Genital herpes complicating pregnancy

Obstetrics and Gynecology

Volumn 106, Issue 4, 2005, Pages 845-856

  Brown, Zane A ^a   Gardella, Carolyn ^b   Wald, Anna ^b   Morrow, Rhoda Ashley ^b   Corey, Lawrence ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ANTIVIRUS AGENT; FAMCICLOVIR; NUCLEOSIDE ANALOG; THROMBOSPONDIN; VALACICLOVIR;

COUNSELING; GENITAL HERPES; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; HIGH RISK POPULATION; HUMAN; KIDNEY FAILURE; NEUTROPENIA; POLYMERASE CHAIN REACTION; PREGNANCY; PRIORITY JOURNAL; REVIEW; SEROLOGY; SIDE EFFECT; THIRD TRIMESTER PREGNANCY; VERTICAL TRANSMISSION; VULVOVAGINITIS;

EID: 25444515225     PISSN: 00297844     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.AOG.0000180779.35572.3a     Document Type: Review

References (94)

1. Fleming D, McQuillan G, Johnson R, Nahmias AJ, Aral SO, Lee FK, et al. Herpes simplex virus type 2 in the United States, 1976 to 1994. N Engl J Med 1997;337:1105-11.
2. Armstrong GL, Schillinger J, Markowitz L, Nahmias AJ, Johnson RE, McQuillan GM, et al. Incidence of herpes simplex virus type 2 infection in the United States. Am J Epidemiol 2001;153:912-20.
3. Brown ZA, Selke SA, Zeh J, Kopelman J, Maslow A, Ashley RL, et al. Acquisition of herpes simplex virus during pregnancy. N Engl J Med 1997;337:509-15.
4. Brown ZA, Wald A, Morrow RA, Selke S, Zeh J, Corey L. Effect of serologic status and cesarean delivery on transmission rates of herpes simplex virus from mother to infant. JAMA 2003;289:203-9.
5. Kimberlin DW. Neonatal herpes simplex infection. Clin Microbiol Rev 2004;17:1-13.
6. Mennemeyer ST, Cyr LP, Whitley RJ. Antiviral therapy for neonatal herpes simplex virus: a cost- effectiveness analysis. Am J Manag Care 1997;3:1551-8.
7. Stanberry L, Cunningham A, Mertz G, Mindel A, Peters B, Reitano M, et al. New developments in the epidemiology, natural history and management of genital herpes. Antiviral Res 1999;42:1-14.
8. Nahmias A, Lee F, Beckman-Nahmias S. Sero-epidemiological and sociological patterns of herpes simplex virus infection in the world. Scand J Infect Dis Suppl 1990;69:19-36.
9. Leone P, Fleming DT, Gilsenan AW, Li L, Justus S. Seroprevalence of herpes simplex virus-2 in suburban primary care offices in the United States. Sex Transm Dis 2004;31:311-6.
10. Kulhanjian J, Soroush V, Au D, Bronzan RN, Yasukawa LL, Weylman LE, et al. Identification of women at unsuspected risk of primary infection with herpes simplex virus type 2 during pregnancy. N Engl J Med 1992;326:916-20.
11. Bryson Y, Dillon M, Bernstein DI, Radolf J, Zakowski P, Garratty E. Risk of acquisition of genital herpes simplex virus type 2 in sex partners of persons with genital herpes: a prospective couple study. J Infect Dis 1993;167:942-6.
12. Wald A, Zeh J, Selke S, Warren T, Ryncarz AS, Ashley R, et al. Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons. N Engl J Med 2000;342:844-50.
13. Ashley RL, Wald A. Genital herpes: review of the epidemic and potential use of type- specific serology. Clin Microbiol Rev 1999;12:1-8.
14. Mertz GJ, Benedetti J, Ashley R, Selke SA, Corey L. Risk factors for the sexual transmission of genital herpes. Ann Intern Med 1992;116:197-202.
15. Mertz GJ, Schmidt O, Jourden JL, Guinan ME, Remington ML, Fahnlander A, et al. Frequency of acquisition of first-episode genital infection with herpes simplex virus from symptomatic and asymptomatic source contacts. Sex Transm Dis 1985;12:33-9.
