Aerobic exercise training decreases plasma asymmetric dimethylarginine concentrations with increase in arterial compliance in postmenopausal women

American Journal of Hypertension

Volumn 27, Issue 3, 2014, Pages 415-421

  Tanahashi, Koichiro ^a   Akazawa, Nobuhiko ^a   Miyaki, Asako ^a   Choi, Youngju ^a   Ra, Song Gyu ^a   Matsubara, Tomoko ^a   Kumagai, Hiroshi ^a   Oikawa, Satoshi ^a   Maeda, Seiji ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

aerobic exercise training; aging; arterial compliance; asymmetric dimethylarginine (ADMA); blood pressure; hypertension

Indexed keywords

AEROBIC EXERCISE TRAINING; AGING; ARTERIAL COMPLIANCE; ASYMMETRIC DIMETHYLARGININE (ADMA); BLOOD PRESSURE; HYPERTENSION.;

AGED; ARGININE; BIOLOGICAL MARKERS; CAROTID ARTERIES; CAROTID INTIMA-MEDIA THICKNESS; COMPLIANCE; DOWN-REGULATION; EXERCISE; FEMALE; HEART RATE; HUMANS; JAPAN; MIDDLE AGED; POSTMENOPAUSE; TIME FACTORS; VASCULAR STIFFNESS;

EID: 84894239162     PISSN: 08957061     EISSN: 19417225     Source Type: Journal    
DOI: 10.1093/ajh/hpt217     Document Type: Article

References (41)

