Anticonvulsant potential of certain new (2 E)-2-[1-Aryl-3-(1 H -imidazol-1-yl)propylidene]- N -(aryl/H)hydrazinecarboxamides

The Scientific World Journal

Volumn 2014, Issue , 2014, Pages

  Attia, Mohamed I ^a,b   Aboul Enein, Mohamed N ^b   El Azzouny, Aida A ^b   Maklad, Yousreya A ^b   Ghabbour, Hazem A ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; HYDRAZINE DERIVATIVE; IMIDAZOLE; IMIDAZOLE DERIVATIVE;

ANIMAL; CHEMISTRY; MALE; MOUSE; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TOXICOLOGY; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTICONVULSANTS; CRYSTALLOGRAPHY, X-RAY; HYDRAZINES; IMIDAZOLES; MALE; MICE; STRUCTURE-ACTIVITY RELATIONSHIP; TOXICOLOGY;

EID: 84893846211     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1155/2014/357403     Document Type: Article

References (23)

1. Browne T. R., Holmes G. L., Primary care: epilepsy. The New England Journal of Medicine 2001 344 15 1145 1151 2-s2.0-0035849184 10.1056/ NEJM200104123441507 (Pubitemid 32285237)
2. Picot M. C., Baldy-Moulinier M., Daurès J. P., Dujols P., Crespel A., The prevalence of epilepsy and pharmacoresistant epilepsy in adults: a population-based study in a Western European country. Epilepsia 2008 49 7 1230 1238 2-s2.0-47249105094 10.1111/j.1528-1167.2008.01579.x (Pubitemid 351991393)
3. Lin Z., Kadaba P. K., Molecular targets for the rational design of antiepileptic drugs and related neuroprotective agents. Medicinal Research Reviews 1997 17 6 537 572 10.1002/(SICI)1098-1128(199711)17:6<537::AID- MED3>3.0.CO;2-2 (Pubitemid 27489491)
4. Wagner M. L., Felbamate: a new antiepileptic drug. The American Journal of Hospital Pharmacy 1994 51 13 1657 1666 2-s2.0-0028278504 (Pubitemid 24219339)
5. Zaccara G., Franciotta D., Perucca E., Idiosyncratic adverse reactions to antiepileptic drugs. Epilepsia 2007 48 7 1223 1244 2-s2.0-34447312716 10.1111/j.1528-1167.2007.01041.x (Pubitemid 47063067)
6. Nardi D., Tajana A., Leonardi A., Pennini R., Portioli F., Magistretti M. J., Subissi A., Synthesis and anticonvulsant activity of N -(benzoylalkyl) imidazoles and N -(ω -phenyl- ω -hydroxyalkyl)imidazoles. Journal of Medicinal Chemistry 1981 24 6 727 731 2-s2.0-0019411165 (Pubitemid 11084151)
7. Graziani G., Tirone F., Barbadoro E., Testa R., Denzimol, a new anticonvulsant drug. I. General anticonvulsant profile. Arzneimittel-Forschung 1983 33 8 1155 1160 2-s2.0-0020601687 (Pubitemid 13030318)
8. Graziani G., Cazzulani P., Luca C., Denzimol, a new anticonvulsant drug. II. General pharmacological activities. Arzneimittel-Forschung 1983 33 8 1161 1168 2-s2.0-0020602684 (Pubitemid 13030319)
9. Graziani G., Barbadoro E., Testa R., Denzimol, a new anticonvulsant drug. III. Toxicological evaluation. Arzneimittel-Forschung 1983 33 8 1168 1173 2-s2.0-0020602685 (Pubitemid 13030320)
10. Dimmock J. R., Vashishtha S. C., Stables J. P., Anticonvulsant properties of various acetylhydrazones, oxamoylhydrazones and semicarbazones derived from aromatic and unsaturated carbonyl compounds. European Journal of Medicinal Chemistry 2000 35 2 241 248 2-s2.0-0034099495 10.1016/S0223-5234(00)00123-9 (Pubitemid 30165687)
11. Alam O., Mullick P., Verma S. P., Gilani S. J., Khan S. A., Siddiqui N., Ahsan W., Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives. European Journal of Medicinal Chemistry 2010 45 6 2467 2472 2-s2.0-77950857514 10.1016/j.ejmech.2010.02.031
