The small heat-shock protein α B-crystallin is essential for the nuclear localization of Smad4: Impact on pulmonary fibrosis

Journal of Pathology

Volumn 232, Issue 4, 2014, Pages 458-472

  Bellaye, Pierre Simon ^a,b   Wettstein, Guillaume ^a,b   Burgy, Olivier ^a,b   Besnard, Valérie ^c   Joannes, Audrey ^c   Colas, Julien ^a,b   Causse, Sébastien ^a,b   Marchal Somme, Joëlle ^c   Fabre, Aurélie ^d   Crestani, Bruno ^c,e,f   Kolb, Martin ^g   Gauldie, Jack ^g   Camus, Philippe ^a,b,h   Garrido, Carmen ^a,b   Bonniaud, Philippe ^a,b,h  

^a Institut Médical de Génétique et d Immunologie   (France)

^b UNIVERSITÉ DE BOURGOGNE   (France)

^c INSERM   (France)

^d ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f BICHAT HOSPITAL   (France)

^g MCMASTER UNIVERSITY   (Canada)

^h DIJON UNIVERSITY HOSPITAL   (France)

Author keywords

fibrogenesis; heat shock proteins; inflammation; TGF 1

Indexed keywords

ALPHA CRYSTALLIN; ALPHA SMOOTH MUSCLE ACTIN; INTERLEUKIN 1BETA; PLASMINOGEN ACTIVATOR INHIBITOR 1; SMAD4 PROTEIN; TRANSCRIPTION FACTOR SLUG; TRANSFORMING GROWTH FACTOR BETA1; UBIQUITIN PROTEIN LIGASE E3; UVOMORULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEOMYCIN-INDUCED PULMONARY FIBROSIS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; FIBROBLAST; FIBROGENESIS; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LUNG FIBROSIS; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UBIQUITINATION; UPREGULATION;

FIBROGENESIS; HEAT-SHOCK PROTEINS; INFLAMMATION; TGF-Β1;

ACTIVE TRANSPORT, CELL NUCLEUS; ALPHA-CRYSTALLIN B CHAIN; ANIMALS; BLEOMYCIN; CELL NUCLEUS; CELLS, CULTURED; COLLAGEN; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; FEMALE; FIBROBLASTS; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; INTERLEUKIN-1BETA; LUNG; MICE; MICE, 129 STRAIN; MICE, KNOCKOUT; RATS, SPRAGUE-DAWLEY; RNA INTERFERENCE; SMAD4 PROTEIN; TRANSCRIPTION FACTORS; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA1; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84893818986     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4314     Document Type: Article

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