Brain-derived neurotrophic factor: Its impact upon neuroplasticity and neuroplasticity inducing transcranial brain stimulation protocols

Neurogenetics

Volumn 15, Issue 1, 2014, Pages 1-11

  Chaieb, L ^a   Antal, A ^a   Ambrus, G G ^a   Paulus, W ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

BDNF; Brain stimulation; Neuroplasticity; Single nucleotide polymorphism; Synaptic plasticity

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; METHIONINE; VALINE;

AMINO ACID SUBSTITUTION; BDNF GENE; BRAIN DEPTH STIMULATION; GENE; GENE EXPRESSION; GENETIC PREDISPOSITION; GENETIC VARIABILITY; HUMAN; NERVE CELL PLASTICITY; NEUROLOGIC DISEASE; NEUROMODULATION; PRIORITY JOURNAL; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CENTRAL NERVOUS SYSTEM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HOMOZYGOTE; HUMANS; LEARNING; MEMORY; METHIONINE; NEURONAL PLASTICITY; NEURONS; POLYMORPHISM, SINGLE NUCLEOTIDE; SYNAPSES; TRANSCRANIAL MAGNETIC STIMULATION; VALINE;

EID: 84894249839     PISSN: 13646745     EISSN: 13646753     Source Type: Journal    
DOI: 10.1007/s10048-014-0393-1     Document Type: Review

References (98)

1. Levi-Montalcini R (1987) The nerve growth factor 35 years later. Science 237(4819):1154-1162
2. Lykissas MG, Batistatou AK, Charalabopoulos KA, Beris AE (2007) The role of neurotrophins in axonal growth, guidance, and regeneration. Curr Neurovasc Res 4(2):143-151
3. Bramham CR, Messaoudi E (2005) BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog Neurobiol 76(2):99-125. doi: 10.1016/j.pneurobio.2005.06.003
4. Lu J, Wu Y, Sousa N, Almeida OF (2005) SMAD pathway mediation of BDNF and TGF beta 2 regulation of proliferation and differentiation of hippocampal granule neurons. Development 132(14):3231-3242. doi: 10.1242/dev.01893
5. Aiyagari AL, Taylor BR, Aurora V, Young SG, Shannon KM (2003) Hematologic effects of inactivating the Ras processing enzyme Rce1. Blood 101(6):2250-2252. doi: 10.1182/blood-2002-07-2250
6. Lu B (2003) Pro-region of neurotrophins: role in synaptic modulation. Neuron 39(5):735-738
7. Lu B (2003) BDNF and activity-dependent synaptic modulation. Learn Mem 10(2):86-98. doi: 10.1101/lm.54603
8. Jeanneteau F, Chao MV (2006) Promoting neurotrophic effects by GPCR ligands. Novartis Found Symp 276:181-189, discussion 189-192, 233-187, 275-181
9. Hanson IM, Seawright A, van Heyningen V (1992) The human BDNF gene maps between FSHB and HVBS1 at the boundary of 11p13-p14. Genomics 13(4):1331-1333
10. Cramer SC, Procaccio V, Americas G, Investigators GIS (2012) Correlation between genetic polymorphisms and stroke recovery: analysis of the GAIN Americas and GAIN International Studies. Eur J Neurol Off J Eur Fed Neurol Soc 19(5):718-724. doi: 10.1111/j.1468-1331.2011.03615.x
11. Kim WS, Lim JY, Shin JH, Park HK, Tan SA, Park KU, Paik NJ (2013) Effect of the presence of brain-derived neurotrophic factor val(66)met polymorphism on the recovery in patients with acute subcortical stroke. Annals Rehabil Med 37(3):311-319. doi: 10.5535/arm.2013.37.3.311
12. Siironen J, Juvela S, Kanarek K, Vilkki J, Hernesniemi J, Lappalainen J (2007) The Met allele of the BDNF Val66Met polymorphism predicts poor outcome among survivors of aneurysmal subarachnoid hemorrhage. Stroke J Cereb Circ 38(10):2858-2860. doi: 10.1161/STROKEAHA.107.485441
