Safety of dermatologic medications in pregnancy and lactation: Part I. Pregnancy

Journal of the American Academy of Dermatology

Volumn 70, Issue 3, 2014, Pages 401.e1-401.e14

  Murase, Jenny E ^a   Heller, Misha M ^b   Butler, Daniel C ^c  

^a Palo Alto Foundation Medical Group   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

acne; antibiotic; antifungal; antihistamines; antiviral; atopic dermatitis; biologics; breast milk; breastfeeding; corticosteroid; cosmetics; fetus; gestation; lactation; medication safety; nursing; phototherapy; pregnancy; psoriasis; surgery; trimester

Indexed keywords

ADRENALIN; ANTIHISTAMINIC AGENT; AZATHIOPRINE; BETA LACTAM ANTIBIOTIC; BIOLOGICAL PRODUCT; BOTULINUM TOXIN A; CALCINEURIN INHIBITOR; CALCIPOTRIOL; COAL TAR; CORTICOSTEROID; COSMETIC; CYCLOSPORIN; DAPSONE; DERMATOLOGICAL AGENT; DOXEPIN; ETRETIN; HYDROQUINONE; HYDROXYCHLOROQUINE; IMMUNOGLOBULIN; ISOTRETINOIN; LIDOCAINE; MACROLIDE; METHOTREXATE; MINOXIDIL; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PSORALEN; RETINOID; RITUXIMAB; TAZAROTENE; UNINDEXED DRUG;

ACNE; ARTICLE; DRUG EXPOSURE; DRUG SAFETY; FOOD AND DRUG ADMINISTRATION; HUMAN; LACTATION; NONHUMAN; PHOTOTHERAPY; PREGNANCY; PRIORITY JOURNAL; PSORIASIS; SYSTEMIC THERAPY; TOPICAL TREATMENT; ULTRAVIOLET A RADIATION; ULTRAVIOLET B RADIATION; UNSPECIFIED SIDE EFFECT;

ACNE; ANTIBIOTIC; ANTIFUNGAL; ANTIHISTAMINES; ANTIVIRAL; ATOPIC DERMATITIS; BIOLOGICS; BREAST MILK; BREASTFEEDING; CORTICOSTEROID; COSMETICS; FETUS; GESTATION; LACTATION; MEDICATION SAFETY; NURSING; PHOTOTHERAPY; PREGNANCY; PSORIASIS; SURGERY; TRIMESTER;

ABNORMALITIES, DRUG-INDUCED; ADMINISTRATION, ORAL; ADMINISTRATION, TOPICAL; ADULT; AUSTRALIA; BREAST FEEDING; DERMATOLOGIC AGENTS; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; EDUCATION, MEDICAL, CONTINUING; EUROPE; FEMALE; GESTATIONAL AGE; HUMANS; LACTATION; PATIENT SAFETY; PHARMACEUTICAL PREPARATIONS; PREGNANCY; PRENATAL CARE; RISK ASSESSMENT; SKIN DISEASES; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION; YOUNG ADULT;

EID: 84894150794     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2013.09.010     Document Type: Review

References (133)

1. S.L. Carmichael, G.M. Shaw, C. Ma, M.M. Werler, S.A. Rasmussen, and E.J. Lammer et al. Maternal corticosteroid use and orofacial clefts Am J Obstet Gynecol 197 2007 e581 e587
2. A. Hviid, and D. Molgaard-Nielsen Corticosteroid use during pregnancy and risk of orofacial clefts CMAJ 183 2011 796 804
3. C.C. Chi, R.T. Mayon-White, and F.T. Wojnarowska Safety of topical corticosteroids in pregnancy: a population-based cohort study J Invest Dermatol 131 2011 884 891
4. C.C. Chi, C.W. Lee, F. Wojnarowska, and G. Kirtschig Safety of topical corticosteroids in pregnancy Cochrane Database Syst Rev 2009 CD007346
5. A.E. Czeizel, and M. Rockenbauer Population-based case-control study of teratogenic potential of corticosteroids Teratology 56 1997 335 340 (Pubitemid 28035180)
6. P. Pradat, E. Robert-Gnansia, G.L. Di Tanna, A. Rosano, A. Lisi, and P. Mastroiacovo et al. First trimester exposure to corticosteroids and oral clefts Birth Defects Res A Clin Mol Teratol 67 2003 968 970 (Pubitemid 38018036)
7. H. Mygind, A.M. Thulstrup, L. Pedersen, and H. Larsen Risk of intrauterine growth retardation, malformations and other birth outcomes in children after topical use of corticosteroid in pregnancy Acta Obstet Gynecol Scand 81 2002 234 239 (Pubitemid 34264139)
