2,4-Diaminothienopyrimidines as orally active antimalarial agents

Journal of Medicinal Chemistry

Volumn 57, Issue 3, 2014, Pages 1014-1022

  González Cabrera, Diego ^a   Le Manach, Claire ^a   Douelle, Frederic ^a   Younis, Yassir ^a   Feng, Tzu Shean ^a   Paquet, Tanya ^a   Nchinda, Aloysius T ^a   Street, Leslie J ^a   Taylor, Dale ^a   De Kock, Carmen ^a   Wiesner, Lubbe ^a   Duffy, Sandra ^b   White, Karen L ^c   Zabiulla, K Mohammed ^d   Sambandan, Yuvaraj ^d   Bashyam, Sridevi ^d   Waterson, David ^e   Witty, Michael J ^e   Charman, Susan A ^c   Avery, Vicky M ^b   Wittlin, Sergio ^f,g   Chibale, Kelly ^a   more..

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b GRIFFITH UNIVERSITY   (Australia)

^c MONASH UNIVERSITY   (Australia)

^d SYNGENE INTERNATIONAL LTD   (India)

^e International Center Cointrin   (Switzerland)

^f SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^g UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADMINISTRATION, ORAL; ANIMALS; ANTIMALARIALS; CELL LINE; DATABASES, CHEMICAL; DRUG RESISTANCE, MULTIPLE; ETHER-A-GO-GO POTASSIUM CHANNELS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MALARIA; MALE; MICE; MICROSOMES, LIVER; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 84894100174     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401760c     Document Type: Article

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