Trans fatty acid intake is inversely related to total sperm count in young healthy men

Human Reproduction

Volumn 29, Issue 3, 2014, Pages 429-440

  Chavarro, Jorge E ^a,b   Mínguez Alarcón, Lidia ^c   Mendiola, Jaime ^c   Cutillas Tolín, Ana ^c   López Espín, José J ^d   Torres Cantero, Alberto M ^c,e  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MURCIA   (Spain)

^d MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^e UNIVERSITY OF MURCIA   (Spain)

Author keywords

fat intake; semen quality; trans fatty acids; young healthy men

Indexed keywords

TRANS FATTY ACID;

ADULT; ARTICLE; CHOLESTEROL INTAKE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; EJACULATION; FAT INTAKE; FOOD FREQUENCY QUESTIONNAIRE; HUMAN; INFERTILITY; MALE; MALE FERTILITY; MORPHOLOGY; NUTRITIONAL ASSESSMENT; PHYSICAL EXAMINATION; QUALITY CONTROL; SEMEN ANALYSIS; SPAIN; SPERM; SPERMATOZOON COUNT; TESTIS FUNCTION; UNIVERSITY STUDENT; YOUNG ADULT;

FAT INTAKE; SEMEN QUALITY; TRANS FATTY ACIDS; YOUNG HEALTHY MEN;

ADOLESCENT; CHOLESTEROL, DIETARY; CROSS-SECTIONAL STUDIES; DIETARY FATS; HUMANS; MALE; SEMEN ANALYSIS; SPERM COUNT; TRANS FATTY ACIDS; YOUNG ADULT;

EID: 84894282898     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/det464     Document Type: Article

References (64)

