Rho kinase phosphorylation promotes ezrin-mediated metastasis in hepatocellular carcinoma

Cancer Research

Volumn 71, Issue 5, 2011, Pages 1721-1729

  Chen, Yong ^a   Wang, Dongmei ^b   Guo, Zhen ^b,d   Zhao, Jun ^a   Wu, Bing ^b   Deng, Hui ^b,d   Zhou, Ti ^a   Xiang, Hongjun ^a   Gao, Fei ^a   Yu, Xue ^b   Liao, Jian ^b,d   Ward, Tarsha ^d   Xia, Peng ^b   Emenari, Chibuzo ^d   Ding, Xia ^c   Thompson, Winston ^d   Ma, Kelong ^b   Zhu, Jingde ^b   Aikhionbare, Felix ^d   Dou, Kefen ^a   Cheng, Shi Yuan ^e   Yao, Xuebiao ^b   more..

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^c BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^d MOREHOUSE SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; EZRIN; RHO KINASE; THREONINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INVASION; CARCINOMA CELL; CELL INVASION; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MASS SPECTROMETRY; MEMBRANE; METASTASIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEOMICS; RNA INTERFERENCE; THROMBOSIS; TUMOR XENOGRAFT;

ANIMALS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CYTOSKELETAL PROTEINS; ENZYME INHIBITORS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MICE; MICE, SCID; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PHOSPHORYLATION; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79952208904     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-4683     Document Type: Article

References (27)

1. Coleman WB. Mechanisms of human hepatocarcinogenesis. Curr Mol Med 2003;3:573-88. (Pubitemid 37168599)
2. Bruix J, Boix L, Sala M, Llovet JM. Focus on hepatocellular carcinoma. Cancer Cell 2004;5:215-19. (Pubitemid 38402113)
3. Nguyen DX, Bos PD, Massagué J. Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 2009;9:274-84.
4. Fidler IJ. The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 2003;3:453-8.
5. Bretscher A, Edwards K, Fehon RG. ERM proteins and merlin: integrators at the cell cortex. Nat Rev Mol Cell Biol 2002;3:586-99.
6. Yao X, Forte JG. Cell biology of acid secretion in gastric parietal cells. Ann Rev Physiol 2003;65:103-31. (Pubitemid 38249149)
7. Yao X, Chaponnier C, Gabbiani G, Forte JG. Polarized distribution of actin isoforms in gastric parietal cells. Mol Biol Cell 1995;6:541-557.
8. Yao X, orte JG. Characterization of the interaction of gastric ezrin with actin. J Biol Chem 1996; 271:7224-29.
9. Zhou R, Cao X, Watson C, Miao Y, Guo Z, Forte JG, et al. Characterization of PKA-mediated phosphorylation of ezrin in gastric parietal cell activation. J Biol Chem 2003;278:35651-9. (Pubitemid 37102339)
10. Zhou R, Zhu L, Kodani A, Hauser P, Yao X, Forte JG. Phosphorylation of ezrin on threonine 567 produces a change in secretory phenotype and repolarizes the gastric parietal cell. J Cell Sci 2005;118:4381-91. (Pubitemid 41556337)
11. Tamura A, Kikuchi S, Hata M, Katsuno T, Matsui T, Hayashi H, et al. Achlorhydria by ezrin knockdown: defects in the formation/ expansion of apical canaliculi in gastric parietal cells. J Cell Biol 2005;169:1-8.
12. Khanna C, Wan X, Bose S, Cassaday R, Olomu O, Mendoza A, et al. The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Nat Med 2004; 10:182-6. (Pubitemid 38524889)
13. Yeh CN, Pang ST, Chen TW, Wu RC, Weng WH, Chen MF. Expression of ezrin is associated with invasion and dedifferentiation of hepatitis B related hepatocellular carcinoma. BMC Cancer 2009;9:233-41
14. Ren L, Hong SH, Cassavaugh J, Osborne T, Chou AJ, Kim SY, et al. The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC. Oncogene 2009;28:792-802.
15. Fang Z, Miao Y, Ding X, Deng H, Liu S, Wang F, et al. Proteomic identification and functional characterization of a novel ARF6 GTPase-activating protein ACAP4. Mol Cell Proteomics 2006;5: 1437-49. (Pubitemid 44323297)
16. Matsui T, Maeda M, Doi Y, Yonemura S, Amano M, Kaibuchi K, et al. Rho-kinase phosphorylates COOH-terminal threonines of ezrin/ radixin/moesin (ERM) proteins and regulates their head-to-tail association. J Cell Biol 1998;140:647-57. (Pubitemid 28134067)
17. Liu D, Ge L, Wang F, Takahashi H, Wang D, Guo Z, et al. Single-molecule detection of phosphorylation-induced plasticity changes during ezrin activation. FEBS Letters 2007;581:3563-71. (Pubitemid 47048208)
18. van 't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002;415:530-6.
19. Kang Y, Siegel PM, Shu W, Drobnjak M, Kakonen SM, Cordón-Cardo C, et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 2003;3:537-49. (Pubitemid 36808649)
20. Gupta GP, Nguyen DX, Chiang AC, Bos PD, Kim JY, Nadal C, et al. Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature 2007;446:765-70. (Pubitemid 46582040)
21. Bos PD, Zhang XH, Nadal C, Shu W, Gomis RR, Nguyen DX, et al. Genes that mediate breast cancer metastasis to the brain. Nature 2009;459:1005-9.
22. Hashimoto S, Onodera Y, Hashimoto A, Tanaka M, Hamaguchi M, Yamada A, et al. Requirement for Arf6 in breast cancer invasive activities. Proc Natl Acad Sci U S A 2004;101:6647-52. (Pubitemid 38586028)
23. Morishige M, Hashimoto S, Ogawa E, Toda Y, Kotani H, Hirose M, et al. GEP100 links epidermal growth factor receptor signaling to Arf6 activation to induce breast cancer invasion. Nat Cell Biol 2008;10:85-92.
24. Sahai E, Marshall CJ. Differing modes of tumor cell invasion have distinct requirements for Rho/ROCK signaling and extracellular proteolysis. Nat Cell Biol 2003; 5:711-19. (Pubitemid 36986778)
25. Takamura M, Sakamoto M, Genda T, Ichida T, Asakura H, Hirohashi S. Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632. Hepatology 2001;33:557-81.
26. Ding S-J, Li Y, Tang Y-X, Jiang MR, Tian B, Liu YK, et al. From proteomic analysis to clinical significance: overexpression of cytokeratin 19 correlates with hepatocellular carcinoma metastasis. Mol Cell Proteomics 2004;3:73-81. (Pubitemid 38697106)
27. Yang HS, Hinds PW. Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype. Mol Cell 2003;11:1163-76. (Pubitemid 36645137)