A potential link between bacterial pathogens and allergic conjunctivitis by dendritic cells

Experimental Eye Research

Volumn 120, Issue , 2014, Pages 118-126

  Deng, Ruzhi ^a,b   Su, Zhitao ^a,b   Lu, Fan ^a   Zhang, Lili ^b,c   Lin, Jing ^b,c   Zhang, Xiaobo ^b   de Paiva, Cintia S ^b   Pflugfelder, Stephen C ^b   Li, De Quan ^b  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b CULLEN EYE INSTITUTE   (United States)

^c QINGDAO UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

Allergic conjunctivitis; Allergy; Dendritic cells; Innate immunity; Mucosal immunology; Thymic stromal lymphopoietin; Toll like receptor

Indexed keywords

B7 ANTIGEN; BACTERIUM LIPOPOLYSACCHARIDE; BLOCKING ANTIBODY; CD40 ANTIGEN; FLAGELLIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 13; MESSENGER RNA; MYELOID DIFFERENTIATION FACTOR 88; OX40 LIGAND; PROTEIN; QUINAZOLINE; THYMIC STROMAL LYMPHOPOIETIN; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TLR5 ANTIBODY; TOLL LIKE RECEPTOR 5; UNCLASSIFIED DRUG;

ALLERGIC CONJUNCTIVITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL LOAD; BONE MARROW DERIVED DENDRITIC CELL; CELL SURFACE; CERVICAL LYMPH NODE; CONJUNCTIVA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; IMMUNOFLUORESCENCE TEST; IN VIVO STUDY; INNATE IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TH2 CELL; WESTERN BLOTTING;

ALLERGIC CONJUNCTIVITIS; ALLERGY; DENDRITIC CELLS; INNATE IMMUNITY; MUCOSAL IMMUNOLOGY; THYMIC STROMAL LYMPHOPOIETIN; TOLL-LIKE RECEPTOR;

ANIMALS; BLOTTING, WESTERN; BONE MARROW CELLS; CELLS, CULTURED; CONJUNCTIVITIS, ALLERGIC; CYTOKINES; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLAGELLIN; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; IMMUNITY, INNATE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; POLYSACCHARIDES, BACTERIAL; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; STROMAL CELLS; TOLL-LIKE RECEPTORS;

EID: 84893814561     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2014.01.014     Document Type: Article

References (46)