1. Attaman JA, Toth TL, Furtado J, Campos H, Hauser R, Chavarro JE. Dietary fat and semen quality among men attending a fertility clinic. Hum Reprod 2012;27:1466-1474.
2. Baylin A, Kabagambe EK, Siles X, Campos H. Adipose tissue biomarkers of fatty acid intake. Am J Clin Nutr 2002;76:750-757.
3. Baylin A, Kim MK, Donovan-Palmer A, Siles X, Dougherty L, Tocco P, Campos H. Fasting whole blood as a biomarker of essential fatty acid intake in epidemiologic studies: comparison with adipose tissue and plasma. Am J Epidemiol 2005;162:373-381.
4. Block G,Woods M, Potosky A, Clifford C. Validation of a self-administered diet history questionnaire using multiple diet records. J Clin Epidemiol 1990; 43:1327-1335.
5. Briefel RR, Johnson CL. Secular trends in dietary intake in the United States. Annu Rev Nutr 2004;24:401-431.
6. Carlsen E, GiwercmanA, Keiding N,Skakkebaek NE. Evidence for decreasing quality of semen during the past 50 years. BMJ 1992;305:609-613.
7. Carlsen E, Swan SH, Petersen JH, Skakkebæk NE. Longitudinal changes in semen parameters in young Danish men from the Copenhagen area. Hum Reprod 2005;20:942-949.
8. Chavarro JE, Furtado J, Toth TL, Ford J, Keller M, Campos H, Hauser R. Trans-fatty acid levels in sperm are associated with sperm concentration among men from an infertility clinic. Fertil Steril 2011;95:1794-1797.
9. Christophersen BO, Hagve TA, Christensen E, Johansen Y, Tverdal S. Eicosapentaenoic-and arachidonic acid metabolism in isolated liver cells. Scand J Clin Lab Invest Suppl 1986;184:55-60.
10. Eskenazi B, Kidd SA, Marks AR, Sloter E, Block G, Wyrobek AJ. Antioxidant intake is associated with semen quality in healthy men. Hum Reprod 2005; 20:1006-1012.
11. Fisch H, Goluboff ET, Olson JH, Feldshuh J, Broder SJ, Barad DH. Semen analyses in 1283 men from the United States over a 25-year period: no decline in quality. Fertil Steril 1996;65:1009-1014.
12. Gaskins A, Colaci D, Mendiola J, Swan SH, Chavarro J. Dietary patterns and semen quality in young men. Hum Reprod 2012;27:2899-2907.
13. Haidl G, Opper C. Changes in lipids and membrane anisotropy in human spermatozoa during epididymal maturation. Hum Reprod 1997; 12:2720-2723.
14. Hall JC, Hadley J, Doman T. Correlation between changes in rat sperm membrane lipids, protein, and the membrane physical state during epididymal maturation. J Androl 1991;12:76-87.
15. Handelsman DJ. Sperm output of healthy men in Australia: magnitude of bias due to self-selected volunteers. Hum Reprod 1997;12:2701-2705.
16. Hanis T, Zidek V, Sachova J, Klir P, Deyl Z. Effects of dietary trans-fatty acids on reproductive performance of Wistar rats. Br J Nutr 1989;61:519-529.
17. Hill EG, Johnson SB, Lawson LD, Mahfouz MM, Holman RT. Perturbation of the metabolism of essential fatty acids by dietary partially hydrogenated vegetable oil. Proc Natl Acad Sci USA 1982;79:953-957.
18. Hulshof KF, van Erp-Baart MA, Anttolainen M, Becker W, Church SM, Couet C, Hermann-Kunz E, Kesteloot H, Leth T, Martins I et al. Intake of fatty acids in western Europe with emphasis on trans fatty acids: the TRANSFAIR Study. Eur J Clin Nutr 1999;53:143-157.
19. Jensen B. Rat testicular lipids and dietary isomeric fatty acids in essential fatty acid deficiency. Lipids 1976;11:179-188.
20. Jensen TK, Heitmann BL, Jensen MB, Halldorsson TI, Andersson AM, Skakkebaek NE, Joensen UN, Lauritsen MP, Christiansen P, Dalgard C et al. High dietary intake of saturated fat is associated with reduced semen quality among 701 young Danish men from the general population. Am J Clin Nutr 2013;97:411-418.
21. Larqué E, Garc?́a-Ruiz PA, Perez-Llamas F, ZamoraS, Gil A. Dietary trans fatty acids alter the compositions of microsomes and mitochondria and the activities of microsome delta6-fatty acid desaturase and glucose-6-phosphatase in livers of pregnant rats. J Nutr 2003; 133:2526-2531.
22. Lenzi A, Gandini L, Maresca V, Rago R, Sgrò P, Dondero F, Picardo M. Fatty acid composition of spermatozoa and immature germ cells. Mol Hum Reprod 2000;6:226-231.
