Quantification of conjunctival TNF-α in aqueous-deficient dry eye

Optometry and Vision Science

Volumn 91, Issue 2, 2014, Pages 156-162

  Caffery, Barbara E ^a   Joyce, Elizabeth ^a   Heynen, Miriam L ^a   Ritter, Robert ^b   Jones, Lyndon A ^a   Senchyna, Michelle ^b  

^a UNIVERSITY OF WATERLOO   (Canada)

^b ALCON RESEARCH LTD   (United States)

Author keywords

Dry eye; Osmolarity

Indexed keywords

MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; COMPARATIVE STUDY; CONJUNCTIVA; EPITHELIUM CELL; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; KERATOCONJUNCTIVITIS SICCA; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SJOEGREN SYNDROME;

ADULT; CONJUNCTIVA; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; KERATOCONJUNCTIVITIS SICCA; MALE; MIDDLE AGED; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SJOGREN'S SYNDROME; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84894070933     PISSN: 10405488     EISSN: 15389235     Source Type: Journal    
DOI: 10.1097/OPX.0000000000000133     Document Type: Article

References (40)

1. Lemp M, Baudouin C, Baum J, Dogru M, Foulks GN, Kinoshita S, Laibson P,McCulley J,Murube J, Pfugfelder SC, RolandoM, Toda I. The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 2007;5: 75-92.
2. Vitali C,Bombardieri S, JonssonR,MoutsopoulosHM,AlexanderEL, Carsons SE, Daniels TE, Fox PC, Fox RI, Kassan SS, Pillemer SR, Talal N, Weisman MH. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002;61: 554-8.
3. Williamson J, Gibson AA, Wilson T, Forrester JV, Whaley K, Dick WC. Histology of the lacrimal gland in keratoconjunctivitis sicca. Br J Ophthalmol 1973;57: 852-8.
4. Konttinen YT, Sorsa T, Hukkanen M, Segerberg M, Kuhlefelt- Sundstrom M, Malmstrom M, Polak JM. Topology of innervation of labial salivary glands by protein gene product 9.5 and synaptophysin immunoreactive nerves in patients with Sjögren's syndrome. J Rheumatol 1992;19: 30-7.
5. Walcott B, Claros N, Patel A, Brink PR. Age-related decrease in innervation density of the lacrimal gland in mouse models of Sjögren's syndrome. Adv Exp Med Biol 1998;438: 917-23.
6. Andoh Y, Shimura S, Sawai T, Sasaki H, Takishima T, Shirato K. Morphometric analysis of airways in Sjögren's syndrome. Am Rev Respir Dis 1993;148: 1358-62.
7. Damato BE, Allan D, Murray SB, Lee WR. Senile atrophy of the human lacrimal gland: the contribution of chronic inflammatory disease. Br J Ophthalmol 1984;68: 674-80.
8. Chisholm DM, Mason DK. Labial salivary gland biopsy in Sjögren's disease. J Clin Pathol 1968;21: 656-60.
9. Solomon A, Dursun D, Liu Z, Xie Y, Macri A, Pflugfelder SC. Proand anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease. Invest Ophthalmol Vis Sci 2001;42: 2283-92.
10. Tishler M, Yaron I, Geyer O, Shirazi I, Naftaliev E, Yaron M. Elevated tear interleukin-6 levels in patients with Sjögren's syndrome. Ophthalmology 1998;105: 2327-9.
11. Yoon KC, Jeong IY, Park YG, Yang SY. Interleukin-6 and tumor necrosis factor-alpha levels in tears of patients with dry eye syndrome. Cornea 2007;26: 431-7.
12. Ohashi Y, Dogru M, Tsubota K. Laboratory findings in tear fluid analysis. Clin Chim Acta 2006;369: 17-28.
13. Yafawi R, Ko M, Sace FP, John-Baptiste A. Limitations of an ocular surface inflammatory biomarker in impression cytology specimens. Cutan Ocul Toxicol 2013;32: 46-53.
14. Epstein SP, Gadaria-Rathod N, Wei Y, Maguire MG, Asbell PA. HLA-DR expression as a biomarker of inflammation for multicenter clinical trials of ocular surface disease. Exp Eye Res 2013;111: 95-104.
15. Jones DT, Monroy D, Ji Z, Atherton SS, Pflugfelder SC. Sjögren's syndrome: cytokine and Epstein-Barr viral gene expression within the conjunctival epithelium. Invest Ophthalmol Vis Sci 1994;35: 3493-504.
16. Brignole F, Pisella PJ, Goldchild M, De Saint Jean M, Goguel A, Baudouin C. Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyes. Invest Ophthalmol Vis Sci 2000;41: 1356-63.
17. Baudouin C, Brignole F, Pisella PJ, De Jean MS, Goguel A. Flow cytometric analysis of the inflammatory marker HLA DR in dry eye syndrome: results from 12 months of randomized treatment with topical cyclosporin A. Adv Exp Med Biol 2002;506: 761-9.
