N-terminal deletion mutants of insulin-like growth factor-II (IGF-II) show Thr7 and Leu8 important for binding to insulin and IGF-I receptors and Leu8 critical for all IGF-II functions

Journal of Biological Chemistry

Volumn 270, Issue 30, 1995, Pages 18013-18018

  Hashimoto, R ^a   Fujiwara, H ^a   Higashihashi, N ^a   Enjoh Kimura, T ^a   Terasawa, H ^a   Fujita Yamaguchi, Y ^a   Inagaki, F ^a   Perdue, J F ^a   Sakano, K I ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; SOMATOMEDIN B; SOMATOMEDIN C RECEPTOR;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; DELETION MUTANT; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS;

3T3 CELLS; AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; DNA; HUMAN; INSULIN-LIKE GROWTH FACTOR II; LEUCINE; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; SEQUENCE DELETION; SUPPORT, U.S. GOV'T, P.H.S.; THREONINE;

EID: 0029038033     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.270.30.18013     Document Type: Article

References (0)