Epigenetic modulation of neuronal apoptosis and cognitive functions in sepsis-associated encephalopathy

Neurological Sciences

Volumn 35, Issue 2, 2014, Pages 283-288

  Fang, Jun ^a   Lian, Yanhong ^a   Xie, Kangjie ^a   Cai, Shunv ^a   Wen, Penglu ^a  

^a ZHEJIANG CANCER HOSPITAL   (China)

Author keywords

Apoptosis; Epigenetics; Hippocampus; Histone deacetylases (HDACs); Learning and memory; Sepsis

Indexed keywords

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BRAIN DISEASES; CELLS, CULTURED; COGNITION DISORDERS; EPIGENESIS, GENETIC; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HYDROXAMIC ACIDS; MALE; MEMORY DISORDERS; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS; SPACE PERCEPTION;

EID: 84893868617     PISSN: 15901874     EISSN: 15903478     Source Type: Journal    
DOI: 10.1007/s10072-013-1508-4     Document Type: Article

References (21)

1. Iacobone E, Bailly-Salin J, Polito A, Friedman D, Stevens RD, Sharshar T (2009) Sepsis-associated encephalopathy and its differential diagnosis. Crit Care Med 37:S331-S336
2. Papadopoulos MC, Davies DC, Moss RF, Tighe D, Bennett ED (2000) Pathophysiology of septic encephalopathy: a review. Crit Care Med 28:3019-3024
3. d'Avila JC, Santiago AP, Amancio RT, Galina A, Oliveira MF, Bozza FA (2008) Sepsis induces brain mitochondrial dysfunction. Crit Care Med 36:1925-1932
4. Weberpals M, Hermes M, Hermann S, Kummer MP, Terwel D, Semmler A, Berger M, Schafers M, Heneka MT (2009) NOS2 gene deficiency protects from sepsis-induced long-term cognitive deficits. J Neurosci 29:14177-14184
5. Semmler A, Hermann S, Mormann F, Weberpals M, Paxian SA, Okulla T, Schafers M, Kummer MP, Klockgether T, Heneka MT (2008) Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism. J Neuroinflammation 5:38
6. Varga-Weisz PD, Becker PB (1998) Chromatin-remodeling factors: machines that regulate? Curr Opin Cell Biol 10:346-353 (Pubitemid 28287046)
7. Yang XJ, Seto E (2007) HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention. Oncogene 26:5310-5318 (Pubitemid 47255917)
8. Jiang Y, Langley B, Lubin FD, Renthal W, Wood MA, Yasui DH, Kumar A, Nestler EJ, Akbarian S, Beckel-Mitchener AC (2008) Epigenetics in the nervous system. J Neurosci 28:11753-11759
9. Levenson JM, Sweatt JD (2005) Epigenetic mechanisms in memory formation. Nat Rev Neurosci 6:108-118 (Pubitemid 40188945)
10. Fischer A, Sananbenesi F, Mungenast A, Tsai LH (2010) Targeting the correct HDAC(s) to treat cognitive disorders. Trends Pharmacol Sci 31:605-617
11. Chen B, Cepko CL (2009) HDAC4 regulates neuronal survival in normal and diseased retinas. Science 323:256-259
12. Li J, Chen J, Ricupero CL, Hart RP, Schwartz MS, Kusnecov A, Herrup K (2012) Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia. Nat Med 18:783-790
13. Kaech S, Banker G (2007) Culturing hippocampal neurons. Nat Protoc 1:2406-2415
14. Geng H, Harvey CT, Pittsenbarger J, Liu Q, Beer TM, Xue C, Qian DZ (2011) HDAC4 protein regulates HIF1alpha protein lysine acetylation and cancer cell response to hypoxia. J Biol Chem 286:38095-38102
15. Huang X, Venet F, Wang YL, Lepape A, Yuan Z, Chen Y, Swan R, Kherouf H, Monneret G, Chung CS, Ayala A (2009) PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis. Proc Natl Acad Sci USA 106:6303-6308
16. Chuang DM, Leng Y, Marinova Z, Kim HJ, Chiu CT (2009) Multiple roles of HDAC inhibition in neurodegenerative conditions. Trends Neurosci 32:591-601
17. Polster BM, Fiskum G (2004) Mitochondrial mechanisms of neural cell apoptosis. J Neurochem 90:1281-1289 (Pubitemid 39223632)
18. Raghupathi R, Strauss KI, Zhang C, Krajewski S, Reed JC, McIntosh TK (2003) Temporal alterations in cellular Bax: Bcl-2 ratio following traumatic brain injury in the rat. J Neurotrauma 20:421-435 (Pubitemid 36617946)
19. Lubin FD, Roth TL, Sweatt JD (2008) Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory. J Neurosci 28:10576-10586
20. Guan JS, Haggarty SJ, Giacometti E, Dannenberg JH, Joseph N, Gao J, Nieland TJ, Zhou Y, Wang X, Mazitschek R, Bradner JE, DePinho RA, Jaenisch R, Tsai LH (2009) HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459:55-60
21. Gaub P, Tedeschi A, Puttagunta R, Nguyen T, Schmandke A, Di Giovanni S (2010) HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation. Cell Death Differ 17:1392-1408