메뉴 건너뛰기




Volumn 45, Issue 2, 2014, Pages 394-402

Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies

(26)  Malik, Rainer a   Bevan, Steve b   Nalls, Michael A c   Holliday, Elizabeth G d,f   Devan, William J g   Cheng, Yu Ching h,i   Ibrahim Verbaas, Carla A j   Verhaaren, Benjamin F J j   Bis, Joshua C k,l   Joon, Aron Y m   De Stefano, Anita L o,p,q   Fornage, Myriam m,n   Psaty, Bruce M k,l,r   Ikram, M Arfan j,s   Launer, Lenore J c   Van Duijn, Cornelia M j,s   Sharma, Pankaj t   Mitchell, Braxton D h,i   Rosand, Jonathan g,u,v   Meschia, James F w   more..


Author keywords

Genetic; Genetics; Polymorphism; Risk assessment; Risk factors

Indexed keywords

GENETICS; POLYMORPHISM, GENETIC; RISK ASSESSMENT; RISK FACTORS;

EID: 84893778384     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.113.002938     Document Type: Article
Times cited : (58)

References (47)
  • 1
    • 0026567697 scopus 로고
    • Epidemiology of stroke
    • Bonita R. Epidemiology of stroke. Lancet. 1992;339:342-344.
    • (1992) Lancet , vol.339 , pp. 342-344
    • Bonita, R.1
  • 2
    • 33646799069 scopus 로고    scopus 로고
    • Global and regional burden of disease and risk factors 2001: Systematic analysis of population health data
    • Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet. 2006;367:1747-1757.
    • (2006) Lancet , vol.367 , pp. 1747-1757
    • Lopez, A.D.1    Mathers, C.D.2    Ezzati, M.3    Jamison, D.T.4    Murray, C.J.5
  • 3
    • 33846185489 scopus 로고    scopus 로고
    • Genetics of ischaemic stroke
    • Dichgans M. Genetics of ischaemic stroke. Lancet Neurol. 2007;6:149-161.
    • (2007) Lancet Neurol , vol.6 , pp. 149-161
    • Dichgans, M.1
  • 4
    • 84870931409 scopus 로고    scopus 로고
    • Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations
    • Bevan S, Traylor M, Adib-Samii P, Malik R, Paul NL, Jackson C, et al. Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations. Stroke. 2012;43:3161-3167.
    • (2012) Stroke , vol.43 , pp. 3161-3167
    • Bevan, S.1    Traylor, M.2    Adib-Samii, P.3    Malik, R.4    Paul, N.L.5    Jackson, C.6
  • 5
    • 84893659261 scopus 로고    scopus 로고
    • Shared genetic susceptibility to ischemic stroke and coronary artery disease: A genome-wide analysis of common variants
    • November 21, 2013. doi: 10.1161/STROKEAHA.113.00270. Accessed December 21, 2013
    • Dichgans M, Malik R, König IR, Rosand J, Clarke R, Gretarsdottir S, et al. Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. Stroke November 21, 2013. doi: 10.1161/STROKEAHA.113.00270. http://stroke.ahajournals. org/content/early/2013/11/21/STROKEAHA.113.002707.long. Accessed December 21, 2013.
    • Stroke
    • Dichgans, M.1    Malik, R.2    König, I.R.3    Rosand, J.4    Clarke, R.5    Gretarsdottir, S.6
  • 6
    • 84863393715 scopus 로고    scopus 로고
    • Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke
    • Bellenguez C, Bevan S, Gschwendtner A, Spencer CC, Burgess AI, Pirinen M, et al. Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nat Genet. 2012;44:328-333.
    • (2012) Nat Genet , vol.44 , pp. 328-333
    • Bellenguez, C.1    Bevan, S.2    Gschwendtner, A.3    Spencer, C.C.4    Burgess, A.I.5    Pirinen, M.6
  • 7
    • 84866930896 scopus 로고    scopus 로고
    • Common variants at 6p21.1 are associated with large artery atherosclerotic stroke
    • Australian Stroke Genetics Collaborative; International Stroke Genetics Consortium; Wellcome Trust Case Control Consortium
