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1
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22744443930
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Febuxostat: A nonpurine, selective inhibitor of xanthine oxidase for the management of hyperuricaemia in patients with gout
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Schumacher HR Jr. Febuxostat: A nonpurine, selective inhibitor of xanthine oxidase for the management of hyperuricaemia in patients with gout. Expert Opin Investig Drugs 2005;14:893-3
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Expert Opin Investig Drugs
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Schumacher Jr., H.R.1
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2
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84871107959
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Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of febuxostat in human plasma
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Wang H, Deng P, Chen X, et al. Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of febuxostat in human plasma. Biomed Chromatogr 2010;27:34-8
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Biomed Chromatogr
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Wang, H.1
Deng, P.2
Chen, X.3
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3
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42749087186
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Febuxostat: A novel non-purine selective inhibitor of xanthine oxidase for the treatment of hyperuricemia in gout
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Yu KH. Febuxostat: A novel non-purine selective inhibitor of xanthine oxidase for the treatment of hyperuricemia in gout. Recent Pat Inflamm Allergy Drug Discov 2007;1:69-5
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(2007)
Recent Pat Inflamm Allergy Drug Discov
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Yu, K.H.1
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4
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28944437578
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Febuxostat compared with allopurinol in patients with hyperuricemia and gout
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Becker MA, Schumacher HR Jr, Wortmann RL, et al. Febuxostat compared with allopurinol in patients with hyperuricemia and gout. N Engl J Med 2005;353:2450-61
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(2005)
N Engl J Med
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Becker, M.A.1
Schumacher Jr., H.R.2
Wortmann, R.L.3
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5
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42249100324
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In vitro drug-drug interaction studies with febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase: Plasma protein binding, identification of metabolic enzymes and cytochrome P450 inhibition
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This study highlights needed information about CYP enzymes participating in the metabolism of febuxostat and potential inhibitory effects of febuxostat on typical CYP reactions
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Mukoyoshi M, Nishimura S, Hoshide S, et al. In vitro drug-drug interaction studies with febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase: Plasma protein binding, identification of metabolic enzymes and cytochrome P450 inhibition. Xenobiotica 2008;38:496-10 . This study highlights needed information about CYP enzymes participating in the metabolism of febuxostat and potential inhibitory effects of febuxostat on typical CYP reactions.
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(2008)
Xenobiotica
, vol.38
, pp. 496-10
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Mukoyoshi, M.1
Nishimura, S.2
Hoshide, S.3
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6
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84879690203
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Establishment of inherent stability of febuxostat and development of a validated stability-indicating method by UPLC according to ICH requirement
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This important study demonstrates the validated UPLC method for febuxostat
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Sahu K SM, Siddiqui Anees A. Establishment of inherent stability of febuxostat and development of a validated stability-indicating method by UPLC according to ICH requirement. Med Chem Res 2013;22:1641-7. This important study demonstrates the validated UPLC method for febuxostat.
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(2013)
Med Chem Res
, vol.22
, pp. 1641-7
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Sahu K, S.M.1
Siddiqui Anees, A.2
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7
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0029867672
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Flavonoidschemistry, metabolism, cardioprotective effects, and dietary sources
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Cook NC, Samman S. Flavonoidschemistry, metabolism, cardioprotective effects, and dietary sources. J Nutr Biochem 1996;7:66-76
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(1996)
J Nutr Biochem
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Cook, N.C.1
Samman, S.2
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8
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0033637140
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The effect of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
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This article describes that the flavonoids, as dietary supplements, have great potential to modulate the activity of CYPs
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Middleton E Jr, Kandaswami C, Theoharides TC. The effect of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmcol Rev 2000;52:673-751. This article describes that the flavonoids, as dietary supplements, have great potential to modulate the activity of CYPs.
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Pharmcol Rev
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, pp. 673-751
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Middleton Jr., E.1
Kandaswami, C.2
Theoharides, T.C.3
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9
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0028172728
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Modulation of adriamycin accumulation and efflux by flavonoids in HCT-15 colon cells. Activation of Pglycoprotein as a putative mechanism
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Critchfield JW, Welsh CJ, Phang JM, et al. Modulation of adriamycin accumulation and efflux by flavonoids in HCT-15 colon cells. Activation of Pglycoprotein as a putative mechanism. Biochem Pharmacol 1994;48:1437-45
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Biochem Pharmacol
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Critchfield, J.W.1
Welsh, C.J.2
Phang, J.M.3
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10
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0037371275
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Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on Pglycoproteinmediated transport
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This noteworthy study reviewed the inhibitory effect of the morin (a flavonoid) on P-gp-mediated transport
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Zhang S, Morris ME. Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on Pglycoproteinmediated transport. J Pharmacol Exp Ther 2003;304:1258-67 . This noteworthy study reviewed the inhibitory effect of the morin (a flavonoid) on P-gp-mediated transport.