23. Leonard AE, Bobik EG, Dorado J, Kroeger PE, Chuang LT, Thurmond JM, Parker-Barnes JM, Das T, Huang YS, Mukerji P. Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids. Biochem J 2000;350:765-770.
24. Mandal MN, Ambasudhan R, Wong PW, Gage PJ, Sieving PA, Ayyagari R. Characterization of mouse orthologue of ELOVL4: genomic organization and spatial and temporal expression. Genomics 2004;83:626-635.
25. Mendiola J, Torres-Cantero AM, Moreno-Grau JM, Ten J, Roca M, Moreno-Grau S, Bernabeu R. Food intake and its relationship with semen quality: a case-control study. Fertil Steril 2009;91:812-818.
26. Mendiola J, Jørgensen N, M?́nguez-Alarcón L, Sarabia-Cos L, Ló pez-Esp?́n JJ, Vivero-Salmerón G, Ruiz-Ruiz KJ, Fernández MF, Olea N, Swan SH et al. Sperm counts may have declined in young university students in Southern Spain. Andrology 2013;1:408-413.
27. Menkveld R, Stander FS, Kotze TJ, Kruger TF, van Zyl JA. The evaluation of morphological characteristics of human spermatozoa according to stricter criteria. Hum Reprod 1990;5:586-592.
28. M?́nguez-Alarcón L, Mendiola J, López-Esp?́n JJ, Sarabia-Cos L, Vivero-Salmerón G, Vioque J, Navarrete-Muñoz EM, Torres-Cantero AM. Dietary intake of antioxidant nutrients is associated with semen quality in young university students. Hum Reprod 2012;27:2807-2814.
29. Nielsen SM, PopkinBM. Changes in beverage intake between 1977 and 2001. Am J Prev Med 2004;27:205-210.
30. Ocké MC, Bueno-de-Mesquita HB, Pols MA, Smit HA, van Staveren WA, Kromhout D. The Dutch EPIC food frequency questionnaire. II. Relative validity and reproducibility for nutrients. Int J Epidemiol 1997; 26:S49-S58.
31. OlleroM, PowersRD, Alvarez JG.Variation of docosahexaenoic acid content in subsets of human spermatozoa at different stages of maturation: implications for sperm lipoperoxidative damage. Mol Reprod Dev 2000; 55:326-334.
32. Palma I, Farran P, Cervera P. Tablas de composición de Alimentos por medidas caseras de consumo habitual en España: CESNID [in Spanish], 4th edn. Spain: McGraw Hill, 2008.
33. Paulsen CA, Berman NG, Wang C. Data from men in greater Seattle area reveals no downward trend in semen quality: further evidence that deterioration of semen quality is not geographically uniform. Fertil Steril 1996;65:1015-1020.
34. Privett OS, Phillips F, Shimasaki H, Nozawa T, Nickell EC. Studies of effects of trans fatty acids in the diet on lipid metabolism in essential fatty acid deficient rats. Am J Clin Nutr 1977;30:1009-1017.
35. Putnam J, Allshouse J, Scott-Kantor L.US per capita food supply trends: more calories, refine carbohydrates and fats. Food Rev 2002;25:2-15.
36. Rana AP, Majumder GC, Misra S, Ghosh A. Lipid changes of goat sperm plasma membrane during epididymal maturation. Biochim Biophys Acta 1991;1061:185-196.
37. Retterstøl K, Haugen TB,Woldseth B, Christophersen BO. A comparative study of the metabolism of n-9, n-6 and n-3 fatty acids in testicular cells from immature rat. Biochim Biophys Acta 1998;1392:59-72.
38. Retterstøl K, Haugen TB, ChristophersenBO.The pathway fromarachidonic to docosapentaenoic acid (20:4n-6 to 22:5n-6) and from eicosapentaenoic to docosahexaenoic acid (20:5n-3 to 22:6n-3) studied in testicular cells from immature rats. Biochim Biophys Acta 2000; 1483:119-131.
39. Saether T, Tran TN, Rootwelt H, Christophersen BO, Haugen TB. Expression and regulation of delta5-desaturase, delta6-desaturase, stearoyl-coenzyme A (CoA) desaturase 1, and stearoyl-CoA desaturase 2 in rat testis. Biol Reprod 2003;69:117-124.
40. Saez Lancellotti TE, Boarelli PV, Monclus MA, Cabrillana ME, Clementi MA, Esp?́nola LS, Cid Barr?́a JL, Vincenti AE, Santi AG, Fornés MW. Hypercholesterolemia impaired sperm functionality in rabbits. PLoS One 2010;5:e13457.
41. Skakkebæk NE, Jørgensen N, Main KM, Rajpert-De Meyts E, Leffers H, Andersson AM, Juul A, Carlsen E, Mortensen GK, Jensen TK et al. Is human fecundity declining? Int J Androl 2006;29:2-11.
42. Spanish Food Safety and Nutrition Agency, 2011. http://www.aesan.msc. es/en/AESAN/web/home.shtml.