16. Mertz GJ, Coombs RW, Ashley R, Jourden J, Remington M, Winter C, et al. Transmission of genital herpes in couples with one symptomatic and one asymptomatic partner: a prospective study. J Infect Dis 1988;157:1169-77.
17. Langenberg A, Corey L, Ashley R, Leong W, Straus S. A prospective study of new infections with herpes simplex virus type 1 and type 2. N Engl J Med 1999;341:1432-8.
18. Fife KH, Bernstein DI, Tu W, Zimet GD, Brady R, Wu J, et al. Predictors of herpes simplex virus type 2 antibody positivity among persons with no history of genital herpes. Sex Transm Dis 2004;31:676-81.
19. Langenberg A, Benedetti J, Jenkins J, Ashley R, Winter C, Corey L. Development of clinically recognizable genital lesions among women previously identified as having "asymptomatic" HSV-2 infection. Ann Intern Med 1989;110:882-7.
20. Lafferty WE, Downey L, Celum C, Wald A. Herpes simplex virus type 1 as a cause of genital herpes: impact on surveillance and prevention. J Infect Dis 2000;181:1454-7.
21. Roberts CM, Poster JR, Spear SJ. Increasing proportion of herpes simplex virus type 1 as a cause of genital herpes infection in college students. Sex Transm Dis 2003;30:797-800.
22. Ribes JA, Steele AD, Seabolt JP, Baker DJ. Six-year study of the incidence of herpes in genital and nongenital cultures in a central Kentucky medical center patient population. J Clin Microbiol 2001;39:3321-5.
23. Mertz GJ, Rosenthal SL, Stanberry LR. Is herpes simplex virus type 1 (HSV-1) now more common than HSV-2 in first episodes of genital herpes? Sex Transm Dis 2003;30:801-2.
24. Wald A, Ericsson M, Krantz E, Selke S, Corey L. Oral shedding of herpes simplex virus type 2 [published erratum appears in Sex Transm Infect 2004;80:546]. Sex Transm Infect 2004;80:272-6.
25. Engelberg R, Carrell D, Krantz E, Corey L, Wald A. Natural history of genital herpes simplex virus type 1 infection. Sex Transm Dis 2003;30:174-7.
26. Wald A, Corey L, Cone R, Hobson A, Davis G, Zeh J. Frequent genital HSV-2 shedding in immunocompetent women: effect of acyclovir treatment. J Clin Invest 1997;99:1092-7.
27. Hensleigh P, Andrews W, Brown Z, Greenspoon J, Yasukawa L, Prober C. Genital herpes during pregnancy: inability to distinguish primary and recurrent infections clinically. Obstet Gynecol 1997;89:891-5.
28. Brown Z, Benedetti J, Watts D, Selke S, Berry S, Ashley RL, et al. A comparison between detailed and simple histories in the diagnosis of genital herpes complicating pregnancy. Am J Obstet Gynecol 1995;172:1299-303.
29. Sexually transmitted diseases treatment guidelines 2002. Centers for Disease Control and Prevention. MMWR Recomm Rep 2002;51(RR-6):1-78.
30. Slomka MJ, Emery L, Munday PE, Moulsdale M, Brown DW. A comparison of PCR with virus isolation and direct antigen detection for diagnosis and typing of genital herpes. J Med Virol 1998;55:177-83.
31. Cone R, Hobson A, Brown Z, Ashley R, Berry S, Winter C, et al. Frequent detection of genital herpes simplex virus DNA by polymerase chain reaction among pregnant women. JAMA 1994;272:792-6.
32. Hobson A, Wald A, Wright N, Corey L. Evaluation of a quantitative competitive PCR assay for measuring of HSV DNA in genital tract secretions. J Clin Microbiol 1997;35:548-52.
33. Wald A, Huang ML, Carrell D, Selke S, Corey L. Polymerase chain reaction for detection of herpes simplex virus (HSV) DNA on mucosal surfaces: comparison with HSV isolation in cell culture. J Infect Dis 2003;188:1345-51.
34. Frederick DM, Bland D, Gollin Y. Fatal disseminated herpes simplex virus infection in a previously healthy pregnant woman: a case report. J Reprod Med 2002;47:591-6.
35. Young E, Chafizadeh E, Oliveira VL, Genta RM. Disseminated herpes-virus infection during pregnancy. Clin Infect Dis 1996;22:51-8.