13. Westbroek EM, Pawlikowska L, Lawton MT, McCulloch CE, Young WL, Kim H (2012) Brain-derived neurotrophic factor Val66Met polymorphism predicts worse functional outcome after surgery in patients with unruptured brain arteriovenous malformation. Stroke J Cereb Circ 43(8):2255-2257. doi: 10.1161/STROKEAHA.112. 663096
14. Xu X, Mill J, Zhou K, Brookes K, Chen CK, Asherson P (2007) Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples. Am J Med Genet B Neuropsychiatr Genet Off Publ Int Soc Psychiatr Genet 144B(1):83-86. doi: 10.1002/ajmg.b.30406
15. Miura I, Zhang JP, Nitta M, Lencz T, Kane JM, Malhotra AK, Yabe H, Correll CU (2014) BDNF Val66Met polymorphism and antipsychotic-induced tardive dyskinesia occurrence and severity: A meta-analysis. Schizophrenia research 14:00038-1. doi: 10.1016/j.schres.2013.12.011
16. Hosang GM, Shiles C, Tansey KE, McGuffin P, Uher R (2014) Interaction between stress and the BDNF Val66Met polymorphism in depression: a systematic review and meta-analysis. BMC Med 12(1):7. doi: 10.1186/1741-7015-12-7
17. Rybakowski JK (2008) BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia. Pharmacogenomics 9(11):1589-1593. doi: 10.2217/14622416.9.11.1589
18. Aid T, Kazantseva A, Piirsoo M, Palm K, Timmusk T (2007) Mouse and rat BDNF gene structure and expression revisited. J Neurosci Res 85(3):525-535. doi: 10.1002/jnr.21139
19. Pruunsild P, Kazantseva A, Aid T, Palm K, Timmusk T (2007) Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters. Genomics 90(3):397-406. doi: 10.1016/j.ygeno.2007.05.004
20. Pattabiraman PP, Tropea D, Chiaruttini C, Tongiorgi E, Cattaneo A, Domenici L (2005) Neuronal activity regulates the developmental expression and subcellular localization of cortical BDNF mRNA isoforms in vivo. Mol Cell Neurosci 28(3):556-570. doi: 10.1016/j.mcn.2004.11.010
21. Chao MV, Bothwell M (2002) Neurotrophins: to cleave or not to cleave. Neuron 33(1):9-12
22. Rosch H, Schweigreiter R, Bonhoeffer T, Barde YA, Korte M (2005) The neurotrophin receptor p75NTR modulates long-term depression and regulates the expression of AMPA receptor subunits in the hippocampus. Proc Natl Acad Sci U S A 102(20):7362-7367. doi: 10.1073/pnas.0502460102
23. Woo NH, Teng HK, Siao CJ, Chiaruttini C, Pang PT, Milner TA, Hempstead BL, Lu B (2005) Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Nat Neurosci 8(8):1069-1077. doi: 10.1038/nn1510
24. Segal RA (2003) Selectivity in neurotrophin signaling: theme and variations. Annu Rev Neurosci 26:299-330. doi: 10.1146/annurev.neuro.26.041002. 131421
25. West AE, Griffith EC, Greenberg ME (2002) Regulation of transcription factors by neuronal activity. Nat Rev Neurosci 3(12):921-931. doi: 10.1038/nrn987
26. Tao X, West AE, Chen WG, Corfas G, Greenberg ME (2002) A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. Neuron 33(3):383-395
27. Murer MG, Yan Q, Raisman-Vozari R (2001) Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease. Prog Neurobiol 63(1):71-124
28. Tongiorgi E, Righi M, Cattaneo A (1997) Activity-dependent dendritic targeting of BDNF and TrkB mRNAs in hippocampal neurons. J Neurosci Off J Soc Neurosci 17(24):9492-9505
29. Lessmann V, Gottmann K, Malcangio M (2003) Neurotrophin secretion: current facts and future prospects. Prog Neurobiol 69(5):341-374
30. Wetmore C, Cao YH, Pettersson RF, Olson L (1991) Brain-derived neurotrophic factor: subcellular compartmentalization and interneuronal transfer as visualized with anti-peptide antibodies. Proc Natl Acad Sci U S A 88(21):9843-9847