    • Holliday EG, Maguire JM, Evans TJ, Koblar SA, Jannes J, Sturm JW, et al; Australian Stroke Genetics Collaborative; International Stroke Genetics Consortium; Wellcome Trust Case Control Consortium. Common variants at 6p21.1 are associated with large artery atherosclerotic stroke. Nat Genet. 2012;44:1147-1151.
    • (2012) Nat Genet , vol.44 , pp. 1147-1151
    • Holliday, E.G.1    Maguire, J.M.2    Evans, T.J.3    Koblar, S.A.4    Jannes, J.5    Sturm, J.W.6
  • 9
    • 79953204259 scopus 로고    scopus 로고
    • Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
    • Cardiogenics; CARDIoGRAM Consortium
    • Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, et al; Cardiogenics; CARDIoGRAM Consortium. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 2011;43:333-338.
    • (2011) Nat Genet , vol.43 , pp. 333-338
    • Schunkert, H.1    König, I.R.2    Kathiresan, S.3    Reilly, M.P.4    Assimes, T.L.5    Holm, H.6
  • 10
    • 84871969762 scopus 로고    scopus 로고
    • Large-scale association analysis identifies new risk loci for coronary artery disease
    • CARDIoGRAMplusC4D Consortium
    • CARDIoGRAMplusC4D Consortium, Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, et al. Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet. 2013;45:25-33.
    • (2013) Nat Genet , vol.45 , pp. 25-33
    • Deloukas, P.1    Kanoni, S.2    Willenborg, C.3    Farrall, M.4    Assimes, T.L.5
  • 11
    • 80053907554 scopus 로고    scopus 로고
    • Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
    • Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011;478:103-109.
    • (2011) Nature , vol.478 , pp. 103-109
    • Ehret, G.B.1    Munroe, P.B.2    Rice, K.M.3    Bochud, M.4    Johnson, A.D.5    Chasman, D.I.6
  • 13
    • 67249112107 scopus 로고    scopus 로고
    • Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke
    • International Stroke Genetics Consortium
    • Gschwendtner A, Bevan S, Cole JW, Plourde A, Matarin M, Ross-Adams H, et al; International Stroke Genetics Consortium. Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke. Ann Neurol. 2009;65:531-539.
    • (2009) Ann Neurol , vol.65 , pp. 531-539
    • Gschwendtner, A.1    Bevan, S.2    Cole, J.W.3    Plourde, A.4    Matarin, M.5    Ross-Adams, H.6
  • 14
    • 84875299446 scopus 로고    scopus 로고
    • Ischemic stroke is associated with the ABO locus: The EuroCLOT study
    • EuroCLOT Investigators; Wellcome Trust Case Control Consortium 2; MOnica Risk, Genetics, Archiving and Monograph; MetaStroke; International Stroke Genetics Consortium
    • Williams FM, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo N, et al; EuroCLOT Investigators; Wellcome Trust Case Control Consortium 2; MOnica Risk, Genetics, Archiving and Monograph; MetaStroke; International Stroke Genetics Consortium. Ischemic stroke is associated with the ABO locus: the EuroCLOT study. Ann Neurol. 2013;73:16-31.
    • (2013) Ann Neurol , vol.73 , pp. 16-31
    • Williams, F.M.1    Carter, A.M.2    Hysi, P.G.3    Surdulescu, G.4    Hodgkiss, D.5    Soranzo, N.6
  • 15
    • 84867645825 scopus 로고    scopus 로고
    • Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): A meta-analysis of genome-wide association studies
    • Australian Stroke Genetics Collaborative Wellcome Trust Case Control Consortium 2 (WTCCC2); International Stroke Genetics Consortium
    • Traylor M, Farrall M, Holliday EG, Sudlow C, Hopewell JC, Cheng YC, et al; Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2); International Stroke Genetics Consortium. Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol. 2012;11:951-962.
    • (2012) Lancet Neurol , vol.11 , pp. 951-962
    • Traylor, M.1    Farrall, M.2    Holliday, E.G.3    Sudlow, C.4    Hopewell, J.C.5    Cheng, Y.C.6
  • 18
