Quantitative analysis of methylation status of the PAX1 gene for detection of cervical cancer

International Journal of Gynecological Cancer

Volumn 20, Issue 4, 2010, Pages 513-519

  Huang, Tien Hung ^a,b   Lai, Hung Chen ^c,d   Liu, Hwan Wun ^b   Lin, Cuei Jyuan ^a,b   Wang, Kai Hung ^a,b   Ding, Dah Ching ^b   Chu, Tang Yuan ^a,b  

^a Department of Research   (Turkey)

^b TZU CHI UNIVERSITY   (Taiwan)

^c TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^d NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Cervical cancer; DNA methylation; Field methylation; HPV test; PAX1

Indexed keywords

PAIRED BOX TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PAX1; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CANCER INVASION; CANCER SCREENING; CARCINOGENESIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DISEASE SEVERITY; DNA METHYLATION; FEMALE; HUMAN; HUMAN TISSUE; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; UTERINE CERVIX BIOPSY; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA IN SITU; WART VIRUS;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CERVICAL INTRAEPITHELIAL NEOPLASIA; CERVIX UTERI; DNA METHYLATION; DNA, VIRAL; FEMALE; HUMANS; MIDDLE AGED; PAIRED BOX TRANSCRIPTION FACTORS; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; POLYMERASE CHAIN REACTION; PROGNOSIS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS; VAGINAL SMEARS; YOUNG ADULT;

EID: 77952277597     PISSN: 1048891X     EISSN: None     Source Type: Journal    
DOI: 10.1111/IGC.0b013e3181c7fe6e     Document Type: Article

References (31)

1. Parkin DM. The global health burden of infection-associated cancers in the year 2002. Int J Cancer. 2006;118:3030-3044.
2. Levi AW, Kelly DP, Rosenthal DL, et al. Atypical squamous cells of undetermined significance in liquid-based cytologic specimens: results of reflex human papillomavirus testing and histologic follow-up in routine practice with comparison of interpretive and probabilistic reporting methods. Cancer. 2003;99:191-197.
3. Huang YK, You SL, Yuan CC, et al. Long-term outcomes of high-risk human papillomavirus infection support a long interval of cervical cancer screening. Br J Cancer. 2008;98:863-869.
4. Dillner J, Rebolj M, Birembaut P, et al. Long term predictive values of cytology and human papillomavirus testing in cervical cancer screening: joint European cohort study. BMJ. 2008;337: a1754.
5. Jones P, Laird P. Cancer epigenetics comes of age. Nat Genet. 1999;21:163-167.
6. Jones PA, Baylin SB. The epigenomics of cancer. Cell. 2007;128:683-692.
7. Steenbergen RD, Kramer D, Braakhuis BJ, et al. TSLC1 gene silencing in cervical cancer cell lines and cervical neoplasia. J Natl Cancer Inst. 2004;96:294-305.
8. Feng Q, Balasubramanian A, Hawes SE, et al. Detection of hypermethylated genes in women with and without cervical neoplasia. J Natl Cancer Inst. 2005;97:273-282.
9. Lai HC, Lin YW, Chang CC, et al. Hypermethylation of two consecutive tumor suppressor genes, BLU and RASSF1A, located at 3p21.3 in cervical neoplasias. Gynecol Oncol. 2007;104:629-635.
10. Kahn SL, Ronnett BM, Gravitt PE, et al. Quantitative methylation-specific PCR for the detection of aberrant DNA methylation in liquid-based Pap tests. Cancer. 2008;114:57-64.
11. Lai H, Lin Y, Huang T, et al. Identification of novel DNA methylation markers in cervical cancer. Int J Cancer. 2008;123:161-167.
12. McGaughran JM, Oates A, Donnai D, et al. Mutations in PAX1 may be associated with Klippel-Feil syndrome. Eur J Hum Genet. 2003;11:468-474.
13. Wallin J, Eibel H, Neubuser A, et al. Pax1 is expressed during development of the thymus epithelium and is required for normal T-cell maturation. Development. 1996;122:23-30.
14. Schnittger S, Rao V, Deutsch U, et al. Pax1, a member of the paired box-containing class of developmental control genes, is mapped to human chromosome 20p11.2 by in situ hybridization (ISH and FISH). Genomics. 1992;14:740-744.
15. Su HY, Lai HC, Lin YW, et al. An epigenetic marker panel for screening and prognostic prediction of ovarian cancer. Int J Cancer. 2009;124:387-393.
16. Eads C, Danenberg K, Kawakami K, et al. MethyLight: a high-throughput assay to measure DNA methylation. Nucleic Acids Res. 2000;28: E32.
17. Ogino S, Kawasaki T, Brahmandam M, et al. Precision and performance characteristics of bisulfite conversion and real-time PCR (MethyLight) for quantitative DNA methylation analysis. J Mol Diagn. 2006;8:209-217.
18. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001;29: e45.
19. Lang D, Powell SK, Plummer RS, et al. PAX genes: roles in development, pathophysiology, and cancer. Biochem Pharmacol. 2007;73:1-14.
20. Galindo RL, Allport JA, Olson EN. A Drosophila model of the rhabdomyosarcoma initiator PAX7-FKHR. Proc Natl Acad Sci U S A. 2006;103:13439-13444.
21. Souabni A, Jochum W, Busslinger M. Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus. Blood. 2007;109:281-289.
22. Robson EJ, He SJ, Eccles MR. A PANorama of PAX genes in cancer and development. Nat Rev Cancer. 2006;6:52-62.
23. Zhou YH, Tan F, Hess KR, et al. The expression of PAX6, PTEN, vascular endothelial growth factor, and epidermal growth factor receptor in gliomas: relationship to tumor grade and survival. Clin Cancer Res. 2003;9:3369-3375.
24. Gerber JK, Richter T, Kremmer E, et al. Progressive loss of PAX9 expression correlates with increasing malignancy of dysplastic and cancerous epithelium of the human oesophagus. J Pathol. 2002;197:293-297.
25. Zhou YH, Wu X, Tan F, et al. PAX6 suppresses growth of human glioblastoma cells. J Neurooncol. 2005;71:223-229.
26. Hata S, Hamada J, Maeda K, et al. PAX4 has the potential to function as a tumor suppressor in human melanoma. Int J Oncol. 2008;33:1065-1071.
27. Coleman WB, Rivenbark AG. Quantitative DNA methylation analysis: the promise of high-throughput epigenomic diagnostic testing in human neoplastic disease. J Mol Diagn. 2006;8:152-156.
28. Wang KH, Liu HW, Lin SR, et al. Field methylation silencing of the protocadherin 10 gene in cervical carcinogenesis as a potential specific diagnostic test from cervical scrapings. Cancer Sci. 2009;100:2175-2180.
29. Hanson JA, Gillespie JW, Grover A, et al. Gene promoter methylation in prostate tumorYassociated stromal cells. J Natl Cancer Inst. 2006;98:255-261.
30. Jones PA, Baylin SB. The epigenomics of cancer. Cell. 2007;128:683-692.
31. Huang Y, You S, Yuan C, et al. Long-term outcomes of high-risk human papillomavirus infection support a long interval of cervical cancer screening. Br J Cancer. 2008;98:863-869.