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Volumn 19, Issue 23, 2011, Pages 7194-7204
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Tyrphostin-like compounds with ubiquitin modulatory activity as possible therapeutic agents for multiple myeloma
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Author keywords
Inhibitors; Jak2 Stat3; Multiple myeloma; Quantum chemical calculations; Small molecules; Synthesis; Tyrphostin analogs
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Indexed keywords
2 CYANO 3 (2 NITROPHENYL) N (1 PHENYLBUTYL)ACRYLAMIDE;
2 CYANO 3 (2,4 DINITROPHENYL) N (1 PHENYLBUTYL)ACRYLAMIDE;
2 CYANO 3 (3 NITROPHENYL) N (1 PHENYLBUTYL)ACRYLAMIDE;
2 CYANO 3 (4 NITROPHENYL) N (1 PHENYLBUTYL)ACRYLAMIDE;
2 CYANO N (CYCLOMETHYLPHENYLPROPYL) 3 (4 HEXYLPHENYL)ACRYLAMIDE;
2 CYANO N (CYCLOMETHYLPHENYLPROPYL) 3 [3 NITRO 4 (PIPERIDIN 1 YL)PHENYL]ACRYLAMIDE;
3 (4 CHLORO 3 NITROPHENYL) 2 CYANO N (CYCLOMETHYLPHENYLPROPYL)ACRYLAMIDE;
3 (6 BROMOPYRIDIN 2 YL) 2 CYANO N (1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL)ACRYLAMIDE;
3 (6 BROMOPYRIDIN 2 YL) 2 CYANO N (2 HYDROXY 1 PHENYLETHYL)ACRYLAMIDE;
3 (6 BROMOPYRIDIN 2 YL) 2 CYANO N (2 HYDROXY 1 PHENYLPROPYL)ACRYLAMIDE;
3 (6 BROMOPYRIDIN 2 YL) 2 CYANO N (2,2,2 TRIFLUORO 1 PHENYLETHYL)ACRYLAMIDE;
3 (6 BROMOPYRIDIN 2 YL) 2 CYANO N (2,3 DIHYDRO 1H INDEN 1 YL)ACRYLAMIDE;
3 (6 BROMOPYRIDIN 2 YL) 2 CYANO N (CYCLOMETHYLPHENYLPROPYL)ACRYLAMIDE;
3 (6 BROMOPYRIDIN 2 YL) 2 CYANO N [1 (2 FLUOROPHENYL)ETHYL]ACRYLAMIDE;
3 (6 BROMOPYRIDIN 2 YL) 2 CYANO N [1 (3 METHOXYPHENYL)ETHYL]ACRYLAMIDE;
3 (6 BROMOPYRIDIN 2 YL) 2 CYANO N [1 (4 FLUOROPHENYL)ETHYL]ACRYLAMIDE;
3 (6 BROMOPYRIDIN 2 YL) 2 CYANO N [1 (4 METHOXYPHENYL)ETHYL]ACRYLAMIDE;
3 (6 BROMOPYRIDIN 2 YL) 2 N [1 (4 CHLOROPHENYL)ETHYL] 2 CYANOACRYLAMIDE;
ANTINEOPLASTIC AGENT;
METHYL 3 [3 (6 BROMOPYRIDIN 2 YL) 2 CYANOACRYLAMIDO] 3 PHENYLPROPANOATE;
N (3 AMINOBENZYL) 3 (6 BROMOPYRIDIN 2 YL) 2 CYANOACRYLAMIDE;
N [1 (4 AMINOPHENYL)ETHYL] 3 (6 BROMOPYRIDIN 2 YL) 2 CYANOACRYLAMIDE;
N [1 (4 BROMOPHENYL)ETHYL] 3 (6 BROMOPYRIDIN 2 YL) 2 CYANOACRYLAMIDE;
N [1 [3,5 BIS(TRIFLUOROMETHYL)PHENYL]ETHYL] 3 (6 BROMOPYRIDIN 2 YL) 2 CYANOACRYLAMIDE;
N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE;
NUCLEOPHILE;
TYRPHOSTIN DERIVATIVE;
UBIQUITIN;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
WP 1130;
APOPTOSIS;
ARTICLE;
CANCER CELL CULTURE;
CONTROLLED STUDY;
CYCLIZATION;
DRUG ACTIVITY;
DRUG SCREENING;
DRUG STRUCTURE;
DRUG SYNTHESIS;
ELECTROPHILICITY;
IC 50;
MULTIPLE MYELOMA;
MYELOMA CELL;
SOLID PHASE SYNTHESIS;
SOLUTION PHASE SYNTHESIS;
STRUCTURE ACTIVITY RELATION;
SYNTHESIS;
THEORETICAL STUDY;
UBIQUITINATION;
ANIMALS;
ANTINEOPLASTIC AGENTS;
CELL LINE, TUMOR;
HUMANS;
JANUS KINASE 2;
MICE;
MICE, NUDE;
MODELS, MOLECULAR;
MULTIPLE MYELOMA;
SIGNAL TRANSDUCTION;
STAT3 TRANSCRIPTION FACTOR;
STRUCTURE-ACTIVITY RELATIONSHIP;
TYRPHOSTINS;
UBIQUITIN;
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EID: 80655146750
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2011.09.057 Document Type: Article |
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Times cited : (8)
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References (27)
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