    • 0027958469 scopus 로고
    • Stroke risk profile: Adjustment for antihypertensive medication. The Framingham Study
    • D'Agostino RB, Wolf PA, Belanger AJ, Kannel WB. Stroke risk profile: adjustment for antihypertensive medication. The Framingham Study. Stroke. 1994;25:40-43.
    • (1994) Stroke , vol.25 , pp. 40-43
    • D'Agostino, R.B.1    Wolf, P.A.2    Belanger, A.J.3    Kannel, W.B.4
  • 19
    • 84866382284 scopus 로고    scopus 로고
    • Routinely available biomarkers improve prediction of long-term mortality in stable coronary artery disease: The Vienna and Ludwigshafen Coronary Artery Disease (VILCAD) risk score
    • Goliasch G, Kleber ME, Richter B, Plischke M, Hoke M, Haschemi A, et al. Routinely available biomarkers improve prediction of long-term mortality in stable coronary artery disease: the Vienna and Ludwigshafen Coronary Artery Disease (VILCAD) risk score. Eur Heart J. 2012;33:2282-2289.
    • (2012) Eur Heart J , vol.33 , pp. 2282-2289
    • Goliasch, G.1    Kleber, M.E.2    Richter, B.3    Plischke, M.4    Hoke, M.5    Haschemi, A.6
  • 21
    • 83655201232 scopus 로고    scopus 로고
    • Vascular biomarkers in the prediction of clinical cardiovascular disease: The Strong Heart Study
    • Roman MJ, Kizer JR, Best LG, Lee ET, Howard BV, Shara NM, et al. Vascular biomarkers in the prediction of clinical cardiovascular disease: the Strong Heart Study. Hypertension. 2012;59:29-35.
    • (2012) Hypertension , vol.59 , pp. 29-35
    • Roman, M.J.1    Kizer, J.R.2    Best, L.G.3    Lee, E.T.4    Howard, B.V.5    Shara, N.M.6
  • 22
    • 84864335233 scopus 로고    scopus 로고
    • Genetic markers enhance coronary risk prediction in men: The MORGAM prospective cohorts
    • Hughes MF, Saarela O, Stritzke J, Kee F, Silander K, Klopp N, et al. Genetic markers enhance coronary risk prediction in men: the MORGAM prospective cohorts. PLoS One. 2012;7:e40922.
    • (2012) PLoS One , vol.7
    • Hughes, M.F.1    Saarela, O.2    Stritzke, J.3    Kee, F.4    Silander, K.5    Klopp, N.6
  • 23
    • 78049314943 scopus 로고    scopus 로고
    • A multilocus genetic risk score for coronary heart disease: Case-control and prospective cohort analyses
    • Ripatti S, Tikkanen E, Orho-Melander M, Havulinna AS, Silander K, Sharma A, et al. A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. Lancet. 2010;376:1393-1400.
    • (2010) Lancet , vol.376 , pp. 1393-1400
    • Ripatti, S.1    Tikkanen, E.2    Orho-Melander, M.3    Havulinna, A.S.4    Silander, K.5    Sharma, A.6
  • 25
    • 78649379906 scopus 로고    scopus 로고
    • Improved prediction of cardiovascular disease based on a panel of single nucleotide polymorphisms identified through genome-wide association studies
    • Davies RW, Dandona S, Stewart AF, Chen L, Ellis SG, Tang WH, et al. Improved prediction of cardiovascular disease based on a panel of single nucleotide polymorphisms identified through genome-wide association studies. Circ Cardiovasc Genet. 2010;3:468-474.
    • (2010) Circ Cardiovasc Genet , vol.3 , pp. 468-474
    • Davies, R.W.1    Dandona, S.2    Stewart, A.F.3    Chen, L.4    Ellis, S.G.5    Tang, W.H.6
  • 26
    • 84893729545 scopus 로고    scopus 로고
    • 23 and Me. Accessed August 2, 2013
    • Stroke Genetic Risk. 23 and Me. Https://www.23andme.Com/health/ stroke/. Accessed August 2, 2013.
    • Stroke Genetic Risk
  • 27
    • 63449100039 scopus 로고    scopus 로고
    • Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts
    • CHARGE Consortium
