메뉴 건너뛰기




Volumn 9, Issue 1, 2014, Pages 273-278

Silencing Kif2a induces apoptosis in squamous cell carcinoma of the oral tongue through inhibition of the PI3K/Akt signaling pathway

Author keywords

Apoptosis; Kinesin 13 family 2a; Phosphatidylinositol 3 kinase; Protein kinase B; Squamous cell carcinoma of the oral tongue

Indexed keywords

APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; HUMANS; INSULIN-LIKE GROWTH FACTOR I; KINESIN; MOUTH NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84893822832     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2013.1804     Document Type: Article
Times cited : (44)

References (17)
  • 1
    • 4143075910 scopus 로고    scopus 로고
    • The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK
    • Ganem NJ and Compton DA: The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK. J Cell Biol 166: 473-478, 2004.
    • (2004) J Cell Biol , vol.166 , pp. 473-478
    • Ganem, N.J.1    Compton, D.A.2
  • 2
    • 27144451193 scopus 로고    scopus 로고
    • Efficient mitosis in human cells lacking poleward microtubule flux
    • Ganem NJ, Upton K and Compton DA: Efficient mitosis in human cells lacking poleward microtubule flux. Curr Biol 15: 1827-1832, 2005.
    • (2005) Curr Biol , vol.15 , pp. 1827-1832
    • Ganem, N.J.1    Upton, K.2    Compton, D.A.3
  • 3
    • 72149125306 scopus 로고    scopus 로고
    • Overexpression of Kif2a promotes the progression and metastasis of squamous cell carcinoma of the oral tongue
    • Wang CQ, Qu X, Zhang XY, et al: Overexpression of Kif2a promotes the progression and metastasis of squamous cell carcinoma of the oral tongue. Oral Oncol 46: 65-69, 2010.
    • (2010) Oral Oncol , vol.46 , pp. 65-69
    • Wang, C.Q.1    Qu, X.2    Zhang, X.Y.3
  • 4
    • 28844448182 scopus 로고    scopus 로고
    • Oncogenic PI3K deregulates transcription and translation
    • Bader AG, Kang S, Zhao L and Vogt PK: Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer 5: 921-929, 2005.
    • (2005) Nat Rev Cancer , vol.5 , pp. 921-929
    • Bader, A.G.1    Kang, S.2    Zhao, L.3    Vogt, P.K.4
  • 5
    • 2142759556 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase signalling pathways in tumor progression, invasion and angiogenesis
    • Brader S and Eccles SA: Phosphoinositide 3-kinase signalling pathways in tumor progression, invasion and angiogenesis. Tumori 90: 2-8, 2004.
    • (2004) Tumori , vol.90 , pp. 2-8
    • Brader, S.1    Eccles, S.A.2
  • 6
    • 3042558151 scopus 로고    scopus 로고
    • Genotypic analysis of esophageal squamous cell carcinoma by molecular cytogenetics and real-time quantitative polymerase chain reaction
    • Yen CC, Chen YJ, Lu KH, et al: Genotypic analysis of esophageal squamous cell carcinoma by molecular cytogenetics and real-time quantitative polymerase chain reaction. Int J Oncol 23: 871-881, 2003.
    • (2003) Int J Oncol , vol.23 , pp. 871-881
    • Yen, C.C.1    Chen, Y.J.2    Lu, K.H.3
  • 7
    • 21344441495 scopus 로고    scopus 로고
    • Accumulation of cytoplasmic beta-catenin correlates with reduced expression of E-cadherin, but not with phosphorylated Akt in esophageal squamous cell carcinoma: Immunohistochemical study
