A GCH1 haplotype confers sex-specific susceptibility to pain crises and altered endothelial function in adults with sickle cell anemia

American Journal of Hematology

Volumn 89, Issue 2, 2014, Pages 187-193

  Belfer, Inna ^a   Youngblood, Victoria ^b   Darbari, Deepika S ^b,c   Wang, Zhengyuan ^b   Diaw, Lena ^b   Freeman, Lita ^b   Desai, Krupa ^b   Dizon, Michael ^b   Allen, Darlene ^b   Cunnington, Colin ^d   Channon, Keith M ^d   Milton, Jacqueline ^e   Hartley, Stephen W ^e   Nolan, Vikki ^f   Kato, Gregory J ^b   Steinberg, Martin H ^e   Goldman, David ^g   Taylor, James G ^b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF MEMPHIS   (United States)

^g NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOPTERIN; FERRITIN; GENOMIC DNA; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; HEMOGLOBIN; HEMOGLOBIN F; LACTATE DEHYDROGENASE;

ADULT; AFRICAN AMERICAN; ALLELE; ALPHA THALASSEMIA; ARTICLE; BLOOD FLOW; COHORT ANALYSIS; EMERGENCY CARE; ENDOPHENOTYPE; FEMALE; FERRITIN BLOOD LEVEL; GCH1 GENE; GENE; GENE REPLICATION; GENETIC RISK; GENETIC TRAIT; GENETIC VARIABILITY; GENOTYPE; GLOMERULUS FILTRATION RATE; HAPLOTYPE; HEMOGLOBIN BLOOD LEVEL; HOMOZYGOTE; HOSPITALIZATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LACTATE DEHYDROGENASE BLOOD LEVEL; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NOCICEPTION; PAIN; PRIORITY JOURNAL; SEX DIFFERENCE; SICKLE CELL ANEMIA; VASCULAR ENDOTHELIUM;

ADULT; ALLELES; ANEMIA, SICKLE CELL; BIOPTERIN; CASE-CONTROL STUDIES; ENDOTHELIUM; FEMALE; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GTP CYCLOHYDROLASE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; PAIN; PAIN MANAGEMENT; PHENOTYPE; PLETHYSMOGRAPHY; SEX FACTORS; TRANSCRIPTOME; VASCULAR DISEASES; YOUNG ADULT;

EID: 84893906480     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.23613     Document Type: Article

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