P-Coumaric acid activates the GABA-a receptor in vitro and is orally anxiolytic in Vivo

Phytotherapy Research

Volumn 28, Issue 2, 2014, Pages 207-211

  Scheepens, Arjan ^a   Bisson, Jean Francois ^b   Skinner, Margot ^a  

^a THE NEW ZEALAND INSTITUTE FOR PLANT AND FOOD RESEARCH LIMITED   (New Zealand)

^b ETAP Ethologie Appliquee   (France)

Author keywords

anxiety; diazepam; functional food; GABA; p coumaric acid; stress

Indexed keywords

ANXIETY; DIAZEPAM; FUNCTIONAL FOOD; GABA; P-COUMARIC ACID; STRESS;

ANIMALS; ANTI-ANXIETY AGENTS; COUMARIC ACIDS; DIAZEPAM; GABA ANTAGONISTS; MALE; MOTOR ACTIVITY; PHYTOCHEMICALS; PICROTOXIN; RATS; RATS, WISTAR; RECEPTORS, GABA-A; SYNAPTIC TRANSMISSION;

EID: 84893816540     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4968     Document Type: Article

References (31)

1. Andreasen MF, Kroon PA, Williamson G, Garcia-Conesa MT,. 2001. Esterase activity able to hydrolyze dietary antioxidant hydroxycinnamates is distributed along the intestine of mammals. J Agric Food Chem 49: 5679-5684.
2. Appel K, Rose T, Fiebich B, Kammler T, Hoffmann C, Weiss G,. 2011. Modulation of the gamma-aminobutyric acid (GABA) system by Passiflora incarnata L. Phytother Res 25: 838-843.
3. Barros MP, Lemos M, Maistro EL, et al,. 2008. Evaluation of antiulcer activity of the main phenolic acids found in Brazilian green propolis. J Ethnopharmacol 120 (3): 372-377.
4. Bok SH, Jeong TS, Park YB, et al,. 2000. Composition containing cinnamic acid derivatives for preventing or treating elevated blood lipid level-related diseases. Patent #WO 00/15215, USA.
5. Campbell EL, Chebib M, Johnston GA,. 2004. The dietary flavonoids apigenin and (-)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABA(A) receptors. Biochem Pharmacol 68: 1631-1638.
6. Chouinard G,. 2004. Issues in the clinical use of benzodiazepines: potency, withdrawal, and rebound. J Clin Psychiatry 65 (Suppl 5): 7-12.
7. Desai R, Ruesch D, Forman SA,. 2009. Gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity. Anesthesiology 111: 774-784.
8. Goutman JD, Waxemberg MD, Donate-Oliver F, Pomata PE, Calvo DJ, 2003. Flavonoid modulation of ionic currents mediated by GABA(A) and GABA(C) receptors. Eur J Pharmacol 461: 79-87.
9. Hu T, Sung SY,. 2004. A trimmed mean approach to finding spatial outliers. Intell Data Anal 8: 79-95.
10. Kavvadias D, Sand P, Youdim KA, et al,. 2004. The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects. Br J Pharmacol 142: 811-820.
11. Konishi Y, Hitomi Y, Yoshioka E,. 2004. Intestinal absorption of p-coumaric and gallic acids in rats after oral administration. J Agric Food Chem 52: 2527-2532.
12. Kruger W, Gilbert D, Hawthorne R, et al,. 2005. A yellow fluorescent protein-based assay for high-throughput screening of glycine and GABAA receptor chloride channels. Neurosci Lett 380: 340-345.
13. Larrosa M, Lodovici M, Morbidelli L, Dolara P,. 2008. Hydrocaffeic and p-coumaric acids, natural phenolic compounds, inhibit UV-B damage in WKD human conjunctival cells in vitro and rabbit eye in vivo. Free Radic Res 42: 903-910.
14. Li P, Wang HZ, Wang XQ, Wu YN,. 1994. The blocking effect of phenolic acid on N-nitrosomorpholine formation in vitro. Biomed Environ Sci 7: 68-78.
15. Luceri C, Giannini L, Lodovici M, et al,. 2007. p-Coumaric acid, a common dietary phenol, inhibits platelet activity in vitro and in vivo. Br J Nutr 97: 458-463.
16. Lupien SJ, McEwen BS, Gunnar MR, Heim C,. 2009. Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Rev Neurosci 10: 434-445.
17. Medina JH, Paladini AC, Wolfman C, et al,. 1990. Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties. Biochem Pharmacol 40: 2227-2231.
18. Millan MJ,. 2003. The neurobiology and control of anxious states. Prog Neurobiol 70: 83-244.
19. Natella F, Nardini M, Belelli F, Scaccini C,. 2007. Coffee drinking induces incorporation of phenolic acids into LDL and increases the resistance of LDL to ex vivo oxidation in humans. Am J Clin Nutr 86: 604-609.
20. Radtke J, Linseisen J, Wolfram G,. 1998. [ Phenolic acid intake of adults in a Bavarian subgroup of the national food consumption survey ]. Z Ernahrungswiss 37: 190-197.
21. Salgueiro JB, Ardenghi P, Dias M, Ferreira MB, Izquierdo I, Medina JH,. 1997. Anxiolytic natural and synthetic flavonoid ligands of the central benzodiazepine receptor have no effect on memory tasks in rats. Pharmacol Biochem Behav 58: 887-891.
22. Stevenson DE, Scheepens A, Hurst RD,. 2010. Progress in the understanding of the bioavailability and metabolism of dietary flavonoids. Int J Med Biol Front 16: 249-300.
23. Takeda H, Tsuji M, Miyamoto J, Matsumiya T,. 2002. Rosmarinic acid and caffeic acid reduce the defensive freezing behavior of mice exposed to conditioned fear stress. Psychopharmacology (Berl) 164: 233-235.
24. Wasowski C, Marder M, Viola H, Medina JH, Paladini AC,. 2002. Isolation and identification of 6-methylapigenin, a competitive ligand for the brain GABA(A) receptors, from Valeriana wallichii. Planta Med 68: 934-936.
25. Wolfman C, Viola H, Paladini A, Dajas F, Medina JH,. 1994. Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea. Pharmacol Biochem Behav 47: 1-4.
26. Yamaguchi M, Lai YL, Uchiyama S, Nakagawa T,. 2008. Oral administration of phytocomponent p-hydroxycinnamic acid prevents bone loss in ovariectomized rats. Mol Cell Biochem 311: 31-36.
27. Yeh CT, Yen GC,. 2006. Modulation of hepatic phase II phenol sulfotransferase and antioxidant status by phenolic acids in rats. J Nutr Biochem 17: 561-569.
28. Yeh CT, Ching LC, Yen GC,. 2008. Inducing gene expression of cardiac antioxidant enzymes by dietary phenolic acids in rats. J Nutr Biochem 20 (3): 163-171.
29. Yu HS, Lee SY, Jang CG,. 2007. Involvement of 5-HT1A and GABAA receptors in the anxiolytic-like effects of Cinnamomum cassia in mice. Pharmacol Biochem Behav 87: 164-170.
30. Zang LY, Cosma G, Gardner H, Shi X, Castranova V, Vallyathan V,. 2000. Effect of antioxidant protection by p-coumaric acid on low-density lipoprotein cholesterol oxidation. Am J Physiol Cell Physiol 279: C954-C960.
31. Zanoli P, Zavatti M, Rivasi M, et al,. 2007. Evidence that the beta-acids fraction of hops reduces central GABAergic neurotransmission. J Ethnopharmacol 109: 87-92.