1. Adema G.J. Dendritic cells from bench to bedside and back. Immunol. Lett. 2009, 122:128-130.
2. Allan R.S., Waithman J., Bedoui S., Jones C.M., Villadangos J.A., Zhan Y., Lew A.M., Shortman K., Heath W.R., Carbone F.R. Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming. Immunity 2006, 25:153-162.
3. Bunyavanich S., Melen E., Wilk J.B., Granada M., Soto-Quiros M.E., Avila L., Lasky-Su J., Hunninghake G.M., Wickman M., Pershagen G., O'Connor G.T., Weiss S.T., Celedomicronn J.C. Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma. Clin. Mol. Allergy 2011, 9:1.
4. Chen Z., de Paiva C.S., Luo L., Kretzer F.L., Pflugfelder S.C., Li D.-Q. Characterization of putative stem cell phenotype in human limbal epithelia. Stem Cells 2004, 22:355-366.
5. Demehri S., Morimoto M., Holtzman M.J., Kopan R. Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. PLoS. Biol. 2009, 7:e1000067.
6. Duez C., Gosset P., Tonnel A.B. Dendritic cells and toll-like receptors in allergy and asthma. Eur. J. Dermatol. 2006, 16:12-16.
7. Hammad H., Chieppa M., Perros F., Willart M.A., Germain R.N., Lambrecht B.N. House dust mite allergen induces asthma via toll-like receptor 4 triggering of airway structural cells. Nat. Med. 2009, 15:410-416.
8. Holgate S.T. The epithelium takes centre stage in asthma and atopic dermatitis. Trends Immunol. 2007, 28:248-251.
9. Ito T., Wang Y.H., Duramad O., Hori T., Delespesse G.J., Watanabe N., Qin F.X., Yao Z., Cao W., Liu Y.J. TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J.Exp. Med. 2005, 202:1213-1223.
10. Iwasaki A. Mucosal dendritic cells. Annu. Rev. Immunol. 2007, 25:381-418.
11. Johnson A.C., Heinzel F.P., Diaconu E., Sun Y., Hise A.G., Golenbock D., Lass J.H., Pearlman E. Activation of toll-like receptor (TLR)2, TLR4, and TLR9 in the mammalian cornea induces MyD88-dependent corneal inflammation. Investig. Ophthalmol. Vis. Sci. 2005, 46:589-595.
12. Kashyap M., Rochman Y., Spolski R., Samsel L., Leonard W.J. Thymic stromal lymphopoietin is produced by dendritic cells. J.Immunol. 2011, 187:1207-1211.
13. Kay A.B. Allergy and allergic diseases. First of two parts. N.Engl. J. Med. 2001, 344:30-37.
14. Kim H.S., Jun S.X., de Paiva C.S., Chen Z., Pflugfelder S.C., Li D.-Q. Phenotypic characterization of human corneal epithelial cells expanded exvivo from limbal explant and single cell cultures. Exp. Eye Res. 2004, 79:41-49.
15. Kinoshita H., Takai T., Le T.A., Kamijo S., Wang X.L., Ushio H., Hara M., Kawasaki J., Vu A.T., Ogawa T., Gunawan H., Ikeda S., Okumura K., Ogawa H. Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA. J.Allergy Clin. Immunol. 2009, 123:179-186.
16. Kumar A., Yu F.S. Toll-like receptors and corneal innate immunity. Curr. Mol. Med. 2006, 6:327-337.
17. Le T.A., Takai T., Vu A.T., Kinoshita H., Chen X., Ikeda S., Ogawa H., Okumura K. Flagellin induces the expression of thymic stromal lymphopoietin in human keratinocytes via toll-like receptor 5. Int. Arch. Allergy Immunol. 2010, 155:31-37.
18. Lee H.C., Ziegler S.F. Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFkappaB. Proc. Natl. Acad. Sci. U. S. A 2007, 104:914-919.
19. Li D.Q., Zhang L., Pflugfelder S.C., de Paiva C.S., Zhang X., Zhao G., Zheng X., Su Z., Qu Y. Short ragweed pollen triggers allergic inflammation through toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways. J.Allergy Clin. Immunol. 2011, 128:1318-1325.
20. Liu Y.J. Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation. J.Allergy Clin. Immunol. 2007, 120:238-244.
21. Liu Y.J., Soumelis V., Watanabe N., Ito T., Wang Y.H., Malefyt R.W., Omori M., Zhou B., Ziegler S.F. TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. Annu. Rev. Immunol. 2007, 25:193-219.
22. Luo L., Li D.-Q., Doshi A., Farley W., Corrales R.M., Pflugfelder S.C. Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface. Investig. Ophthalmol. Vis. Sci. 2004, 45:4293-4301.
23. Ma P., Bian F., Wang Z., Zheng X., Chotikavanich S., Pflugfelder S.C., Li D.Q. Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines. Investig. Ophthalmol. Vis. Sci. 2009, 50:2702-2709.
24. Matsuda A., Ebihara N., Yokoi N., Kawasaki S., Tanioka H., Inatomi T., de Waal M.R., Hamuro J., Kinoshita S., Murakami A. Functional role of thymic stromal lymphopoietin in chronic allergic keratoconjunctivitis. Investig. Ophthalmol. Vis. Sci. 2010, 51:151-155.
25. Medzhitov R., Janeway C. Innate immune recognition: mechanisms and pathways. Immunol. Rev. 2000, 173:89-97.