31. Furukawa S, Sugihara Y, Iwasaki F, Fukumitsu H, Nitta A, Nomoto H, Furukawa Y (1998) Brain-derived neurotrophic factor-like immunoreactivity in the adult rat central nervous system predominantly distributed in neurons with substantial amounts of brain-derived neurotrophic factor messenger RNA or responsiveness to brain-derived neurotrophic factor. Neuroscience 82(3):653-670
32. Cooney JR, Hurlburt JL, Selig DK, Harris KM, Fiala JC (2002) Endosomal compartments serve multiple hippocampal dendritic spines from a widespread rather than a local store of recycling membrane. J Neurosci Off J Soc Neurosci 22(6):2215-2224
33. Aoki C, Wu K, Elste A, Len G, Lin S, McAuliffe G, Black IB (2000) Localization of brain-derived neurotrophic factor and TrkB receptors to postsynaptic densities of adult rat cerebral cortex. J Neurosci Res 59(3):454-463
34. Wetmore C, Olson L, Bean AJ (1994) Regulation of brain-derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors. J Neurosci Off J Soc Neurosci 14(3 Pt 2):1688-1700
35. Gartner A, Staiger V (2002) Neurotrophin secretion from hippocampal neurons evoked by long-term-potentiation-inducing electrical stimulation patterns. Proc Natl Acad Sci U S A 99(9):6386-6391. doi: 10.1073/pnas.092129699
36. Schinder AF, Poo M (2000) The neurotrophin hypothesis for synaptic plasticity. Trends Neurosci 23(12):639-645
37. Mei F, Nagappan G, Ke Y, Sacktor TC, Lu B (2011) BDNF facilitates L-LTP maintenance in the absence of protein synthesis through PKMzeta. PLoS One 6(6):e21568. doi: 10.1371/journal.pone.0021568
38. Grande I, Fries GR, Kunz M, Kapczinski F (2010) The role of BDNF as a mediator of neuroplasticity in bipolar disorder. Psychiatr Investig 7(4):243-250. doi: 10.4306/pi.2010.7.4.243
39. Zuccato C, Cattaneo E (2009) Brain-derived neurotrophic factor in neurodegenerative diseases. Nat Rev Neurol 5(6):311-322. doi: 10.1038/nrneurol.2009.54
40. Patterson SL, Abel T, Deuel TA, Martin KC, Rose JC, Kandel ER (1996) Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron 16(6):1137-1145
41. Oliff HS, Berchtold NC, Isackson P, Cotman CW (1998) Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus. Brain Res Mol Brain Res 61(1-2):147-153
42. Ranieri F, Podda MV, Riccardi E, Frisullo G, Dileone M, Profice P, Pilato F, Di Lazzaro V, Grassi C (2012) Modulation of LTP at rat hippocampal CA3-CA1 synapses by direct current stimulation. J Neurophysiol 107(7):1868-1880. doi: 10.1152/jn.00319.2011
43. Kojima M, Klein RL, Hatanaka H (2002) Pre- and post-synaptic modification by neurotrophins. Neurosci Res 43(3):193-199
44. Zakharenko SS, Patterson SL, Dragatsis I, Zeitlin SO, Siegelbaum SA, Kandel ER, Morozov A (2003) Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP at hippocampal CA1-CA3 synapses. Neuron 39(6):975-990
45. Gooney M, Messaoudi E, Maher FO, Bramham CR, Lynch MA (2004) BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signaling events. Neurobiol Aging 25(10):1323-1331. doi: 10.1016/j. neurobiolaging.2004.01.003
46. Xu B, Gottschalk W, Chow A, Wilson RI, Schnell E, Zang K, Wang D, Nicoll RA, Lu B, Reichardt LF (2000) The role of brain-derived neurotrophic factor receptors in the mature hippocampus: modulation of long-term potentiation through a presynaptic mechanism involving TrkB. J Neurosci Off J Soc Neurosci 20(18):6888-6897