8. A. Mahe, J.L. Perret, F. Ly, F. Fall, J.P. Rault, and A. Dumont The cosmetic use of skin-lightening products during pregnancy in Dakar, Senegal: a common and potentially hazardous practice Trans R Soc Trop Med Hyg 101 2007 183 187 (Pubitemid 44835343)
9. C.C. Chi, G. Kirtschig, W. Aberer, J.P. Gabbud, J. Lipozenč ić, and S. Kárpáti et al. Evidence-based (S3) guideline on topical corticosteroids in pregnancy Br J Dermatol 165 2011 943 952
10. C. Schaefer, P.W.J. Peters, and R.K. Miller Drugs during pregnancy and lactation: treatment options and risk assessment 2nd ed. 2007 Elsevier Academic Press Boston
11. R.C. Zangar, D.L. Springer, R.L. Buschbom, and D.D. Mahlum Comparison of fetotoxic effects of a dermally applied complex organic mixture in rats and mice Fundam Appl Toxicol 13 1989 662 669 (Pubitemid 20061125)
12. M.E. Franssen, G.J. van der Wilt, P.C. de Jong, R.P. Bos, and W.P. Arnold A retrospective study of the teratogenicity of dermatological coal tar products Acta Derm Venereol 79 1999 390 391 (Pubitemid 29414979)
13. Dovonex [product insert] 2011 Warner Chilcott Rockaway (NJ)
14. R.D. Kozlowski, J.V. Steinbrunner, A.H. MacKenzie, J.D. Clough, W.S. Wilke, and A.M. Segal Outcome of first-trimester exposure to low-dose methotrexate in eight patients with rheumatic disease Am J Med 88 1990 589 592 (Pubitemid 20192270)
15. C. Nguyen, A.J. Duhl, C.S. Escallon, and K.J. Blakemore Multiple anomalies in a fetus exposed to low-dose methotrexate in the first trimester Obstet Gynecol 99 2002 599 602 (Pubitemid 34246297)
16. V.T. Armenti, K.M. Ahlswede, B.A. Ahlswede, B.E. Jarrell, M.J. Moritz, and J.F. Burke National transplantation Pregnancy Registry-outcomes of 154 pregnancies in cyclosporine-treated female kidney transplant recipients Transplantation 57 1994 502 506 (Pubitemid 24075792)
17. V.T. Armenti, J.S. Radomski, M.J. Moritz, W.J. Gaughan, R. Gulati, and C.H. McGrory et al. Report from the National Transplantation Pregnancy Registry (NTPR): outcomes of pregnancy after transplantation Clin Transpl 2005 69 83
18. B. Bar Oz, R. Hackman, T. Einarson, and G. Koren Pregnancy outcome after cyclosporine therapy during pregnancy: a meta-analysis Transplantation 71 2001 1051 1055 (Pubitemid 32448816)
19. V. Lamarque, M.F. Leleu, C. Monka, and P. Krupp Analysis of 629 pregnancy outcomes in transplant recipients treated with Sandimmun Transplant Proc 29 1997 2480 (Pubitemid 27373797)
20. V.T. Armenti, C.H. McGrory, J.R. Cater, J.S. Radomski, and M.J. Moritz Pregnancy outcomes in female renal transplant recipients Transplant Proc 30 1998 1732 1734 (Pubitemid 28399295)
21. I. Nulman, M. Sgro, M. Barrera, D. Chitayat, J. Cairney, and G. Koren Long-term neurodevelopment of children exposed in utero to ciclosporin after maternal renal transplant Paediatr Drugs 12 2010 113 122
22. P. Cochat, S. Decramer, E. Robert-Gnansia, L. Dubourg, and P. Audra Renal outcome of children exposed to cyclosporine in utero Transplant Proc 36 2 Suppl 2004 208S 210S (Pubitemid 38373862)
23. F.A. Shaheen, M.H. al-Sulaiman, and A.A. al-Khader Long-term nephrotoxicity after exposure to cyclosporine in utero Transplantation 56 1993 224 225 (Pubitemid 23220606)