43. Stokes-Riner A, Thurston SW, Brazil C, Guzick D, Liu F, Overstreet JW, Wang C, Sparks A, Redmon JB, Swan SH. One semen sample or 2? Insights from a study of fertile men. J Androl 2007;28:638-643.
44. Stroud CK, Nara TY, Roqueta-Rivera M, Radlowski EC, Lawrence P, Zhang Y, Cho BH, Segre M, Hess RA, Brenna JT et al. Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration. J Lipid Res 2009;50:1870-1880.
45. Subar AF, Thompson FE, Kipnis V, Midthune D, Hurwitz P, McNutt S, McIntosh A, Rosenfeld S. Comparative validation of the Block, Willett, and National Cancer Institute food frequency questionnaires: the Eating at America's Table Study. Am J Epidemiol 2001;154:1089-1099.
46. Sun Q, Ma J, Campos H, Hankinson SE, Hu FB. Comparison between plasma and erythrocyte fatty acid content as biomarkers of fatty acid intake in US women. Am J Clin Nutr 2007;86:74-81.
47. Swan SH, Elkin EP, Fenster L. Have sperm densities declined? A reanalysis of global trend data. Environ Health Perspect 1997;105:1228-1232.
48. Swan SH, Elkin EP, Fenster L. The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996. Environ Health Perspect 2000;108:961-966.
49. Tvrdik P, Westerberg R, Silve S, AsadiA, JakobssonA,Cannon B, LoisonG, Jacobsson A. Role of a newmammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids. J Cell Biol 2000;149: 707-718.
50. U.S. Department of Agriculture. Agricultural Research Service 2010 National Nutrient Database for Standard Reference, Release 23. Nutrient Data Laboratory 2010. http://www.ars.usda.gov/ba/bhnrc/ndl.
51. Varela-Moreiras G, Avila JM, Cuadrado C, del Pozo S, Ruiz E, Moreiras O. Evaluation of food consumption and dietary patterns in Spain by the Food Consumption Survey: updated information. Eur J Clin Nutr 2010; 64:37-43.
52. Veaute C, Andreoli MF, Racca A, Bailat A, Scalerandi MV, Bernal C, Malan Borel I. Effects of isomeric fatty acids on reproductive parameters in mice. Am J Reprod Immunol 2007;58:487-496.
53. Vierula M, Niemi M, Keiski A, Saaranen M, Saarikoski S, Suominen J. High and unchanged sperm counts of Finnish men. Int J Androl 1996;19:11-17.
54. Vioque J. Validez de la evaluación de la ingesta dietética [in Spanish]. In: Serra-Majem L, Aranceta J, Mataix J (eds). Nutrición y Salud Pública. Métodos, Bases Cient?́ficas y Aplicaciones. Barcelona, Spain: Masson, 1995.
55. Vioque J, Gonzalez L. Validity of a food frequency questionnaire (preliminary results). Eur J Cancer Prev 1991;1:19-20.
56. Vioque J,Weinbrenner T, Asensio L, Castelló A, Young I, Fletcher A. Plasma concentrations of carotenoids and vitamin C are better correlated with dietary intake in normal weight than overweight and obese elderly subjects. Br J Nutr 2007;97:977-986.
57. Vioque J, Navarrete-Muñoz EM, Gimenez-Monzó D, HeraMG,Granado F, Young IS, Ramón R, Ballester F, Murcia M, Rebagliato M et al. Reproducibility and validity of a food frequency questionnaire among pregnant women in a Mediterranean area. Nutr J 2013;12:26.
58. Vujkovic M, de Vries JH, Dohle GR, Bonsel GJ, Lindemans J, Macklon NS, van der Spek PJ, Steegers EA, Steegers-Theunissen RP. Associations between dietary patterns and semen quality in men undergoing IVF/ICSI treatment. Hum Reprod 2009;24:1304-1312.
59. Weng HY, Hsueh YH, Messam LL, Hertz-Picciotto I. Methods of covariate selection: directed acyclic graphs and the change-in-estimate procedure. Am J Epidemiol 2009;169:1182-1190.
60. Willett W. Nutritional Epidemiology, 3rd edn. Oxford: Oxford University Press, 2013.
61. Willett WC, Sampson L, Stampfer MJ, Rosner B, Bain C, Witschi J, Hennekens CH, Speizer FE. Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol 1985;122:51-65.
62. Willett W. Nutritional Epidemiology, 2nd edn. Oxford: Oxford University Press, 1998.
63. World Health Organization.WHOLaboratory Manual for the Examination and Processing of Human Semen, 5th edn. Geneva, Switzerland: WHO Press, 2010.
64. Zhang K, Kniazeva M, Han M, Li W, Yu Z, Yang Z, Li Y, Metzker ML, Allikmets R, Zack DJ et al. A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Nat Genet 2001;27:89-93.