47. Gottschalk W, Pozzo-Miller LD, Figurov A, Lu B (1998) Presynaptic modulation of synaptic transmission and plasticity by brain-derived neurotrophic factor in the developing hippocampus. J Neurosci Off J Soc Neurosci 18(17):6830-6839
48. Figurov A, Pozzo-Miller LD, Olafsson P, Wang T, Lu B (1996) Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus. Nature 381(6584):706-709. doi: 10.1038/381706a0
49. Korb E, Finkbeiner S (2011) Arc in synaptic plasticity: from gene to behavior. Trends Neurosci 34(11):591-598. doi: 10.1016/j.tins.2011.08.007
50. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, Lu B, Weinberger DR (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112(2):257-269
51. Pezawas L, Verchinski BA, Mattay VS, Callicott JH, Kolachana BS, Straub RE, Egan MF, Meyer-Lindenberg A, Weinberger DR (2004) The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. J Neurosci Off J Soc Neurosci 24(45):10099-10102. doi: 10.1523/JNEUROSCI.2680-04.2004
52. Bueller JA, Aftab M, Sen S, Gomez-Hassan D, Burmeister M, Zubieta JK (2006) BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects. Biol Psychiatr 59(9):812-815. doi: 10.1016/j.biopsych.2005.09. 022
53. Montag C, Weber B, Fliessbach K, Elger C, Reuter M (2009) The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression. Psychol Med 39(11):1831-1839. doi: 10.1017/S0033291709005509
54. Karnik MS, Wang L, Barch DM, Morris JC, Csernansky JG (2010) BDNF polymorphism rs6265 and hippocampal structure and memory performance in healthy control subjects. Psychiatry Res 178(2):425-429. doi: 10.1016/j.psychres.2009. 09.008
55. Richter-Schmidinger T, Alexopoulos P, Horn M, Maus S, Reichel M, Rhein C, Lewczuk P, Sidiropoulos C, Kneib T, Perneczky R, Doerfler A, Kornhuber J (2011) Influence of brain-derived neurotrophic-factor and apolipoprotein E genetic variants on hippocampal volume and memory performance in healthy young adults. J Neural Transm 118(2):249-257. doi: 10.1007/s00702-010-0539-8
56. Sublette ME, Baca-Garcia E, Parsey RV, Oquendo MA, Rodrigues SM, Galfalvy H, Huang YY, Arango V, Mann JJ (2008) Effect of BDNF val66met polymorphism on age-related amygdala volume changes in healthy subjects. Prog Neuro-psychopharmacol Biol Psychiatry 32(7):1652-1655. doi: 10.1016/j.pnpbp. 2008.06.009
57. Hariri AR, Goldberg TE, Mattay VS, Kolachana BS, Callicott JH, Egan MF, Weinberger DR (2003) Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neurosci Offi J Soc Neurosci 23(17):6690-6694
58. Dempster E, Toulopoulou T, McDonald C, Bramon E, Walshe M, Filbey F, Wickham H, Sham PC, Murray RM, Collier DA (2005) Association between BDNF val66 met genotype and episodic memory. Am J Med Genet B Neuropsychiatr Genet Off Publ Int Soc Psychiatr Genet 134B(1):73-75. doi: 10.1002/ajmg.b.30150
59. Goldberg TE, Iudicello J, Russo C, Elvevag B, Straub R, Egan MF, Weinberger DR (2008) BDNF Val66Met polymorphism significantly affects d' in verbal recognition memory at short and long delays. Biol Psychol 77(1):20-24. doi: 10.1016/j.biopsycho.2007.08.009
60. Cathomas F, Vogler C, Euler-Sigmund JC, de Quervain DJ, Papassotiropoulos A (2010) Fine-mapping of the brain-derived neu-rotrophic factor (BDNF) gene supports an association of the Val66Met polymorphism with episodic memory. Int J Neuropsychopharmacol Off Sci J Coll Int Neuropsychopharmacol 13(8):975-980. doi: 10.1017/S1461145710000519
