-
1
-
-
79961076378
-
Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing
-
Ducimetière F, Lurkin A, Ranchère-Vince D et al. Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing. PLoS ONE 6 (8), e20294 (2011).
-
(2011)
PLoS ONE
, vol.6
, Issue.8
, pp. e20294
-
-
Ducimetière, F.1
Lurkin, A.2
Ranchère-Vince, D.3
-
2
-
-
23844442937
-
Soft-tissue sarcomas in adults
-
Clark MA, Fisher C, Judson I, Thomas JM. Soft-tissue sarcomas in adults. N. Engl. J. Med. 353, 701–711 (2005).
-
(2005)
N. Engl. J. Med
, vol.353
, pp. 701-711
-
-
Clark, M.A.1
Fisher, C.2
Judson, I.3
Thomas, J.M.4
-
3
-
-
84873893872
-
Treating metastatic soft-tissue or bone sarcomas – potential role of ridaforolimus
-
Keedy VL. Treating metastatic soft-tissue or bone sarcomas – potential role of ridaforolimus. Onco. Targets Ther. 5, 153–160 (2012).
-
(2012)
Onco. Targets Ther
, vol.5
, pp. 153-160
-
-
Keedy, V.L.1
-
4
-
-
84873250219
-
Systemic therapy in soft tissue sarcomas: past, present, and future
-
Purohit S, Bhise R, Appachu S, Lakshmaiah KC, Govindbabu K. Systemic therapy in soft tissue sarcomas: past, present, and future. Indian J. Surg. Oncol. 2 (4), 327–331 (2011).
-
(2011)
Indian J. Surg. Oncol
, vol.2
, Issue.4
, pp. 327-331
-
-
Purohit, S.1
Bhise, R.2
Appachu, S.3
Lakshmaiah, K.C.4
Govindbabu, K.5
-
5
-
-
84858002307
-
Systemic therapy for advanced soft tissue sarcomas
-
Riedel RF. Systemic therapy for advanced soft tissue sarcomas. Cancer 118, 1474–1485 (2012).
-
(2012)
Cancer
, vol.118
, pp. 1474-1485
-
-
Riedel, R.F.1
-
6
-
-
0036892122
-
Results of randomised studies of the EORTC Soft Tissue and Bone Sarcoma Group (STBSG) with two different ifosfamide regimens in first- and second-line chemotherapy in advanced soft tissue sarcoma patients
-
van Oosterom AT, Mouridsen HT, Nielsen OS et al. Results of randomised studies of the EORTC Soft Tissue and Bone Sarcoma Group (STBSG) with two different ifosfamide regimens in first- and second-line chemotherapy in advanced soft tissue sarcoma patients. Eur. J. Cancer 38, 2397–2406 (2002).
-
(2002)
Eur. J. Cancer
, vol.38
, pp. 2397-2406
-
-
van Oosterom, A.T.1
Mouridsen, H.T.2
Nielsen, O.S.3
-
7
-
-
26444442333
-
A phase II trial of temozolomide as a 6-week, continuous, oral schedule in patients with advanced soft tissue sarcoma: a study by the Spanish Group for Research on Sarcomas
-
Garcia del Muro X, Lopez-Pousa A, Martin J et al. A phase II trial of temozolomide as a 6-week, continuous, oral schedule in patients with advanced soft tissue sarcoma: a study by the Spanish Group for Research on Sarcomas. Cancer 104, 1706–1712 (2005).
-
(2005)
Cancer
, vol.104
, pp. 1706-1712
-
-
Garcia del Muro, X.1
Lopez-Pousa, A.2
Martin, J.3
-
8
-
-
78649406088
-
New drugs in the management of sarcoma
-
Moore M, Desai J. New drugs in the management of sarcoma. Cancer Forum 34 (3), 140–146 (2010).
-
(2010)
Cancer Forum
, vol.34
, Issue.3
, pp. 140-146
-
-
Moore, M.1
Desai, J.2
-
10
-
-
80053383254
-
Activity of eribulin mesylate in patients with soft-tissue sarcoma: a phase 2 study in four independent histological subtypes
-
Schöffski P, Ray-Coquard IL, Cioffi A et al. Activity of eribulin mesylate in patients with soft-tissue sarcoma: a phase 2 study in four independent histological subtypes. Lancet Oncol. 12, 1045–1052 (2011).
-
(2011)
Lancet Oncol
, vol.12
, pp. 1045-1052
-
-
Schöffski, P.1
Ray-Coquard, I.L.2
Cioffi, A.3
-
11
-
-
0027256397
-
Randomized comparison of doxorubicin alone versus ifosfamide plus doxorubicin or mitomycin, doxorubicin, and cisplatin against advanced soft tissue sarcomas
-
Edmonson JH, Ryan LM, Blum RH et al. Randomized comparison of doxorubicin alone versus ifosfamide plus doxorubicin or mitomycin, doxorubicin, and cisplatin against advanced soft tissue sarcomas. J. Clin. Oncol. 11, 1269–1275 (1993).
-
(1993)
J. Clin. Oncol
, vol.11
, pp. 1269-1275
-
-
Edmonson, J.H.1
Ryan, L.M.2
Blum, R.H.3
-
12
-
-
0029005580
-
Doxorubicin versus CYVADIC versus doxorubicin plus ifosfamide in first-line treatment of advanced soft tissue sarcomas: a randomized study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
-
Santoro A, Tursz T, Mouridsen H et al. Doxorubicin versus CYVADIC versus doxorubicin plus ifosfamide in first-line treatment of advanced soft tissue sarcomas: a randomized study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. J. Clin. Oncol. 13, 1537–1545 (1995).
