Carvacrol prevents methotrexateinduced renal oxidative injury and renal damage in rats

Clinical and Investigative Medicine

Volumn 37, Issue 1, 2014, Pages

  Bozkurt, Mehtap ^a   Em, Serda ^a   Oktayoglu, Pelin ^a   Turkcu, Gul ^a   Yuksel, Hatice ^a   Sariyildiz, Mustafa A ^a   Caglayan, Mehmet ^a   Batmaz, Ibrahim ^a   Nas, Kemal ^a   Bozkurt, Yasar ^a   Kuyumcu, Mahir ^b  

^a DICLE UNIVERSITY   (Turkey)

^b Diyarbakir Education and Research Hospital ^*  (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CARVACROL; FOLIC ACID ANTAGONIST; MALONALDEHYDE; METHOTREXATE; TERPENE;

ANIMAL; ARTICLE; DRUG EFFECT; KIDNEY; MALE; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; RAT; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; FOLIC ACID ANTAGONISTS; KIDNEY; MALE; MALONDIALDEHYDE; METHOTREXATE; MONOTERPENES; OXIDATIVE STRESS; RATS; RATS, WISTAR;

EID: 84894078752     PISSN: 0147958X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Tian H, Cronstein BN. Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis. Bulletin of the NYU hospital for joint diseases. 2007;65(3):168-73.
2. Widemann BC, Adamson PC. Understanding and managing methotrexate nephrotoxicity. The oncologist. 2006;ll(6):694-703.
3. Widemann BC, Balis FM, Kempf-Bielack B, Bielack S, Pratt CB, Ferrari S, et al. High-dose methotrexate-induced nephrotoxicity in patients with osteosarcoma. Cancer. 2004;100(10):2222-32.
4. Braun J, Rau R. An update on methotrexate. Current opinion in rheumatology. 2009;21(3):216-23.
5. Yarris JP, Hunter AJ. Roy Hertz, M.D. (1909-2002): the cure of choriocarcinoma and its impact on the development of chemotherapy for cancer. Gynecologic oncology. 2003;89(2):193-8.
6. Hempel L, Misselwitz J, Fleck C, Kentouche K, Leder C, Appenroth D, et al. Influence of high-dose methotrexate therapy (HD-MTX) on glomerular and tubular kidney function. Medical and pediatric oncology. 2003;40(6):348-54.
7. Izzedine H, Launay-Vacher V, Karie S, Caramella C, de Person F, Deray G. Is low-dose methotrexate nephrotoxic ? Case report and review of the literature. Clinical nephrology. 2005;64(4):315-9.
8. Kintzel PE. Anticancer drug-induced kidney disorders. Drug safety: an international journal of medical toxicology and drug experience. 2001;24(l):19-38.
9. Devrim E, Cetin R, Kilicoglu B, Erguder BI, Avci A, Durak I. Methotrexate causes oxidative stress in rat kidney tissues. Renal failure. 2005;27(6):771-3.
10. Oktem F, Yilmaz HR, Ozguner F, Olgar S, Ayata A, Uzare E, et al. Methotrexate-induced renal oxidative stress in rats: the role of a novel antioxidant caffeic acid phenethyl ester. Toxicology and industrial health. 2006;22(6):241-7.
11. Miyazono Y, Gao F, Horie T. Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats. Scandinavian journal of gastroenterology. 2004;39(11): 1119-27.
12. Jahovic N, Cevik H, Sehirli AO, Yegen BC, Sener G. Melatonin prevents methotrexate-induced hepatorenal oxidative injury in rats. Journal of pineal research. 2003;34(4):282-7.
13. Kolli VK, Abraham P, Isaac B, Selvakumar D. Neutrophil infiltration and oxidative stress may play a critical role in methotrexate-induced renal damage. Chemotherapy. 2009;55(2):83-90.
14. Tumen G, Kirimer N, Ermin N, Baser KH. The essential oil of Satureja cuneifolia. Planta medica. 1998;64(l):81-3.
15. Hajhashemi V, Ghannadi A, Pezeshkian SK. Antinociceptive and anti-inflammatory effects of Satureja hortensis L. extracts and essential oil. Journal of ethnopharmacology. 2002;82(2-3):83-7.
16. Baser KH. Biological and pharmacological activities of carvacrol and carvacrol bearing essential oils. Current pharmaceutical design. 2008;14(29):3106-19.
17. Sokmen M, Serkedjieva J, Daferera D, Gulluce M, Polissiou M, Tepe B, et al. In vitro antioxidant, antimicrobial, and antiviral activities of the essential oil and various extracts from herbal parts and callus cultures of Origanum acutidens. Journal of agricultural and food chemistry. 2004;52(l l):3309-12.