36. Kang AH, Graves CR. Herpes simplex hepatitis in pregnancy: a case report and review of the literature. Obstet Gynecol Surv 1999;54:463-8.
37. Dupuis O, Audibert F, Fernandez H, Frydman R. Herpes simplex virus encephalitis in pregnancy. Obstet Gynecol 1999;94:810-2.
38. Hollier LM, Scott LL, Murphree SS, Wendel GD Jr. Postpartum endometritis caused by herpes simplex virus. Obstet Gynecol 1997;89 suppl:836-8.
39. Hixson M, Collins JH. Postpartum herpes simplex endometritis: a case report. J Reprod Med 2001;46:849-52.
40. Roizman B, Sears A. Herpes simplex viruses and their replication. In: Fields BN, Knipe DM, Howley PM, Chanock RM, Melnick JL, Monath TP, Roizman B, editors. Virology. 3rd ed. Philadelphia (PA): Lippincott-Raven; 1996. p 2231.
41. Ashley R. Performance and use of HSV type-specific serology test kits. Herpes 2002;9:38-45.
42. Ashley RL, Militoni J, Lee F, Nahmias A, Corey L. Comparison of Western blot (Immunoblot) and glycoprotein G-specific immunodot enzyme assay for detecting antibodies to herpes simplex virus types 1 and 2 in human sera. J Clin Microbiol 1988;26:662-7.
43. Morrow RA, Friedrich D. Inaccuracy of certain commercial enzyme immunoassays in diagnosing genital infections with herpes simplex virus types 1 or 2. Am J Clin Pathol 2003;120:839-44.
44. Ashley RL, Eagleton M, Pfeiffer N. Ability of a rapid serology test to detect seroconversion to herpes simplex virus type 2 glycoprotein G soon after infection. J Clin Microbiol 1999;37: 1632-3.
45. Ashley RL, Wald A, Eagleton M. Premarket evaluation of the POCkit HSV-2 type-specific serologic test in culture-documented cases of genital herpes simplex virus type 2. Sex Transm Dis 2000;27:266-9.
46. Ashley-Morrow R, Nollkamper J, Robinson N, Bishop N, Smith J. Performance of Focus ELISA tests for herpes simplex virus type 1 (HSV-1) and HSV-2 antibodies among women in ten diverse geographic locations. Clin Microbiol Infect 2004;10:530-6.
47. Saville M, Brown D, Burgess C, Perry K, Barton S, Cowan F, et al. An evaluation of near patient tests for detecting herpes simplex virus type-2 antibody. Sex Transm Infect 2000;76:381-2.
48. Ribes JA, Hayes M, Smith A, Winters JL, Baker DJ. Comparative performance of herpes simplex virus type 2-specific serologic assays from Meridian Diagnostics and MRL diagnostics. J Clin Microbiol 2001;39:3740-2.
49. Eis-Hubinger AM, Daumer M, Matz B, Schneweis KE. Evaluation of three glycoprotein G2-based enzyme immunoassays for detection of antibodies to herpes simplex virus type 2 in human sera. J Clin Microbiol 1999;37:1242-6.
50. Prince HE, Ernst CE, Hogrefe WR. Evaluation of an enzyme immunoassay system for measuring herpes simplex virus (HSV) type 1-specific and HSV type 2-specific IgG antibodies. J Clin Lab Anal 2000;14:13-6.
51. Ashley R, Cent A, Maggs V, Corey L. Inability of enzyme immunoassays to discriminate between infections with herpes simplex virus type 1 and 2. Ann Intern Med 1991;115:520-6.
52. American College of Obstetricians and Gynecologists. Management of genital herpes in pregnancy. ACOG Practice Bulletin 8. Washington, DC: ACOG; 1999.
53. Bryson YJ, Dillon M, Lovett M, Acuna G, Taylor S, Cherry JD, et al. Treatment of first episodes of genital herpes simplex virus infections with oral acyclovir: a randomized double-blind controlled trial in normal subjects. N Engl J Med 1983;308:916-20.
54. Vontver LA, Hickok DE, Brown Z, Reid L, Corey L. Recurrent genital herpes simplex virus infection in pregnancy: infant outcome and frequency of asymptomatic recurrences. Am J Obstet Gynecol 1982;143:75-84.
