Carnitine deficiency in chronic critical illness

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 17, Issue 2, 2014, Pages 200-209

  Bonafé, Luisa ^a   Berger, Mette M ^a   Que, Yok Ai ^a   Mechanick, Jeffrey I ^b  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Carnitine deficiency; Chronic critical illness; Fatty acid metabolism; Malnutrition; Mitochondrial dysfunction; Renal replacement therapy

Indexed keywords

CARDIOMYOPATHIES; CARNITINE; CHRONIC DISEASE; CRITICAL ILLNESS; FATTY ACIDS; HUMANS; HYPERAMMONEMIA; MITOCHONDRIA; MUSCULAR DISEASES;

EID: 84894185673     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0000000000000037     Document Type: Review

References (46)

1. Scurlock C, Raikhelkar JK, Mechanick JI. Impact of new technologies on metabolic care in the intensive care unit. Curr Opin Clin Nutr Metab Care 2009; 12:196-200.
2. Schulman RC, Mechanick JI. Metabolic and nutrition support in the chronic critical illness syndrome. Respir Care 2012; 57:977-978; 958-977; discussion.
3. Heyland DK, Dhaliwal R. Role of glutamine supplementation in critical illness given the results of the REDOXS study. JPEN J Parenter Enteral Nutr 2013; 37:442-443.
4. Wolf A, Weir P, Segar P, et al. Impaired fatty acid oxidation in propofol infusion syndrome. Lancet 2001; 357:606-607.
5. Hatamkhani S, Karimzadeh I, Elyasi S, et al. Carnitine and sepsis: a review of an old clinical dilemma. J Pharm Pharm Sci 2013; 16:414-423.
6. Demarquoy J, Georges B, Rigault C, et al. Radioisotopic determination of L-carnitine content in foods commonly eaten in Western countries. Food Chem 2004; 86:137-142.
7. Ribas GS, Vargas CR, Wajner M. L-carnitine supplementation as a potential antioxidant therapy for inherited neurometabolic disorders. Gene 2014; 533:469-476.
8. Manzanares W, Langlois PL, Hardy G. Update on antioxidant micronutrients in the critically ill. Curr Opin Clin Nutr Metab Care 2013; 16:719-725.
9. Magoulas PL, El-Hattab AW. Systemic primary carnitine deficiency: an overview of clinical manifestations, diagnosis, and management. Orphanet J Rare Dis 2012; 7:68.
10. Margolis AM, Heverling H, Pham PA, Stolbach A. A review of the toxicity of HIV medications. J Med Toxicol 2013. [Epub ahead of print]
11. Eknoyan G, Latos DL, Lindberg J. National Kidney Foundation Carnitine Consensus Conference. Practice recommendations for the use of L-carnitine in dialysis-related carnitine disorder. National Kidney Foundation Carnitine Consensus Conference. Am J Kidney Dis 2003; 41:868-876.
12. Molyneux R, Seymour AM, Bhandari S. Value of carnitine therapy in kidney dialysis patients and effects on cardiac function from human and animal studies. Curr Drug Targets 2012; 13:285-293.
13. Wasserstein AG. L-carnitine supplementation in dialysis: treatment in quest of disease. Semin Dial 2013; 26:11-15.
14. Le Borgne F, Guyot S, Logerot M, et al. Exploration of lipid metabolism in relation with plasma membrane properties of duchenne muscular dystrophy cells: influence of L-carnitine. PLos One 2012; 7:e49346.
15. Flanagan JL, Simmons PA, Vehige J, et al. Role of carnitine in disease. Nutr Metab (Lond) 2010; 7:30.
16. Finsterer J, Ohnsorge P. Influence of mitochondrion-toxic agents on the cardiovascular system. Regul Toxicol Pharmacol 2013; 67:434-445.
17. Zhou X, Liu F, Zhai S. Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review. Asia Pac J Clin Nutr 2007; 16 (Suppl 1):383-390.
18. Ferrari R, Merli E, Cicchitelli G, et al. Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: a review. Ann N Y Acad Sci 2004; 1033:79-91.
19. DiNicolantonio JJ, Lavie CJ, Fares H, et al. L-carnitine in the secondary prevention of cardiovascular disease: systematic review and meta-analysis. Mayo Clin Proc 2013; 88:544-551.
20. Cesar LA, Gowdak LH, Mansur AP. The metabolic treatment of patients with coronary artery disease: effects on quality of life and effort angina. Curr Pharm Des 2009; 15:841-849.