-
(1995)
J. Clin. Oncol
, vol.13
, pp. 1537-1545
-
-
Santoro, A.1
Tursz, T.2
Mouridsen, H.3
-
13
-
-
84866757432
-
Histology- and non-histology-driven therapy for treatment of soft tissue sarcomas
-
Casali PG. Histology- and non-histology-driven therapy for treatment of soft tissue sarcomas. Ann. Oncol. 23 (Suppl. 10), x167 – x169 (2012).
-
(2012)
Ann. Oncol
, vol.23
, pp. x167-x169
-
-
Casali, P.G.1
-
14
-
-
34247586993
-
Gemcitabine and vinorelbine combination chemotherapy for patients with advanced soft tissue sarcomas: results of a phase II trial
-
Dileo P, Morgan JA, Zahrieh D et al. Gemcitabine and vinorelbine combination chemotherapy for patients with advanced soft tissue sarcomas: results of a phase II trial. Cancer 109, 1863–1869 (2007).
-
(2007)
Cancer
, vol.109
, pp. 1863-1869
-
-
Dileo, P.1
Morgan, J.A.2
Zahrieh, D.3
-
15
-
-
0027280571
-
An intergroup phase III randomized study of doxorubicin and dacarbazine with or without ifosfamide and mesna in advanced soft tissue and bone sarcomas
-
Antman K, Crowley J, Balcerzak SP et al. An intergroup phase III randomized study of doxorubicin and dacarbazine with or without ifosfamide and mesna in advanced soft tissue and bone sarcomas. J. Clin. Oncol. 11, 1276–1285 (1993).
-
(1993)
J. Clin. Oncol
, vol.11
, pp. 1276-1285
-
-
Antman, K.1
Crowley, J.2
Balcerzak, S.P.3
-
16
-
-
34447572873
-
Randomized phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas: results of sarcoma alliance for research through collaboration study 002
-
Maki RG, Wathen JK, Patel SR et al. Randomized phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas: results of sarcoma alliance for research through collaboration study 002. J. Clin. Oncol. 25, 2755–2763 (2007).
-
(2007)
J. Clin. Oncol
, vol.25
, pp. 2755-2763
-
-
Maki, R.G.1
Wathen, J.K.2
Patel, S.R.3
-
17
-
-
84865692760
-
Histology-specific therapy for advanced soft tissue sarcoma and benign connective tissue tumors
-
Silk AW, Schuetze SM. Histology-specific therapy for advanced soft tissue sarcoma and benign connective tissue tumors. Curr. Treat. Options Oncol. 13, 285–298 (2012).
-
(2012)
Curr. Treat. Options Oncol
, vol.13
, pp. 285-298
-
-
Silk, A.W.1
Schuetze, S.M.2
-
18
-
-
78649347321
-
Targeted therapies in soft tissue sarcomas
-
Judson I. Targeted therapies in soft tissue sarcomas. Ann. Oncol. 22 (Suppl. 7), vii277–280 (2010).
-
(2010)
Ann. Oncol
, vol.22
, pp. vii277-vii280
-
-
Judson, I.1
-
19
-
-
80355149465
-
Targeted agents for sarcoma: is individualized therapy possible in such a diverse tumor type?
-
Riedel RF. Targeted agents for sarcoma: is individualized therapy possible in such a diverse tumor type? Semin. Oncol. 38 (5), (Suppl. 3), S30 – S42 (2011).
-
(2011)
Semin. Oncol
, vol.38
, Issue.5
, pp. S30-S42
-
-
Riedel, R.F.1
-
20
-
-
85015934614
-
Targeted therapy in sarcoma: should we be lumpers or splitters?
-
Riedel RF, Maki RG, Wagner AJ. Targeted therapy in sarcoma: should we be lumpers or splitters? ASCO Meeting Library 652–657 (2012).
-
(2012)
ASCO Meeting Library
, pp. 652-657
-
-
Riedel, R.F.1
Maki, R.G.2
Wagner, A.J.3
-
21
-
-
79251591976
-
Updating progress in sarcoma therapy with mTOR inhibitors
-
Blay JY. Updating progress in sarcoma therapy with mTOR inhibitors. Ann. Oncol. 22, 280–287 (2011).
-
(2011)
Ann. Oncol
, vol.22
, pp. 280-287
-
-
Blay, J.Y.1
-
22
-
-
66949160777
-
Targeting the mTOR pathway using deforolimus in cancer therapy
-
Mahalingam D, Sankhala K, Mita A, Giles F, Mita MM. Targeting the mTOR pathway using deforolimus in cancer therapy. Future Oncol. 5 (3), 291–303 (2009).
-
(2009)
Future Oncol
, vol.5
, Issue.3
, pp. 291-303
-
-
Mahalingam, D.1
Sankhala, K.2
Mita, A.3
Giles, F.4
Mita, M.M.5
-
23
-
-
79955785100
-
Pushing the envelope in the mTOR pathway. The second generation of inhibitors
-
Vilar E, Perez-Garcia J, Tabernero J. Pushing the envelope in the mTOR pathway. The second generation of inhibitors. Mol. Cancer Ther. 10 (3), 395–403 (2011).