26. Nolan G.P., Ghosh S., Liou H.C., Tempst P., Baltimore D. DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide. Cell 1991, 64:961-969.
27. Ohbayashi M., Manzouri B., Flynn T., Toda M., Ikeda Y., Nakamura T., Ono S.J. Dynamic changes in conjunctival dendritic cell numbers, anatomical position and phenotype during experimental allergic conjunctivitis. Exp. Mol. Pathol. 2007, 83:216-223.
28. Ortiz-Stern A., Kanda A., Mionnet C., Cazareth J., Lazzari A., Fleury S., Dombrowicz D., Glaichenhaus N., Julia V. Langerin+ dendritic cells are responsible for LPS-induced reactivation of allergen-specific Th2 responses in postasthmatic mice. Mucosal Immunol. 2011, 4:343-353.
29. Piggott D.A., Eisenbarth S.C., Xu L., Constant S.L., Huleatt J.W., Herrick C.A., Bottomly K. MyD88-dependent induction of allergic Th2 responses to intranasal antigen. J.Clin. Investig. 2005, 115:459-467.
30. Prescott S.L., Noakes P., Chow B.W., Breckler L., Thornton C.A., Hollams E.M., Ali M., van den Biggelaar A.H., Tulic M.K. Presymptomatic differences in toll-like receptor function in infants who have allergy. J.Allergy Clin. Immunol. 2008, 122:391-399. 399.
31. Randolph G.J., Angeli V., Swartz M.A. Dendritic-cell trafficking to lymph nodes through lymphatic vessels. Nat. Rev. Immunol. 2005, 5:617-628.
32. Rank M.A., Kobayashi T., Kozaki H., Bartemes K.R., Squillace D.L., Kita H. IL-33-activated dendritic cells induce an atypical TH2-type response. J.Allergy Clin. Immunol. 2009, 123:1047-1054.
33. Reche P.A., Soumelis V., Gorman D.M., Clifford T., Liu M., Travis M., Zurawski S.M., Johnston J., Liu Y.J., Spits H., de Waal M.R., Kastelein R.A., Bazan J.F. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. J.Immunol. 2001, 167:336-343.
34. Reginald K., Westritschnig K., Werfel T., Heratizadeh A., Novak N., Focke-Tejkl M., Hirschl A.M., Leung D.Y., Elisyutina O., Fedenko E., Valenta R. Immunoglobulin E antibody reactivity to bacterial antigens in atopic dermatitis patients. Clin. Exp. Allergy 2011, 41:357-369.
35. Rescigno M., Urbano M., Valzasina B., Francolini M., Rotta G., Bonasio R., Granucci F., Kraehenbuhl J.P., Ricciardi-Castagnoli P. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat. Immunol. 2001, 2:361-367.
36. Sallusto F., Lanzavecchia A. The instructive role of dendritic cells on T-cell responses. Arthritis Res. 2002, 4(Suppl.3):S127-S132.
37. Song X.J., Li D.-Q., Farley W., Luo L.H., Heuckeroth R.O., Milbrandt J., Pflugfelder S.C. Neurturin-deficient mice develop dry eye and keratoconjunctivitis Sicca. Investig. Ophthalmol. Vis. Sci. 2003, 44:4223-4229.
38. Soumelis V., Reche P.A., Kanzler H., Yuan W., Edward G., Homey B., Gilliet M., Ho S., Antonenko S., Lauerma A., Smith K., Gorman D., Zurawski S., Abrams J., Menon S., McClanahan T., de Waal-Malefyt R.R., Bazan F., Kastelein R.A., Liu Y.J. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat. Immunol. 2002, 3:673-680.
39. Spadoni I., Iliev I.D., Rossi G., Rescigno M. Dendritic cells produce TSLP that limits the differentiation of Th17 cells, fosters Treg development, and protects against colitis. Mucosal Immunol. 2012, 5:184-193.
40. Yang M., Kumar R.K., Foster P.S. Pathogenesis of steroid-resistant airway hyperresponsiveness: interaction between IFN-gamma and TLR4/MyD88 pathways. J.Immunol. 2009, 182:5107-5115.
41. Ying S., O'Connor B., Ratoff J., Meng Q., Fang C., Cousins D., Zhang G., Gu S., Gao Z., Shamji B., Edwards M.J., Lee T.H., Corrigan C.J. Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease. J.Immunol. 2008, 181:2790-2798.
42. Yoon K.C., de Paiva C.S., Qi H., Chen Z., Farley W.J., Li D.Q., Pflugfelder S.C. Expression of Th-1 chemokines and chemokine receptors on the ocular surface of C57BL/6 mice: effects of desiccating stress. Investig. Ophthalmol. Vis. Sci. 2007, 48:2561-2569.
43. Zhang Z., Hener P., Frossard N., Kato S., Metzger D., Li M., Chambon P. Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma. Proc. Natl. Acad. Sci. U. S. A 2009, 106:1536-1541.
44. Zheng X., de Paiva C.S., Li D.Q., Farley W.J., Pflugfelder S.C. Desiccating stress promotion of Th17 differentiation by ocular surface tissues through a dendritic cell-mediated pathway. Investig. Ophthalmol. Vis. Sci. 2010, 51:3083-3091.
45. Zheng X., Ma P., de Paiva C.S., Cunningham M.A., Hwang C.S., Pflugfelder S.C., Li D.Q. TSLP and downstream molecules in experimental mouse allergic conjunctivitis. Investig. Ophthalmol. Vis. Sci. 2010, 51:3076-3082.
46. Ziegler S.F. The role of thymic stromal lymphopoietin (TSLP) in allergic disorders. Curr. Opin. Immunol. 2010, 22:795-799.