24. J.D. Carter, J. Valeriano, and F.B. Vasey Tumor necrosis factor-alpha inhibition and VATER association: a causal relationship J Rheumatol 33 2006 1014 1017
25. J.D. Carter, A. Ladhani, L.R. Ricca, J. Valeriano, and F.B. Vasey A safety assessment of tumor necrosis factor antagonists during pregnancy: a review of the Food and Drug Administration database J Rheumatol 36 2009 635 641
26. E.E. Winger, and J.L. Reed Was risk properly assessed in Carter, et al's safety assessment of tumor necrosis factor antagonists during pregnancy? J Rheumatol 36 2009 2122
27. S.M. Verstappen, Y. King, K.D. Watson, D.P. Symmons, K.L. Hyrich BSRBR Control Centre Consortium Anti-TNF therapies and pregnancy: outcome of 130 pregnancies in the British Society for Rheumatology Biologics Register Ann Rheum Dis 70 2011 823 826
28. E.A. Vasiliauskas, J.A. Church, N. Silverman, M. Barry, S.R. Targan, and M.C. Dubinsky Case report: evidence for transplacental transfer of maternally administered infliximab to the newborn Clin Gastroenterol Hepatol 4 2006 1255 1258 (Pubitemid 44512222)
29. K. Cheent, J. Nolan, S. Shariq, L. Kiho, A. Pal, and J. Arnold Case report: fatal case of disseminated BCG infection in an infant born to a mother taking infliximab for Crohn's disease J Crohns Colitis 4 2010 603 605
30. P.L. Martin, C. Sachs, N. Imai, H. Tsusaki, S. Oneda, and Q. Jiao et al. Development in the cynomolgus macaque following administration of ustekinumab, a human anti-IL-12/23p40 monoclonal antibody, during pregnancy and lactation Birth Defects Res B Dev Reprod Toxicol 89 2010 351 363
31. C. Chambers, G. Koren, Z.N. Tutuncu, D. Johnson, and K.L. Jones Are new agents used to treat rheumatoid arthritis safe to take during pregnancy? Organization of Teratology Information Specialists (OTIS) study Can Fam Physician 53 2007 409 412 (Pubitemid 46536564)
32. C. Fotiadou, E. Lazaridou, E. Sotiriou, and D. Ioannides Spontaneous abortion during ustekinumab therapy J Dermatol Case Rep 6 2012 105 107
33. Y.S. Bae, A.S. Van Voorhees, S. Hsu, N.J. Korman, M.G. Lebwohl, and M. Young et al. Review of treatment options for psoriasis in pregnant or lactating women: from the Medical Board of the National Psoriasis Foundation J Am Acad Dermatol 67 2012 459 477
34. L.T. EI-Saie, A.R. Rabie, M.I. Kamel, A.K. Seddeik, and M.L. Elsaie Effect of narrowband ultraviolet B phototherapy on serum folic acid levels in patients with psoriasis Lasers Med Sci 26 2011 481 485
35. A. Juzeniene, K.T. Stokke, P. Thune, and J. Moan Pilot study of folate status in healthy volunteers and in patients with psoriasis before and after UV exposure J Photochem Photobiol B 101 2010 111 116
36. P. Lapunzina Ultraviolet light-related neural tube defects? Am J Med Genet 67 1996 106
37. K.K. Park, and J.E. Murase Narrowband UV-B phototherapy during pregnancy and folic acid depletion Arch Dermatol 148 2012 132 133
38. R.S. Stern, and R. Lange Outcomes of pregnancies among women and partners of men with a history of exposure to methoxsalen photochemotherapy (PUVA) for the treatment of psoriasis Arch Dermatol 127 1991 347 350
39. J.G. Gunnarskog, A.J. Kallen, B.G. Lindelof, and B. Sigurgeirsson Psoralen photochemotherapy (PUVA) and pregnancy Arch Dermatol 129 1993 320 323 (Pubitemid 23077447)
40. A. Makol, K. Wright, and S. Amin Rheumatoid arthritis and pregnancy: safety considerations in pharmacological management Drugs 71 2011 1973 1987