-
(2011)
Mol. Cancer Ther
, vol.10
, Issue.3
, pp. 395-403
-
-
Vilar, E.1
Perez-Garcia, J.2
Tabernero, J.3
-
24
-
-
58149385663
-
Deforolimus (AP23573) a novel mTOR inhibitor in clinical development
-
Mita M, Sankhala K, Abdel-Karim I, Mita A, Giles F. Deforolimus (AP23573) a novel mTOR inhibitor in clinical development. Expert Opin. Investig. Drugs 17 (12), 1947–1954 (2008).
-
(2008)
Expert Opin. Investig. Drugs
, vol.17
, Issue.12
, pp. 1947-1954
-
-
Mita, M.1
Sankhala, K.2
Abdel-Karim, I.3
Mita, A.4
Giles, F.5
-
25
-
-
77957870285
-
mTOR mediated anti-cancer drug discovery
-
Liu Q, Thoreen C, Wang J, Sabatini D, Gray NS. mTOR mediated anti-cancer drug discovery. Drug Discov. Today Ther. Strateg. 6 (2), 47–55 (2009).
-
(2009)
Drug Discov. Today Ther. Strateg
, vol.6
, Issue.2
, pp. 47-55
-
-
Liu, Q.1
Thoreen, C.2
Wang, J.3
Sabatini, D.4
Gray, N.S.5
-
26
-
-
72849150434
-
Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy
-
Yuan R, Kay A, Berg WJ, Lebwohl, D. Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy. J. Hematol. Oncol. 2 (45), 1–12 (2009).
-
(2009)
J. Hematol. Oncol
, vol.2
, Issue.45
, pp. 1-12
-
-
Yuan, R.1
Kay, A.2
Berg, W.J.3
Lebwohl, D.4
-
27
-
-
0016724057
-
Rapamycin (AY-22,989), a new antifungal antiobiotic I. Taxonomy of the producing streptomycete and isolation of the active principle
-
Vézina C, Kudelski A, Seghal SN. Rapamycin (AY-22,989), a new antifungal antiobiotic I. Taxonomy of the producing streptomycete and isolation of the active principle. J. Antibiot. (Tokyo) 28 (10), 721–726 (1975).
-
(1975)
J. Antibiot. (Tokyo)
, vol.28
, Issue.10
, pp. 721-726
-
-
Vézina, C.1
Kudelski, A.2
Seghal, S.N.3
-
28
-
-
33746637660
-
Current development of mTOR inhibitors as anticancer agents
-
Faivre S, Kroemer G, Raymond E. Current development of mTOR inhibitors as anticancer agents. Nat. Rev. Drug Discov. 5, 671–688 (2006).
-
(2006)
Nat. Rev. Drug Discov
, vol.5
, pp. 671-688
-
-
Faivre, S.1
Kroemer, G.2
Raymond, E.3
-
29
-
-
84055206678
-
New developments in mammalian target of rapamycin inhibitors for the treatment of sarcomas
-
Agulnik M. New developments in mammalian target of rapamycin inhibitors for the treatment of sarcomas. Cancer 118, 1486–1497 (2012).
-
(2012)
Cancer
, vol.118
, pp. 1486-1497
-
-
Agulnik, M.1
-
30
-
-
54249130444
-
Targeting the mammalian target of rapamycin in myxoid chondrosarcoma
-
Merimsky O, Bernstein-Molho R, Sagi-Eisenberg R. Targeting the mammalian target of rapamycin in myxoid chondrosarcoma. Anticancer Drugs 19, 1019–1021 (2008).
-
(2008)
Anticancer Drugs
, vol.19
, pp. 1019-1021
-
-
Merimsky, O.1
Bernstein-Molho, R.2
Sagi-Eisenberg, R.3
-
31
-
-
77649215630
-
Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: targeting the pathogenic activation of mTORC1 in tumors
-
Wagner AJ, Malinowska-Kolodziej I, Morgan JA et al. Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: targeting the pathogenic activation of mTORC1 in tumors. J. Clin. Oncol. 28, 835–840 (2010).
-
(2010)
J. Clin. Oncol
, vol.28
, pp. 835-840
-
-
Wagner, A.J.1
Malinowska-Kolodziej, I.2
Morgan, J.A.3
-
32
-
-
84871207566
-
Clinical activity of mTOR inhibition in combination with cyclophosphamide in the treatment of recurrent unresectable chondrosarcomas
-
Bernstein-Molho R, Kollender Y, Issakov J et al. Clinical activity of mTOR inhibition in combination with cyclophosphamide in the treatment of recurrent unresectable chondrosarcomas. Cancer Chemother. Pharmacol. 70, 855–860 (2012).
-
(2012)
Cancer Chemother. Pharmacol
, vol.70
, pp. 855-860
-
-
Bernstein-Molho, R.1
Kollender, Y.2
Issakov, J.3
-
33
-
-
77649217619
-
Sirolimus and temsirolimus for epithelioid angiomyolipoma
-
Wolff N, Kabbani W, Bradley T, Raj G, Watumull L, Brugarolas J. Sirolimus and temsirolimus for epithelioid angiomyolipoma. J. Clin. Oncol. 28, e65 – e68 (2010).
-
(2010)
J. Clin. Oncol
, vol.28
, pp. e65-e68
-
-
Wolff, N.1
Kabbani, W.2
Bradley, T.3
Raj, G.4
Watumull, L.5
Brugarolas, J.6
-
34
-
-
34248232916
-
Sirolimus reduced tumor-related morbidity and resulted in biochemical and radiographic response in patients with progressive sarcoma
-
(Abstract)
-
Schuetze SM, Baker LH, Maki RG. Sirolimus reduced tumor-related morbidity and resulted in biochemical and radiographic response in patients with progressive sarcoma. J. Clin. Oncol. (Abstract) 24, 9503 (2006).
