Effect of intersubject variability of extrathoracic morphometry, lung airways dimensions and respiratory parameters on particle deposition

Journal of Thoracic Disease

Volumn 3, Issue 3, 2011, Pages 156-170

  Hussain, Majid ^a,b   Renate, Winker Heil ^a   Werner, Hofmann ^a  

^a UNIVERSITY OF SALZBURG   (Austria)

^b Higher Education Commission of Pakistan   (Pakistan)

Author keywords

Extrathoracic geometry; Intersubject variability; Lung airways; Lung deposition modeling

Indexed keywords

EID: 84861994693     PISSN: 20721439     EISSN: 20776624     Source Type: Journal    
DOI: 10.3978/j.issn.2072-1439.2011.04.03     Document Type: Article

References (43)

1. Sarangapani R, Wexler AS. Modelling particle deposition in extrathoracic airways. J Aerosol Sci Technol 2000;32:72-89.
2. Martonen TB, Zhang Z, Yue G, Musante CJ. Fine particle deposition within human nasal airways. Inhal Toxicol 2003;15:283-303.
3. Sosnowski TR, Moskal A, Gradon L. Dynamics of oropharyngeal aerosol transport and deposition with the realistic flow pattern. Inhal Toxicol 2006;18:773-80.
4. Sosnowski TR, Moskal A, Gradon, L. Mechanism of aerosol particle deposition in the oro-pharynx under non-steady airflow. Ann Occup Hyg 2007;51:19-25.
5. Wang SM, Inthavong K, Wen J, Tu JY, Xue CL. Comparison of micron and nanoparticle deposition patterns in a realistic human nasal cavity. Respir Physiol & Neur 2009;166:142-51.
6. International Commission on Radiological Protection (ICRP). Human respiratory tract model for radiological protection. Publication 66. Oxford: Elsevier Science; 1994.
7. Rasmussen TR, Swift DL, Hilberg O, Pedersen OF. Influence of nasal passage geometry on aerosol particle deposition in the nose. J Aerosol Med 1990;3:15-25.
8. Swift DL. Inspiratory inertial deposition of aerosols in human nasal airway replicate casts: implication for the proposed NCRP lung model. Rad Protec Dosimet 1991;38:29-34.
9. Zhang L, Yu CP. Empirical equations for nasal deposition of inhaled particles in small laboratory animals and humans. Aerosol Sci Technol 1993;19:51-6.
10. Cheng YS. Aerosol deposition in the extrathoracic region. Aerosol Sci Technol 2003;37:659-71.
11. Grgic B, Finlay WH, Burnell PKP, Heenan AF. In vitro intersubject and intrasubject deposition measurement in realistic mouth-throat gemetires. J Aerosol Sci 2004;35:1025-40.
12. Garcia GJM, Tewksbury EW, Wong BA, Kimbell JS. Interindividual Variability in Nasal Filtration as a Function of Nasal Cavity Geometry. J Aerosol Med & Pul Drug Deliv 2009;22:139-56.
13. Hofmann W, Bergmann R, Ménache MG. The effect of intersubject variability in airway morphology on intersubject variations in particle deposition. J Aerosol Sci 1998;29:s943-4.
14. Hofmann W, Asgharian B, Winkler-Heil R. Modeling intersubject variability of particle deposition in human lungs. J Aerosol Sci 2002;33:219-35.
15. Hofmann W, Morawska L, Bergmann R. Environmental tobacco smoke deposition in the human respiratory tract: Differences between experimental and theoretical approaches. J Aerosol Med 2001;14:317-26.
16. Hofmann W, Morawska L, Winkler-Heil R, Moustafa M. Deposition of combustion aerosols in the human respiratory tract: Comparison of theoretical predictions with experimental data considering nonspherical shape. Inhal Toxicol 2009;21:1154-64.
17. Cheng KH, Cheng YS, Yeh HS, Raymond A, Guilmette, Steven Q, et al. In vivo measurement of nasal airway dimension and ultrafine aerosol deposition in the human nasal and oral airways. J Aerosol Sci 1996;5:85- 801.
18. Effmann EL, Fram, Evan K, Peter VK, Donald R. Tracheal cross-sectional area in children. Radiology 1983;149:137-40.
19. Hofmann W, Koblinger L. Monte Carlo modeling of aerosol deposition in human lungs. Part II: Deposition fractions and their parameter variations. J Aerosol Sci 1990;21:675-88.