41. G.G. Briggs RF, and S.J. Yaffe Drugs in pregnancy and lactation 8th ed. 2008 Lippincott Williams & Wilkins Philadelphia (PA)
42. L. Park-Wyllie, P. Mazzotta, A. Pastuszak, M.E. Moretti, L. Beique, and L. Hunnisett et al. Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiological studies Teratology 62 2000 385 392
43. C. Abarientos, K. Sperber, D.L. Shapiro, W.S. Aronow, C.P. Chao, and J.Y. Ash Hydroxychloroquine in systemic lupus erythematosus and rheumatoid arthritis and its safety in pregnancy Expert Opin Drug Saf 10 2011 705 714
44. P. Garner, and A.M. Gulmezoglu Drugs for preventing malaria in pregnant women Cochrane Database Syst Rev 2006 CD000169
45. R.A. Levy, V.S. Vilela, M.J. Cataldo, R.C. Ramos, J.L. Duarte, and B.R. Tura et al. Hydroxychloroquine (HCQ) in lupus pregnancy: double-blind and placebo-controlled study Lupus 10 2001 401 404 (Pubitemid 32578614)
46. G. Ruiz-Irastorza, M. Ramos-Casals, P. Brito-Zeron, and M.A. Khamashta Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review Ann Rheum Dis 69 2010 20 28
47. K. Sperber, C. Hom, C.P. Chao, D. Shapiro, and J. Ash Systematic review of hydroxychloroquine use in pregnant patients with autoimmune diseases Pediatr Rheumatol Online J 7 2009 9
48. A. Osadchy, T. Ratnapalan, and G. Koren Ocular toxicity in children exposed in utero to antimalarial drugs: review of the literature J Rheumatol 38 2011 2504 2508
49. G. Klinger, Y. Morad, C.A. Westall, C. Laskin, K.A. Spitzer, and G. Koren et al. Ocular toxicity and antenatal exposure to chloroquine or hydroxychloroquine for rheumatic diseases Lancet 358 2001 813 814 (Pubitemid 32868737)
50. M.E. Clowse, L. Magder, F. Witter, and M. Petri Hydroxychloroquine in lupus pregnancy Arthritis Rheum 54 2006 3640 3647 (Pubitemid 44737176)
51. P.M. Izmirly, N. Costedoat-Chalumeau, C.N. Pisoni, M.A. Khamashta, M.Y. Kim, and A. Saxena et al. Maternal use of hydroxychloroquine is associated with a reduced risk of recurrent anti-SSA/Ro-antibody-associated cardiac manifestations of neonatal lupus Circulation 126 2012 76 82
52. F. Nosten, R. McGready, U. d'Alessandro, A. Bonell, F. Verhoeff, and C. Menendez et al. Antimalarial drugs in pregnancy: a review Curr Drug Saf 1 2006 1 15
53. B.J. Brabin, T.A. Eggelte, M. Parise, and F. Verhoeff Dapsone therapy for malaria during pregnancy: maternal and fetal outcomes Drug Saf 27 2004 633 648 (Pubitemid 38980449)
54. Y.S. Thornton, and E.T. Bowe Neonatal hyperbilirubinemia after treatment of maternal leprosy South Med J 82 1989 668 (Pubitemid 19195199)
55. D.R. Hocking Neonatal haemolytic disease due to dapsone Med J Aust 1 1968 1130 1131
56. M. Kim, S. Rostas, and S. Gabardi Mycophenolate fetal toxicity and risk evaluation and mitigation strategies Am J Transplant 13 2013 1383 1389
57. K. Schoner, J. Steinhard, J. Figiel, and H. Rehder Severe facial clefts in acrofacial dysostosis: a consequence of prenatal exposure to mycophenolate mofetil? Obstet Gynecol 111 2 Pt 2 2008 483 486 (Pubitemid 351156472)
58. A. Perez-Aytes, A. Ledo, V. Boso, P. Sáenz, E. Roma, and J.L. Poveda et al. In utero exposure to mycophenolate mofetil: a characteristic phenotype? Am J Med Genet A 146A 2008 1 7
59. Cellcept: medication guide. Washington, DC: US Food and Drug Administration. Available at: http://www.fda.gov/downloads/Drugs/DrugSafety/ UCM170919.pdf. Accessed May 2013.