-
(2006)
J. Clin. Oncol.
, vol.24
, pp. 9503
-
-
Schuetze, S.M.1
Baker, L.H.2
Maki, R.G.3
-
35
-
-
40449091406
-
Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program
-
Houghton PJ, Morton CL, Kolb EA et al. Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program. Pediatr. Blood Cancer 50, 799–805 (2008).
-
(2008)
Pediatr. Blood Cancer
, vol.50
, pp. 799-805
-
-
Houghton, P.J.1
Morton, C.L.2
Kolb, E.A.3
-
36
-
-
73949122305
-
Stage 2 combination testing of rapamycin with cytotoxic agents by the Pediatric Preclinical Testing Program
-
Houghton PJ, Morton CL, Gorlick R et al. Stage 2 combination testing of rapamycin with cytotoxic agents by the Pediatric Preclinical Testing Program. Mol. Cancer Ther. 9, 101–112 (2010).
-
(2010)
Mol. Cancer Ther
, vol.9
, pp. 101-112
-
-
Houghton, P.J.1
Morton, C.L.2
Gorlick, R.3
-
37
-
-
51649124020
-
Pharmacodynamic-guided modified continuous reassessment method-based, dose-finding study of rapamycin in adult patients with solid tumors
-
Jimeno A, Rudek MA, Kulesza P et al. Pharmacodynamic-guided modified continuous reassessment method-based, dose-finding study of rapamycin in adult patients with solid tumors. J. Clin. Oncol. 26, 4172–4179 (2008).
-
(2008)
J. Clin. Oncol
, vol.26
, pp. 4172-4179
-
-
Jimeno, A.1
Rudek, M.A.2
Kulesza, P.3
-
38
-
-
79958775065
-
A phase I study of sirolimus and bevacizumab in patients with advanced malignancies
-
Cohen EE, Sharma M, Janisch LA et al. A phase I study of sirolimus and bevacizumab in patients with advanced malignancies. Eur. J. Cancer 47 (10) (2011).
-
(2011)
Eur. J. Cancer
, vol.47
, Issue.10
-
-
Cohen, E.E.1
Sharma, M.2
Janisch, L.A.3
-
39
-
-
79955068897
-
Temsirolimus in advanced leiomyosarcomas: patterns of response and correlation with the activation of the mammalian target of rapamycin pathway
-
Italiano A, Kind M, Stoeckle E, Jones N, Coindre JM, Bui B. Temsirolimus in advanced leiomyosarcomas: patterns of response and correlation with the activation of the mammalian target of rapamycin pathway. Anticancer Drugs 22 (5), 463–467 (2011).
-
(2011)
Anticancer Drugs
, vol.22
, Issue.5
, pp. 463-467
-
-
Italiano, A.1
Kind, M.2
Stoeckle, E.3
Jones, N.4
Coindre, J.M.5
Bui, B.6
-
40
-
-
77953341782
-
Treatment with the mTOR inhibitor temsirolimus in patients with malignant PEComa
-
Italiano A, Delcambre C, Hostein I et al. Treatment with the mTOR inhibitor temsirolimus in patients with malignant PEComa. Ann. Oncol. 21, 1135–1137 (2010).
-
(2010)
Ann. Oncol
, vol.21
, pp. 1135-1137
-
-
Italiano, A.1
Delcambre, C.2
Hostein, I.3
-
41
-
-
2942735384
-
Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
-
Raymond E, Alexandre J, Faivre S et al. Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. J. Clin. Oncol. 22, 2336–2347 (2004).
-
(2004)
J. Clin. Oncol
, vol.22
, pp. 2336-2347
-
-
Raymond, E.1
Alexandre, J.2
Faivre, S.3
-
42
-
-
33750321673
-
A phase I and pharmacokinetic study of temsirolimus (CCI-779) administered intravenously daily for 5 days every 2 weeks to patients with advanced cancer
-
Hidalgo M, Buckner JC, Erlichman C et al. A phase I and pharmacokinetic study of temsirolimus (CCI-779) administered intravenously daily for 5 days every 2 weeks to patients with advanced cancer. Clin. Cancer Res. 12, 5755–5763 (2006).
-
(2006)
Clin. Cancer Res
, vol.12
, pp. 5755-5763
-
-
Hidalgo, M.1
Buckner, J.C.2
Erlichman, C.3
-
43
-
-
77952236657
-
Phase I, pharmacokinetic study of temsirolimus administered orally to patients with advanced cancer
-
Buckner JC, Forouzesh B, Erlichman C et al. Phase I, pharmacokinetic study of temsirolimus administered orally to patients with advanced cancer. Invest. New Drugs 28, 334–342 (2010).
-
(2010)
Invest. New Drugs
, vol.28
, pp. 334-342
-
-
Buckner, J.C.1
Forouzesh, B.2
Erlichman, C.3
-
44
-
-
84860506226
-
Insulin growth factor-receptor (IGF-1R) antibody cixutumumab combined with the mTOR inhibitor temsirolimus in patients with refractory Ewing's sarcoma family tumors
-
Naing A, LoRusso P, Fu S et al. Insulin growth factor-receptor (IGF-1R) antibody cixutumumab combined with the mTOR inhibitor temsirolimus in patients with refractory Ewing's sarcoma family tumors. Clin. Cancer Res. 18 (9), 2625–2631 (2012).