61. Kambeitz JP, Bhattacharyya S, Kambeitz-Ilankovic LM, Valli I, Collier DA, McGuire P (2012) Effect of BDNF val(66)met polymorphism on declarative memory and its neural substrate: a meta-analysis. Neurosci Biobehav Rev 36(9):2165-2177. doi: 10.1016/j.neubiorev.2012.07.002
62. Dodds CM, Henson RN, Miller SR, Nathan PJ (2013) Overestimation of the effects of the BDNF val66met polymorphism on episodic memory-related hippocampal function: a critique of a recent meta-analysis. Neurosci Biobehav Rev 37(4):739-741. doi: 10.1016/j.neubiorev.2013.01.019
63. Beste C, Baune BT, Domschke K, Falkenstein M, Konrad C (2010) Paradoxical association of the brain-derived-neurotrophic-factor val66met genotype with response inhibition. Neuroscience 166(1):178-184. doi: 10.1016/j.neuroscience. 2009.12.022
64. Rybakowski JK, Borkowska A, Skibinska M, Hauser J (2006) Illness-specific association of val66met BDNF polymorphism with performance on Wisconsin Card Sorting Test in bipolar mood disorder. Mol Psychiatry 11(2):122-124. doi: 10.1038/sj.mp.4001765
65. Nagel IE, Chicherio C, Li SC, von Oertzen T, Sander T, Villringer A, Heekeren HR, Backman L, Lindenberger U (2008) Human aging magnifies genetic effects on executive functioning and working memory. Front Hum Neurosci 2:1. doi: 10.3389/neuro.09.001.2008
66. Rybakowski JK, Borkowska A, Czerski PM, Skibinska M, Hauser J (2003) Polymorphism of the brain-derived neurotrophic factor gene and performance on a cognitive prefrontal test in bipolar patients. Bipolar Disord 5(6):468-472
67. Rybakowski JK, Borkowska A, Skibinska M, Szczepankiewicz A, Kapelski P, Leszczynska-Rodziewicz A, Czerski PM, Hauser J (2006) Prefrontal cognition in schizophrenia and bipolar illness in relation to Val66Met polymorphism of the brain-derived neurotrophic factor gene. Psychiatry Clin Neurosci 60(1):70-76. doi: 10.1111/j.1440-1819.2006.01462.x
68. Banner H, Bhat V, Etchamendy N, Joober R, Bohbot VD (2011) The brain-derived neurotrophic factor Val66Met polymorphism is associated with reduced functional magnetic resonance imaging activity in the hippocampus and increased use of caudate nucleus-dependent strategies in a human virtual navigation task. Eur J Neurosci 33(5):968-977. doi: 10.1111/j.1460-9568.2010. 07550.x
69. Wiener M, Lohoff FW, Coslett HB (2011) Double dissociation of dopamine genes and timing in humans. J Cogn Neurosci 23(10):2811-2821. doi: 10.1162/jocn.2011.21626
70. Cerasa A, Tongiorgi E, Fera F, Gioia MC, Valentino P, Liguori M, Manna I, Zito G, Passamonti L, Nistico R, Quattrone A (2010) The effects of BDNF Val66Met polymorphism on brain function in controls and patients with multiple sclerosis: an imaging genetic study. Behav Brain Res 207(2):377-386. doi: 10.1016/j.bbr.2009.10.022
71. Joundi RA, Lopez-Alonso V, Lago A, Brittain JS, Fernandez-Del-Olmo M, Gomez-Garre P, Mir P, Jenkinson N, Cheeran B, Brown P (2012) The effect of BDNF val66met polymorphism on visuomotor adaptation. Exp Brain Res Exp Hirnforsch Exp Cereb 223(1):43-50. doi: 10.1007/s00221-012-3239-9
72. Tsai SJ, Hong CJ, Yu YW, Chen TJ (2004) Association study of a brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and personality trait and intelligence in healthy young females. Neuropsychobiology 49(1):13-16. doi: 10.1159/000075333
