Exercise-induced alterations of retinal vessel diameters and cardiovascular risk reduction in obesity

Atherosclerosis

Volumn 216, Issue 2, 2011, Pages 433-439

  Hanssen, H ^a,c   Nickel, T ^b   Drexel, V ^a   Hertel, G ^a   Emslander, I ^b   Sisic, Z ^b   Lorang, D ^a   Schuster, T ^a   Kotliar, K E ^a   Pressler, A ^a   Schmidt Trucksass A ^c   Weis, M ^b   Halle, M ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Asymmetric dimethylarginine; Exercise; Nitric oxide; Obesity; Retinal microcirculation

Indexed keywords

DIMETHYLARGININASE; MESSENGER RNA; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE;

ADULT; ARTERIOLAR TO VENULAR DIAMETER RATIO; ARTICLE; ATHLETE; CARDIOVASCULAR PARAMETERS; CARDIOVASCULAR RISK; CLINICAL ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; EXERCISE; FITNESS; HUMAN; LEAN BODY WEIGHT; MALE; MICROCIRCULATION; MICROVASCULATURE; OBESITY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RETINA BLOOD VESSEL; RISK REDUCTION; RUNNING;

ADULT; ARGININE; ATHLETES; CARDIOVASCULAR DISEASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXERCISE; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; NITRIC OXIDE; OBESITY; QUESTIONNAIRES; RETINAL VESSELS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 79957989086     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2011.02.009     Document Type: Article

References (35)