-
(2012)
Clin. Cancer Res
, vol.18
, Issue.9
, pp. 2625-2631
-
-
Naing, A.1
LoRusso, P.2
Fu, S.3
-
45
-
-
79960698959
-
A phase 2 study of temsirolimus (CCI-779) in patients with soft tissue sarcomas: a study of the Mayo Phase 2 Consortium (P2C)
-
Okuno S, Bailey H, Mahoney MR et al. A phase 2 study of temsirolimus (CCI-779) in patients with soft tissue sarcomas: a study of the Mayo Phase 2 Consortium (P2C). Cancer 117 (15), 3468–3475 (2011).
-
(2011)
Cancer
, vol.117
, Issue.15
, pp. 3468-3475
-
-
Okuno, S.1
Bailey, H.2
Mahoney, M.R.3
-
46
-
-
84655175068
-
Phase II study of temsirolimus in children with high-grade glioma, neuroblastoma, and rhabdomyosarcoma
-
Geoerger B, Kieran MW, Grupp S et al. Phase II study of temsirolimus in children with high-grade glioma, neuroblastoma, and rhabdomyosarcoma. Eur. J. Cancer 48 (2), 253–262 (2012).
-
(2012)
Eur. J. Cancer
, vol.48
, Issue.2
, pp. 253-262
-
-
Geoerger, B.1
Kieran, M.W.2
Grupp, S.3
-
47
-
-
79957876262
-
Dramatic tumor response to everolimus for malignant epithelioid angiomyolipoma
-
Shitara K, Yatabe Y, Mizota A, Sano T, Nimura Y, Muro K. Dramatic tumor response to everolimus for malignant epithelioid angiomyolipoma. Jpn J. Clin. Oncol. 41, 814–816 (2011).
-
(2011)
Jpn J. Clin. Oncol
, vol.41
, pp. 814-816
-
-
Shitara, K.1
Yatabe, Y.2
Mizota, A.3
Sano, T.4
Nimura, Y.5
Muro, K.6
-
48
-
-
33748059560
-
Oncogenic Kit signaling and therapeutic intervention in a mouse model of gastrointestinal stromal tumor
-
Rossi F, Ehlers I, Agosti V et al. Oncogenic Kit signaling and therapeutic intervention in a mouse model of gastrointestinal stromal tumor. Proc. Natl Acad. Sci. USA 103: 12843–12848 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 12843-12848
-
-
Rossi, F.1
Ehlers, I.2
Agosti, V.3
-
49
-
-
34250013899
-
The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas
-
Hernando E, Charytonowicz E, Dudas ME et al. The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas. Nat. Med. 13, 748–753 (2007).
-
(2007)
Nat. Med
, vol.13
, pp. 748-753
-
-
Hernando, E.1
Charytonowicz, E.2
Dudas, M.E.3
-
50
-
-
43249086546
-
Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors
-
O'Donnell A, Faivre S, Burris HA III et al. Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors. J. Clin. Oncol. 26, 1588–1595 (2008).
-
(2008)
J. Clin. Oncol
, vol.26
, pp. 1588-1595
-
-
O'Donnell, A.1
Faivre, S.2
Burris, H.A.3
-
51
-
-
43249131245
-
Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors
-
Tabernero J, Rojo F, Calvo E et al. Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors. J. Clin. Oncol. 26, 1603–1610 (2008).
-
(2008)
J. Clin. Oncol
, vol.26
, pp. 1603-1610
-
-
Tabernero, J.1
Rojo, F.2
Calvo, E.3
-
52
-
-
36049023679
-
Phase I study of everolimus in pediatric patients with refractory solid tumors
-
Fouladi M, Laningham F, Wu J et al. Phase I study of everolimus in pediatric patients with refractory solid tumors. J. Clin. Oncol. 25, 4806–4812 (2007).
-
(2007)
J. Clin. Oncol
, vol.25
, pp. 4806-4812
-
-
Fouladi, M.1
Laningham, F.2
Wu, J.3
-
53
-
-
79951816312
-
Combination mTOR and IGF-1R inhibition: phase I trial of everolimus and figitumumab in patients with advanced sarcomas and other solid tumors
-
Quek R, Wang Q, Morgan JA et al. Combination mTOR and IGF-1R inhibition: phase I trial of everolimus and figitumumab in patients with advanced sarcomas and other solid tumors. Clin. Cancer Res. 17 (4), 871–879 (2011).
-
(2011)
Clin. Cancer Res
, vol.17
, Issue.4
, pp. 871-879
-
-
Quek, R.1
Wang, Q.2
Morgan, J.A.3
-
54
-
-
78751647387
-
Multicenter, triple-arm, single-stage, phase II trial to determine the efficacy and safety of everolimus (RAD001) in patients with refractory bone or soft tissue sarcomas including GIST
-
Richter S, Pink D, Hohenberger P et al. Multicenter, triple-arm, single-stage, phase II trial to determine the efficacy and safety of everolimus (RAD001) in patients with refractory bone or soft tissue sarcomas including GIST. J. Clin. Oncol. (Abstract) 28 (Suppl. 15), 10038 (2010).
-
(2010)
J. Clin. Oncol. (Abstract)
, vol.28
, pp. 10038
-
-
Richter, S.1
Pink, D.2
Hohenberger, P.3
-
55
-
-
77957171405
-
A phase I-II study of everolimus (RAD001) in combination with imatinib in patients with imatinib-resistant gastrointestinal stromal tumors
-
Schoffski P, Reichardt P, Blay JY et al. A phase I-II study of everolimus (RAD001) in combination with imatinib in patients with imatinib-resistant gastrointestinal stromal tumors. Ann. Oncol. 21, 1990–1998 (2010).
