Purification and characterization of aminoglycoside phosphotransferase APH(6)-Id, a streptomycin-inactivating enzyme

Molecular and Cellular Biochemistry

Volumn 387, Issue 1-2, 2014, Pages 207-216

  Ashenafi, Meseret ^a   Ammosova, Tatiana ^a   Nekhai, Sergei ^a   Byrnes, W Malcolm ^a  

^a HOWARD UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Aminoglycoside phosphotransferase; Antibiotic resistance; APH(6) Id; Streptomycin

Indexed keywords

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; KINETICS; MICROBIAL SENSITIVITY TESTS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RECOMBINANT PROTEINS; STREPTOMYCES; STREPTOMYCIN;

EID: 84893822339     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1886-1     Document Type: Article

References (41)

1. Jones D, Metzger HJ, Schatz A, Waksman SA (1944) Control of gram-negative bacteria in experimental animals by streptomycin. Science 100:103-105
2. Carter AP, Clemons WM, Broderson DE, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V (2000) Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature 407:340-348
3. Davis BD (1987) Mechanism of bactericidal action of aminoglycosides. Microbiol Rev 51:341-350 (Pubitemid 17150318)
4. Wright GD (1999) Aminoglycoside-modifying enzymes. Curr Opin Microbiol 2:499-503 (Pubitemid 29477176)
5. Piepersberg W (1996) Streptomycin and related aminoglycosides. In: Vining LC, Stuttard C (eds) Genetics and biochemistry of antibiotic production. Butterworth Heinemann, Halifax, pp 531-570
6. Distler J, Mansouri K, Mayer G, Stockmann M, Piepersberg W (1992) Streptomycin biosynthesis and its regulation in Streptomycetes. Gene 115:105-111
7. Lim C-K, Smith MCM, Petty J, Baumberg S, Wootton JC (1989) Streptomyces griseus streptomycin phosphotransferase: expression of its gene in Escherichia coli and sequence homology with other antibiotic phosphotransferases and with eukaryotic protein kinases. J Gen Microbiol 135:3289-3302 (Pubitemid 20034310)
8. Sugiyama M, Sakamoto M, Mochizuki H, Nimi O, Nomi R (1983) Purification and characterization of streptomycin 6-kinase, an enzyme implicated in self-protection of a streptomycin-producing micro-organism. J Gen Microbiol 129:1683-1687 (Pubitemid 13044269)
9. Heinzel P, Werbitzky O, Distler J, Piepersbert W (1988) A second streptomycin resistance gene from Streptomyces griseus codes for streptomycin-3″-phosphotransferase. Relationships between antibiotic and protein kinases. Arch Microbiol 150:184-192
10. Shaw KJ, Rather PN, Hare RS, Miller GH (1993) Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. Microbiol Rev 57:138-163 (Pubitemid 23078440)
11. Mazodier P, Cossart P, Giraud E, Gasser F (1985) Completion of the nucleotide sequence of the central region of Tn5 confirms the presence of three resistance genes. Nucleic Acids Res 13:195-205
12. Scholz P, Haring V, Wittmann-Liebold B, Ashman D, Bagdasarian M, Scherzinger E (1989) Complete nucleotide sequence and gene organization of the broad-host-range plasmid RSF1010. Gene 75:271-288 (Pubitemid 19100128)
13. Sundin GW, Bender CL (1993) Ecological and genetic analysis of copper and streptomycin resistance in Pseudomonas syringae pv. Syringae. Appl Environ Microbiol 59:1018-1024 (Pubitemid 23096636)
14. Chiou C-S, Jones AL (1993) Nucleotide sequence analysis of a transposon (Tn5393) carrying streptomycin resistance genes in Erwinia amylovora and other gram-negative bacteria. J Bacteriol 175:732-740 (Pubitemid 23046936)
15. Chiou C-S, Jones AL (1995) Expression and identification of the strA-strB gene pair from streptomycin-resistant Erwinia amylovora. Gene 152:47-51
16. Sundin GW, Bender CL (1996) Dissemination of the strA-strB streptomycin-resistance genes among commensal and pathogenic bacteria from humans, animals, and plants. Mol Ecol 5:133-143
17. Sundin GW (2000) Examination of base pair variants of the strA-strB streptomycin resistance genes from bacterial pathogens of humans, animals and plants. J Antimicrob Chemother 46:848-849
18. Pezella C, Ricci A, DiGiannatale E, Luzzi I, Carattoli A (2004) Tetracycline and streptomycin resistance genes, transposons, and plasmids in Salmonella enterica isolates from animals in Italy. Antimicrob Agents Chemother 48:903-908 (Pubitemid 38280342)
