Genotoxicity but not the AhR-mediated activity of PAHs is inhibited by other components of complex mixtures of ambient air pollutants

Toxicology Letters

Volumn 225, Issue 3, 2014, Pages 350-357

  Líbalová, Helena ^a   Krčková, Simona ^b   Uhlířová, Kateřina ^a   Milcová, Alena ^a   Schmuczerová, Jana ^a   Ciganek, Miroslav ^b   Kléma, Jiri ^c   Machala, Miroslav ^b   Šrám, Radim J ^a   Topinka, Jan ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Czech Republic)

^b VETERINARY RESEARCH INSTITUTE   (Czech Republic)

^c CZECH TECHNICAL UNIVERSITY IN PRAGUE   (Czech Republic)

Author keywords

Air pollution; Benzo a pyrene; Complex mixtures; DNA adducts; PAHs; PM2.5

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; BENZO[A]PYRENE; BENZO[K]FLUORANTHENE; CYP1A1 PROTEIN, HUMAN; CYP1B1 PROTEIN, HUMAN; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; DRUG MIXTURE; FLUORENE DERIVATIVE; PARTICULATE MATTER; RNA; UNSPECIFIC MONOOXYGENASE;

CHEMISTRY; COMPARATIVE STUDY; CZECH REPUBLIC; DRUG EFFECTS; DRUG MIXTURE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LUNG; METABOLISM; MUTAGEN TESTING; PARTICULATE MATTER; PHYSIOLOGY; PROCEDURES; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TOXICITY; TUMOR CELL LINE;

ARYL HYDROCARBON HYDROXYLASES; BENZO(A)PYRENE; CELL LINE, TUMOR; COMPLEX MIXTURES; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1B1; CZECH REPUBLIC; FLUORENES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LUNG; MUTAGENICITY TESTS; PARTICULATE MATTER; RECEPTORS, ARYL HYDROCARBON; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA;

EID: 84893822518     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2014.01.028     Document Type: Article

References (28)