-
(2010)
Ann. Oncol
, vol.21
, pp. 1990-1998
-
-
Schoffski, P.1
Reichardt, P.2
Blay, J.Y.3
-
56
-
-
79958698108
-
Ridaforolimus (AP23573; MK-8669), a potent mTOR inhibitor, has broad antitumor activity and can be optimally administered using intermittent dosing regimens
-
Rivera VM, Squillace RM, Miller D et al. Ridaforolimus (AP23573; MK-8669), a potent mTOR inhibitor, has broad antitumor activity and can be optimally administered using intermittent dosing regimens. Mol. Cancer Ther. 10, 1059–1071 (2011).
-
(2011)
Mol. Cancer Ther
, vol.10
, pp. 1059-1071
-
-
Rivera, V.M.1
Squillace, R.M.2
Miller, D.3
-
57
-
-
80053944575
-
Antitumor activity of ridaforolimus and potential cell-cycle determinants of sensitivity in sarcoma and endometrial cancer models
-
Squillace RM, Miller D, Cookson M et al. Antitumor activity of ridaforolimus and potential cell-cycle determinants of sensitivity in sarcoma and endometrial cancer models. Mol. Cancer Ther. 10, 1959–1968 (2011).
-
(2011)
Mol. Cancer Ther
, vol.10
, pp. 1959-1968
-
-
Squillace, R.M.1
Miller, D.2
Cookson, M.3
-
58
-
-
17044411266
-
Phase I, pharmacokinetic (PK), and pharmacodynamic (PD) study of AP23573, an mTOR inhibitor, administered IV daily X 5 every other week in patients (pts) with refractory or advanced malignancies
-
Mita MM, Rowinsky EK, Goldston ML et al. Phase I, pharmacokinetic (PK), and pharmacodynamic (PD) study of AP23573, an mTOR inhibitor, administered IV daily X 5 every other week in patients (pts) with refractory or advanced malignancies. J. Clin. Oncol. (Abstract) 22 (Suppl. 14), 3076 (2004).
-
(2004)
J. Clin. Oncol. (Abstract)
, vol.22
, pp. 3076
-
-
Mita, M.M.1
Rowinsky, E.K.2
Goldston, M.L.3
-
59
-
-
8344238409
-
A phase I trial of a novel mTOR inhibitor AP23573 administered weekly (wkly) in patients (pts) with refractory or advanced malignancies: a pharmacokinetic (PK) and pharmacodynamic (PD) analysis
-
Desai AA, Janisch L, Berk LR et al. A phase I trial of a novel mTOR inhibitor AP23573 administered weekly (wkly) in patients (pts) with refractory or advanced malignancies: a pharmacokinetic (PK) and pharmacodynamic (PD) analysis. J. Clin. Oncol. (Abstract) 22 (Suppl. 14), 3150 (2004).
-
(2004)
J. Clin. Oncol. (Abstract)
, vol.22
, pp. 3150
-
-
Desai, A.A.1
Janisch, L.2
Berk, L.R.3
-
60
-
-
38649140450
-
Phase I trial of the novel mammalian target of rapamycin inhibitor deforolimus (AP23573; MK-8669) administered intravenously daily for 5 days every 2 weeks to patients with advanced malignancies
-
Mita MM, Mita AC, Chu QS et al. Phase I trial of the novel mammalian target of rapamycin inhibitor deforolimus (AP23573; MK-8669) administered intravenously daily for 5 days every 2 weeks to patients with advanced malignancies. J. Clin. Oncol. 26, 361–367 (2008).
-
(2008)
J. Clin. Oncol
, vol.26
, pp. 361-367
-
-
Mita, M.M.1
Mita, A.C.2
Chu, Q.S.3
-
61
-
-
63149129641
-
A phase I trial to determine the safety, tolerability, and maximum tolerated dose of deforolimus in patients with advanced malignancies
-
Hartford CM, Desai AA, Janisch L et al. A phase I trial to determine the safety, tolerability, and maximum tolerated dose of deforolimus in patients with advanced malignancies. Clin. Cancer Res. 15, 1428–1434 (2009).
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 1428-1434
-
-
Hartford, C.M.1
Desai, A.A.2
Janisch, L.3
-
62
-
-
84862272611
-
Analysis of the pharmacodynamic activity of the mTOR inhibitor ridaforolimus (AP23573, MK-8669) in a phase 1 clinical trial
-
Berk L, Mita MM, Kreisberg J et al. Analysis of the pharmacodynamic activity of the mTOR inhibitor ridaforolimus (AP23573, MK-8669) in a phase 1 clinical trial. Cancer Chemother. Pharmacol. 69, 1369–1377 (2012).
-
(2012)
Cancer Chemother. Pharmacol
, vol.69
, pp. 1369-1377
-
-
Berk, L.1
Mita, M.M.2
Kreisberg, J.3
-
63
-
-
72849129290
-
Pharmacokinetics of oral deforolimus (AP23573, MK-8669)
-
Fetterly GJ, Mita MM, Britten CD et al. Pharmacokinetics of oral deforolimus (AP23573, MK-8669). J. Clin. Oncol. (Abstract) 26 (Suppl. 15), 14555 (2008).
