Keratin 9 is required for the structural integrity and terminal differentiation of the palmoplantar epidermis

Journal of Investigative Dermatology

Volumn 134, Issue 3, 2014, Pages 754-763

  Fu, Dun Jack ^a   Thomson, Calum ^a   Lunny, Declan P ^b   Dopping Hepenstal, Patricia J ^c   McGrath, John A ^d   Smith, Frances J D ^a   Irwin McLean, W H ^a   Pedrioli, Deena M Leslie ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

^c ST THOMAS HOSPITAL   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN 14; CYTOKERATIN 16; CYTOKERATIN 2; CYTOKERATIN 5; CYTOKERATIN 6; CYTOKERATIN 9;

ACANTHOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALLUS; CELL PROLIFERATION; CONTROLLED STUDY; DIFFERENTIATION; EPIDERMIS; EPIDERMOLYTIC PALMOPLANTAR KERATODERMA; FOOT PAD; HISTOLOGY; HISTOPATHOLOGY; HYPERKERATOSIS; HYPERPIGMENTATION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MOUSE; NONHUMAN; NULL ALLELE; PALMOPLANTAR EPIDERMIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AGE FACTORS; ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOSKELETON; DISEASE MODELS, ANIMAL; EPIDERMIS; HYPERPIGMENTATION; KERATIN-9; KERATODERMA, PALMOPLANTAR, EPIDERMOLYTIC; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; RNA, SMALL INTERFERING;

EID: 84894103604     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2013.356     Document Type: Article

References (30)

1. Candi E, Cipollone R, Rivetti di Val Cervo P et al. (2008) p63 in epithelial development. Cell Mol Life Sci 65:3126-333
2. Candi E, Schmidt R, Melino G (2005) The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol 6:328-400
3. Chan YM, Ka-Leung Cheng D, Nga-Yin Cheung A et al. (2000) Female urethral adenocarcinoma arising from urethritis glandularis. Gynecol Oncol 79:511-44
4. Cook HC (1974) Manual of Histological Demonstration Techniques, Butterworths, London, 314p.
5. Coulombe PA, Tong X, Mazzalupo S et al. (2004) Great promises yet to be fulfilled: defining keratin intermediate filament function in vivo. Eur J Cell Biol 83:735-466
6. Haines RL, Lane EB (2012) Keratins and disease at a glance. J Cell Sci 125:3923-88
7. Jonkman MF, Heeres K, Pas HH et al. (1996) Effects of keratin 14 ablation on the clinical and cellular phenotype in a kindred with recessive epidermolysis bullosa simplex. J Invest Dermatol 107:764-99
8. Knapp AC, Franke WW, Heid H et al. (1986) Cytokeratin No. 9, an epidermal type I keratin characteristic of a special program of keratinocyte differentiation displaying body site specificity. J Cell Biol 103:657-677
9. Leachman SA, Kaspar RL, Fleckman P et al. (2005) Clinical and pathological features of pachyonychia congenita. J Investig Dermatol Symp Proc 10:3-177
10. Leigh IM, Navsaria H, Purkis PE et al. (1995) Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro. Br J Dermatol 133:501-111
11. Leslie Pedrioli DM, Fu DJ, Gonzalez-Gonzalez E et al. (2012) Generic and personalized RNAi therapeutics for a dominant-negative epidermal fragility disorder. J Invest Dermatol 132:1627-355
12. Lessard JC, Coulombe PA (2012) Keratin 16-null mice develop palmoplantar keratoderma, a hallmark feature of pachyonychia congenita and related disorders. J Invest Dermatol 132:1384-911
13. Lloyd C, Yu QC, Cheng J et al. (1995) The basal keratin network of stratified squamous epithelia: defining K15 function in the absence of K14. J Cell Biol 129:1329-444
14. Lu H, Zimek A, Chen J et al. (2006) Keratin 5 knockout mice reveal plasticity of keratin expression in the corneal epithelium. Eur J Cell Biol 85:803-111
15. Magin TM, Schroder R, Leitgeb S et al. (1998) Lessons from keratin 188 knockout mice: formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver-specific keratin 8-positive aggregates. J Cell Biol 140:1441-511
16. McLean WH, Irvine AD (2007) Disorders of keratinisation: from rare to common genetic diseases of skin and other epithelial tissues. Ulster Med J 76:72-822
17. McLean WH, Rugg EL, Lunny DP et al. (1995) Keratin 16 and keratin 177 mutations cause pachyonychia congenita. Nat Genet 9:273-88
18. McLean WHI, Moore CBT (2011) Keratin disorders-from gene to therapy. Hum Mol Genet 20:R189-977
19. Morais P, Mota A, Baudrier T et al. (2009) Epidermolytic hyperkeratosis with palmoplantar keratoderma in a patient with KRT10 mutation. Eur J Dermatol 19:333-66
20. Oji V, Tadini G, Akiyama M et al. (2010) Revised nomenclature and classification of inherited ichthyoses: results of the First Ichthyosis Consensus Conference in Soreze 2009. J Am Acad Dermatol 63: 607-411
21. Omary MB, Coulombe PA, McLean WHI (2004) Intermediate filament proteins and their associated diseases. New Eng J Med 351:2087-1000
22. Peters B, Kirfel J, Bussow H et al. (2001) Complete cytolysis and neonatal lethality in keratin 5 knockout mice reveal its fundamental role in skin integrity and in epidermolysis bullosa simplex. Mol Biol Cell 12:1775-899
23. Porter RM, Lane EB (2003) Phenotypes, genotypes and their contribution to understanding keratin function. Trends Genet 19:278-855
24. Reichelt J, Bussow H, Grund C et al. (2001) Formation of a normal epidermis supported by increased stability of keratins 5 and 14 in keratin 10 null mice. Mol Biol Cell 12:1557-688
25. Reichelt J, Magin TM (2002) Hyperproliferation, induction of c-Myc and 14-3- 3sigma, but no cell fragility in keratin-10-null mice. J Cell Sci 115:2639-500
26. Schweizer J, Baust I, Winter H (1989) Identification of murine type I keratin 9 (73 kDa) and its immunolocalization in neonatal and adult mouse foot sole epidermis. Exp Cell Res 184:193-2066
27. Smith F (2003) The molecular genetics of keratin disorders. Am J Clin Dermatol 4:347-644
28. Swensson O, Langbein L, McMillan JR et al. (1998) Specialized keratin expression pattern in human ridged skin as an adaptation to high physical stress. Br J Dermatol 139:767-755
29. Wong P, Colucci-Guyon E, Takahashi K et al. (2000) Introducing a null mutation in the mouse K6alpha and K6beta genes reveals their essential structural role in the oral mucosa. J Cell Biol 150:921-88
30. Yamaguchi Y, Brenner M, Hearing VJ (2007) The regulation of skin pigmentation. J Biol Chem 282:27557-611