1. Andrysík Z., Vondráček J., Marvanová S., Ciganek M., Neča J., Pěnčíková K., Mahadevan B., Topinka J., Baird W.M., Kozubík A., Machala M. Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: the role of polycyclic aromatic hydrocarbons. Mutat. Res. 2011, 714:53-62.
2. Bell M.L. Assessment of the health impacts of particulate matter characteristics. Res. Rep. Health Eff. Inst. 2012, 5-38.
3. Bell M.L., Dominici F., Ebisu K., Zeger S.L., Samet J.M. Spatial and temporal variation in PM(2.5) chemical composition in the United States for health effects studies. Environ. Health Perspect. 2007, 115:989-995.
4. Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. Royal Stat. Soc. 1995, 57:289-300.
5. Bornholdt J., Saber A.T., Sharma A.K., Savolainen K., Vogel U., Wallin H. Inflammatory response and genotoxicity of seven wood dusts in the human epithelial cell line A549. Mutat. Res. 2007, 632:78-88.
6. Courter L.A., Musafia-Jeknic T., Fischer K., Bildfell R., Giovanini J., Pereira C., Baird W.M. Urban dust particulate matter alters PAH-induced carcinogenesis by inhibition of CYP1A1 and CYP1B1. Toxicol. Sci. 2007, 95:63-73.
7. Courter L.A., Pereira C., Baird W.M. Diesel exhaust influences carcinogenic PAH-induced genotoxicity and gene expression in human breast epithelial cells in culture. Mutat. Res. 2007, 625:72-82.
8. Culp S.J., Gaylor D.W., Sheldon W.G., Goldstein L.S., Beland F.A. A comparison of the tumors induced by coal tar and benzo[a]pyrene in a 2-year bioassay. Carcinogenesis 1998, 19:117-124.
9. Gerde P., Muggenburg B.A., Lundborg M., Dahl A.R. The rapid alveolar absorption of diesel soot-adsorbed benzo[a]pyrene: bioavailability, metabolism and dosimetry of an inhaled particle-borne carcinogen. Carcinogenesis 2001, 22:741-749.
10. Giard D.J., Aaronson S.A., Todaro G.J., Arnstein P., Kersey J.H., Dosik H., Parks W.P. In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors. J. Natl. Cancer Inst. 1973, 51:1417-1423.
11. 32P-postlabeling analysis of aromatic carcinogen:DNA adducts. Cancer Res. 1985, 45:5656-5662.
12. Gutierrez-Castillo M.E., Roubicek D.A., Cebrian-Garcia M.E., De Vizcaya-Ruiz A., Sordo-Cedeno M., Ostrosky-Wegman P. Effect of chemical composition on the induction of DNA damage by urban airborne particulate matter. Environ. Mol. Mutagen. 2006, 47:199-211.
13. Hansen T., Seidel A., Borlak J. The environmental carcinogen 3-nitrobenzanthrone and its main metabolite 3-aminobenzanthrone enhance formation of reactive oxygen intermediates in human A549 lung epithelial cells. Toxicol. Appl. Pharmacol. 2007, 221:222-234.
14. Hitoshi K., Katoh M., Suzuki T., Ando Y., Nadai M. Single-walled carbon nanotubes downregulate stress-responsive genes in human respiratory tract cells. Biol. Pharm. Bull. 2012, 35:455-463.
15. Lanone S., Rogerieux F., Geys J., Dupont A., Maillot-Marechal E., Boczkowski J., Lacroix G., Hoet P. Comparative toxicity of 24 manufactured nanoparticles in human alveolar epithelial and macrophage cell lines. Part Fibre Toxicol. 2009, 6:14.
16. Lewtas J. Air pollution combustion emissions: characterization of causative agents and mechanisms associated with cancer, reproductive, and cardiovascular effects. Mutat. Res. 2007, 636:95-133.
17. Libalova H., Uhlirova K., Klema J., Machala M., Sram R.J., Ciganek M., Topinka J. Global gene expression changes in human embryonic lung fibroblasts induced by organic extracts from respirable air particles. Part Fibre Toxicol. 2012, 9:1.
18. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25:402-408.
19. Mahadevan B., Marston C.P., Luch A., Dashwood W.M., Brooks E., Pereira C., Doehmer J., Baird W.M. Competitive inhibition of carcinogen-activating CYP1A1 and CYP1B1 enzymes by a standardized complex mixture of PAH extracted from coal tar. Int. J. Cancer 2007, 120:1161-1168.
20. Osornio-Vargas A.R., Bonner J.C., Alfaro-Moreno E., Martinez L., Garcia-Cuellar C., Ponce-de-Leon Rosales S., Miranda J., Rosas I. Proinflammatory and cytotoxic effects of Mexico City air pollution particulate matter in vitro are dependent on particle size and composition. Environ. Health Perspect. 2003, 111:1289-1293.
21. Perrone M.G., Gualtieri M., Ferrero L., Lo Porto C., Udisti R., Bolzacchini E., Camatini M. Seasonal variations in chemical composition and in vitro biological effects of fine PM from Milan. Chemosphere 2010, 78:1368-1377.
22. Phillips D.H., Castegnaro M. Standardization and validation of DNA adduct postlabelling methods: report of interlaboratory trials and production of recommended protocols. Mutagenesis 1999, 14:301-315.
23. Pope C.A., Ezzati M., Dockery D.W. Fine-particulate air pollution and life expectancy in the United States. N. Engl. J. Med. 2009, 360:376-386.
24. 32P-postlabeling test for structurally diverse DNA adducts. Carcinogenesis 1986, 7:1543-1551.
25. Sevastyanova O., Binkova B., Topinka J., Sram R.J., Kalina I., Popov T., Novakova Z., Farmer P.B. In vitro genotoxicity of PAH mixtures and organic extract from urban air particles part II: human cell lines. Mutat. Res. 2007, 620:123-134.
26. Steenhof M., Gosens I., Strak M., Godri K.J., Hoek G., Cassee F.R., Mudway I.S., Kelly F.J., Harrison R.M., Lebret E., Brunekreef B., Janssen N.A., Pieters R.H. In vitro toxicity of particulate matter (PM) collected at different sites in the Netherlands is associated with PM composition, size fraction and oxidative potential-the RAPTES project. Part Fibre Toxicol. 2011, 8:26.
27. Topinka J., Marvanova S., Vondracek J., Sevastyanova O., Novakova Z., Krcmar P., Pencikova K., Machala M. DNA adducts formation and induction of apoptosis in rat liver epithelial 'stem-like' cells exposed to carcinogenic polycyclic aromatic hydrocarbons. Mutat. Res. 2008, 638:122-132.
28. Topinka J., Rossner P., Milcova A., Schmuczerova J., Svecova V., Sram R.J. DNA adducts and oxidative DNA damage induced by organic extracts from PM2.5 in an acellular assay. Toxicol. Lett. 2011, 202:186-192.