73. Nissen MJ, Bullemer P (1987) Attentional requirements of learning - evidence from performance-measures. Cogn Psychol 19(1):1-32. doi: 10.1016/0010-0285(87)90002-8
74. Witte AV, Kurten J, Jansen S, Schirmacher A, Brand E, Sommer J, Floel A (2012) Interaction of BDNF and COMT polymorphisms on paired-associative stimulation-induced cortical plasticity. J Neurosci Off J Soc Neurosci 32(13):4553-4561. doi: 10.1523/JNEUROSCI.6010-11.2012
75. Freundlieb N, Philipp S, Schneider SA, Bruggemann N, Klein C, Gerloff C, Hummel FC (2012) No association of the BDNF val66met polymorphism with implicit associative vocabulary and motor learning. PLoS One 7(11):e48327. doi: 10.1371/journal.pone.0048327
76. Kleim JA, Chan S, Pringle E, Schallert K, Procaccio V, Jimenez R, Cramer SC (2006) BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex. Nat Neurosci 9(6):735-737. doi: 10.1038/nn1699
77. Li Voti P, Conte A, Suppa A, Iezzi E, Bologna M, Aniello MS, Defazio G, Rothwell JC, Berardelli A (2011) Correlation between cortical plasticity, motor learning and BDNF genotype in healthy subjects. Exp Brain Res Exp Hirnforsch Exp Cereb 212(1):91-99. doi: 10.1007/s00221-011-2700-5
78. McHughen SA, Cramer SC (2013) The BDNF val(66)met polymorphism is not related to motor function or short-term cortical plasticity in elderly subjects. Brain Res 1495:1-10. doi: 10.1016/j.brainres.2012.12.004
79. Cirillo J, Hughes J, Ridding M, Thomas PQ, Semmler JG (2012) Differential modulation of motor cortex excitability in BDNF Met allele carriers following experimentally induced and use-dependent plasticity. Eur J Neurosci 36(5):2640-2649. doi: 10.1111/j.1460-9568.2012.08177.x
80. Soliman F, Glatt CE, Bath KG, Levita L, Jones RM, Pattwell SS, Jing D, Tottenham N, Amso D, Somerville LH, Voss HU, Glover G, Ballon DJ, Liston C, Teslovich T, Van Kempen T, Lee FS, Casey BJ (2010) A genetic variant BDNF polymorphism alters extinction learning in both mouse and human. Science 327(5967):863-866. doi: 10.1126/science.1181886
81. Hallett M (2000) Transcranial magnetic stimulation and the human brain. Nature 406(6792):147-150. doi: 10.1038/35018000
82. Eide FF, Vining ER, Eide BL, Zang K, Wang XY, Reichardt LF (1996) Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling. J Neurosci Off J Soc Neurosci 16(10):3123-3129
83. Wang HY, Crupi D, Liu J, Stucky A, Cruciata G, Di Rocco A, Friedman E, Quartarone A, Ghilardi MF (2011) Repetitive transcranial magnetic stimulation enhances BDNF-TrkB signaling in both brain and lymphocyte. J Neurosci Off J Soc Neurosci 31(30):11044-11054. doi: 10.1523/JNEUROSCI.2125-11.2011
84. Levine ES, Dreyfus CF, Black IB, Plummer MR (1995) Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors. Proc Natl Acad Sci U S A 92(17):8074-8077
85. Wang F, Geng X, Tao HY, Cheng Y (2010) The restoration after repetitive transcranial magnetic stimulation treatment on cognitive ability of vascular dementia rats and its impacts on synaptic plasticity in hippocampal CA1 area. J Mol Neurosci 41(1):145-155. doi: 10.1007/s12031-009-9311-7, MN
86. Cheeran B, Talelli P, Mori F, Koch G, Suppa A, Edwards M, Houlden H, Bhatia K, Greenwood R, Rothwell JC (2008) A common polymorphism in the brain-derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS. J Physiol 586(Pt 23):5717-5725. doi: 10.1113/jphysiol.2008.159905
