TLR4-MyD88/Mal-NF-kB axis is involved in infection of HSV-2 in human cervical epithelial cells

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Liu, Hongya ^a,b   Chen, Kai ^a,b   Feng, Wenqiang ^a,b   Wu, Xinxing ^a   Li, Hui ^a,b  

^a WUHAN UNIVERSITY   (China)

^b WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CYTOKINE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 6; MYELOID DIFFERENTIATION FACTOR 88; SHORT HAIRPIN RNA; TOLL LIKE RECEPTOR 4;

ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; FEMALE; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; HOST CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; INNATE IMMUNITY; INTRACELLULAR SIGNALING; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; UTERINE CERVIX EPITHELIUM; WESTERN BLOTTING;

CERVIX UTERI; CYTOKINES; EPITHELIAL CELLS; FEMALE; HERPESVIRUS 2, HUMAN; HUMANS; MYELIN AND LYMPHOCYTE-ASSOCIATED PROTEOLIPID PROTEINS; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; PHOSPHORYLATION; TOLL-LIKE RECEPTOR 4;

EID: 84894260421     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0080327     Document Type: Article

References (42)

1. Paz-Bailey G, Ramaswamy M, Hawkes SJ, Geretti AM (2007) Herpes simplex virus type 2: epidemiology and management options in developing countries. Sex Transm Infect 83: 16-22. (Pubitemid 46293800)
2. Schacker T (2001) The role of HSV in the transmission and progression of HIV. Herpes 8: 46-49.
3. Whitley RJ (2002) Herpes simplex virus infection. Semin Pediatr Infect Dis 13: 6-11.
4. Whitley RJ (1991) Herpes simplex virus infections of the central nervous system. Encephalitis and neonatal herpes. Drugs 42: 406-427.
5. Corey L, Bodsworth N, Mindel A, Patel R, Schacker T, et al. (2007) An update on short-course episodic and prevention therapies for herpes genitalis. Herpes 14 Suppl 1: 5A-11A. (Pubitemid 47233676)
6. Koelle DM (2006) Vaccines for herpes simplex virus infections. Curr Opin Investig Drugs 7: 136-141.
7. Chan T, Barra NG, Lee AJ, Ashkar AA (2011) Innate and adaptive immunity against herpes simplex virus type 2 in the genital mucosa. J Reprod Immunol 88: 210-218.
8. Andersen JM, Al-Khairy D, Ingalls RR (2006) Innate immunity at the mucosal surface: role of toll-like receptor 3 and toll-like receptor 9 in cervical epithelial cell responses to microbial pathogens. Biol Reprod 74: 824-831.
9. Sato A, Iwasaki A (2004) Induction of antiviral immunity requires Toll-like receptor signaling in both stromal and dendritic cell compartments. Proc Natl Acad Sci U S A 101: 16274-16279. (Pubitemid 39552835)
10. Kawai T, Akira S (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11: 373-384.
11. Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124: 783-801. (Pubitemid 43261452)
12. Sato A, Linehan MM, Iwasaki A (2006) Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells. Proc Natl Acad Sci U S A 103: 17343-17348. (Pubitemid 44788971)
13. Lund J, Sato A, Akira S, Medzhitov R, Iwasaki A (2003) Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med 198: 513-520. (Pubitemid 36976063)
14. Kurt-Jones EA, Belko J, Yu C, Newburger PE, Wang J, et al. (2005) The role of toll-like receptors in herpes simplex infection in neonates. J Infect Dis 191: 746-748. (Pubitemid 40271064)
15. Lund JM, Linehan MM, Iijima N, Iwasaki A (2006) Cutting Edge: Plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ. J Immunol 177: 7510-7514. (Pubitemid 44846264)
16. Nazli A, Yao XD, Smieja M, Rosenthal KL, Ashkar AA, et al. (2009) Differential induction of innate anti-viral responses by TLR ligands against Herpes simplex virus, type 2, infection in primary genital epithelium of women. Antiviral Res 81: 103-112.
17. Finberg RW, Knipe DM, Kurt-Jones EA (2005) Herpes simplex virus and toll-like receptors. Viral Immunol 18: 457-465.
18. Hochrein H, Schlatter B, O'Keeffe M, Wagner C, Schmitz F, et al. (2004) Herpes simplex virus type-1 induces IFN-alpha production via Toll-like receptor 9-dependent and -independent pathways. Proc Natl Acad Sci U S A 101: 11416-11421. (Pubitemid 39038361)