18. Stern ME, Gao J, Schwalb TA, Ngo M, Tieu DD, Chan CC, Reis BL, Whitcup SM, Thompson D, Smith JA. Conjunctival T-cell subpopulations in Sjögren's and non-Sjögren's patients with dry eye. Invest Ophthalmol Vis Sci 2002;43: 2609-14.
19. Pisella PJ, Brignole F, Debbasch C, Lozato PA, Creuzot-Garcher C, Bara J, Saiag P, Warnet JM, Baudouin C. Flow cytometric analysis of conjunctival epithelium in ocular rosacea and keratoconjunctivitis sicca. Ophthalmology 2000;107: 1841-9.
20. Rolando M, Barabino S, Mingari C, Moretti S, Giuffrida S, Calabria G. Distribution of conjunctival HLA-DR expression and the pathogenesis of damage in early dry eyes. Cornea 2005;24: 951-4.
21. Jones DT, Monroy D, Ji Z, Pflugfelder SC. Alterations of ocular surface gene expression in Sjögren's syndrome. Adv Exp Med Biol 1998;438: 533-6.
22. Pflugfelder SC, Jones D, Ji Z, Afonso A, Monroy D. Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjögren's syndrome keratoconjunctivitis sicca. Curr Eye Res 1999;19: 201-11.
23. Baudouin C, Becquet F, Saint-Jean M, Kantelip B, Deschamps F. Ocular surface defense mechanisms. In: Hoang-Xuan T, Baudouin C, Creuzot-Garcher C, eds. Inflammatory Diseases of the Conjunctiva. Stuttgart, Germany: Georg Thieme Verlag; 2001: 27-50.
24. Khera TK, Dick AD, Nicholson LB. Mechanisms of TNFalpha regulation in uveitis: focus on RNA-binding proteins. Prog Retin Eye Res 2010;29: 610-21.
25. Qidwai T, Khan F. Tumour necrosis factor gene polymorphism and disease prevalence. Scand J Immunol 2011;74: 522-47.
26. Liedtke C, Trautwein C. The role of TNF and Fas dependent signaling in animal models of inflammatory liver injury and liver cancer. Eur J Cell Biol 2012;91: 582-9.
27. Roescher N, Tak PP, Illei GG. Cytokines in Sjögren's syndrome: potential therapeutic targets. Ann Rheum Dis 2010;69: 945-8.
28. Bowman SJ. Biologic therapies in primary Sjögren's syndrome. Curr Pharm Biotechnol 2012;13: 1997-2008.
29. LaFrance MW, Kehinde LE, Fullard RJ. Multiple cytokine analysis in human tears: an optimized procedure for cytometric bead-based assay. Curr Eye Res 2008;33: 525-44.
30. Li S, Sack R, Vijmasi T, Sathe S, Beaton A, Quigley D, Gallup M, McNamara NA. Antibody protein array analysis of the tear film cytokines. Optom Vis Sci 2008;85: 653-60.
31. Behrens A, Doyle JJ, Stern L, Chuck RS, McDonnell PJ, Azar DT, Dua HS, Hom M, Karpecki PM, Laibson PR, Lemp MA, Meisler DM, Del Castillo JM, O'Brien TP, Pflugfelder SC, Rolando M, Schein OD, Seitz B, Tseng SC, van Setten G, Wilson SE, Yiu SC. Dysfunctional tear syndrome: a Delphi approach to treatment recommendations. Cornea 2006;25: 900-7.
32. Caffery B, Heynen M, Joyce E, Jones L, Ritter R, 3rd, Senchyna M. MUC1 expression in Sjögren's syndrome, KCS, and control subjects. Mol Vis 2010;16: 1720-7.
33. Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. 4th ed. New York, NY: Garland Science; 2002: 831-906.
34. Schaumberg DA, Nichols JJ, Papas EB, Tong L, Uchino M, Nichols KK. The InternationalWorkshop onMeibomian GlandDysfunction: report of the subcommittee on the epidemiology of, and associated risk factors for, MGD. Invest Ophthalmol Vis Sci 2011;52: 1994-2005.
35. Niederkorn J, Stern M, Pflugfelder S, de Paiva C, Corrales R, Gao J, et al. Desiccating stress induces T cellYmediated Sjögren's syndromeYlike lacrimal keratoconjunctivitus. J Immunol 2006;176: 3950-7.
36. Nichols KK, Nichols JJ, Lynn Mitchell G. The relation between tear film tests in patients with dry eye disease. Ophthalmic Physiol Opt 2003;23: 553-60.
37. Caffery B, Joyce E, Heynen ML, Jones L, Ritter R, 3rd, Gamache DA, Senchyna M. MUC16 expression in Sjögren's syndrome, KCS, and control subjects. Mol Vis 2008;14: 2547-55.
38. Mathers WD, Lane JA, Zimmerman MB. Tear film changes associated with normal aging. Cornea 1996;15: 229-34.
39. Patel S, Farrell JC. Age-related changes in precorneal tear film stability. Optom Vis Sci 1989;66: 175-8.
40. Pillemer SR,Matteson EL, Jacobsson LT,Martens PB,Melton LJ, 3rd, O'Fallon WM, Fox PC. Incidence of physician-diagnosed primary Sjögren's syndrome in residents ofOlmsted County,Minnesota.Mayo Clinic Proc 2001;76: 593-9.