60. J.P. Gisbert Safety of immunomodulators and biologics for the treatment of inflammatory bowel disease during pregnancy and breast-feeding Inflamm Bowel Dis 16 2010 881 895
61. J.M. Davison, H. Dellagrammatikas, and J.M. Parkin Maternal azathioprine therapy and depressed haemopoiesis in the babies of renal allograft patients Br J Obstet Gynaecol 92 1985 233 239 (Pubitemid 15146698)
62. J. Zerner, K.L. Doil, J. Drewry, and D.A. Leeber Intrauterine contraceptive device failures in renal transplant patients J Reprod Med 26 1981 99 102 (Pubitemid 11056672)
63. A.R. Ahmed, and H.M. Gurcan Use of intravenous immunoglobulin therapy during pregnancy in patients with pemphigus vulgaris J Eur Acad Dermatol Venereol 25 2011 1073 1079
64. D.C. Gan, B. Welsh, and M. Webster Successful treatment of a severe persistent case of pemphigoid gestationis with antepartum and postpartum intravenous immunoglobulin followed by azathioprine Australas J Dermatol 53 2012 66 69
65. K. Marzusch, H. Tinneberg, G. Mueller-Eckhardt, S.V. Kaveri, B. Hinney, and C. Redman Is immunotherapy justified for recurrent spontaneous abortion? Lancet 339 1992 1543
66. J.G. Routsias, N.C. Kyriakidis, D.M. Friedman, C. Llanos, R. Clancy, and H.M. Moutsopoulos et al. Association of the idiotype:antiidiotype antibody ratio with the efficacy of intravenous immunoglobulin treatment for the prevention of recurrent autoimmune-associated congenital heart block Arthritis Rheum 63 2011 2783 2789
67. D. Sidiropoulos, U. Herrmann Jr., A. Morell, G. von Muralt, and S. Barandun Transplacental passage of intravenous immunoglobulin in the last trimester of pregnancy J Pediatr 109 1986 505 508 (Pubitemid 16014284)
68. E.F. Chakravarty, E.R. Murray, A. Kelman, and P. Farmer Pregnancy outcomes after maternal exposure to rituximab Blood 117 2011 1499 1506
69. I. Saxen Letter: cleft palate and maternal diphenhydramine intake Lancet 1 1974 407 408
70. B. Kallen, and P.O. Olausson No increased risk of infant hypospadias after maternal use of loratadine in early pregnancy Int J Med Sci 3 2006 106 107 (Pubitemid 44035234)
71. S. Kar, A. Krishnan, K. Preetha, and A. Mohankar A review of antihistamines used during pregnancy J Pharmacol Pharmacother 3 2012 105 108
72. S. Zierler, and D. Purohit Prenatal antihistamine exposure and retrolental fibroplasia Am J Epidemiol 123 1986 192 196 (Pubitemid 16189712)
73. C.N. Broussard, and J.E. Richter Nausea and vomiting of pregnancy Gastroenterol Clin North Am 27 1998 123 151 (Pubitemid 28156192)
74. A. Lione, and A.R. Scialli The developmental toxicity of the H1 histamine antagonists Reprod Toxicol 10 1996 247 255
75. R. Serreau, M. Komiha, F. Blanc, F. Guillot, and E. Jacqz-Aigrain Neonatal seizures associated with maternal hydroxyzine hydrochloride in late pregnancy Reprod Toxicol 20 2005 573 574 (Pubitemid 41393848)
76. R.F. Smith, G.G. Wharton, S.L. Kurtz, K.M. Mattran, and A.R. Hollenbeck Behavioral effects of mid-pregnancy administration of lidocaine and mepivacaine in the rat Neurobehav Toxicol Teratol 8 1986 61 68 (Pubitemid 16110972)
77. O.P. Heinonen, D. Slone, and S. Shapiro Birth defects and drugs in pregnancy 1977 Publishing Sciences Group Littleton (MA)
