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Volumn 22, Issue 4, 2014, Pages 1450-1458
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Degrasyn-like symmetrical compounds: Possible therapeutic agents for multiple myeloma (MM-I)
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Author keywords
Degrasyn; Inhibitors; Jak2 Stat3; Multiple myeloma; Small molecules; Synthesis
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Indexed keywords
(1,3 PHENYLENE)BIS(2 CYANO N 1 PHENYL ETHYL)ACRYLAMIDE;
3,3' (1,3 PHENYLENE)BIS(2 CYANO N PHENYLETHYL)ACRYLAMIDE;
3,3' (1,3 PHENYLENE)BIS[2 CYANO N (1 PHENYLPROPYL)ACRYLAMIDE];
3,3' (1,3 PHENYLENE)BIS[2 CYANO N 1(4 METHOXYPHENYL)ETHYL]ACRYLAMIDE;
3,3' (1,3 PHENYLENE)BIS[2CYANO N [CYCLOPROPYL(PHENYL)METHYL]ACRYLAMIDE];
3,3' (1,4 PHENYLENE)BIS[2 CYANO N (2 HYDROXY 1 PHENYLETHYL)ACRYLAMIDE];
3,3' (1,4 PHENYLENE)BIS[N(2 CHLOROBENZYL) 2 CYANOACRYLAMIDE];
3,3' (PYRIDINE 2,6 DIYL)BIS[2 CYANO N (2 HYDROXY 1 PHENYLETHYL)ACRYLAMIDE];
3,3' [5 [2 CYANO 3 OXO 3 (1 PHENYLPROYL)PROP 1 EN 1 YL] 1,3 PHENYLENE]BIS(2 CYANO N 1 PHENYLPROPYL)ACRYLAMIDE;
ANTINEOPLASTIC AGENT;
CP 2005;
DEGRASYN;
DEGRASYN LIKE SYMMETRICAL COMPOUND;
N,N [1,3 PHENYLENEBIS(METHYLENE)]BIS[2 CYANO 3 [4 (HEXYLOXY)PHENYL]ACRYLAMIDE];
N,N [1,3 PHENYLENEBIS(METHYLENE)]BIS[3 (BENZO[B]THIOPHEN 3 YL) 2 CYANOACRYLAMIDE];
N,N' [1,3 PHENYLENEBIS(METHYLENE)BIS[3 (2,2' BITHIOPHEN) 5 YL] 2 CYANOACRYLAMIDE];
N,N' [1,3 PHENYLENEBIS(METHYLENE)]BIS[2 CYANO 3 (1H IMIDAZOL 5 YL)ACRYLAMIDE];
N,N' [1,3 PHENYLENEBIS(METHYLENE)]BIS[2 CYANO 3 (1H INDOL 3 YL)ACRYLAMIDE];
N,N' [1,3 PHENYLENEBIS(METHYLENE)]BIS[2 CYANO 3 (1H INDOL 5 YL)ACRYLAMIDE];
N,N' [1,3 PHENYLENEBIS(METHYLENE)]BIS[2 CYANO 3 (3 HYDROXY 4 NITROPHENYL)ACRYLAMIDE];
N,N' [1,3 PHENYLENEBIS(METHYLENE)]BIS[2 CYANO 3 (3,4 DICHLOROPHENYL)ACRYLAMIDE];
N,N' [1,3 PHENYLENEBIS(METHYLENE)]BIS[2 CYANO 3 (3,4 DIMETHOXYPHENYL)ACRYLAMIDE];
N,N' [1,3 PHENYLENEBIS(METHYLENE)]BIS[2 CYANO 3 (4PHENYLTHIOPHEN 2 YL)ACRYLAMIDE];
N,N' [1,3 PHENYLENEBIS(METHYLENE)]BIS[2 CYANO 3 (6 METHOXYPYRIDIN 2 YL)ACRYLAMIDE];
N,N' [1,3 PHENYLENEBIS(METHYLENE)]BIS[2 CYANO 3 [4 (PIPERIDIN 1 YL)PHENYL]ACRYLAMIDE];
N,N' [1,3 PHENYLENEBIS(METHYLENE)]BIS[3 (3 BROMO 4 HYDROXYPHENYL) 2 CYANOACRYLAMIDE];
N,N' [1,3 PHENYLENEBIS(METHYLENE)]BIS[3 (6 BROMOPYRIDIN 2 YL) 2 CYANOACRYLAMIDE];
N,N' [1,3 PHENYLENEBIS(METHYLENE)]BIS[3(6 CHLORO 2 FLUORO 3 METHYLPHENYL) 2 CYANOACRYLAMIDE];
T 5165804;
T 5221251;
T 5229060;
UNCLASSIFIED DRUG;
WP 1130;
ANTINEOPLASTIC ACTIVITY;
ARTICLE;
BIOINFORMATICS;
CANCER CELL CULTURE;
CONCENTRATION RESPONSE;
CONTROLLED STUDY;
DRUG BINDING SITE;
DRUG CYTOTOXICITY;
DRUG POTENCY;
DRUG SCREENING;
DRUG SYNTHESIS;
ENZYME INHIBITION;
HUMAN;
HUMAN CELL;
IC 50;
IN VITRO STUDY;
MANTLE CELL LYMPHOMA;
MULTIPLE MYELOMA;
STRUCTURE ACTIVITY RELATION;
DEGRASYN;
INHIBITORS;
JAK2/STAT3;
MULTIPLE MYELOMA;
SMALL MOLECULES;
SYNTHESIS;
ANTINEOPLASTIC AGENTS;
CELL LINE, TUMOR;
CELL SURVIVAL;
DIMERIZATION;
HUMANS;
MODELS, MOLECULAR;
MULTIPLE MYELOMA;
NITRILES;
PYRIDINES;
UBIQUITIN THIOLESTERASE;
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EID: 84893775586
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2013.12.048 Document Type: Article |
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Times cited : (12)
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References (20)
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