21. Ali FN, Carman TL. Medical management for chronic atherosclerotic peripheral arterial disease. Drugs 2012; 72:2073-2085.
22. Malaguarnera M. Carnitine derivatives: clinical usefulness. Curr Opin Gastroenterol 2012; 28:166-176.
23. Cuturic M, Abramson RK, Moran RR, et al. Serum carnitine levels and levocarnitine supplementation in institutionalized Huntington's disease patients. Neurol Sci 2013; 34:93-98.
24. Karalija A, Novikova LN, Kingham PJ, et al. Neuroprotective effects of N-acetylcysteine and acetyl-L-carnitine after spinal cord injury in adult rats. PLoS One 2012; 7:e41086.
25. Nicolson GL. Mitochondrial dysfunction and chronic disease: treatment with natural supplements. Altern Ther Health Med 2013. [Epub ahead of print]
26. Evangeliou A, Vlassopoulos D. Carnitine metabolism and deficit: when supplementation is necessary? Curr Pharm Biotechnol 2003; 4:211-219.
27. Wennberg A, Hyltander A, Sjoberg A, et al. Prevalence of carnitine depletion in critically ill patients with undernutrition. Metabolism 1992; 41: 165-171.
28. Sarma S, Gheorghiade M. Nutritional assessment and support of the patient with acute heart failure. Curr Opin Crit Care 2010; 16:413-418.
29. Awad S, Lobo DN. Metabolic conditioning to attenuate the adverse effects of perioperative fasting and improve patient outcomes. Curr Opin Clin Nutr Metab Care 2012; 15:194-200.
30. Wolfe RR, Martini WZ. Changes in intermediary metabolism in severe surgical illness. World J Surg 2000; 24:639-647.
31. Pignatelli P, Tellan G, Marandola M, et al. Effect of L-carnitine on oxidative stress and platelet activation after major surgery. Acta anaesthesiologica Scandinavica 2011; 55:1022-1028.
32. Foster KJ, Lin S, Turck CJ. Current and emerging strategies for treating hepatic encephalopathy. Crit Care Nurs Clin North Am 2010; 22:341-350.
33. Rousseau AF, Losser MR, Ichai C, Berger MM. ESPEN endorsed recommendations: nutritional therapy in major burns. Clin Nutr 2013; 32:497-502.
34. Berger MM, Shenkin A, Revelly JP, et al. Copper, selenium, zinc and thiamine balances during continuous venovenous hemodiafiltration in critically ill patients. Am J Clin Nutr 2004; 80:410-416.
35. Engle TE. Copper and lipid metabolism in beef cattle: a review. J Anim Sci 2011; 89:591-596.
36. Berger MM, Baines M, Raffoul W, et al. Trace element supplements after major burnsmodulate antioxidant status and clinical course by way of increased tissue trace element concentration. Am J Clin Nutr 2007; 85:1293-1300.
37. Scheinkestel CD, Adams F, Mahony L, et al. Impact of increasing parenteral protein loads on amino acid levels and balance in critically ill anuric patients on continuous renal replacement therapy. Nutrition 2003; 19:733-740.
38. Ruderman NB, Saha AK, Vavvas D, Witters LA. Malonyl-CoA, fuel sensing, and insulin resistance. Am J Physiol 1999; 276:E1-E18.
39. Roepstorff C, Halberg N, Hillig T, et al. Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise. Am J Physiol Endocrinol Metab 2005; 288:E133-E142.
40. Koeth RA, Wang Z, Levison BS, et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med 2013; 19:576-585.
41. Ferguson JF. Meat-loving microbes: do steak-eating bacteria promote atherosclerosis? Circ Cardiovasc Genet 2013; 6:308-309.
42. Wu J, Corr PB. Influence of long-chain acylcarnitines on voltage-dependent calcium current in adult ventricular myocytes. Am J Physiol 1992; 263:H410-H417.
43. Ferro F, Ouille A, Tran TA, et al. Long-chain acylcarnitines regulate the hERG channel. PLoS One 2012; 7:e41686.
44. Arnold GL, Van Hove J, Freedenberg D, et al. A Delphi clinical practice protocol for the management of very long chain acyl-CoA dehydrogenase deficiency. Mol Genet Metab 2009; 96:85-90.
45. Mattick JS, Kamisoglu K, Ierapetritou MG, et al. Branched-chain amino acid supplementation: impact on signaling and relevance to critical illness. Wiley Interdiscip Rev Syst Biol Med 2013; 5:449-460.
46. Singer P. From mitochondrial disturbances to energy requirements. World Rev Nutr Diet 2013; 105:1-11.