19. Krug A, Luker GD, Barchet W, Leib DA, Akira S, et al. (2004) Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. Blood 103: 1433-1437. (Pubitemid 38168659)
20. Paludan SR, Bowie AG, Horan KA, Fitzgerald KA (2011) Recognition of herpesviruses by the innate immune system. Nat Rev Immunol 11: 143-154.
21. Zhao X, Deak E, Soderberg K, Linehan M, Spezzano D, et al. (2003) Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2. J Exp Med 197: 153-162. (Pubitemid 36152310)
22. MacDonald EM, Savoy A, Gillgrass A, Fernandez S, Smieja M, et al. (2007) Susceptibility of human female primary genital epithelial cells to herpes simplex virus, type-2 and the effect of TLR3 ligand and sex hormones on infection. Biol Reprod 77: 1049-1059. (Pubitemid 350197982)
23. Yao XD, Rosenthal KL (2011) Herpes simplex virus type 2 virion host shutoff protein suppresses innate dsRNA antiviral pathways in human vaginal epithelial cells. J Gen Virol 92: 1981-1993.
24. Li H, Li X, Wei Y, Tan Y, Liu X, et al. (2009) HSV-2 induces TLRs and NF-kappaB-dependent cytokines in cervical epithelial cells. Biochem Biophys Res Commun 379: 686-690.
25. Verstak B, Nagpal K, Bottomley SP, Golenbock DT, Hertzog PJ, et al. (2009) MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses. J Biol Chem 284: 24192-24203.
26. Kollewe C, Mackensen AC, Neumann D, Knop J, Cao P, et al. (2004) Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling. J Biol Chem 279: 5227-5236. (Pubitemid 38220541)
27. Lagos D, Vart RJ, Gratrix F, Westrop SJ, Emuss V, et al. (2008) Toll-like receptor 4 mediates innate immunity to Kaposi sarcoma herpesvirus. Cell Host Microbe 4: 470-483.
28. Yasuda K, Richez C, Uccellini MB, Richards RJ, Bonegio RG, et al. (2009) Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes. J Immunol 183: 3109-3117.
29. Thon JN, Peters CG, Machlus KR, Aslam R, Rowley J, et al. (2012) T granules in human platelets function in TLR9 organization and signaling. J Cell Biol 198: 561-574.
30. Takeuchi O, Akira S (2010) Pattern recognition receptors and inflammation. Cell 140: 805-820.
31. Zhang SY, Jouanguy E, Ugolini S, Smahi A, Elain G, et al. (2007) TLR3 deficiency in patients with herpes simplex encephalitis. Science 317: 1522-1527. (Pubitemid 47417427)
32. Kurt-Jones EA, Chan M, Zhou S, Wang J, Reed G, et al. (2004) Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Proc Natl Acad Sci U S A 101: 1315-1320. (Pubitemid 38182686)
33. Georgel P, Jiang Z, Kunz S, Janssen E, Mols J, et al. (2007) Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. Virology 362: 304-313. (Pubitemid 46678142)
34. Kagan JC, Medzhitov R (2006) Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell 125: 943-955. (Pubitemid 43795199)
35. Rowe DC, McGettrick AF, Latz E, Monks BG, Gay NJ, et al. (2006) The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. Proc Natl Acad Sci U S A 103: 6299-6304.
36. Tanimura N, Saitoh S, Matsumoto F, Akashi-Takamura S, Miyake K (2008) Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling. Biochem Biophys Res Commun 368: 94-99.
37. Santoro MG, Rossi A, Amici C (2003) NF-kappaB and virus infection: who controls whom. Embo J 22: 2552-2560. (Pubitemid 36712353)
38. Sin WX, Li P, Yeong JP, Chin KC (2012) Activation and regulation of interferon-beta in immune responses. Immunol Res 53: 25-40.
39. Honda K, Yanai H, Negishi H, Asagiri M, Sato M, et al. (2005) IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434: 772-777. (Pubitemid 44739521)
40. Kagan JC, Su T, Horng T, Chow A, Akira S, et al. (2008) TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol 9: 361-368. (Pubitemid 351405105)
41. Baege AC, Berger A, Schlegel R, Veldman T, Schlegel R (2002) Cervical epithelial cells transduced with the papillomavirus E6/E7 oncogenes maintain stable levels of oncoprotein expression but exhibit progressive, major increases in hTERT gene expression and telomerase activity. Am J Pathol 160: 1251-1257. (Pubitemid 34411629)
42. Miller J, Dakic A, Chen R, Palechor-Ceron N, Dai Y, et al. (2013) HPV16 E7 protein and hTERT proteins defective for telomere maintenance cooperate to immortalize human keratinocytes. PLoS Pathog 9: e1003284.