1. Adams K.F., Schatzkin A., Harris T.B., et al. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N Engl J Med 2006, 355(8 (August 24)):763-778.
2. Pischon T., Boeing H., Hoffmann K., et al. General and abdominal adiposity and risk of death in Europe. N Engl J Med 2008, 359(20 (November 13)):2105-2120.
3. Wildman R.P., Mackey R.H., Bostom A., Thompson T., Sutton-Tyrrell K. Measures of obesity are associated with vascular stiffness in young and older adults. Hypertension 2003, 42(4 (October)):468-473.
4. Jonk A.M., Houben A.J., de Jongh R.T., Serne E.H., Schaper N.C., Stehouwer C.D. Microvascular dysfunction in obesity: a potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension. Physiology (Bethesda) 2007, 22:252-260. (August).
5. Kwa V.I. Our eyes: windows to our souls or crystal balls?. Lancet Neurol 2006, 5(2 (February)):108-110.
6. Tedeschi-Reiner E., Strozzi M., Skoric B., Reiner Z. Relation of atherosclerotic changes in retinal arteries to the extent of coronary artery disease. Am J Cardiol 2005, 96(8 (October 15)):1107-1109.
7. Wang J.J., Mitchell P., Leung H., Rochtchina E., Wong T.Y., Klein R. Hypertensive retinal vessel wall signs in a general older population: the Blue Mountains Eye Study. Hypertension 2003, 42(4 (October)):534-541.
8. Wang J.J., Liew G., Klein R., et al. Retinal vessel diameter cardiovascular mortality: pooled data analysis from two older populations. Eur Heart J 2007, 28(16 (August)):1984-1992.
9. Wong T.Y., Klein R., Sharrett A.R., et al. Retinal arteriolar narrowing and risk of coronary heart disease in men and women. The Atherosclerosis Risk in Communities Study. JAMA 2002, 287(9 (March 6)):1153-1159.
10. Ikram M.K., de Jong F.J., Bos M.J., et al. Retinal vessel diameters and risk of stroke: the Rotterdam Study. Neurology 2006, 66(9 (May 9)):1339-1343.
11. Wang J.J., Taylor B., Wong T.Y., et al. Retinal vessel diameters and obesity: a population-based study in older persons. Obesity (Silver Spring) 2006, 14(2 (February)):206-214.
12. Hamdy O., Ledbury S., Mullooly C., et al. Lifestyle modification improves endothelial function in obese subjects with the insulin resistance syndrome. Diabetes Care 2003, 26(7 (July)):2119-2125.
13. Krcma M., Cechurova D., Jankovec Z., Lacigova S., Zourek M., Rusavy Z. Effect of mild increase of physical activity on microvasculary reactivity in obese subjects with diabetes mellitus type 2. Exp Clin Endocrinol Diabetes 2009, 117(3 (March)):150-152.
14. Dorner G.T., Garhofer G., Kiss B., et al. Nitric oxide regulates retinal vascular tone in humans. Am J Physiol Heart Circ Physiol 2003, 285(2 (August)):H631-H636.
15. Hemminki V., Laakso J., Kahonen M., et al. Plasma asymmetric dimethylarginine and retinal vessel diameters in middle-aged men. Metabolism 2007, 56(10 (October)):1305-1310.
16. Mugge A., Hanefeld C., Boger R.H. Plasma concentration of asymmetric dimethylarginine and the risk of coronary heart disease: rationale and design of the multicenter CARDIAC study. Atheroscler Suppl 2003, 4(4 (December)):29-32.
17. Wanby P., Teerlink T., Brudin L., et al. Asymmetric dimethylarginine (ADMA) as a risk marker for stroke and TIA in a Swedish population. Atherosclerosis 2006, 185(2 (April)):271-277.
18. Stuhlinger M.C., Abbasi F., Chu J.W., et al. Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitor. JAMA 2002, 287(11 (March 20)):1420-1426.
19. Eid H.M., Arnesen H., Hjerkinn E.M., Lyberg T., Seljeflot I. Relationship between obesity, smoking, and the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine. Metabolism 2004, 53(12 (December)):1574-1579.
20. Ogawa T., Kimoto M., Watanabe H., Sasaoka K. Metabolism of NG,NG-and NG,N'G-dimethylarginine in rats. Arch Biochem Biophys 1987, 252(2 (February 1)):526-537.
21. Vallance P., Leiper J. Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathway. Arterioscler Thromb Vasc Biol 2004, 24(6 (June)):1023-1030.
22. Gomes V.A., Casella-Filho A., Chagas A.C., Tanus-Santos J.E. Enhanced concentrations of relevant markers of nitric oxide formation after exercise training in patients with metabolic syndrome. Nitric Oxide 2008, 19(4 (December)):345-350.
23. Richter B., Niessner A., Penka M., et al. Endurance training reduces circulating asymmetric dimethylarginine and myeloperoxidase levels in persons at risk of coronary events. Thromb Haemost 2005, 94(6 (December)):1306-1311.
24. Fletcher G.F., Balady G.J., Amsterdam E.A., et al. Exercise standards for testing and training: a statement for healthcare professionals from the American Heart Association. Circulation 2001, 104(14 (October 2)):1694-1740.
25. Hubbard L.D., Brothers R.J., King W.N., et al. Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerosis Risk in Communities Study. Ophthalmology 1999, 106(12 (December)):2269-2280.
26. Nickel T., Deutschmann A., Hanssen H., Summo C., Wilbert-Lampen U. Modification of endothelial biology by acute and chronic stress hormones. Microvasc Res 2009, August 5.
27. Schulze F., Wesemann R., Schwedhelm E., et al. Determination of asymmetric dimethylarginine (ADMA) using a novel ELISA assay. Clin Chem Lab Med 2004, 42(12):1377-1383.
28. Dayal S., Rodionov R.N., Arning E., et al. Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia. Am J Physiol Heart Circ Physiol 2008, 295(2 (August)):H816-H825.
29. Wong T.Y., Duncan B.B., Golden S.H., et al. Associations between the metabolic syndrome and retinal microvascular signs: the Atherosclerosis Risk In Communities study. Invest Ophthalmol Vis Sci 2004, 45(9 (September)):2949-2954.
30. Ikram M.K., Witteman J.C., Vingerling J.R., Breteler M.M., Hofman A., de Jong P.T. Retinal vessel diameters and risk of hypertension: the Rotterdam Study. Hypertension 2006, 47(2 (February)):189-194.
31. Wong T.Y., Islam F.M., Klein R., et al. Retinal vascular caliber, cardiovascular risk factors, and inflammation: the multi-ethnic study of atherosclerosis (MESA). Invest Ophthalmol Vis Sci 2006, 47(6 (June)):2341-2350.
32. Klein R., Klein B.E., Knudtson M.D., Wong T.Y., Tsai M.Y. Are inflammatory factors related to retinal vessel caliber? The Beaver Dam Eye Study. Arch Ophthalmol 2006, 124(1 (January)):87-94.
33. Kasapis C., Thompson P.D. The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review. J Am Coll Cardiol 2005, 45(10 (May 17)):1563-1569.
34. Haefliger I.O., Meyer P., Flammer J., Luscher T.F. The vascular endothelium as a regulator of the ocular circulation: a new concept in ophthalmology?. Surv Ophthalmol 1994, 39(2 (September)):123-132.
35. Vallance P., Leone A., Calver A., Collier J., Moncada S. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 1992, 339(8793 (March 7)):572-575.