Conjunctival flora antibiotic resistance patterns after serial intravitreal injections without postinjection topical antibiotics

American Journal of Ophthalmology

Volumn 157, Issue 3, 2014, Pages

  Hsu, Jason ^a   Gerstenblith, Adam T ^a   Garg, Sunir J ^a   Vander, James F ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; POVIDONE IODINE; QUINOLONE DERIVATIVE; VASCULOTROPIN;

ADULT; AGED; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL FLORA; BACTERIAL GROWTH; BACTERIUM CULTURE; BACTERIUM ISOLATION; CLINICAL ARTICLE; CLINICAL PRACTICE; CLINICAL TRIAL; COAGULASE NEGATIVE STAPHYLOCOCCUS; CONJUNCTIVAL FLORA; CONTROLLED STUDY; FEMALE; HUMAN; MALE; MIDDLE AGED; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETINA MACULA AGE RELATED DEGENERATION; RETINA MACULA EDEMA; RETINA VEIN OCCLUSION; TOPICAL ANESTHESIA; VERY ELDERLY; YOUNG ADULT;

ADMINISTRATION, TOPICAL; ADULT; AGED; AGED, 80 AND OVER; ANGIOGENESIS INHIBITORS; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS, LOCAL; ANTIBIOTIC PROPHYLAXIS; BACTERIA; CONJUNCTIVA; DRUG RESISTANCE, BACTERIAL; ENDOPHTHALMITIS; FEMALE; HUMANS; INTRAVITREAL INJECTIONS; MACULAR EDEMA; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; POVIDONE-IODINE; PROSPECTIVE STUDIES; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WET MACULAR DEGENERATION;

EID: 84894028841     PISSN: 00029394     EISSN: 18791891     Source Type: Journal    
DOI: 10.1016/j.ajo.2013.10.003     Document Type: Article

References (28)