18. Karkabounas S, Kostoula OK, Daskalou T, Veltsistas P, Karamouzis M, Zelovitis I, et al. Anticarcinogenic and antiplatelet effects of carvacrol. Experimental oncology. 2006;28(2):121-5.
19. Beena, Kumar D, Rawat DS. Synthesis and antioxidant activity of thymol and carvacrol based Schiff bases. Bioorganic & medicinal chemistry letters. 2013;23(3):641-5.
20. Chericoni S, Prieto JM, Iacopini P, Cioni P, Morelli I. In vitro activity of the essential oil of Cinnamomum zeylanicum and eugenol in peroxynitrite-induced oxidative processes. Journal of agricultural and food chemistry. 2005;53(12):4762-5.
21. Mezzoug N, Elhadri A, Dallouh A, Amkiss S, Skali NS, Abrini J, et al. Investigation of the mutagenic and antimutagenic effects of Origanum compactum essential oil and some of its constituents. Mutation research. 2007;629(2):100-10.
22. Canbek M, Uyanoglu M, Bayramoglu G, Senturk H, Erkasap N, Koken T, et al. Effects of carvacrol on defects of ischemia-reperfusion in the rat liver. Phytomedicine: international journal of phytotherapy and phytopharmacology. 2008;15(6-7):447-52.
23. Aristatile B, Al-Numair KS, Veeramani C, Pugalendi KV. Effect of carvacrol on hepatic marker enzymes and antioxidant status in D-galactosamine-induced hepatotoxicity in rats. Fundamental & clinical pharmacology. 2009;23(6):757-65.
24. Gil HW, Seok SJ, Jeong DS, Yang JO, Lee EY, Hong SY. Plasma level of malondialdehyde in the cases of acute paraquat intoxication. Clinical toxicology. 2010;48(2):149-52.
25. Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clinical biochemistry. 2004;37(2):l 12-9.
26. Erel O. A new automated colorimetric method for measuring total oxidant status. Clinical biochemistry. 2005;38(12):1103-ll.
27. Bolukbas C, Bolukbas FF, Horoz M, Asian M, Celik H, Erel O. Increased oxidative stress associated with the severity of the liver disease in various forms of hepatitis B virus infection. BMC infectious diseases. 2005;5:95.
28. Bozkurt Y, Bozkurt M, Turkcu G, Sancaktutar AA, Soylemez H, Penbegul N, et al. Caffeic acid phenethyl ester protects kidneys against acetylsalicylic acid toxicity in rats. Renal failure. 2012;34(9):1150-5.
29. Uzar E, Koyuncuoglu HR, Uz E, Yilmaz HR, Kutluhan S, Kilbas S, et al. The activities of antioxidant enzymes and the level of malondialdehyde in cerebellum of rats subjected to methotrexate: protective effect of caffeic acid phenethyl ester. Molecular and cellular biochemistry. 2006;291(l-2):63-8.
30. Garcia-Garcia R, Lopez-Malo A, Palou E. Bactericidal action of binary and ternary mixtures of carvacrol, thymol, and eugenol against Listeria innocua. Journal of food science. 2011;76(2):M95-100.
31. Ahmad A, Khan A, Akhtar F, Yousuf S, Xess I, Khan LA, et al. Fungicidal activity of thymol and carvacrol by disrupting ergosterol biosynthesis and membrane integrity against Candida. European journal of clinical microbiology & infectious diseases: official publication of the European Society of Clinical Microbiology. 201 l;30(l):41-50.
32. Tang X, Chen S, Wang L. Purification and identification of carvacrol from the root of Stellera chamaejasme and research on its insecticidal activity. Natural product research. 2011;25(3):320-5.
33. Jayakumar S, Madankumar A, Asokkumar S, Raghunandhakumar S, Gokula dhas K, Kamaraj S, et al. Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats. Molecular and cellular biochemistry. 2012;360(l-2):51-60.
34. Arunasree KM. Anti-proliferative effects of carvacrol on a human metastatic breast cancer cell line, MDA-MB 231. Phytomedicine: international journal of phytotherapy and phytopharmacology. 2010;17(8-9):581-8.
35. Sikka SC. Oxidative stress and role of antioxidants in normal and abnormal sperm function. Frontiers in bioscience: a journal and virtual library. 1996; 1:e78-86.
36. Jahovic N, Sener G, Cevik H, Ersoy Y, Arbak S, Yegen BC. Amelioration of methotrexate-induced enteritis by melatonin in rats. Cell biochemistry and function. 2004;22(3):169-78.