Akt/Ezrin Tyr353/NF-κB pathway regulates EGF-induced EMT and metastasis in tongue squamous cell carcinoma

British Journal of Cancer

Volumn 110, Issue 3, 2014, Pages 695-705

  Wang, Y ^a   Lin, Z ^a   Sun, L ^a,b   Fan, S ^a   Huang, Z ^a   Zhang, D ^a   Yang, Z ^a   Li, J ^a,b,c   Chen, W ^a,c  

^a SUN YAT SEN UNIVERSITY   (China)

^b Guangdong Higher Education Institutes   (China)

^c Oral and Cranio maxillofacial Surgery Center   (China)

Author keywords

EMT; Ezrin; metastasis; NF kB; tongue squamous cell carcinoma

Indexed keywords

ANIMALS; CADHERINS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CYTOSKELETAL PROTEINS; EPIDERMAL GROWTH FACTOR; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; NEOPLASM METASTASIS; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TONGUE NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84893771162     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2013.770     Document Type: Article

References (40)

1. Al Moustafa AE, Achkhar A, Yasmeen A (2012) EGF-receptor signaling and epithelial-mesenchymal transition in human carcinomas. Front Biosci (School Ed) 4: 671-684.
2. Arpin M, Chirivino D, Naba A, Zwaenepoel I (2011) Emerging role for ERM proteins in cell adhesion and migration. Cell Adhes Migr 5: 199-206.
3. Baumgartner M, Sillman A, Blackwood E, Srivastava JMN, Schilling JW, Wright JH, Barber DL (2006) The Nck-interacting kinase phosphorylates ERM proteins for formation of lamellipodium by growth factors. Proc Natl Acad Sci USA 103: 13391-13396.
4. Chai KX, Cheng J-C, Auersperg N, Leung PCK (2012) EGF-induced EMT and invasiveness in serous borderline ovarian tumor cells: a possible step in the transition to low-grade serous carcinoma cells? PLoS One 7: e34071.
5. Chaudhury A, Hussey GS, Ray PS, Jin G, Fox PL, Howe PH (2010) TGF-b-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI. Nat Cell Biol 12: 286-293.
6. Chen Y, Wang D, Guo Z, Zhao J, Wu B, Deng H, Zhou T, Xiang H, Gao F, Yu X, Liao J, Ward T, Xia P, Emenari C, Ding X, Thompson W, Ma K, Zhu J, Aikhionbare F, Dou K, Cheng SY, Yao X (2011) Rho kinase phosphorylation promotes ezrin-mediated metastasis in hepatocellular carcinoma. Cancer Res 71: 1721-1729.
7. Chiang Y, Chou C, Hsu K, Huang Y, Shen M (2008) EGF upregulates Na\+/H\+ exchanger NHE1 by post-translational regulation that is important for cervical cancer cell invasiveness. J Cell Physiol 214: 810-819.
8. Chuan YC, Iglesias-Gato D, Fernandez-Perez L, Cedazo-Minguez A, Pang ST, Norstedt G, Pousette Å, Flores-Morales A (2009) Ezrin mediates c-Myc actions in prostate cancer cell invasion. Oncogene 29: 1531-1542.
9. Crepaldi TGA, Comoglio PM, Louvard D, Arpin M (1997) ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells. J Cell Biol 138: 423-434.
10. Elliott BE, Meens JA, SenGupta SK, Louvard D, Arpin M (2005) The membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells. Breast Cancer Res 7: R365.
11. Gan Y, Shi C, Inge L, Hibner M, Balducci J, Huang Y (2010) Differential roles of ERK and Akt pathways in regulation of EGFR-mediated signaling and motility in prostate cancer cells. Oncogene 29: 4947-4958.
12. Gautreau A, Poullet P, Louvard D, Arpin M (1999) Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinaseAkt pathway. Proc Natl Acad Sci USA 96: 7300-7305.
13. Gavert N, Ben-Shmuel A, Lemmon V, Brabletz T, Ben-Ze'ev A (2010) Nuclear factor-kB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells. J Cell Sci 123: 2135-2143.
14. Gupta GP, Massagué J (2006) Cancer metastasis: building a framework. Cell 127: 679-695.
15. Hardy KM, Booth BW, Hendrix MJC, Salomon DS, Strizzi L (2010) ErbB/EGF signaling and EMT in mammary development and breast cancer. J Mammary Gland Biol Neoplasia 15: 191-199.
16. Huber MA, Kraut N, Beug H (2005) Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol 17: 548-558.
17. Huber MA, Baumann B, Grünert S, Sommer A, Pehamberger H, Kraut N, Beug H, Wirth T (2004) NF-kB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J Clin Invest 114: 569-581.
18. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ (2009) Cancer statistics, 2009. CA Cancer J Clin 59: 225-249.
19. Kalluri R, Weinberg RA (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119: 1420-1428.
20. Khanna C, Wan X, Bose S, Cassaday R, Olomu O, Mendoza A, Yeung C, Gorlick R, Hewitt SM, Helman LJ (2004) The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Nat Med 10: 182-186.
21. Kudo-Saito C, Shirako H, Takeuchi T, Kawakami Y (2009) Cancer metastasis is accelerated through immunosuppression during snail-induced EMT of cancer cells. Cancer Cell 15: 195-206.
22. Kuo WC, Yang KT, Hsieh SL, Lai MZ (2009) Ezrin is a negative regulator of death receptor-induced apoptosis. Oncogene 29: 1374-1383.
23. Lim S, Ryu J, Shin JA, Shin MJ, Ahn YK, Kim JJ, Han KH (2009) Tumor necrosis factor-a potentiates RhoA-mediated monocyte transmigratory activity in vivo at a picomolar level. Arterioscler Thromb Vasc Biol 29: 2138-2145.
24. Louvet-Vallée S (2000) ERM proteins from cellular architecture to cell signaling. Biol Cell 92: 305-316.
25. Min C, Eddy SF, Sherr DH, Sonenshein GE (2008) NF-kB and epithelial to mesenchymal transition of cancer. J Cell Biochem 104: 733-744.
26. Polyak K, Weinberg RA (2009) Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 9: 265-273.
27. Ren L, Hong SH, Cassavaugh J, Osborne T, Chou AJ, Kim SY, Gorlick R, Hewitt SM, Khanna C (2008) The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC. Oncogene 28: 792-802.
28. Sánchez-Tilló E, Lázaro A, Torrent R, Cuatrecasas M, Vaquero EC, Castells A, Engel P, Postigo A (2010) ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1.Oncogene 29: 3490-3500.
29. Sano D, Myers Jeffrey N. (2007) Metastasis of squamous cell carcinoma of the oral tongue. Cancer Metast Rev 26: 645-662.
30. Shin SY, Rath O, Zebisch A, Choo SM, Kolch W, Cho KH (2010) Functional roles of multiple feedback loops in extracellular signal-regulated kinase and Wnt signaling pathways that regulate epithelial-mesenchymal transition. Cancer Res 70: 6715-6724.
31. Sizemore S, Cicek M, Sizemore N, Ng KP, Casey G (2007) Podocalyxin increases the aggressive phenotype of breast and prostate cancer cells in vitro through its interaction with ezrin. Cancer Res 67: 6183-6191.
32. Srivastava J, Elliott B, Louvard D, Arpin M (2005) Src-dependent Ezrin phosphorylation in adhesion-mediated signaling. Mol Biol Cell 16: 1481-1490.
33. Sun L, Yao Y, Liu B, Lin Z, Lin L, Yang M, Zhang W, Chen W, Pan C, Liu Q, Song E, Li J (2012) MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1. Oncogene 31: 432-445.
34. Thiery JP, Acloque H, Huang RYJ, Nieto MA (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890.
35. Thiery JP, Sleeman JP (2006) Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7: 131-142.
36. Vanacker J-M, Zheng S, Huang J, Zhou K, Zhang C, Xiang Q, Tan Z, Wang T, Fu X (2011) 17b-Estradiol enhances breast cancer cell motility and invasion via extra-nuclear activation of actin-binding protein Ezrin. PLoS One 6: e22439.
37. Vuoriluoto K, Haugen H, Kiviluoto S, Mpindi JP, Nevo J, Gjerdrum C, Tiron C, Lorens JB, Ivaska J (2010) Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer. Oncogene 30: 1436-1448.
38. Wellner U, Schubert J, Burk UC, Schmalhofer O, Zhu F, Sonntag A, Waldvogel B, Vannier C, Darling D, Az Hausen, Brunton VG, Morton J, Sansom O, Schüler J, Stemmler MP, Herzberger C, Hopt U, Keck T, Brabletz S, Brabletz T (2009) The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol 11: 1487-1495.
39. Wu Y, Deng J, Rychahou PG, Qiu S, Evers BM, Zhou BP (2009) Stabilization of Snail by NF-kB is required for inflammation-induced cell migration and invasion. Cancer Cell 15: 416-428.
40. Yip MK, Seow HF (2012) Activation of phosphatidylinositol 3-kinase/Akt signaling by EGF downregulates membranous E-cadherin and b-catenin and enhances invasion in nasopharyngeal carcinoma cells. Cancer lett 318: 162-172.