78. H. Nau Clinical pharmacokinetics in pregnancy and perinatology. I. Placental transfer and fetal side effects of local anaesthetic agents Dev Pharmacol Ther 8 1985 149 181 (Pubitemid 15041500)
79. T.K. Abboud, S. David, S. Nagappala, J. Costandi, T. Yanagi, and S. Haroutunian et al. Maternal, fetal, and neonatal effects of lidocaine with and without epinephrine for epidural anesthesia in obstetrics Anesth Analg 63 1984 973 979 (Pubitemid 15201297)
80. S.M. Sweeney, and M.E. Maloney Pregnancy and dermatologic surgery Dermatol Clin 24 2006 205 214 (Pubitemid 44308152)
81. J. Shapiro Safety of topical minoxidil solution: a one-year, prospective, observational study J Cutan Med Surg 7 2003 322 329 (Pubitemid 37410453)
82. C. Smorlesi, A. Caldarella, L. Caramelli, S. Di Lollo, and F. Moroni Topically applied minoxidil may cause fetal malformation: a case report Birth Defects Res A Clin Mol Teratol 67 2003 997 1001 (Pubitemid 38018043)
83. N. Rojansky, S.J. Fasouliotis, I. Ariel, and M. Nadjari Extreme caudal agenesis. Possible drug-related etiology? J Reprod Med 47 2002 241 245 (Pubitemid 34260673)
84. J.F. Li Yim, and C.R. Weir Botulinum toxin and pregnancy-a cautionary tale Strabismus 18 2010 65 66
85. M.A. Aranda, A. Herranz, J. del Val, S. Bellido, and P. Garcia-Ruiz Botulinum toxin A during pregnancy, still a debate Eur J Neurol 19 2012 e81 e82
86. J.M. Polo, J. Martin, and J. Berciano Botulism and pregnancy Lancet 348 1996 195
87. L. Robin, D. Herman, and R. Redett Botulism in a pregnant women N Engl J Med 335 1996 823 824
88. E.H. St Clair, J.H. DiLiberti, and M.L. O'Brien Letter: observations of an infant born to a mother with botulism J Pediatr 87 1975 658
89. G.A. Morrison, C. Lang, and S. Huda Botulism in a pregnant intravenous drug abuser Anaesthesia 61 2006 57 60 (Pubitemid 43336629)
90. K. Magri, V. Bresson, and C. Barbier Botulism and pregnancy [in French] J Gynecol Obstet Biol Reprod (Paris) 35 2006 624 626
91. R.C. Wester, J. Melendres, X. Hui, R. Cox, S. Serranzana, and H. Zhai et al. Human in vivo and in vitro hydroquinone topical bioavailability, metabolism, and disposition J Toxicol Environ Health A 54 1998 301 317 (Pubitemid 28428813)
92. W.J. Krasavage, A.M. Blacker, J.C. English, and S.J. Murphy Hydroquinone: a developmental toxicity study in rats Fundam Appl Toxicol 18 1992 370 375
93. G. Camera, and P. Pregliasco Ear malformation in baby born to mother using tretinoin cream Lancet 339 1992 687
94. A.H. Lipson, F. Collins, and W.S. Webster Multiple congenital defects associated with maternal use of topical tretinoin Lancet 341 1993 1352 1353 (Pubitemid 23148136)
95. S.M. Colley, I. Walpole, V.A. Fabian, and B.A. Kakulas Topical tretinoin and fetal malformations Med J Aust 168 1998 467
96. C. Navarre-Belhassen, P. Blanchet, D. Hillaire-Buys, P. Sarda, and J.P. Blayac Multiple congenital malformations associated with topical tretinoin Ann Pharmacother 32 1998 505 506 (Pubitemid 28166621)
97. S.S. Jick, B.Z. Terris, and H. Jick First trimester topical tretinoin and congenital disorders Lancet 341 1993 1181 1182 (Pubitemid 23137115)