87. Antal A, Chaieb L, Moliadze V, Monte-Silva K, Poreisz C, Thirugnanasambandam N, Nitsche MA, Shoukier M, Ludwig H, Paulus W (2010) Brain-derived neurotrophic factor (BDNF) gene polymorphisms shape cortical plasticity in humans. Brain Stimulation 3(4):230-237. doi: 10.1016/j.brs.2009. 12.003
88. Jayasekeran V, Pendleton N, Holland G, Payton A, Jefferson S, Michou E, Vasant D, Ollier B, Horan M, Rothwell J, Hamdy S (2011) Val66Met in brain-derived neurotrophic factor affects stimulus-induced plasticity in the human pharyngeal motor cortex. Gastroenterology 141(3):827-836. doi: 10.1053/j.gastro.2011.05.047, e821-823
89. Nakamura K, Enomoto H, Hanajima R, Hamada M, Shimizu E, Kawamura Y, Sasaki T, Matsuzawa D, Sutoh C, Shirota Y, Terao Y, Ugawa Y (2011) Quadri-pulse stimulation (QPS) induced LTP/LTD was not affected by Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene. Neurosci Lett 487(3):264-267. doi: 10.1016/j.neulet.2010.10.034
90. Mastroeni C, Bergmann TO, Rizzo V, Ritter C, Klein C, Pohlmann I, Brueggemann N, Quartarone A, Siebner HR (2013) Brain-derived neurotrophic factor - a major player in stimulation-induced homeostatic metaplasticity of human motor cortex? PLoS One 8(2):e57957. doi: 10.1371/journal.pone.0057957
91. Ziemann U, Paulus W, Nitsche MA, Pascual-Leone A, Byblow WD, Berardelli A, Siebner HR, Classen J, Cohen LG, Rothwell JC (2008) Consensus: Motor cortex plasticity protocols. Brain Stimulation 1(3):164-182. doi: 10.1016/j.brs.2008. 06.006
92. Missitzi J, Gentner R, Geladas N, Politis P, Karandreas N, Classen J, Klissouras V (2011) Plasticity in human motor cortex is in part genetically determined. J Physiol 589(Pt 2):297-306. doi: 10.1113/jphysiol.2010.200600
93. Fritsch B, Reis J, Martinowich K, Schambra HM, Ji Y, Cohen LG, Lu B (2010) Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learning. Neuron 66(2):198-204. doi: 10.1016/j.neuron.2010.03.035
94. Di Lazzaro V, Manganelli F, Dileone M, Notturno F, Esposito M, Capasso M, Dubbioso R, Pace M, Ranieri F, Minicuci G, Santoro L, Uncini A (2012) The effects of prolonged cathodal direct current stimulation on the excitatory and inhibitory circuits of the ipsilateral and contralateral motor cortex. J Neural Transm 119(12):1499-1506. doi: 10.1007/s00702-012-0845-4
95. Brunoni AR, Kemp AH, Shiozawa P, Cordeiro Q, Valiengo LC, Goulart AC, Coprerski B, Lotufo PA, Brunoni D, Perez AB, Fregni F, Bensenor IM (2013) Impact of 5-HTTLPR and BDNF polymorphisms on response to sertraline versus transcranial direct current stimulation: implications for the serotonergic system. Eur Neuropsychopharmacol J Eur Coll Neuropsychopharmacol 23(11):1530-1540. doi: 10.1016/j.euroneuro.2013.03.009
96. Hashimoto R, Moriguchi Y, Yamashita F, Mori T, Nemoto K, Okada T, Hori H, Noguchi H, Kunugi H, Ohnishi T (2008) Dose-dependent effect of the Val66Met polymorphism of the brain-derived neurotrophic factor gene on memory-related hippocampal activity. Neurosci Res 61(4):360-367
97. Ho BC, Milev P, O'Leary DS, Librant A, Andreasen NC, Wassink TH (2006) Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers. Arch Gen Psychiatry 63(7):731-740
98. Bocchio-Chiavetto L, Miniussi C, Zanardini R, Gazzoli A, Bignotti S, Specchia C, Gennarelli M (2008) 5-HTTLPR and BDNF Val66Met polymorphisms and response to rTMS treatment in drug resistant depression. Neurosci Lett 437(2):130-134