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J Pharmacol Exp Ther
, vol.304
, pp. 1258-67
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Zhang, S.1
Morris, M.E.2
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11
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33748684356
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Altered pharmacokinetics of paclitaxel by the concomitant use of morin in rats
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This study investigated the effects of orally administered morin, an inhibitor of CYP3A and P-gp, on the pharmacokinetics of orally and intravenously administered paclitaxel in rats
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Choi BC, Choi JS, Han HK. Altered pharmacokinetics of paclitaxel by the concomitant use of morin in rats. Int J Pharm 2006;323:81-5. This study investigated the effects of orally administered morin, an inhibitor of CYP3A and P-gp, on the pharmacokinetics of orally and intravenously administered paclitaxel in rats.
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(2006)
Int J Pharm
, vol.323
, pp. 81-5
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Choi, B.C.1
Choi, J.S.2
Han, H.K.3
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12
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84856252862
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Reduced bioavailability of tamoxifen and its metabolite 4-hydroxytamoxifen after oral administration with biochanin A (an isoflavone) in rats
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Singh SP, Wahajuddin Raju KS, et al. Reduced bioavailability of tamoxifen and its metabolite 4-hydroxytamoxifen after oral administration with biochanin A (an isoflavone) in rats. Phytother Res 2011;26:303-7
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(2011)
Phytother Res
, vol.26
, pp. 303-7
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Singh, S.P.1
Wahajuddin Raju, K.S.2
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13
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28744436977
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Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells
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Kitagawa S, Nabekura T, Takahashi T, et al. Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells. Biol Pharm Bull 2005;28:2274-8
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Biol Pharm Bull
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Kitagawa, S.1
Nabekura, T.2
Takahashi, T.3
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14
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0037154405
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Flavonoids - potent and versatile biologically active compounds interacting with cytochromes P450
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This important study demonstrates that the use of morin could modulate the activity of metabolic enzymes, including CYPs
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Hodek P, Trefil P, Stiborova M. Flavonoids - potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact 2002;139:1-21 . This important study demonstrates that the use of morin could modulate the activity of metabolic enzymes, including CYPs.
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Chem Biol Interact
, vol.139
, pp. 1-21
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Hodek, P.1
Trefil, P.2
Stiborova, M.3
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15
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0032865554
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Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components
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Eagling VA, Profit L, Back DJ. Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components. Br J Clin Pharmacol 1999;48:543-52
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Br J Clin Pharmacol
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Eagling, V.A.1
Profit, L.2
Back, D.J.3
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16
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84880145520
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Effect of Morin on pharmacokinetics of Piracetam in rats, in vitro enzyme kinetics and metabolic stability assay using rapid UPLC method
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Sahu K, Shaharyar M, Siddiqui AA. Effect of Morin on pharmacokinetics of Piracetam in rats, in vitro enzyme kinetics and metabolic stability assay using rapid UPLC method. Drug Test Anal 2013;5:581-8
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Drug Test Anal
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Sahu, K.1
Shaharyar, M.2
Siddiqui, A.A.3
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17
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84894193367
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Takeda Pharmaceuticals America. Uloric (febuxostat) tablets prescribing information. Deerfield, II; 2009 (Reference ID: 2898038)
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Takeda Pharmaceuticals America. Uloric (febuxostat) tablets prescribing information. Deerfield, II; 2009 (Reference ID: 2898038)
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18
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58449111594
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Enhanced tamoxifen bioavailability after oral administration of tamoxifen in rats pretreated with naringin
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Choi JS, Kang KW. Enhanced tamoxifen bioavailability after oral administration of tamoxifen in rats pretreated with naringin. Arch Pharm Res 2008;31:1631-6
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Arch Pharm Res
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Choi, J.S.1
Kang, K.W.2
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27544454323
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Localization and mRNA expression of CYP3A and P-glycoprotein in human duodenum as a function of age
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Fakhoury M, Litalien C, Medard Y, et al. Localization and mRNA expression of CYP3A and P-glycoprotein in human duodenum as a function of age. Drug Metab Dispos 2005;33:1603-7
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Fakhoury, M.1
Litalien, C.2
Medard, Y.3
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0035666034
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Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4
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Wang E, Lew K, Barecki M, et al. Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chem Res Toxicol 2001;14:1596-603
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Chem Res Toxicol
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Wang, E.1
Lew, K.2
Barecki, M.3
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