98. L. Shapiro, A. Pastuszak, G. Curto, and G. Koren Safety of first-trimester exposure to topical tretinoin: prospective cohort study Lancet 350 1997 1143 1144 (Pubitemid 27454011)
99. A. Panchaud, C. Csajka, P. Merlob, C. Schaefer, M. Berlin, and M. De Santis et al. Pregnancy outcome following exposure to topical retinoids: a multicenter prospective study J Clin Pharmacol 52 2012 1844 1851
100. A. Menter Pharmacokinetics and safety of tazarotene J Am Acad Dermatol 43 2 Pt 3 2000 S31 S35
101. S. Nacht, D. Yeung, J.N. Beasley Jr., M.D. Anjo, and H.I. Maibach Benzoyl peroxide: percutaneous penetration and metabolic disposition J Am Acad Dermatol 4 1981 31 37 (Pubitemid 11137313)
102. A. Berard, L. Azoulay, G. Koren, L. Blais, S. Perreault, and D. Oraichi Isotretinoin, pregnancies, abortions and birth defects: a population-based perspective Br J Clin Pharmacol 63 2007 196 205 (Pubitemid 46072106)
103. M.E. Maloney, and S.P. Stone Isotretinoin and iPledge: a view of results J Am Acad Dermatol 65 2011 418 419
104. A.H. Hall, and B.H. Rumack POISINDEX Information Systems Micromedex, volume 157 2013 CCIS Englewood (CO)
105. A. Heikkila, and R. Erkkola Review of beta-lactam antibiotics in pregnancy. The need for adjustment of dosage schedules Clin Pharmacokinet 27 1994 49 62 (Pubitemid 24211096)
106. B.A. Kallen, P. Otterblad Olausson, and B.R. Danielsson Is erythromycin therapy teratogenic in humans? Reprod Toxicol 20 2005 209 214 (Pubitemid 40725070)
107. J.H. Lewis Drug hepatotoxicity in pregnancy Eur J Gastroenterol Hepatol 3 1991 883 891
108. W.M. McCormack, H. George, A. Donner, L.F. Kodgis, S. Alpert, and E.W. Lowe et al. Hepatotoxicity of erythromycin estolate during pregnancy Antimicrob Agents Chemother 12 1977 630 635 (Pubitemid 8209365)
109. M.F. Trexler, T.G. Fraser, and M.P. Jones Fulminant pseudomembranous colitis caused by clindamycin phosphate vaginal cream Am J Gastroenterol 92 1997 2112 2113 (Pubitemid 27476262)
110. E. Eggermont, N. Logghe, W. Van De Casseye, M. Casteels-Van Daele, J. Jaeken, and J. Cosemans et al. Haemorrhagic disease of the newborn in the offspring of rifampicin and isoniazid treated mothers Acta Paediatr Belg 29 1976 87 90
111. K.C. Gupta, and M.Y. Ali Failure of oral contraceptive with rifampicin Med J Zambia 15 1980 23 (Pubitemid 11011588)
112. J. Yang, R.H. Xie, D. Krewski, Y.J. Wang, M. Walker, and S.W. Wen Exposure to trimethoprim/sulfamethoxazole but not other FDA category C and D anti-infectives is associated with increased risks of preterm birth and low birth weight Int J Infect Dis 15 2011 e336 e341
113. J.T. Andersen, M. Petersen, E. Jimenez-Solem, K. Broedbaek, E.W. Andersen, and N.L. Andersen et al. Trimethoprim use in early pregnancy and the risk of miscarriage: a register-based nationwide cohort study Epidemiol Infect 141 2013 1749 1755
114. B.J. Kinzie, and J.W. Taylor Trimethoprim and folinic acid Ann Intern Med 101 1984 565 (Pubitemid 14018064)
115. M. Berkovitch, A. Pastuszak, M. Gazarian, M. Lewis, and G. Koren Safety of the new quinolones in pregnancy Obstet Gynecol 84 1994 535 538 (Pubitemid 24311144)
116. H. Jick, L.B. Holmes, J.R. Hunter, S. Madsen, and A. Stergachis First-trimester drug use and congenital disorders JAMA 246 1981 343 346 (Pubitemid 12251384)
