Ionic liquid mediated synthesis of mono- and bis-spirooxindole- hexahydropyrrolidines as cholinesterase inhibitors and their molecular docking studies

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 4, 2014, Pages 1318-1328

  Kia, Yalda ^a   Osman, Hasnah ^a   Kumar, Raju Suresh ^b   Basiri, Alireza ^c   Murugaiyah, Vikneswaran ^c  

^a SCHOOL OF PHYSICS   (Malaysia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c SCHOOL OF PHARMACEUTICAL SCIENCES   (Malaysia)

Author keywords

1,3 Dipolar cycloaddition; AChE; Alzheimer's disease; BChE; Enzyme kinetic study and molecular docking; Spiropyrrolidines

Indexed keywords

1,3-DIPOLAR CYCLOADDITION; ACHE; ALZHEIMER'S DISEASE; BCHE; ENZYME KINETIC STUDY AND MOLECULAR DOCKING; SPIROPYRROLIDINES;

ACETYLCHOLINESTERASE; ANIMALS; BINDING SITES; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; CRYSTALLOGRAPHY, X-RAY; HUMANS; INDOLES; IONIC LIQUIDS; KINETICS; MOLECULAR CONFORMATION; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PYRROLIDINES; SPIRO COMPOUNDS; TORPEDO;

EID: 84893814040     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.01.002     Document Type: Article

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