19. Shaw PC, Liang AC, Kam KC, Ling JM (1996) Presence of strA-strB gene within a streptomycin-resistance operon in a clinical isolate of Shigella flexneri. Pathology 28:356-358 (Pubitemid 27170926)
20. Collins AC III, Ashenafi M, Saunders AA, Byrnes WM (2007) Cloning and expression of streptomycin-inactivating enzymes APH(6)-Ia and APH(6)-Id. Cell Mol Biol 53:74-79 (Pubitemid 46799954)
21. National Committee for Clinical Laboratory Standards, NCCLS (1990) Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved Standard M7-A2, 2nd edn. NCCLS, Villanova
22. National Committee for Clinical Laboratory Standards (1990) Performance standards for antimicrobial disk susceptibility tests. Approved Standard M2-A4, 4th edn. NCCLS, Villanova
23. Michael SS, Duch M, Paludan K, Jorgensen P, Finn SP (1992) Measurement of hygromycin B phosphotransferase activity in crude mammalian cell extracts by a simple dot-blot assay. Gene 112:257-260
24. Luedtke NW, Schepartz A (2005) Lanthanide-mediated phosphoester hydrolysis and phosphate elimination from phosphopeptides. Chem Commun 43:5426-5428 (Pubitemid 41689377)
25. Martindale W (1982) The extra pharmacopoeia, 28th edn. Pharmaceutical Press, London
26. Collins III AC (2007b) Cloning, sequencing and expression of the gene for streptomycin-inactivating enzyme APH(6)-Ia from Streptomyces griseus. Dissertation, Howard University
27. Perlin MH, McCarty SC, Greer JP (1988) Coupled spectrofluorometric assay for aminoglycoside phosphotransferases. Anal Biochem 171:145-149
28. Fromm HJ, Zewe V (1962) Kinetic studies of yeast hexokinase. J Biol Chem 237:3027-3032
29. Siregar JJ, Miroshnikov K, Mobashery S (1995) Purification, characterization, and investigation of the mechanism of aminoglycoside 3′-phosphotransferase type Ia. Biochemistry 34:12681-12688
30. van Overbeek LS, Wellington EMH, Egan S, Smalla K, Heuer H, Collard J-M, Guillaume G, Karagouni AD, Nikolakopoulou TL, van Elsas JD (2002) Prevalence of streptomycin-resistance genes in bacterial populations in European habitats. FEMS Microbiol Ecol 42:277-288 (Pubitemid 35351422)
31. Ramón-García S, Otal I, Martín C, Gómez-Lus R, Aínsa JA (2006) Novel streptomycin resistance gene from Mycobacterium fortuitum. Antimicrob Agents Chemother 50:3920-3922 (Pubitemid 44684917)
32. McKay GA, Wright GD (1995) Kinetic mechanism of aminoglycoside phosphotransferase type IIIa: evidence for a Theorell-Chance mechanism. J Biol Chem 270:24686-24692
33. Thompson PR, Hughes DW, Cianciotto NP, Wright GD (1998) Spectinomycin kinase from Legionella pneumophila: characterization of substrate specificity and identification of catalytically important residues. J Biol Chem 273:14788-14795 (Pubitemid 28272765)
34. Tolba S, Egan S, Kallifidas D, Wellington EHM (2002) Distribution of streptomycin resistance and biosynthesis genes in streptomycetes recovered from different soil sites. FEMS Microbiol Ecol 42:269-276 (Pubitemid 35351421)
35. Wiener P, Egan S, Wellington EMH (1998) Evidence for transfer of antibiotic resistance genes in soil populations of streptomycetes. Mol Ecol 7:120501216 (Pubitemid 28428493)
36. Egan S, Wiener P, Kallifidas D, Wellington EMH (1998) Transfer of streptomycin biosynthesis gene clusters within Streptomycetes isolated from soil. Appl Environ Microbiol 64:5061-5063 (Pubitemid 28557888)
37. Anderson AS, Clark DJ, Gibbons PH, Sigmund JM (2002) The detection of diverse aminoglycoside phosphotransferases within natural populations of actinomycetes. J Ind Microbiol Biotechnol 29:60-69 (Pubitemid 34988939)
38. Benveniste R, Davies J (1973) Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria. Proc Natl Acad Sci USA 70:2276-2280
39. Davies J, Wright GD (1997) Bacterial resistance to aminoglycoside antibiotics. Trends Microbiol 5:234-240 (Pubitemid 27348681)
40. Todar KG (2012) Todar's online textbook of bacteriology. http://textbookofbacteriology.net/index.html. Accessed 3 May 2012
41. McKay GA, Thompson PR, Wright GD (1994) Broad spectrum aminoglycoside phosphotransferase type III from Enterococcus: overexpression, purification, and substrate specificity. Biochemistry 33:6936-6944 (Pubitemid 24190818)