amyloid in Alzheimer's disease. Science, 330(6012), 1774.
28. Nixon, R. A., Mathews, P. M., & Cataldo, A. M. (2001). The neuronal endosomal-lysosomal system in Alzheimer's disease. Journal of Alzheimer's Disease, 3(1), 97-107.
29. Nixon, R. A., Wegiel, J., Kumar, A., Yu, W. H., Peterhoff, C., Cataldo, A., et al. (2005). Extensive involvement of autophagy in Alzheimer disease: An immuno-electron microscopy study. Journal of Neuropathology and Experimental Neurology, 64(2), 113-122.
30. Perez, A., Morelli, L., Cresto, J. C., & Castano, E. M. (2000). Degradation of soluble amyloid β-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains. Neurochemical Research, 25(2), 247-255.
31. Schwagerl, A. L., Mohan, P. S., Cataldo, A. M., Vonsattel, J. P., Kowall, N. W., & Nixon, R. A. (1995). Elevated levels of the endosomal-lysosomal proteinase cathepsin D in cerebrospinal fluid in Alzheimer disease. Journal of Neurochemistry, 64(1), 443-446.
32. Sonnen, J. A., Montine, K. S., Quinn, J. F., Kaye, J. A., Breitner, J. C., & Montine, T. J. (2008). Biomarkers for cognitive impairment and dementia in elderly people. Lancet Neurol, 7(8), 704-714.
33. Sundelöf, J., Sundstrom, J., Hansson, O., Eriksdotter-Jonhagen, M., Giedraitis, V., Larsson, A., et al. (2010). Higher cathepsin B levels in plasma in Alzheimer's disease compared to healthy controls. Journal of Alzheimer's Disease, 22(4), 1223-1230.
34. Sze, C. I., Bi, H., Kleinschmidt-DeMasters, B. K., Filley, C. M., & Martin, L. J. (2000). Selective regional loss of exocytotic presynaptic vesicle proteins in Alzheimer's disease brains. Journal of the Neurological Sciences, 175(2), 81-90.
35. Terry, R. D., Gonatas, N. K., & Weiss, M. (1964). Ultrastructural studies in Alzheimer's presenile dementia. American Journal of Pathology, 44, 269-297.
36. Upadhya, S. C., & Hegde, A. N. (2007). Role of the ubiquitin proteasome system in Alzheimer's disease. BMC Biochemistry, 8(Suppl 1), S12.
37. Vandermeeren, M., Mercken, M., Vanmechelen, E., Six, J., van de Voorde, A., Martin, J. J., et al. (1993). Detection of tau proteins in normal and Alzheimer's disease cerebrospinal fluid with a sensitive sandwich enzyme-linked immunosorbent assay. Journal of Neurochemistry, 61(5), 1828-1834.
38. Vanderstichele, H., Van Kerschaver, E., Hesse, C., Davidsson, P., Buyse, M. A., Andreasen, N., et al. (2000). Standardization of measurement of β-amyloid(1-42) in cerebrospinal fluid and plasma. Amyloid, 7(4), 245-258.
39. Vanmechelen, E., Vanderstichele, H., Davidsson, P., Van Kerschaver, E., Van Der Perre, B., Sjogren, M., et al. (2000). Quantification of tau phosphorylated at threonine 181 in human cerebrospinal fluid: A sandwich ELISA with a synthetic phosphopeptide for standardization. Neuroscience Letters, 285(1), 49-52.
40. Yang, D. S., Kumar, A., Stavrides, P., Peterson, J., Peterhoff, C. M., Pawlik, M., et al. (2008). Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease. American Journal of Pathology, 173(3), 665-681.
41. Yu, W. H., Cuervo, A. M., Kumar, A., Peterhoff, C. M., Schmidt, S. D., Lee, J. H., et al. (2005). Macroautophagy - a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease. Journal of Cell Biology, 171(1), 87-98.
42. Zetterberg, H., Wahlund, L. O., & Blennow, K. (2003). Cerebrospinal fluid markers for prediction of Alzheimer's disease. Neuroscience Letters, 352(1), 67-69.
43. Zougman, A., Pilch, B., Podtelejnikov, A., Kiehntopf, M., Schnabel, C., Kumar, C., et al. (2008). Integrated analysis of the cerebrospinal fluid peptidome and proteome. Journal of Proteome Research, 7(1), 386-399.