117. C.T. King, P.D. Rogers, J.D. Cleary, and S.W. Chapman Antifungal therapy during pregnancy Clin Infect Dis 27 1998 1151 1160 (Pubitemid 29242465)
118. F.W. Rosa, C. Hernandez, and W.A. Carlo Griseofulvin teratology, including two thoracopagus conjoined twins Lancet 1 1987 171 (Pubitemid 17015867)
119. P. Mastroiacovo, T. Mazzone, L.D. Botto, M.A. Serafini, A. Finardi, and L. Caramelli et al. Prospective assessment of pregnancy outcomes after first-trimester exposure to fluconazole Am J Obstet Gynecol 175 1996 1645 1650 (Pubitemid 27021041)
120. S.S. Jick Pregnancy outcomes after maternal exposure to fluconazole Pharmacotherapy 19 1999 221 222 (Pubitemid 29072033)
121. W. Inman, G. Pearce, and L. Wilton Safety of fluconazole in the treatment of vaginal candidiasis. A prescription-event monitoring study, with special reference to the outcome of pregnancy Eur J Clin Pharmacol 46 1994 115 118 (Pubitemid 24101326)
122. H.T. Sorensen, G.L. Nielsen, C. Olesen, H. Larsen, F.H. Steffensen, and H.C. Schønheyder et al. Risk of malformations and other outcomes in children exposed to fluconazole in utero Br J Clin Pharmacol 48 1999 234 238 (Pubitemid 29349461)
123. J.I. Mason, B.A. Murry, M. Olcott, and J.J. Sheets Imidazole antimycotics: inhibitors of steroid aromatase Biochem Pharmacol 34 1985 1087 1092 (Pubitemid 15054417)
124. L. Kragie, S.D. Turner, C.J. Patten, C.L. Crespi, and D.M. Stresser Assessing pregnancy risks of azole antifungals using a high throughput aromatase inhibition assay Endocr Res 28 2002 129 140 (Pubitemid 35415186)
125. Z.A. Brown, C. Gardella, A. Wald, R.A. Morrow, and L. Corey Genital herpes complicating pregnancy Obstet Gynecol 106 2005 845 856 (Pubitemid 41362194)
126. 1998 guidelines for treatment of sexually transmitted diseases. Centers for Disease Control and Prevention MMWR Recomm Rep 47 1998 1 111
127. A. Einarson, A. Costei, S. Kalra, M. Rouleau, and G. Koren The use of topical 5% imiquimod during pregnancy: a case series Reprod Toxicol 21 2006 1 2 (Pubitemid 43048767)
128. R. Strobel, and G. Rohrborn Mutagenic and cell transforming activities of 1-chlor-2,4-dinitrobenzene (DNCB) and squaric-acid-dibutylester (SADBE) Arch Toxicol 45 1980 307 314 (Pubitemid 10029601)
129. J. Eriksson Non-mutagenic carcinogens: mechanisms and test methods, vol. 601 1997 Ekspressen Tryk & Kopicenter Copenhagen, Denmark
130. A. Akhavan, and S. Bershad Topical acne drugs: review of clinical properties, systemic exposure, and safety Am J Clin Dermatol 4 2003 473 492 (Pubitemid 36871766)
131. A. Borkhardt, M. Wilda, U. Fuchs, L. Gortner, and I. Reiss Congenital leukaemia after heavy abuse of permethrin during pregnancy Arch Dis Child Fetal Neonatal Ed 88 2003 F436 F437
132. O.T. Mytton, R. McGready, S.J. Lee, C.H. Roberts, E.A. Ashley, and V.I. Carrara et al. Safety of benzyl benzoate lotion and permethrin in pregnancy: a retrospective matched cohort study BJOG 114 2007 582 587 (Pubitemid 46587960)
133. A. Addis, S. Sharabi, and M. Bonati Risk classification systems for drug use during pregnancy: are they a reliable source of information? Drug Safety 23 2000 245 253