Keratin 5 knockout mice reveal plasticity of keratin expression in the corneal epithelium

European Journal of Cell Biology

Volumn 85, Issue 8, 2006, Pages 803-811

  Lu, Hong ^a   Zimek, Alexander ^b   Chen, Jian ^a   Hesse, Michael ^a   Büssow, Heinrich ^a   Weber, Klaus ^b   Magin, Thomas M ^a  

^a UNIVERSITY OF BONN   (Germany)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

Cornea; Epidermolysis bullosa simplex; Intermediate filaments; Keratins; Regeneration

Indexed keywords

KERATIN;

ADOLESCENT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CORNEA EPITHELIUM; CORNEA LIMBUS; CYTOLYSIS; CYTOSKELETON; EPITHELIUM CELL; GENE DELETION; GENETIC CODE; MECHANICAL STRESS; MOUSE; MOUSE STRAIN; NEWBORN; NONHUMAN; PANCREAS CARCINOMA; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; STEM CELL; TISSUE DIFFERENTIATION; WILD TYPE;

MAMMALIA; RODENTIA;

EID: 33746196660     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcb.2006.04.001     Document Type: Article

References (41)

1. Chaloin-Dufau C., Pavitt I., Delorme P., and Dhouailly D. Identification of keratins 3 and 12 in corneal epithelium of vertebrates. Epithelial Cell Biol. 2 (1993) 120-125
2. Chiaromonte F., Yap V.B., and Miller W. Scoring pairwise genomic sequence alignments. Pac. Symp. Biocomput. 115-126 (2002)
3. Coulombe P.A., Hutton M.E., Letai A., Hebert A., Paller A.S., and Fuchs E. Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: genetic and functional analyses. Cell 66 (1991) 1301-1311
4. Galvin S., Loomis C., Manabe M., Dhouailly D., and Sun T.T. The major pathways of keratinocyte differentiation as defined by keratin expression: an overview. Adv. Dermatol. 4 (1989) 277-299 (Discussion 300)
5. Hatzfeld M., and Franke W.W. Pair formation and promiscuity of cytokeratins: formation in vitro of heterotypic complexes and intermediate-sized filaments by homologous and heterologous recombinations of purified polypeptides. J. Cell Biol. 101 (1985) 1826-1841
6. Herzog F., Winter H., and Schweizer J. The large type II 70-kDa keratin of mouse epidermis is the ortholog of human keratin K2e. J. Invest. Dermatol. 102 (1994) 165-170
7. Hesse M., Zimek A., Weber K., and Magin T.M. Comprehensive analysis of keratin gene clusters in humans and rodents. Eur. J. Cell Biol. 83 (2004) 19-26
8. Karolchik D., Baertsch R., Diekhans M., Furey T.S., Hinrichs A., Lu Y.T., Roskin K.M., Schwartz M., Sugnet C.W., Thomas D.J., Weber R.J., Haussler D., and Kent W.J. The UCSC genome browser database. Nucleic Acids Res. 31 (2003) 51-54
9. Koster M.I., Kim S., Huang J., Williams T., and Roop D.R. TAp63alpha induces AP-2gamma as an early event in epidermal morphogenesis. Dev. Biol. 289 (2006) 253-261
10. Kurpakus M.A., Maniaci M.T., and Esco M. Expression of keratins K12, K4 and K14 during development of ocular surface epithelium. Curr. Eye Res. 13 (1994) 805-814
11. Lane E.B., Rugg E.L., Navsaria H., Leigh I.M., Heagerty A.H., Ishida-Yamamoto A., and Eady R.A. A mutation in the conserved helix termination peptide of keratin 5 in hereditary skin blistering. Nature 356 (1992) 244-246
12. Lindblad-Toh K. Genome sequencing: three's company. Nature 428 (2004) 475-476