20. Koblinger L, Hofmann W. Monte Carlo modeling of aerosol deposition in human lungs: Part I: Simulation of particle transport in a stochastic lung structure. J Aerosol Sci 1990;21:661-74.
21. Hofmann W, Begmann W, Koblinger L. Characterization of local particle deposition pattern in human and rate lungs by different morphometric parameters. J Aerosol Sci 1999;30:651-67.
22. Hofmann W, Sturm R, Fleming JS, Conway JH, Bolt L. Simulation of threedimensional particle deposition patterns in human lungs and comparison with experimental SPECT data. J Aerosol Sci 2005;39:771-81.
23. Hofmann W, Winkler-Heil R, Balásházy I. The effect of morphological variability on surface deposition densities of inhaled particles in human bronchial and acinar airways. Inhal Toxicol 2006;18:809-19.
24. Raabe OG, Yeh HC, Schum GM, Phalen R. Tracheobronchial Geometry: Human, Dog, Rat, Hamster. Lovelace Foundation Report LF-53. Albuquerque, NM: Lovelace Foundation; 1976.
25. Haefeli-Bleuer B, Weibel ER. Morphometry of the human pulmonary acinus. Anat Rec 1988;220:401-14.
26. Ingham DB. Diffusion of aerosol in the entrance region of a smooth symmetrical pipe. J Aerosol Sci 1991;22:253-7.
27. Cohen BS, Asgharian B. Deposition of ultrafine particles in upper airways. J Aerosol Sci 1990;21:789-97.
28. Yeh HC, Schum GM. Models of human lung airways and their application to inhaled particle deposition. Bull Math Biophys 1980;42:461-80.
29. Zhang L, Asgharian B, Anjilvel S. Inertial deposition of particles in the human upper airway bifurcations. J. Aerosol Sci Technol 1997;26:97-110.
30. Asgharian B, Owen T, Price OT. Deposition of ultrafine (NANO) particles in the human lung. Inhal Toxicol 2007;19:1045-54.
31. National Council on Radiation Protection and Measurements (NCRP). Deposition, retention, and dosimetry of inhaled radioactive substances. Bethesda, MD;1997.
32. Borgström L, Olsson B, Thorsson L. Degree of throat deposition can explain the variability in lung deposition of inhaled drugs. J Aerosol Med 2006;19:473-83.
33. Kim CS, Hu SC, Dewitt P, Gerrity TR. Assessment of regional deposition of inhaled particles in human lungs by serial bolus delivery method. J Appl Physiol 1996;81:2203-13.
34. Kim CS, Hu S. Regional deposition of inhaled particles in human lungs: Comparison between men and women. J Appl Physiol 1998;84:1834-44.
35. Kim CS, Jaques PA. Analysis of total respiratory deposition of inhaled ultrafine particles in adult subjects at various breathing patterns. J Aerosol Sci Technol 2004;38:525-40.
36. Kim CS, Jaques PA. Total lung deposition of ultrafine particles in elderly subjects during controlled breathing. Inhal Toxicol 2005;17:387-99.
37. Kim CS, Hu SC. Total respiratory tract deposition of fine micrometer-sized particles in healthy adults: empirical equations for gender and breathing pattern. J Appl Physiol 2006;101:401-12.
38. Swift DL, Montassier N, Hopke PK, Karpen-Hayes K, Cheng YS, Su YF, et al. Inspiratory deposition of ultrafine particles in human nasal replicate casts. J Aerosol Sci 1992;23:65-72.
39. Rudolf G, Gebhart J, Heyder J, Schiller CF, Stahlhofen W. An empirical formula describing aerosol deposition in man for any particle size. J Aerosol Sci 1986;17:350-5.
40. Stahlhofen W, Rudolf G, James AC. Intercomparison of experimental regional aerosol deposition data. J Aerosol Med 1989;2:285-308.
41. Cheng YS, Yamada Y, Yeh HC. Deposition of ultrafine aerosols in a human oral cast. Aerosol Sci Technol 1990;12:1075-81.
42. Yeh HC, Cuddihy RG, Phalen RF, Chang IY. Comparisons of calculated respiratory tract deposition of particles based on the proposed NCRP model and ICRP 66 model. Aerosol Sci Technol 1996;25:134-40.
43. Yu CP, Diu CK, Soong TT. Statistical analysis of aerosol deposition in nose and mouth. Am Ind Hyg Assoc J 1981;42:726-33.