    • Psaty BM, O'Donnell CJ, Gudnason V, Lunetta KL, Folsom AR, Rotter JI, et al; CHARGE Consortium. Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: design of prospective meta-analyses of genome-wide association studies from 5 cohorts. Circ Cardiovasc Genet. 2009;2:73-80.
    • (2009) Circ Cardiovasc Genet , vol.2 , pp. 73-80
    • Psaty, B.M.1    O'Donnell, C.J.2    Gudnason, V.3    Lunetta, K.L.4    Folsom, A.R.5    Rotter, J.I.6
  • 28
    • 79251601596 scopus 로고    scopus 로고
    • Guidelines for the primary prevention of stroke: A guideline for healthcare professionals from the American Heart Association/American Stroke Association
    • American Heart Association Stroke Council; Council on Cardiovascular Nursing; Council on Epidemiology and Prevention; Council for High Blood Pressure Research Council on Peripheral Vascular Disease, and Interdisciplinary Council on Quality of Care and Outcomes Research
    • Goldstein LB, Bushnell CD, Adams RJ, Appel LJ, Braun LT, Chaturvedi S, et al; American Heart Association Stroke Council; Council on Cardiovascular Nursing; Council on Epidemiology and Prevention; Council for High Blood Pressure Research, Council on Peripheral Vascular Disease, and Interdisciplinary Council on Quality of Care and Outcomes Research. Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42:517-584.
    • (2011) Stroke , vol.42 , pp. 517-584
    • Goldstein, L.B.1    Bushnell, C.D.2    Adams, R.J.3    Appel, L.J.4    Braun, L.T.5    Chaturvedi, S.6
  • 29
    • 77951487868 scopus 로고    scopus 로고
    • Cardiovascular risk prediction: Basic concepts, current status, and future directions
    • Lloyd-Jones DM. Cardiovascular risk prediction: basic concepts, current status, and future directions. Circulation. 2010;121:1768-1777.
    • (2010) Circulation , vol.121 , pp. 1768-1777
    • Lloyd-Jones, D.M.1
  • 31
    • 73449129712 scopus 로고    scopus 로고
    • From disease association to risk assessment: An optimistic view from genome-wide association studies on type 1 diabetes
    • Wei Z, Wang K, Qu HQ, Zhang H, Bradfield J, Kim C, et al. From disease association to risk assessment: an optimistic view from genome-wide association studies on type 1 diabetes. PLoS Genet. 2009;5:e1000678.
    • (2009) PLoS Genet , vol.5
    • Wei, Z.1    Wang, K.2    Qu, H.Q.3    Zhang, H.4    Bradfield, J.5    Kim, C.6
  • 32
    • 84875700256 scopus 로고    scopus 로고
    • Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies
    • 405e1
    • Chatterjee N, Wheeler B, Sampson J, Hartge P, Chanock SJ, Park JH. Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies. Nat Genet. 2013;45:400-405, 405e1.
    • (2013) Nat Genet , vol.45 , pp. 400-405
    • Chatterjee, N.1    Wheeler, B.2    Sampson, J.3    Hartge, P.4    Chanock, S.J.5    Park, J.H.6
  • 33
  • 34
    • 0020524559 scopus 로고
    • A method of comparing the areas under receiver operating characteristic curves derived from the same cases
    • Hanley JA, McNeil BJ. A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology. 1983;148:839-843.
    • (1983) Radiology , vol.148 , pp. 839-843
    • Hanley, J.A.1    McNeil, B.J.2
  • 35
    • 78649477601 scopus 로고    scopus 로고
    • Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers
    • Pencina MJ, D'Agostino RB Sr, Steyerberg EW. Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers. Stat Med. 2011;30:11-21.
    • (2011) Stat Med , vol.30 , pp. 11-21
    • Pencina, M.J.1    D'Agostino Sr., R.B.2    Steyerberg, E.W.3
  • 38
    • 55649105963 scopus 로고    scopus 로고
    • Clinical risk factors, DNA variants, and the development of type 2 diabetes
    • Lyssenko V, Jonsson A, Almgren P, Pulizzi N, Isomaa B, Tuomi T, et al. Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med. 2008;359:2220-2232.