-
(2008)
J. Clin. Oncol. (Abstract)
, vol.26
, pp. 14555
-
-
Fetterly, G.J.1
Mita, M.M.2
Britten, C.D.3
-
64
-
-
84859806868
-
Phase I study for ridaforolimus, an oral mTOR inhibitor, in Japanese patients with advanced solid tumors
-
Seki Y, Yamamoto N, Tamura Y et al. Phase I study for ridaforolimus, an oral mTOR inhibitor, in Japanese patients with advanced solid tumors. Cancer Chemother. Pharmacol. 69, 1099–1105 (2012).
-
(2012)
Cancer Chemother. Pharmacol
, vol.69
, pp. 1099-1105
-
-
Seki, Y.1
Yamamoto, N.2
Tamura, Y.3
-
65
-
-
79954511415
-
A multicenter, first-in-pediatrics phase I study of ridaforolimus (AP23573, MK-8669) in patients (pts) with refractory solid tumors
-
Gore L, Trippett TM, Katzenstein HM et al. A multicenter, first-in-pediatrics phase I study of ridaforolimus (AP23573, MK-8669) in patients (pts) with refractory solid tumors. J. Clin. Oncol. (Abstract) 28 (Suppl. 15), 9531 (2010).
-
(2010)
J. Clin. Oncol. (Abstract)
, vol.28
, pp. 9531
-
-
Gore, L.1
Trippett, T.M.2
Katzenstein, H.M.3
-
66
-
-
84862280018
-
The effect of multiple doses of rifampin and ketoconazole on the single-dose pharmacokinetics of ridaforolimus
-
Stroh M, Palcza J, McCrea J et al. The effect of multiple doses of rifampin and ketoconazole on the single-dose pharmacokinetics of ridaforolimus. Cancer Chemother. Pharmacol. 69, 1247–1253 (2012).
-
(2012)
Cancer Chemother. Pharmacol
, vol.69
, pp. 1247-1253
-
-
Stroh, M.1
Palcza, J.2
McCrea, J.3
-
67
-
-
84863445040
-
The minimal impact of food on the pharmacokinetics of ridaforolimus
-
Stroh M, Li X, Marsilio S et al. The minimal impact of food on the pharmacokinetics of ridaforolimus. Cancer Chemother. Pharmacol. 70, 177–182 (2012).
-
(2012)
Cancer Chemother. Pharmacol
, vol.70
, pp. 177-182
-
-
Stroh, M.1
Li, X.2
Marsilio, S.3
-
68
-
-
84875633556
-
Phase I/IIa trial of the mammalian target of rapamycin inhibitor ridaforolimus (AP23573; MK-8669) administered orally in patients with refractory or advanced malignancies and sarcoma
-
Mita MM, Poplin E, Britten CD et al. Phase I/IIa trial of the mammalian target of rapamycin inhibitor ridaforolimus (AP23573; MK-8669) administered orally in patients with refractory or advanced malignancies and sarcoma. Ann. Oncol. 24, 1104–1111 (2013).
-
(2013)
Ann. Oncol
, vol.24
, pp. 1104-1111
-
-
Mita, M.M.1
Poplin, E.2
Britten, C.D.3
-
69
-
-
78049513393
-
Phase IB study of the mTOR inhibitor ridaforolimus with capecitabine
-
Perotti A, Locatelli A, Sessa C et al. Phase IB study of the mTOR inhibitor ridaforolimus with capecitabine. J. Clin. Oncol. 28 (30), 4554–4561 (2010).
-
(2010)
J. Clin. Oncol
, vol.28
, Issue.30
, pp. 4554-4561
-
-
Perotti, A.1
Locatelli, A.2
Sessa, C.3
-
70
-
-
73849119080
-
Phase Ib study of weekly mammalian target of rapamycin inhibitor ridaforolimus (AP23573; MK-8669) with weekly paclitaxel
-
Cessa C, Tosi D, Viganò L et al. Phase Ib study of weekly mammalian target of rapamycin inhibitor ridaforolimus (AP23573; MK-8669) with weekly paclitaxel. Ann. Oncol. 21, 1315–1322 (2010).
-
(2010)
Ann. Oncol
, vol.21
, pp. 1315-1322
-
-
Cessa, C.1
Tosi, D.2
Viganò, L.3
-
71
-
-
77956579297
-
A phase I study of the oral mTOR inhibitor ridaforolimus (RIDA) in combination with the IGF-1R antibody dalotozumab (DALO) in patients (pts) with advanced solid tumors
-
Di Cosimo, Bendell JC, Cervantes-Ruiperez A et al. A phase I study of the oral mTOR inhibitor ridaforolimus (RIDA) in combination with the IGF-1R antibody dalotozumab (DALO) in patients (pts) with advanced solid tumors. J. Clin. Oncol. (Abstract) 28 (Suppl. 15), 3008 (2010).
-
(2010)
J. Clin. Oncol. (Abstract)
, vol.28
, pp. 3008
-
-
Di Cosimo1
Bendell, J.C.2
Cervantes-Ruiperez, A.3
-
72
-
-
84855556875
-
A phase 2 study of the mTOR inhibitor ridaforolimus (AP23573; MK 8669) in patients with advanced bone and soft tissue sarcomas
-
Chawla SP, Staddon AP, Baker LH et al. A phase 2 study of the mTOR inhibitor ridaforolimus (AP23573; MK 8669) in patients with advanced bone and soft tissue sarcomas. J. Clin. Oncol. 30 (1), 78–84 (2012).