13. Liu C.Y., Zhu G., Westerhausen-Larson A., Converse R., Kao C.W., Sun T.T., and Kao W.W. Cornea-specific expression of K12 keratin during mouse development. Curr. Eye Res. 12 (1993) 963-974
14. Liu C.Y., Zhu G., Converse R., Kao C.W., Nakamura H., Tseng S.C., Mui M.M., Seyer J., Justice M.J., Stech M.E., Hansen G.M., and Kao W.W. Characterization and chromosomal localization of the cornea-specific murine keratin gene Krt1.12. J. Biol. Chem. 269 (1994) 24627-24636
15. Lloyd C., Yu Q.C., Cheng J., Turksen K., Degenstein L., Hutton E., and Fuchs E. The basal keratin network of stratified squamous epithelia: defining K15 function in the absence of K14. J. Cell Biol. 129 (1995) 1329-1344
16. Lu L., Reinach P.S., and Kao W.W. Corneal epithelial wound healing. Exp. Biol. Med. (Maywood) 226 (2001) 653-664
17. Lu H., Hesse M., Peters B., and Magin T.M. Type II keratins precede type I keratins during early embryonic development. Eur. J. Cell Biol. 84 (2005) 709-718
18. Magin T.M., Schroder R., Leitgeb S., Wanninger F., Zatloukal K., Grund C., and Melton D.W. Lessons from keratin 18 knockout mice: formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver-specific keratin 8-positive aggregates. J. Cell Biol. 140 (1998) 1441-1451
19. Magin T.M., Reichelt J., and Hatzfeld M. Emerging functions: diseases and animal models reshape our view of the cytoskeleton. Exp. Cell Res. 301 (2004) 91-102
20. Murphy, W.J., Stanyon, R., O'Brien, S.J., 2001. Evolution of mammalian genome organization inferred from comparative gene mapping. Genome Biol. 2, REVIEWS0005.
21. O'Guin W.M., Galvin S., Schermer A., and Sun T.T. Patterns of keratin expression define distinct pathways of epithelial development and differentiation. Curr. Top. Dev. Biol. 22 (1987) 97-125
22. Paladini R.D., and Coulombe P.A. The functional diversity of epidermal keratins revealed by the partial rescue of the keratin 14 null phenotype by keratin 16. J. Cell Biol. 146 (1999) 1185-1201
23. Perng M.D., Sandilands A., Kuszak J., Dahm R., Wegener A., Prescott A.R., and Quinlan R.A. The intermediate filament systems in the eye lens. Methods Cell Biol. 78 (2004) 597-624
24. Peters B., Kirfel J., Bussow H., Vidal M., and Magin T.M. Complete cytolysis and neonatal lethality in keratin 5 knockout mice reveal its fundamental role in skin integrity and in epidermolysis bullosa simplex. Mol. Biol. Cell 12 (2001) 1775-1789
25. Quinlan R.A., Schiller D.L., Hatzfeld M., Achtstatter T., Moll R., Jorcano J.L., Magin T.M., and Franke W.W. Patterns of expression and organization of cytokeratin intermediate filaments. Ann. NY Acad. Sci. 455 (1985) 282-306
26. Reichelt J., Bussow H., Grund C., and Magin T.M. Formation of a normal epidermis supported by increased stability of keratins 5 and 14 in keratin 10 null mice. Mol. Biol. Cell 12 (2001) 1557-1568
27. Schermer A., Galvin S., and Sun T.T. Differentiation-related expression of a major 64 K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells. J. Cell Biol. 103 (1986) 49-62
28. Schwartz S., Kent W.J., Smit A., Zhang Z., Baertsch R., Hardison R.C., Haussler D., and Miller W. Human-mouse alignments with BLASTZ. Genome Res. 13 (2003) 103-107
29. Sevel D., and Isaacs R. A re-evaluation of corneal development. Trans. Am. Ophthalmol. Soc. 86 (1988) 178-207