1. Hodes RJ, Lakatta EG, McNeil CT. Another modifiable risk factor for cardiovascular disease? Some evidence points to arterial stiffness. J Am Geriatr Soc 1995; 43:581-582.
2. Rowe JW. Clinical consequences of age-related impairments in vascular compliance. Am J Cardiol 1987; 60:68G-71G.
3. Tanaka H, Dinenno FA, Monahan KD, Clevenger CM, DeSouza CA, Seals DR. Aging, habitual exercise, and dynamic arterial compliance. Circulation 2000; 102:1270-1275.
4. Moreau KL, Donato AJ, Seals DR, DeSouza CA, Tanaka H. Regular exercise, hormone replacement therapy and the age-related decline in carotid arterial compliance in healthy women. Cardiovasc Res 2003; 57:861-868.
5. Yoshizawa M, Maeda S, Miyaki A, Misono M, Choi Y, Shimojo N, Ajisaka R, Tanaka H. Additive beneficial effects of lactotripeptodes and aerobic exercise on arterial compliance in postmenopausal women. Am J Physiol Heart Circ Physiol 2009; 297:H1899-H1903.
6. Moreau KL, Donato AJ, Seals DR, DeSouza CA, Tanaka H. Regular exercise, hormone replacement therapy and the age-related decline in carotid arterial compliance in healthy women. Cardiovasc Res 2003; 57:861-868.
7. Kelm M, Schrader J. Control of coronary vascular tone by nitric oxide. Circ Res 1990; 66:1561-1575.
8. Wilkinson IB, Franklin SS, Cockcroft JR. Nitric oxide and the regulation of large artery stiffness: from physiology to pharmacology. Hypertension. 2004; 44:112-116.
9. Sugawara J, Komine H, Hayashi K, Yoshizawa M, Yokoi T, Otsuki T, Shimojo N, Miyauchi T, Maeda S, Tanaka H. Effect of systemic nitric oxide synthase inhibition on arterial stiffness in humans. Hypertens Res 2007; 30:411-415.
10. F?stermann U, M?zel T. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation. 2006; 113:1708-1714.
11. Cooke JP. Asymmetrical dimethylarginine: the Uber marker? Circulation 2004; 109:1813-1818.
12. Miyazaki H, Matsuoka H, Cooke JP, Usui M, Ueda S, Okuda S, Imaizumi T. Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis. Circulation 1999; 99:1141-1146.
13. Schulze F, Maas R, Freese R, Schwedhelm E, Silberhorn E, B?er RH. Determination of a reference value for N(G), N(G)-dimethyl-Larginine in 500 subjects. Eur J Clin Invest 2005; 35:622-626.
14. Sugawara J, Akazawa N, Miyaki A, Choi Y, Tanabe Y, Imai T, Maeda S. Effect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women: pilot study. Am J Hypertens 2012; 25:651-656.
15. Shimizu K, Kimura F, Akimoto T, Akama T, Kuno S, Kono I. Effect of free-living daily physical activity on salivary secretory IgA in elderly. Med Sci Sports Exerc 2007; 39:593-598.
16. Cortez-Cooper MY, Supak JA, Tanaka H. A new device for automatic measurements of arterial stiffness and ankle-brachial index. Am J Cardiol 2003; 91:1519-1522.
17. Tanaka H, Seals DR, Monahan KD, Clevenger CM, DeSouza CA, Dinenno FA. Regular aerobic exercise and the age-related increase in carotid artery intima e media thickness in healthy men. J Appl Physiol 2002; 92:1458-1464.
18. Beaver WL, Wasserman K, Whipp BJ. A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol 1986; 60:2020-2027.
19. B?er RH, Bode-B?er SM, Szuba A, Tsao PS, Chan JR, Tangphao O, Blaschke TF, Cooke JP. Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia. Circulation 1998; 98:1842-1847.
20. Valkonen VP, P?v?H, Salonen JT, Lakka TA, Lehtim?i T, Laakso J, Laaksonen R. Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine. Lancet 2001; 358:2127-2128.
21. Usui M, Matsuoka H, Miyazaki H, Ueda S, Okuda S, Imaizumi T. Increased endogenous nitric oxide synthase inhibitor in patients with congestive heart failure. Life Sci 1998; 62:2425-2430.
22. Dimitrow PP, Undas A, Bober M, Tracz W, Dubiel JS. Plasma biomarkers of endothelial dysfunction in patients with hypertrophic cardiomyopathy. Pharmacol Rep 2007; 59:715-720.
23. Gomes VA, Casella-Filho A, Chagas AC, Tanus-Santos JE. Enhanced concentrations of relevant markers of nitric oxide formation after exercise training in patients with metabolic syndrome. Nitric Oxide 2008; 19:345-350.
24. Maeda S, Miyauchi T, Kakiyama T, Sugawara J, Iemitsu M, Irukayama-Tomobe Y, Murakami H, Kumagai Y, Kuno S, Matsuda M. Effects of exercise training of 8 weeks and detraining on plasma levels of endothelium-derived factors, endothelin-1 and nitric oxide, in healthy young humans. Life Sci 2001; 69:1005-1016.
25. Maeda S, Tanabe T, Otsuki T, Sugawara J, Iemitsu M, Miyauchi T, Kuno S, Ajisaka R, Matsuda M. Moderate regular exercise increases basal production of nitric oxide in elderly women. Hypertens Res 2004; 27:947-953.
26. Furuki K, Adachi H, Enomoto M, Otsuka M, Fukami A, Kumagae S, Matsuoka H, Nanjo Y, Kakuma T, Imaizumi T. Plasma level of asymmetric dimethylarginine (ADMA) as a predictor of carotid intimamedia thickness progression: six-year prospective study using carotid ultrasonography. Hypertens Res 2008; 31:1185-1189.
27. Spence AL, Carter HH, Naylor LH, Green DJ. A prospective randomized longitudinal study involving 6 months of endurance or resistance exercise. Conduit artery adaptation in humans. J Physiol 2013; 591:1265-1275.
28. Tanaka H, Seals DR, Monahan KD, Clevenger CM, DeSouza CA, Dinenno FA. Regular aerobic exercise and the age-related increase in carotid artery intima-media thickness in healthy men. J Appl Physiol 2002; 92:1458-1464.
29. Thijssen DH, de Groot PC, Smits P, Hopman MT. Vascular adaptations to 8-week cycling training in older men. Acta Physiol 2007; 190:221-228.
30. Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda S. Effects of curcumin intake and aerobic exercise training on arterial compliance in postmenopausal women. Artery Res 2013; 7:67-72.
31. Maeda S, Sugawara J, Yoshizawa M, Otsuki T, Shimojo N, Jesmin S, Ajisaka R, Miyauchi T, Tanaka H. Involvement of endothelin-1 in habitual exercise-induced increase in arterial compliance. Acta Physiol 2009; 196:223-229.
32. Sydow K, M?zel T. ADMA and oxidative stress. Atheroscler Suppl 2003; 4:41-51.
33. Bełtowski J, Kedra A. Asymmetric dimethylarginine (ADMA) as a target for pharmacotherapy. Pharmacol Rep 2006; 58:159-178.
34. Tan B, Jiang DJ, Huang H, Jia SJ, Jiang JL, Hu CP, Li YJ. Taurine protects against low-density lipoprotein-induced endothelial dysfunction by the DDAH/ADMA pathway. Vascul Pharmacol 2007; 46:338-345.
35. Elosua R, Molina L, Fito M, Arquer A, Sanchez-Quesada JL, Covas MI, Ordo?z-Llanos J, Marrugat J. Response of oxidative stress biomarkers to a 16-week aerobic physical activity program, and to acute physical activity, in healthy young men and women. Atherosclerosis 2003; 167: 327-334.
36. Choi Y, Maeda S, Otsuki T, Miyaki A, Shimojo N, Yoshizawa M, Shiraki H, Ajisaka R. Oxidative stress and arterial stiffness in strength-and endurance-trained athletes. Artery Res 2010; 4:52-58.
37. Ito A, Tsao PS, Adimoolam S, Kimoto M, Ogawa T, Cooke JP. Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 1999; 99:3092-3095.
38. Palm F, Onozato ML, Luo Z, Wilcox CS. Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems. Am J Physiol Heart Circ Physiol 2007; 293:3227-3245.
39. Hanssen H, Nickel T, Drexel V, Hertel G, Emslander I, Sisic Z, Lorang D, Schuster T, Kotliar KE, Pressler A, Schmidt-Trucks?s A, Weis M, Halle M. Exercise-induced alterations of retinal vessel diameters and cardiovascular risk reduction in obesity. Atherosclerosis 2011; 216:433-439.
40. Komine H, Asai Y, Yokoi T, Yoshizawa M. Non-invasive assessment of arterial stiffness using oscillometric blood pressure measurement. Biomed Eng Online 2012; 11:6.
41. Sydow K, Mondon CE, Cooke JP. Insulin resistance: potential role of the endogenous nitric oxide synthase inhibitor ADMA. Vasc Med 2005; 10:S35-S43.