-
(2012)
J. Clin. Oncol
, vol.30
, Issue.1
, pp. 78-84
-
-
Chawla, S.P.1
Staddon, A.P.2
Baker, L.H.3
-
73
-
-
84867924809
-
Phase III, placebo-controlled trial (SUCCEED) evaluating ridaforolimus as maintenance therapy in advanced sarcoma patients following clinical benefit from prior standard cytotoxic chemotherapy: long-term (≥24 months) overall survival results
-
Blay JY, Chawla SP, Ray-Coquard I et al. Phase III, placebo-controlled trial (SUCCEED) evaluating ridaforolimus as maintenance therapy in advanced sarcoma patients following clinical benefit from prior standard cytotoxic chemotherapy: long-term (≥24 months) overall survival results. J. Clin. Oncol. (Abstract) 30 (Suppl. 15), 10010 (2012).
-
(2012)
J. Clin. Oncol. (Abstract)
, vol.30
, pp. 10010
-
-
Blay, J.Y.1
Chawla, S.P.2
Ray-Coquard, I.3
-
74
-
-
0036189675
-
Progression-free rate as the principal end-point for phase II trials in soft-tissue sarcomas
-
van Glabbeke M, Verweij J, Judson I et al. Progression-free rate as the principal end-point for phase II trials in soft-tissue sarcomas. Eur. J. Cancer 38, 543–549 (2002).
-
(2002)
Eur. J. Cancer
, vol.38
, pp. 543-549
-
-
van Glabbeke, M.1
Verweij, J.2
Judson, I.3
-
75
-
-
84875257898
-
A review of oral toxicity associated with mTOR inhibitor therapy in cancer patients
-
(In press).
-
Martins F, Augusto de Oliveira M, Wang Q et al. A review of oral toxicity associated with mTOR inhibitor therapy in cancer patients. Oral. Oncol. (2013) (In press).
-
(2013)
Oral. Oncol
-
-
Martins, F.1
Augusto de Oliveira, M.2
Wang, Q.3
-
76
-
-
33646357786
-
Measuring response in a post-RECIST world: from black and white to shades of grey
-
Michaelis LC, Ratain MJ. Measuring response in a post-RECIST world: from black and white to shades of grey. Nat. Rev. Cancer 6, 409–414 (2006).
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 409-414
-
-
Michaelis, L.C.1
Ratain, M.J.2
-
77
-
-
79251550038
-
Different view of sarcoma statistics
-
(Accessed 29 March 2013)
-
Darling JA. Different view of sarcoma statistics (2009). http://sarcomahelp.org/sarcoma_statistics.html (Accessed 29 March 2013)
-
(2009)
-
-
Darling, J.A.1
-
78
-
-
85027915754
-
-
(Accessed 29 March 2013)
-
US National Institute of Health. NCI SEER Cancer Statistics (2009). http://seer.cancer.gov/statistics/ (Accessed 29 March 2013)
-
(2009)
-
-
-
79
-
-
85027915945
-
® is first in over a decade approved by FDA to prevent organ rejection in adult liver transplant patients
-
(Accessed 29 March 2013)
-
® is first in over a decade approved by FDA to prevent organ rejection in adult liver transplant patients (2013). www.novartis.com/newsroom/media-releases/en/2013/1678805.shtml (Accessed 29 March 2013)
-
(2013)
-
-
Novartis1
-
80
-
-
79953193886
-
ARIAD announces full enrollment in phase 3 Succeed trial evaluating ridaforolimus in patients with metastatic sarcomas
-
(Accessed 29 March 2013)
-
Merck. ARIAD announces full enrollment in phase 3 Succeed trial evaluating ridaforolimus in patients with metastatic sarcomas (2009). www.merck.com/licensing/news-and-events/ariad-press-release.html (Accessed 29 March 2013)
-
(2009)
-
-
Merck1
-
81
-
-
85027915946
-
-
(Accessed 29 March 2013)
-
Merck and ARIAD announce European Medicines Agency accepts marketing authorization application for ridaforolimus, investigational mTOR inhibitor (2011). www.merck.com/licensing/news-and-events/Ariad4-press-release.html (Accessed 29 March 2013)
-
(2011)
-
-
-
82
-
-
85027916084
-
FDA accepts new drug application filing for ridaforolimus, investigational mTOR inhibitor
-
(Accessed 29 March 2013)
-
Merck. FDA accepts new drug application filing for ridaforolimus, investigational mTOR inhibitor (2011). www.mercknewsroom.com/press-release/research-development-news/fda-accepts-new-drug-application-filing-ridaforolimus-invest (Accessed 29 March 2013)
-
(2011)
-
-
Merck1
-
83
-
-
85027915847
-
Merck receives complete response letter from U.S. Food and Drug Administration for investigational medicine ridaforolimus
-
(Accessed 29 March 2013)
-
Merck. Merck receives complete response letter from U.S. Food and Drug Administration for investigational medicine ridaforolimus (2012). www.mercknewsroom.com/press-release/research-and-development-news/merck-receives-complete-response-letter-us-food-and-drug (Accessed 29 March 2013)
-
(2012)
-
-
Merck1
-
84
-
-
85027915601
-
Merck provides update on EU Marketing Authorization Application for ridaforolimus
-
(Accessed 29 March 2013)
-
Merck. Merck provides update on EU Marketing Authorization Application for ridaforolimus (2012). www.mercknewsroom.com/press-release/research-and-development-news/merck-provides-update-eu-marketing-authorization-applica (Accessed 29 March 2013)
-
(2012)
-
-
Merck1
|