Langerin + Dermal DC, but not Langerhans cells, are required for effective CD8-mediated immune responses after skin scarification with vaccinia Virus

Journal of Investigative Dermatology

Volumn 134, Issue 3, 2014, Pages 686-694

  Seneschal, Julien ^a,b   Jiang, Xiaodong ^a   Kupper, Thomas S ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b INSERM U1035 ^*  (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; DIPHTHERIA TOXIN; LANGERIN; OVALBUMIN; CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; CD103 ANTIGEN; GAMMA INTERFERON; HOMING RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER MORTALITY; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CROSS PRESENTATION; DENDRITIC CELL; FEMALE; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; LANGERHANS CELL; LYMPHOCYTE PROLIFERATION; MOUSE; MOUSE MODEL; NONHUMAN; POXVIRUS INFECTION; PRIORITY JOURNAL; SKIN CELL; SKIN SCAR; T CELL DEPLETION; T CELL LYMPHOMA; T LYMPHOCYTE ACTIVATION; VACCINIA VIRUS; WILD TYPE; ANTIGEN SPECIFICITY; CELL PROLIFERATION; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; FLOW CYTOMETRY; SPLEEN CELL; TARGET CELL; TUMOR GROWTH; TUMOR IMMUNITY; UPREGULATION; VACCINIA;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, SURFACE; CD8-POSITIVE T-LYMPHOCYTES; CICATRIX; DERMIS; FEMALE; IMMUNIZATION; IMMUNOLOGIC MEMORY; LANGERHANS CELLS; LECTINS, C-TYPE; MANNOSE-BINDING LECTINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SKIN; SMALLPOX; SMALLPOX VACCINE; VACCINIA VIRUS;

EID: 84894103936     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2013.418     Document Type: Article

References (33)

1. Allan RS, Smith CM, Belz GT et al. (2003) Epidermal viral immunity induced by CD8alpha-dendritic cells but not by Langerhans cells. Science 301:1925-88
2. Bedoui S, Whitney PG, Waithman J et al. (2009) Cross-presentation of viral and self antigens by skin-derived CD103-dendritic cells. Nat Immunol 10:488-955
3. Bobr A, Olvera-Gomez I, Igyarto BZ et al. (2010) Acute ablation of Langerhans cells enhances skin immune responses. J Immunol 185:4724-88
4. Brewig N, Kissenpfennig A, Malissen B et al. (2009) Priming of CD8-and CD4-T cells in experimental leishmaniasis is initiated by different dendritic cell subtypes. J Immunol 182:774-833
5. Bursch LS, Wang L, Igyarto B et al. (2007) Identification of a novel population of Langerin-dendritic cells. J Exp Med 204:3147-566
6. Chahroudi A, Garber DA, Reeves P et al. (2006) Differences and similarities in viral life cycle progression and host cell physiology after infection of human dendritic cells with modified vaccinia virus Ankara and vaccinia virus. J Virol 80:8469-811
7. Eidsmo L, Allan R, Caminschi I et al. (2009) Differential migration of epidermal and dermal dendritic cells during skin infection. J Immunol 182:3165-722
8. Ginhoux F, Collin MP, Bogunovic M et al. (2007) Blood-derived dermal Langerin-dendritic cells survey the skin in the steady state. J Exp Med 204:3133-466
9. Hammarlund E, Lewis MW, Hansen SG et al. (2003) Duration of antiviral immunity after smallpox vaccination. Nat Med 9:1131-77
10. Heath WR, Carbone FR (2009) Dendritic cell subsets in primary and secondary T cell responses at body surfaces. Nat Immunol 10:1237-444
11. Henri S, Poulin LF, Tamoutounour S et al. (2010) CD207-CD103-dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells. J Exp Med 207:189-2066
12. Iborra S, Izquierdo HM, Martinez-Lopez M et al. (2012) The DC receptor DNGR-1 mediates cross-priming of CTLs during vaccinia virus infection in mice. J Clin Invest 122:1628-433
13. Igyarto BZ, Haley K, Ortner D et al. (2011) Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses. Immunity 35:260-722
14. Igyarto BZ, Jenison MC, Dudda JC et al. (2009) Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10. J Immunol 183:5085-933
15. Jenne L, Hauser C, Arrighi JF et al. (2000) Poxvirus as a vector to transduce human dendritic cells for immunotherapy: abortive infection but reduced APC function. Gene Ther 7:1575-833
16. Jiang X, Clark RA, Liu L et al. (2012) Skin infection generates non-migratory memory CD8-T(RM) cells providing global skin immunity. Nature 483:227-311
17. Kaplan DH (2010) In vivo function of Langerhans cells and dermal dendritic cells. Trends Immunol 31:446-511
18. Kaplan DH, Jenison MC, Saeland S et al. (2005) Epidermal langerhans celldeficient mice develop enhanced contact hypersensitivity. Immunity 23:611-200
19. Kaplan DH, Kissenpfennig A, Clausen BE (2008) Insights into Langerhans cell function from Langerhans cell ablation models. Eur J Immunol 38:2369-766
20. Kissenpfennig A, Henri S, Dubois B et al. (2005) Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 22:643-544
21. Liu L, Fuhlbrigge RC, Karibian K et al. (2006) Dynamic programming of CD8-T cell trafficking after live viral immunization. Immunity 25:511-200
22. Liu L, Zhong Q, Tian T et al. (2010) Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity. Nat Med 16:224-77
23. Merad M, Ginhoux F, Collin M (2008) Origin, homeostasis and function of Langerhans cells and other Langerin-expressing dendritic cells. Nat Rev 8:935-477
24. Poulin LF, Henri S, de Bovis B et al. (2007) The dermis contains Langerin-dendritic cells that develop and function independently of epidermal Langerhans cells. J Exp Med 204:3119-311
25. Robert C, Fuhlbrigge RC, Kieffer JD et al. (1999) Interaction of dendritic cells with skin endothelium: a new perspective on immunosurveillance. J Exp Med 189:627-366
26. Romani N, Thurnher M, Idoyaga J et al. (2010) Targeting of antigens to skin dendritic cells: possibilities to enhance vaccine efficacy. Immunol Cell Biol 88:424-300
27. Seneschal J, Clark RA, Gehad A et al. (2012) Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells. Immunity 36:873-844
28. Shen X, Wong SB, Buck CB et al. (2002) Direct priming and cross-priming contribute differentially to the induction of CD8-CTL following exposure to vaccinia virus via different routes. J Immunol 169:4222-99
29. Sparber F, Tripp CH, Hermann M et al. (2010) Langerhans cells and dermal dendritic cells capture protein antigens in the skin: possible targets for vaccination through the skin. Immunobiology 215:770-99
30. Steinman RM (2008) Dendritic cells in vivo: a key target for a new vaccine science. Immunity 29:319-244
31. Stewart AJ, Devlin PM (2006) The history of the smallpox vaccine. J Infect 52:329-344
32. Vremec D, Pooley J, Hochrein H et al. (2000) CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen. J Immunol 164:2978-866
33. Zahner SP, Kel JM, Martina CA et al. (2011) Conditional deletion of TGFbetaR11 using Langerin-Cre mice results in Langerhans cell deficiency and reduced contact hypersensitivity. J Immunol 187:5069-766