55. Frenkel LM, Brown ZA, Bryson YJ, Corey L, Unadkat JD, Hensleigh PA, et al. Pharmacokinetics of acyclovir in the term human pregnancy and neonate. Am J Obstet Gyn 1991;164:569-76.
56. Kimberlin DF, Weller S, Whidey RJ, Andrews WW, Hauth JC, Lakeman F, et al. Pharmacokinetics of oral valacyclovir and acyclovir in late pregnancy. Am J Obstet Gynecol 1998;179:846-51.
57. Beutner KR. Valacyclovir: a review of its antiviral activity, pharmacokinetic properties, and clinical efficacy. Antiviral Res 1995;28:281-90.
58. Stone KM, Reiff-Eldridge R, White AD, Cordero JF, Brown Z, Alexander ER, et al. Pregnancy outcomes following systemic prenatal acyclovir exposure: Conclusions from the international acyclovir pregnancy registry, 1984-1999. Birth Defects Res A Clin Mol Teratol 2004;70:201-7.
59. Kimberlin D, Lin C-Y, Jacobs R, Powell DA, Corey L, Gruber WC, et al. Safety and efficacy of high-dose intravenous acyclovir in the management of neonatal herpes simplex virus infections. Pediatrics 2001;108:230-8.
60. Tyring SK, Baker D, Snowden W. Valacyclovir for herpes simplex virus infections: long-term safety and sustained efficacy after 20 years' experience with acyclovir. J Infect Dis 2002;186 suppl 1:S40-6.
61. Whitley RJ, Roizman B. Herpes simplex virus infections. Lancet 2001;357:1513-8.
62. Brown ZA, Benedetti J, Ashley R, Burchett S, Selke S, Berry S, et al. Neonatal herpes simplex virus infection in relation to asymptomatic maternal infection at the time of labor. N Engl J Med 1991;324:1247-52.
63. Boucher FD, Yasukawa LL, Bronzan RN, Hensleigh PA, Arvin AM, Prober CG. A prospective evaluation of primary genital herpes simplex virus type 2 infections acquired during pregnancy. Pediatr Infect Dis J 1990;9:499-504.
64. Sullivan-Bolyai JZ, Fife KH, Jacobs RF, Z M, Corey L. Disseminated neonatal herpes simplex virus type 1 from a maternal breast lesion. Pediatrics 1983;71:455-7.
65. Kimberlin D, Lin C-Y, Jacobs R, Powell DA, Frenkel LM, Gruber WC, et al. Natural history of neonatal herpes simplex virus infections in the acyclovir era. Pediatrics 2001;108:223-9.
66. Whitley R, Corey L, Arvin A, Lakeman FD, Sumaya CV, Wright PF, et al. Changing presentation of herpes simplex virus infection in neonates. J Infect Dis 1988;158:109-16.
67. Koelle DM, Benedetti J, Langenberg A, Corey L. Asymptomatic reactivation of herpes simplex virus in women after first episode of genital herpes. Ann Intern Med 1992;116:433-7.
68. Whitley R, Arvin A, Prober C, Corey L, Burchett S, Plotkin S, et al. Predictors of morbidity and mortality in neonates with herpes simplex infections. N Engl J Med 1991;324:450-4.
69. van Everdingen JJ, Peeters MF, ten Have P. Neonatal herpes policy in The Netherlands: five years after a consensus conference. J Perinat Med 1993;21:371-5.
70. Gardella C, Brown ZA, Wald A, Morrow RA, Selke S, Krantz E, et al. Poor correlation between genital lesions and detection of herpes simplex virus in women in labor. Obstet Gynecol 2005;106:268-74.
71. Arvin A, Hensleigh P, Prober C, Au DS, Yasukawa LL, Wittek AE, et al. Failure of antepartum maternal cultures to predict the infant's risk of exposure to herpes simplex virus at delivery. N Engl J Med 1986;315:796-800.
72. Braig S, Luton D, Sibony O, Elinger C, Boissinot C, Blot, Oury JF. Acyclovir prophylaxis in late pregnancy prevents recurrent genital herpes and viral shedding. Eur J Obstet Gynecol Reprod Biol 2001;96:55-8.
73. Scott LL, Sanchez PJ, Jackson GL, Zeray F, Wendel GD Jr. Acyclovir suppression to prevent cesarean delivery after first-episode genital herpes. Obstet Gynecol 1996;87:69-73.