1. R.J. Campbell, S.E. Bronskill, C.M. Bell, J.M. Paterson, M. Whitehead, and S.S. Gill Rapid expansion of intravitreal drug injection procedures, 2000 to 2008: a population-based analysis Arch Ophthalmol 128 3 2010 359 362
2. D.M. Brown, P.K. Kaiser, and M. Michels et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration N Engl J Med 355 14 2006 1432 1444
3. R.D. Jager, W.F. Mieler, and J.W. Miller Age-related macular degeneration N Engl J Med 358 24 2008 2606 2617
4. P.J. Rosenfeld, D.M. Brown, and J.S. Heier et al. Ranibizumab for neovascular age-related macular degeneration N Engl J Med 355 14 2006 1419 1431
5. P.A. Campochiaro, J.S. Heier, and L. Feiner et al. Ranibizumab for macular edema following branch retinal vein occlusion: six-month primary end point results of a phase III study Ophthalmology 117 6 2010 1102 1112.e1
6. Q.D. Nguyen, S.M. Shah, and A.A. Khwaja et al. Two-year outcomes of the ranibizumab for edema of the macula in diabetes (READ-2) study Ophthalmology 117 11 2010 2146 2151
7. D.R. Fintak, G.K. Shah, and K.J. Blinder et al. Incidence of endophthalmitis related to intravitreal injection of bevacizumab and ranibizumab Retina 28 10 2008 1395 1399
8. D.S. Fong, P. Custis, J. Howes, and J.W. Hsu Intravitreal bevacizumab and ranibizumab for age-related macular degeneration a multicenter, retrospective study Ophthalmology 117 2 2010 298 302
9. S.J. Kim, H.S. Toma, N.K. Midha, E.F. Cherney, F.M. Recchia, and T.J. Doherty Antibiotic resistance of conjunctiva and nasopharynx evaluation study: a prospective study of patients undergoing intravitreal injections Ophthalmology 117 12 2010 2372 2378
10. A.R. Bhavsar, C.R. Stockdale, and F.L. Ferris 3rd et al. Update on risk of endophthalmitis after intravitreal drug injections and potential impact of elimination of topical antibiotics Arch Ophthalmol 130 6 2012 809 810
11. E. Milder, J. Vander, C. Shah, and S. Garg Changes in antibiotic resistance patterns of conjunctival flora due to repeated use of topical antibiotics after intravitreal injection Ophthalmology 119 7 2012 1420 1424
12. S.J. Kim, and H.S. Toma Antimicrobial resistance and ophthalmic antibiotics: 1-year results of a longitudinal controlled study of patients undergoing intravitreal injections Arch Ophthalmol 129 9 2011 1180 1188
13. S.J. Kim, and H.S. Toma Ophthalmic antibiotics and antimicrobial resistance a randomized, controlled study of patients undergoing intravitreal injections Ophthalmology 118 7 2011 1358 1363
14. C.P. Shah, S.J. Garg, and J.F. Vander et al. Outcomes and risk factors associated with endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor agents Ophthalmology 118 10 2011 2028 2034
15. G.A. Lalwani, H.W. Flynn Jr., and I.U. Scott et al. Acute-onset endophthalmitis after clear corneal cataract surgery (1996-2005). Clinical features, causative organisms, and visual acuity outcomes Ophthalmology 115 3 2008 473 476
16. M.P. Simunovic, R.B. Rush, A.P. Hunyor, and A.A. Chang Endophthalmitis following intravitreal injection versus endophthalmitis following cataract surgery: clinical features, causative organisms and post-treatment outcomes Br J Ophthalmol 96 6 2012 862 866
17. E. Chen, M.Y. Lin, J. Cox, and D.M. Brown Endophthalmitis after intravitreal injection: the importance of viridans streptococci Retina 31 8 2011 1525 1533
18. H. Mino De Kaspar, A.S. Hoepfner, and M. Engelbert et al. Antibiotic resistance pattern and visual outcome in experimentally-induced Staphylococcus epidermidis endophthalmitis in a rabbit model Ophthalmology 108 3 2001 470 478
19. S.S. Bhatt, K.E. Stepien, and K. Joshi Prophylactic antibiotic use after intravitreal injection: effect on endophthalmitis rate Retina 31 10 2011 2032 2036
20. C.S. Cheung, A.W. Wong, A. Lui, P.J. Kertes, R.G. Devenyi, and W.C. Lam Incidence of endophthalmitis and use of antibiotic prophylaxis after intravitreal injections Ophthalmology 119 8 2012 1609 1614
21. S.F. Bloomfield Significance of biocide usage and antimicrobial resistance in domiciliary environments J Appl Microbiol 92 Suppl: 2002 144S 157S
22. R. Chuanchuen, K. Beinlich, T.T. Hoang, A. Becher, R.R. Karkhoff-Schweizer, and H.P. Schweizer Cross-resistance between triclosan and antibiotics in Pseudomonas aeruginosa is mediated by multidrug efflux pumps: exposure of a susceptible mutant strain to triclosan selects nfxB mutants overexpressing MexCD-OprJ Antimicrob Agents Chemother 45 2 2001 428 432
23. A.D. Russell Biocide use and antibiotic resistance: the relevance of laboratory findings to clinical and environmental situations Lancet Infect Dis 3 12 2003 794 803
24. A.D. Russell, U. Tattawasart, J.Y. Maillard, and J.R. Furr Possible link between bacterial resistance and use of antibiotics and biocides Antimicrob Agents Chemother 42 8 1998 2151
25. U. Tattawasart, J.Y. Maillard, J.R. Furr, and A.D. Russell Development of resistance to chlorhexidine diacetate and cetylpyridinium chloride in Pseudomonas stutzeri and changes in antibiotic susceptibility J Hosp Infect 42 3 1999 219 229
26. T. Suzuki, Y. Kawamura, T. Uno, Y. Ohashi, and T. Ezaki Prevalence of Staphylococcus epidermidis with biofilm-forming ability in isolates from conjunctiva and facial skin Am J Ophthalmol 140 5 2005 844 850
27. B. Lanker Klossner, H.R. Widmer, and F. Frey Nondevelopment of resistance by bacteria during hospital use of povidone-iodine Dermatology 195 Suppl 2 1997 10 13
28. A.R. Bhavsar, J.M. Googe Jr., and C.R. Stockdale et al. Risk of endophthalmitis after intravitreal drug injection when topical antibiotics are not required: the diabetic retinopathy clinical research network laser-ranibizumab-triamcinolone clinical trials Arch Ophthalmol 127 12 2009 1581 1583