    • (2008) N Engl J Med , vol.359 , pp. 2220-2232
    • Lyssenko, V.1    Jonsson, A.2    Almgren, P.3    Pulizzi, N.4    Isomaa, B.5    Tuomi, T.6
  • 39
    • 56749101779 scopus 로고    scopus 로고
    • Genotype score in addition to common risk factors for prediction of type 2 diabetes
    • Meigs JB, Shrader P, Sullivan LM, McAteer JB, Fox CS, Dupuis J, et al. Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med. 2008;359:2208-2219.
    • (2008) N Engl J Med , vol.359 , pp. 2208-2219
    • Meigs, J.B.1    Shrader, P.2    Sullivan, L.M.3    McAteer, J.B.4    Fox, C.S.5    Dupuis, J.6
  • 40
    • 84864762687 scopus 로고    scopus 로고
    • A genetic risk score based on direct associations with coronary heart disease improves coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC) but not in the Rotterdam and Framingham Offspring Studies
    • Brautbar A, Pompeii LA, Dehghan A, Ngwa JS, Nambi V, Virani SS, et al. A genetic risk score based on direct associations with coronary heart disease improves coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC), but not in the Rotterdam and Framingham Offspring, Studies. Atherosclerosis. 2012;223:421-426.
    • (2012) Atherosclerosis , vol.223 , pp. 421-426
    • Brautbar, A.1    Pompeii, L.A.2    Dehghan, A.3    Ngwa, J.S.4    Nambi, V.5    Virani, S.S.6
  • 41
    • 71849098862 scopus 로고    scopus 로고
    • Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: A weighted genetic risk score
    • Steering committee of the BENEFIT study; Steering committee of the BEYOND study; Steering committee of the LTF study; Steering committee of the CCR1 study
    • De Jager PL, Chibnik LB, Cui J, Reischl J, Lehr S, Simon KC, et al; Steering committee of the BENEFIT study; Steering committee of the BEYOND study; Steering committee of the LTF study; Steering committee of the CCR1 study. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. Lancet Neurol. 2009;8:1111-1119.
    • (2009) Lancet Neurol , vol.8 , pp. 1111-1119
    • De Jager, P.L.1    Chibnik, L.B.2    Cui, J.3    Reischl, J.4    Lehr, S.5    Simon, K.C.6
  • 43
    • 65949099120 scopus 로고    scopus 로고
    • Genetic risk prediction-are we there yet?
    • Kraft P, Hunter DJ. Genetic risk prediction-are we there yet? N Engl J Med. 2009;360:1701-1703.
    • (2009) N Engl J Med , vol.360 , pp. 1701-1703
    • Kraft, P.1    Hunter, D.J.2
  • 44
    • 1842576536 scopus 로고    scopus 로고
    • Heritability of ischemic stroke in relation to age, vascular risk factors, and subtypes of incident stroke in population-based studies
    • Schulz UG, Flossmann E, Rothwell PM. Heritability of ischemic stroke in relation to age, vascular risk factors, and subtypes of incident stroke in population-based studies. Stroke. 2004;35:819-824.
    • (2004) Stroke , vol.35 , pp. 819-824
    • Schulz, U.G.1    Flossmann, E.2    Rothwell, P.M.3
  • 45
    • 0043124261 scopus 로고    scopus 로고
    • Differences in vascular risk factors between etiological subtypes of ischemic stroke: Importance of population-based studies
    • Schulz UG, Rothwell PM. Differences in vascular risk factors between etiological subtypes of ischemic stroke: importance of population-based studies. Stroke. 2003;34:2050-2059.
    • (2003) Stroke , vol.34 , pp. 2050-2059
    • Schulz, U.G.1    Rothwell, P.M.2
  • 47
    • 56049123219 scopus 로고    scopus 로고
    • Decoding cryptogenic cardioembolism
    • Meschia JF. Decoding cryptogenic cardioembolism. Ann Neurol. 2008;64:364-366.
    • (2008) Ann Neurol , vol.64 , pp. 364-366
    • Meschia, J.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.