High methylation rate of LMX1A, NKX6-1, PAX1, PTPRR, SOX1, and ZNF582 genes in cervical adenocarcinoma

International Journal of Gynecological Cancer

Volumn 24, Issue 2, 2014, Pages 201-209

  Chang, Cheng Chang ^a,b   Huang, Rui Lan ^b,c   Wang, Hui Chen ^b   Liao, Yu Ping ^b   Yu, Mu Hsien ^a   Lai, Hung Cheng ^a,b,c  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Adenocarcinoma of the cervix; Bisulfite pyrosequencing; DNA methylation; Real time quantitative methylation specific PCR

Indexed keywords

BISULFITE; GENOMIC DNA; TRANSCRIPTION FACTOR SOX1;

ADENOCARCINOMA; ARTICLE; CONTROLLED STUDY; DNA METHYLATION; FEMALE; HUMAN; HUMAN TISSUE; LMX1A GENE; NKX6 1 GENE; ONCOGENE; PAX1 GENE; PRIORITY JOURNAL; PTPRR GENE; PYROSEQUENCING; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION SITE; UTERINE CERVIX ADENOCARCINOMA; UTERINE CERVIX CARCINOMA; ZNF582 GENE;

ADENOCARCINOMA; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; DNA METHYLATION; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LIM-HOMEODOMAIN PROTEINS; PAIRED BOX TRANSCRIPTION FACTORS; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 7; SOXB1 TRANSCRIPTION FACTORS; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS;

EID: 84893767570     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1097/IGC.0000000000000054     Document Type: Article

References (27)

1. Forouzanfar MH, Foreman KJ, Delossantos AM, et al. Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis. Lancet. 2011;378:1461-1484.
2. Wang SS, Sherman ME, Hildesheim A, et al. Cervical adenocarcinoma and squamous cell carcinoma incidence trends among white women and black women in the United States for 1976-2000. Cancer. 2004;100:1035-1044.
3. Visioli CB, Zappa M, Ciatto S, et al. Increasing trends of cervical adenocarcinoma incidence in Central Italy despite Extensive Screening Programme, 1985-2000. Cancer Detect Prev. 2004;28:461-464.
4. Bulk S, Visser O, Rozendaal L, et al. Cervical cancer in the Netherlands 1989-1998: Decrease of squamous cell carcinoma in older women, increase of adenocarcinoma in youngerwomen. Int J Cancer. 2005;113:1005-1009.
5. Sasieni P, Castanon A, Cuzick J. Screening and adenocarcinoma of the cervix. Int J Cancer. 2009;125:525-529.
6. Bosch FX, Lorincz A, Muñoz N, et al. The causal relation between human papillomavirus and cervical cancer. J Clin Pathol. 2002;55:244-265.
7. Castellsagué X, Díaz M, de Sanjosé S, et al. Worldwide human papillomavirus etiology of cervical adenocarcinoma and its cofactors: implications for screening and prevention. J Natl Cancer Inst. 2006;98:303-315.
8. Szalmás A, Kónya J. Epigenetic alterations in cervical carcinogenesis. Semin Cancer Biol. 2009;19:144-152.
9. Wilting SM, Snijders PJ, Meijer GA, et al. Increased gene copy numbers at chromosome 20q are frequent in both squamous cell carcinomas and adenocarcinomas of the cervix. J Pathol. 2006;209:220-230.
10. Sova P, Feng Q, Geiss G, et al. Discovery of novel methylation biomarkers in cervical carcinoma by global demethylation and microarray analysis. Cancer Epidemiol Biomarkers Prev. 2006;15:114-123.
11. Lai HC, Lin YW, Huang TH, et al. Identification of novel DNA methylation markers in cervical cancer. Int J Cancer. 2008;123:161-167.
12. Lai HC, Lin YW, Huang RL, et al. Quantitative DNA methylation analysis detects cervical intraepithelial neoplasms type 3 and worse. Cancer. 2010;116:4266-4274.
13. Kang S, Kim JW, Kang GH, et al. Comparison of DNA hypermethylation patterns in different types of uterine cancer: cervical squamous cell carcinoma, cervical adenocarcinoma and endometrial adenocarcinoma. Int J Cancer. 2006;118:2168-2171.
14. van der Meide WF, Snellenberg S, Meijer CJ, et al. Promoter methylation analysis of WNT/β-catenin signaling pathway regulators to detect adenocarcinoma or its precursor lesion of the cervix. Gynecol Oncol. 2011;123:116-122.
15. Su PH, Lin YW, Huang RL, et al. Epigenetic silencing of PTPRR activates MAPK signaling, promotes metastasis and serves as a biomarker of invasive cervical cancer. Oncogene. 2013;32:15-26.
16. Huang RL, Chang CC, Su PH, et al. Methylomic analysis identifies frequent DNA methylation of zinc finger protein 582 (ZNF582) in cervical neoplasms. PLoS One. 2012;7:e41060.
17. Chu TY, Hwang KS, Yu MH, et al. A research-based tumor tissue bank of gynecologic oncology: characteristics of nucleic acids extracted from normal and tumor tissues from different sites. Int J Gynecol Cancer. 2002;12:171-176.
18. Liu CY, Chao TK, Su PH, et al. Characterization of LMX-1A as a metastasis suppressor in cervical cancer. J Pathol. 2009;219:222-231.
19. Ekonomou A, Kazanis I, Malas S, et al. Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1. PLoS Biol. 2005;3:e186.
20. Robson EJ, He SJ, Eccles MR. A PANorama of PAX genes in cancer and development. Nat Rev Cancer. 2006;6:52-62.
21. Fukuda H, Takahashi J, Watanabe K, et al. Fluorescenceactivated cell sorting-based purification of embryonic stem cell-derived neural precursors averts tumor formation after transplantation. Stem Cells. 2006;24:763-771.
22. Nguyen LV, Vanner R, Dirks P, et al. Cancer stem cells: an evolving concept. Nat Rev Cancer. 2012;12:133-143.
23. Todaro M, Lombardo Y, Stassi G. Evidences of cervical cancer stem cells derived from established cell lines. Cell Cycle. 2010;9:1238-1239.
24. Steenbergen RD, Ongenaert M, Snellenberg S, et al. Methylation-specific digital karyotyping of HPV16E6E7-expressing human keratinocytes identifies novel methylation events in cervical carcinogenesis. J Pathol. 2013;231:53-62.
25. Tsao CM, Yan MD, Shih YL, et al. SOX1 functions as a tumor suppressor by antagonizing the WNT/β-catenin signaling pathway in hepatocellular carcinoma. Hepatology. 2012;56:2277-2287.
26. Huang TH, Lai HC, Liu HW, et al. Quantitative analysis of methylation status of the PAX1 gene for detection of cervical cancer. Int J Gynecol Cancer. 2010;20:513-519.
27. Chao TK, Ke FY, Liao YP, et al. Triage of cervical cytological diagnoses of atypical squamous cells by DNA methylation of paired boxed gene 1 (PAX1). Diagn Cytopathol. 2013;41:41-46.