    • Zhang G, Zhou X, Xue L, et al: Accumulation of cytoplasmic beta-catenin correlates with reduced expression of E-cadherin, but not with phosphorylated Akt in esophageal squamous cell carcinoma: immunohistochemical study. Pathol Int 55: 310-317, 2005.
    • (2005) Pathol Int , vol.55 , pp. 310-317
    • Zhang, G.1    Zhou, X.2    Xue, L.3
  • 8
    • 67650999753 scopus 로고    scopus 로고
    • Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway
    • Bian Y, Terse A, Du J, et al: Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway. Cancer Res 69: 5918-5926, 2009.
    • (2009) Cancer Res , vol.69 , pp. 5918-5926
    • Bian, Y.1    Terse, A.2    Du, J.3
  • 9
    • 70349101615 scopus 로고    scopus 로고
    • Overexpression and activation of Akt2 protein in oral squamous cell carcinoma
    • Iamaroon A and Krisanaprakornkit S: Overexpression and activation of Akt2 protein in oral squamous cell carcinoma. Oral Oncol 45: e175-e179, 2009.
    • (2009) Oral Oncol , vol.45
    • Iamaroon, A.1    Krisanaprakornkit, S.2
  • 11
    • 4544342570 scopus 로고    scopus 로고
    • Nuclear factor-kappaB: The enemy within
    • Aggarwal BB: Nuclear factor-kappaB: the enemy within. Cancer Cell 6: 203-208, 2004.
    • (2004) Cancer Cell , vol.6 , pp. 203-208
    • Aggarwal, B.B.1
  • 12
    • 33745180526 scopus 로고    scopus 로고
    • Evi1 is a survival factor which conveys resistance to both TGFbeta-and taxol-mediated cell death via PI3K/AKT
    • Liu Y, Chen L, Ko TC, Fields AP and Thompson EA: Evi1 is a survival factor which conveys resistance to both TGFbeta-and taxol-mediated cell death via PI3K/AKT. Oncogene 25: 3565-3575, 2006.
    • (2006) Oncogene , vol.25 , pp. 3565-3575
    • Liu, Y.1    Chen, L.2    Ko, T.C.3    Fields, A.P.4    Thompson, E.A.5
  • 13
    • 36148964068 scopus 로고    scopus 로고
    • Id-1 activation of PI3K/Akt/NFκB signaling pathway and its significance in promoting survival of esophageal cancer cells
    • Li B, Cheung PY, Wang X, Tsao SW, Ling MT, Wong YC and Cheung AL: Id-1 activation of PI3K/Akt/NFκB signaling pathway and its significance in promoting survival of esophageal cancer cells. Carcinogenesis 28: 2313-2320, 2007.
    • (2007) Carcinogenesis , vol.28 , pp. 2313-2320
    • Li, B.1    Cheung, P.Y.2    Wang, X.3    Tsao, S.W.4    Ling, M.T.5    Wong, Y.C.6    Cheung, A.L.7
  • 14
    • 15444371092 scopus 로고    scopus 로고
    • Nicotine inactivation of the proapoptotic function of Bax through phosphorylation
    • Xin M and Deng X: Nicotine inactivation of the proapoptotic function of Bax through phosphorylation. J Biol Chem 280: 1078l-10789, 2005.
    • (2005) J Biol Chem , vol.280
    • Xin, M.1    Deng, X.2
  • 16
    • 24044551995 scopus 로고    scopus 로고
    • PI3K/Akt/mTOR pathway as a target for cancer therapy
    • Morgensztern D and McLeod HL: PI3K/Akt/mTOR pathway as a target for cancer therapy. Anticancer Drugs 16: 797-803, 2005.
    • (2005) Anticancer Drugs , vol.16 , pp. 797-803
    • Morgensztern, D.1    McLeod, H.L.2
  • 17
    • 33646185371 scopus 로고    scopus 로고
    • RNAi-mediated gene silencing in non-human primates
    • Zimmermann TS, Lee AC, Akinc A, et al: RNAi-mediated gene silencing in non-human primates. Nature 441: 111-114, 2006.
    • (2006) Nature , vol.441 , pp. 111-114
    • Zimmermann, T.S.1    Lee, A.C.2    Akinc, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.