12. Aboul-Enein M. N., El-Azzouny A. A., Attia M. I., Maklad Y. A., Amin K. M., Abdel-Rehim M., El-Behairy M. F., Design and synthesis of novel stiripentol analogues as potential anticonvulsants. European Journal of Medicinal Chemistry 2012 47 1 360 369 2-s2.0-84855789914 10.1016/j.ejmech.2011.11.004
13. Aboul-Enein M. N., El-Azzouny A. A. E., Attia M. I., Saleh O. A., Kansoh A. L., Synthesis and anti- Candida potential of certain novel 1-[(3-substituted-3-phenyl)propyl]-1 H -imidazoles. Archiv der Pharmazie 2011 344 12 794 801 2-s2.0-82955228142 10.1002/ardp.201000224
14. Roman G., Mares M., Nastasa V., A novel antifungal agent with broad spectrum: 1-(4-biphenylyl)-3-(1 H -imidazol-1-yl)-1-propanone. Archiv der Pharmazie 2013 346 2 110 118 10.1002/ardp.201200287
15. Wan J., Peng Z. Z., Li X. M., Ouyang P. K., Zhang S. S., 3-(1 H -lmidazol-1-yl)-1-(4-methoxyphenyl)-propan-1-one. Acta Crystallographica E 2005 61 part 8 o2585 o2586 2-s2.0-32244449401 10.1107/S1600536805022385 (Pubitemid 43213737)
16. Attia M. I., Ghabbour H. A., El-Azzouny A. A., Al-Deeb O. A., Almutairi M. S., Fun H. K., Synthesis and single crystal X-ray structure of new (2 E)-2-[3-(1 H -imidazol-1-yl)-1-phenylpropylidene]- N - phenylhydrazinecarboxamide. Journal of Chemistry 2013 2013 5 515309 10.1155/2013/515309
17. Attia M. I., Aboul-Enein M. N., El-Brollosy N. R., Ng S. W., Tiekink E. R. T., 1-{(E)-[3-(1 H -Imidazol-1-yl)-1-phenylpropylidene]amino}-3-(2- methylphenyl)urea. Acta Crystallographica E 2012 68 part 6 o1848 o1849 10.1107/S1600536812022659
18. Attia M. I., Aboul-Enein M. N., El-Brollosy N. R., Ng S. W., Tiekink E. R. T., 1-{(E)-[3-(1 H -Imidazol-1-yl)-1-(4-methoxyphenyl)propylidene]amino}-3- (2-methylphenyl)urea. Acta Crystallographica E 2012 68 part 6 o1799 o1800 10.1107/S1600536812021903
19. Krall R. L., Penry J. K., White B. G., Kupferberg H. J., Swinyard E. A., Antiepileptic drug development-II: anticonvulsant drug screening. Epilepsia 1978 19 4 409 428 2-s2.0-0018129707 (Pubitemid 9016848)
20. Luszczki J. J., Czuczwar M., Gawlik P., Sawiniec-Pozniak G., Czuczwar K., Czuczwar S. J., 7-Nitroindazole potentiates the anticonvulsant action of some second-generation antiepileptic drugs in the mouse maximal electroshock-induced seizure model. Journal of Neural Transmission 2006 113 9 1157 1168 2-s2.0-33747886423 10.1007/s00702-005-0417-y (Pubitemid 44291011)
21. Dunham N. W., Miya T. S., A note on a simple apparatus for detecting neurological deficit in rats and mice. Journal of the American Pharmaceutical Association 1957 46 3 208 209 2-s2.0-70449177837
22. Porter R. J., Cereghino J. J., Gladding G. D., Hessie B. J., Kupferberg H. J., Scoville B., White B. G., Antiepileptic drug development program. Cleveland Clinic Quarterly 1984 51 2 293 305 2-s2.0-0021611548 (Pubitemid 14038030)
23. Dimmock J. R., Pandeya S. N., Quail J. W., Pugazhenthi U., Allen T. M., Kao G. Y., Balzarini J., de Clercq E., Evaluation of the semicarbazones, thiosemicarbazones and bis-carbohydrazones of some aryl alicyclic ketones for anticonvulsant and other biological properties. European Journal of Medicinal Chemistry 1995 30 4 303 314 2-s2.0-0029053795 10.1016/0223-5234(96)88238-9