74. Brocklehurst P, Kinghorn G, Carney O, Helsen K, Ross E, Ellis E, et al. A randomised placebo controlled trial of suppressive acyclovir in late pregnancy in women with recurrent genital herpes infection. Br J Obstet Gynaecol 1998;105:275-80.
75. Scott LL, Hollier LM, McIntire D, Sanchez PJ, Jackson GL, Wendel GD Jr. Acyclovir suppression to prevent recurrent genital herpes at delivery. Infect Dis Obstet Gynecol 2002;10:71-7.
76. Watts DH, Brown ZA, Money D, Selke S, Huang ML, Sacks SL, et al. A double-blind, randomized, placebo-controlled trial of acyclovir in late pregnancy for the reduction of herpes simplex virus shedding and cesarean delivery. Am J Obstet Gynecol 2003;188:836-43.
77. Sheffield JS, Hollier LM, Hill JB, Stuart GS, Wendel GD. Acyclovir prophylaxis to prevent herpes simplex virus recurrence at delivery: a systematic review. Obstet Gynecol 2003;102:1396-403.
78. Casper C, Wald A. Condom use and the prevention of genital herpes acquisition. Herpes 2002;9:10-4.
79. Corey L, Wald A, Patel R, Sacks SL, Tyring SK, Warren T, et al. Once-daily valacyclovir to reduce the risk of transmission of genital herpes. N Engl J Med 2004;350(1):11-20.
80. Bartellas E, Crane JM, Daley M, Bennett KA, Hutchens D. Sexuality and sexual activity in pregnancy. BJOG 2000;107:964-8.
81. von Sydow K. Sexuality during pregnancy and after childbirth: a metacontent analysis of 59 studies. J Psychosom Res 1999;47:27-49.
82. Vonau B, Low-Beer N, Barton SE, Smith JR. Antenatal serum screening for genital herpes: a study of knowledge and attitudes of women at a central London hospital. Br J Obstet Gynaecol 1997;104:347-9.
83. Edmiston N, O'Sullivan M, Charters D, Chuah J, Pallis L. Study of knowledge of genital herpes infection and attitudes to testing for genital herpes among antenatal clinic attendees. Aust N Z J Obstet Gynaecol 2003;43:351-3.
84. Miyai T, Turner KR, Kent CK, Klausner J. The psychosocial impact of testing individuals with no history of genital herpes for herpes simplex virus type 2. Sex Transm Dis 2004;31:517-21.
85. Thung SF, Grobman WA. The cost-effectiveness of routine antenatal screening for maternal herpes simplex virus-1 and -2 antibodies. Am J Obstet Gynecol 2005;192:483-8.
86. Baker D, Brown Z, Hollier LM, Wendel G, Hulme L, Griffiths D, et al. Cost-effectiveness of herpes simplex virus type 2 serologic testing and antiviral therapy in pregnancy. Am J Obstet Gynecol 2004;191:2074-84.
87. Spruance SL. Pathogenesis of herpes simplex labialis: excretion of virus in the oral cavity.J Clin Microbiol 1984;19:675-9.
88. Feder Jr HM, Geller RW. Herpetic whitlow of the great toe. N Engl J Med 1992;326:1295-6.
89. Fischer RG, Livingood JC. Vesiculobullous lesion on the right fifth toe. Clinical Infectious Diseases 2005;40:579-80, 609-10.
90. American Academy of Pediatrics Committee on Drugs. The transfer of drugs and other chemicals into human milk. Pediatrics 2001;108(3):776-89.
91. Sheffield JS, Fish DN, Hollier LM, Cadematori S, Nobles BJ, Wendel GD Jr. Acyclovir concentrations in human breast milk after valaciclovir administration. Am J Obstet Gynecol 2002;186:100-2.
92. Meyer LJ, de Miranda P, Sheth N, Spruance S. Acyclovir in human breast milk. Am J Obstet Gynecol. 1988;158:586-8.
93. Taddio A, Klein J, Koren G. Acyclovir excretion in human breast milk. Ann Pharmacother 1994;28:585-7.
94. Lau RJ, Emery MG, Galinsky RE. Unexpected accumulation of acyclovir in breast milk with estimation of infant exposure. Obstet Gynecol. 1987;69 suppl:468-71.