30. Sun T.T., Eichner R., Nelson W.G., Tseng S.C., Weiss R.A., Jarvinen M., and Woodcock-Mitchell J. Keratin classes: molecular markers for different types of epithelial differentiation. J. Invest. Dermatol. 81 (1983) 109s-115s
31. Swensson O., Langbein L., McMillan J.R., Stevens H.P., Leigh I.M., McLean W.H., Lane E.B., and Eady R.A. Specialized keratin expression pattern in human ridged skin as an adaptation to high physical stress. Br. J. Dermatol. 139 (1998) 767-775
32. Talbot D., Loring J., and Schorle H. Spatiotemporal expression pattern of keratins in skin of AP-2alpha-deficient mice. J. Invest. Dermatol. 113 (1999) 816-820
33. Tong X., and Coulombe P.A. A novel mouse type I intermediate filament gene, keratin 17n (K17n), exhibits preferred expression in nail tissue. J. Invest. Dermatol. 122 (2004) 965-970
34. Vassar R., Coulombe P.A., Degenstein L., Albers K., and Fuchs E. Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease. Cell 64 (1991) 365-380
35. Waterston R.H., Lindblad-Toh K., Birney E., Rogers J., Abril J.F., Agarwal P., Agarwala R., Ainscough R., Alexandersson M., An P., Antonarakis S.E., Attwood J., Baertsch R., Bailey J., Barlow K., Beck S., Berry E., Birren B., Bloom T., Bork P., Botcherby M., Bray N., Brent M.R., Brown D.G., Brown S.D., Bult C., Burton J., Butler J., Campbell R.D., Carninci P., Cawley S., Chiaromonte F., Chinwalla A.T., Church D.M., Clamp M., Clee C., Collins F.S., Cook L.L., Copley R.R., Coulson A., Couronne O., Cuff J., Curwen V., Cutts T., Daly M., David R., Davies J., Delehaunty K.D., Deri J., Dermitzakis E.T., Dewey C., Dickens N.J., Diekhans M., Dodge S., Dubchak I., Dunn D.M., Eddy S.R., Elnitski L., Emes R.D., Eswara P., Eyras E., Felsenfeld A., Fewell G.A., Flicek P., Foley K., Frankel W.N., Fulton L.A., Fulton R.S., Furey T.S., Gage D., Gibbs R.A., Glusman G., Gnerre S., Goldman N., Goodstadt L., Grafham D., Graves T.A., Green E.D., Gregory S., Guigo R., Guyer M., Hardison R.C., Haussler D., Hayashizaki Y., Hillier L.W., Hinrichs A., Hlavina W., Holzer T., Hsu F., Hua A., Hubbard T., Hunt A., Jackson I., Jaffe D.B., Johnson L.S., Jones M., Jones T.A., Joy A., Kamal M., Karlsson E.K., et al. Initial sequencing and comparative analysis of the mouse genome. Nature 420 (2002) 520-562
36. Wolosin J.M., Budak M.T., and Akinci M.A. Ocular surface epithelial and stem cell development. Int. J. Dev. Biol. 48 (2004) 981-991
37. Wong P., and Coulombe P.A. Loss of keratin 6 (K6) proteins reveals a function for intermediate filaments during wound repair. J. Cell Biol. 163 (2003) 327-337
38. Wu R.L., Chen T.T., and Sun T.T. Functional importance of an Sp1- and an NFκB-related nuclear protein in a keratinocyte-specific promoter of rabbit K3 keratin gene. J. Biol. Chem. 269 (1994) 28450-28459
39. Yamada S., Wirtz D., and Coulombe P.A. Pairwise assembly determines the intrinsic potential for self-organization and mechanical properties of keratin filaments. Mol. Biol. Cell 13 (2002) 382-391
40. Zhang H., Hara M., Seki K., Fukuda K., and Nishida T. Eyelid fusion and epithelial differentiation at the ocular surface during mouse embryonic development. Jpn. J. Ophthalmol. 49 (2005) 195-204
41. Zieske J.D. Corneal development associated with eyelid opening. Int. J. Dev. Biol. 48 (2004) 903-911